Genotype-Phenotype Map Characteristics of an In silico Heart Cell

scientific article (publication date: 2011)

Genotype-Phenotype Map Characteristics of an In silico Heart Cell is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FPHYS.2011.00106
P932PMC publication ID3246639
P698PubMed publication ID22232604
P5875ResearchGate publication ID221736058

P50authorPeter HunterQ21165168
Jon Olav VikQ41047870
Steven NiedererQ50080157
Arne B GjuvslandQ63184870
P2093author name stringNicolas P Smith
Stig W Omholt
Liren Li
Kristin Tøndel
P2860cites workBioModels Database: a free, centralized database of curated, published, quantitative kinetic models of biochemical and cellular systemsQ25255639
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Nonlinear regulation enhances the phenotypic expression of trans-acting genetic polymorphismsQ33291673
Threshold-dominated regulation hides genetic variation in gene expression networksQ33308922
Allele interaction--single locus genetics meets regulatory biologyQ33534703
A mathematical model of the murine ventricular myocyte: a data-driven biophysically based approach applied to mice overexpressing the canine NCX isoformQ33639827
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Nonlinear developmental processes as sources of dominanceQ33954727
A vision and strategy for the virtual physiological human in 2010 and beyond.Q34150028
Ionic charge conservation and long-term steady state in the Luo-Rudy dynamic cell modelQ34177010
hERG potassium channels and cardiac arrhythmiaQ34504394
Gene regulatory networks generating the phenomena of additivity, dominance and epistasis.Q34609611
The rise of computational biologyQ34664811
Genetics and arrhythmiasQ35044190
Statistical epistasis is a generic feature of gene regulatory networksQ35598444
Pharmacogenetics and cardiac ion channelsQ36339192
When parameters in dynamic models become phenotypes: a case study on flesh pigmentation in the chinook salmon (Oncorhynchus tshawytscha).Q36724294
An improved numerical method for strong coupling of excitation and contraction models in the heartQ36946189
Mouse, man, and meaning: bridging the semantics of mouse phenotype and human diseaseQ37380310
Coupling multi-physics models to cardiac mechanics.Q37633660
Sensitivity of NFAT cycling to cytosolic calcium concentration: implications for hypertrophic signals in cardiac myocytesQ39872361
The selective values of alleles in a molecular network model are context dependent.Q41863973
Genetics. Life after GWA studiesQ42431997
A meta-analysis of cardiac electrophysiology computational models.Q44630361
The CellML Model RepositoryQ45357709
Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 geneQ46071152
Computer model of action potential of mouse ventricular myocytes.Q47606383
High-throughput functional curation of cellular electrophysiology modelsQ49128735
P4510describes a project that usesggplot2Q326489
P407language of work or nameEnglishQ1860
P921main subjectphenotypeQ104053
in silicoQ192572
P304page(s)106
P577publication date2011-12-28
P1433published inFrontiers in PhysiologyQ2434141
P1476titleGenotype-Phenotype Map Characteristics of an In silico Heart Cell
P478volume2

Reverse relations

cites work (P2860)
Q38080836Bridging the genotype-phenotype gap: what does it take?
Q35557637Cell-specific cardiac electrophysiology models
Q34720263Effect of regulatory architecture on broad versus narrow sense heritability
Q33833167Insight into model mechanisms through automatic parameter fitting: a new methodological framework for model development.
Q38050130Interpreting genetic effects through models of cardiac electromechanics
Q30527792Multi-way metamodelling facilitates insight into the complex input-output maps of nonlinear dynamic models
Q34229563Parameters in dynamic models of complex traits are containers of missing heritability.
Q46802128Quantifying inter-species differences in contractile function through biophysical modelling
Q40442620Towards causally cohesive genotype-phenotype modelling for characterization of the soft-tissue mechanics of the heart in normal and pathological geometries.
Q38851199Using a system of differential equations that models cattle growth to uncover the genetic basis of complex traits.
Q34325461Virtual patients and sensitivity analysis of the Guyton model of blood pressure regulation: towards individualized models of whole-body physiology

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