Increased breadth and depth of cytotoxic T lymphocytes responses against HIV-1-B Nef by inclusion of epitope variant sequences

scientific article (publication date: 28 March 2011)

Increased breadth and depth of cytotoxic T lymphocytes responses against HIV-1-B Nef by inclusion of epitope variant sequences is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2011PLoSO...617969R
P356DOI10.1371/JOURNAL.PONE.0017969
P932PMC publication ID3065451
P698PubMed publication ID21464919
P5875ResearchGate publication ID51000157

P50authorJames MullinsQ57555076
David C. NickleQ106615189
Christian BranderQ42392436
P2093author name stringMorgane Rolland
Todd M Allen
Nicole Frahm
Nebojsa Jojic
Wenjie Deng
David E Heckerman
P2860cites workA Mathematical Theory of CommunicationQ724029
Computer aids to protein sequence determinationQ72681354
Recognition of variant HIV-1 epitopes from diverse viral subtypes by vaccine-induced CTLQ80363097
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Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndromeQ24648628
The influence of HLA genotype on AIDSQ28202903
Reconstruction and Function of Ancestral Center-of-Tree Human Immunodeficiency Virus Type 1 ProteinsQ29010789
Coping with viral diversity in HIV vaccine designQ33283060
HIV-1 group M conserved elements vaccineQ33308246
Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeysQ33712291
Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeysQ33712578
HLA-B63 presents HLA-B57/B58-restricted cytotoxic T-lymphocyte epitopes and is associated with low human immunodeficiency virus loadQ33911914
Cellular immune responses to HIV.Q34223069
Selection on the human immunodeficiency virus type 1 proteome following primary infectionQ35101338
Consistent cytotoxic-T-lymphocyte targeting of immunodominant regions in human immunodeficiency virus across multiple ethnicitiesQ36954486
HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case-cohort analysisQ37413781
Design, expression, and processing of epitomized hepatitis C virus-encoded CTL epitopesQ39926728
The flexibility of the TCR allows recognition of a large set of naturally occurring epitope variants by HIV-specific cytotoxic T lymphocytesQ40795693
Long-term survivors of HIV-1 infectionQ40947468
Human immunodeficiency virus type 1 (HIV-1)-specific T cell responses correlate with control of acute HIV-1 infection in macaquesQ41080755
Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infectionQ43542210
Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants.Q51926211
Quantitation of HIV-1-Specific Cytotoxic T Lymphocytes and Plasma Load of Viral RNAQ56930699
CD8+ T-cell responses to different HIV proteins have discordant associations with viral loadQ57259602
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectcytotoxicityQ246181
P304page(s)e17969
P577publication date2011-03-28
P1433published inPLOS OneQ564954
P1476titleIncreased breadth and depth of cytotoxic T lymphocytes responses against HIV-1-B Nef by inclusion of epitope variant sequences
P478volume6

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cites work (P2860)
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Q40485544A study of vaccine-induced immune pressure on breakthrough infections in the Phambili phase 2b HIV-1 vaccine efficacy trial
Q34490157Autologous HIV-1 clade-B Nef peptides elicit increased frequency, breadth and function of CD8+ T-cells compared to consensus peptides
Q34414726CD8 and CD4 epitope predictions in RV144: no strong evidence of a T-cell driven sieve effect in HIV-1 breakthrough sequences from trial participants.
Q90436552Co-morbidities of HIV infection: role of Nef-induced impairment of cholesterol metabolism and lipid raft functionality
Q35927376Conservation analysis of dengue virus T-cell epitope-based vaccine candidates using Peptide block entropy
Q36414604Correlates of protective cellular immunity revealed by analysis of population-level immune escape pathways in HIV-1.
Q54269440Cross-reactive microbial peptides can modulate HIV-specific CD8+ T cell responses.
Q37967232Current status and perspectives of plant-based candidate vaccines against the human immunodeficiency virus (HIV).
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Q34653619HIV-1 p24(gag) derived conserved element DNA vaccine increases the breadth of immune response in mice
Q34055991Intra- and inter-clade cross-reactivity by HIV-1 Gag specific T-cells reveals exclusive and commonly targeted regions: implications for current vaccine trials
Q34984237Nef-specific CD8+ T cell responses contribute to HIV-1 immune control
Q41169502The APPEESFRS Peptide, Restricted by the HLA-B*35:01 Molecule, and the APPEESFRF Variant Derived from an Autologous HIV-1 Strain Induces Polyfunctional Responses in CD8+ T Cells.

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