Clostridium perfringens epsilon toxin targets granule cells in the mouse cerebellum and stimulates glutamate release

scientific article (publication date: 30 September 2010)

Clostridium perfringens epsilon toxin targets granule cells in the mouse cerebellum and stimulates glutamate release is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2010PLoSO...513046L
P356DOI10.1371/JOURNAL.PONE.0013046
P932PMC publication ID2948003
P698PubMed publication ID20941361
P5875ResearchGate publication ID47404640

P50authorFrédéric DoussauQ48495294
P2093author name stringJean-Luc Dupont
Michel R Popoff
Jean de Barry
Bernard Poulain
Emmanuel Jover
Jean-Louis Bossu
Etienne Lonchamp
Corinne Mbebi-Liegeois
Raphaël Courjaret
Laetitia Wioland
P2860cites workClostridium perfringens epsilon-toxin shows structural similarity to the pore-forming toxin aerolysinQ28272468
Calbindin in cerebellar Purkinje cells is a critical determinant of the precision of motor coordinationQ28508875
Intermediate filaments: structure, dynamics, function, and diseaseQ29615442
Neurotoxicity of Clostridium perfringens epsilon-toxin for the rat hippocampus via the glutamatergic system.Q32063141
Clostridium perfringens epsilon toxin increases the small intestinal permeability in mice and ratsQ33504574
Clostridium perfringens epsilon-toxin increases permeability of single perfused microvessels of rat mesenteryQ33946914
Cellular and subcellular distribution of 2',3'-cyclic nucleotide 3'-phosphodiesterase and its mRNA in the rat central nervous system.Q52250537
Functional Implication of Neuronal Calcium Sensor-1 and Phosphoinositol 4-Kinase-β Interaction in Regulated Exocytosis of PC12 CellsQ58423720
Clostridium perfringens epsilon toxin causes excessive release of glutamate in the mouse hippocampusQ74063723
High sensitivity of mouse neuronal cells to tetanus toxin requires a GPI-anchored proteinQ34102597
The identification and structure of the membrane-spanning domain of the Clostridium septicum alpha toxinQ34289001
Microbiological, biological, and chemical weapons of warfare and terrorismQ34695957
Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animalQ35836597
Development and application of an oral challenge mouse model for studying Clostridium perfringens type D infectionQ35947178
Clostridium perfringens epsilon-toxin forms a heptameric pore within the detergent-insoluble microdomains of Madin-Darby canine kidney cells and rat synaptosomesQ38363668
Identification of the channel-forming domain of Clostridium perfringens Epsilon-toxin (ETX).Q39786707
Clostridium perfringens epsilon-toxin acts on MDCK cells by forming a large membrane complexQ39847606
Pore-forming epsilon toxin causes membrane permeabilization and rapid ATP depletion-mediated cell death in renal collecting duct cells.Q40120089
High-affinity binding of Clostridium perfringens epsilon-toxin to rat brain.Q40149063
Purification and characterization of Clostridium sordellii lethal toxin and cross-reactivity with Clostridium difficile cytotoxin.Q40162220
In-Vitro Effects of Clostridium Welchii Type-D Epsilon Toxin on Guinea-Pig, Mouse, Rabbit and Sheep CellsQ40166883
Changes in ganglioside content affect the binding of Clostridium perfringens epsilon-toxin to detergent-resistant membranes of Madin-Darby canine kidney cells.Q40444007
Clostridium perfringens epsilon toxin rapidly decreases membrane barrier permeability of polarized MDCK cellsQ40667038
Cleavage of a C-terminal peptide is essential for heptamerization of Clostridium perfringens epsilon-toxin in the synaptosomal membraneQ40816552
Clostridium perfringens epsilon toxin induces a rapid change of cell membrane permeability to ions and forms channels in artificial lipid bilayersQ40816853
Evaluation of a new cytotoxicity assay for Clostridium perfringens type D epsilon toxinQ41487737
Deletion of Cav2.1(alpha1(A)) subunit of Ca2+-channels impairs synaptic GABA and glutamate release in the mouse cerebellar cortex in cultured slices.Q43187050
The predominant neural stem cell isolated from postnatal and adult forebrain but not early embryonic forebrain expresses GFAP.Q43483505
Dynamics of membrane lipid domains in neuronal cells differentiated in cultureQ44535897
Immunocytochemical Localization of Synaptophysin on the Smooth-Surfaced Tubular Membranes Present in Nerve Terminal and Preterminal Areas in the Rat Cerebellar CortexQ44648756
The pathology of peracute experimental Clostridium perfringens type D enterotoxemia in sheepQ45087351
Diagnosis of Clostridium perfringens intestinal infections in sheep and goats.Q45976581
Riluzole blocks persistent Na+ and Ca2+ currents and modulates release of glutamate via presynaptic NMDA receptors on neonatal rat hypoglossal motoneurons in vitroQ46620497
Binding of epsilon-toxin from Clostridium perfringens in the nervous systemQ46649465
Oligomerization of Clostridium perfringens epsilon-toxin is dependent upon membrane fluidity in liposomesQ46875807
Localization of synapsin-I and PSD-95 in developing postnatal rat cerebellar cortexQ47217634
Effect of epsilon toxin-GFP on MDCK cells and renal tubules in vivoQ47316006
A syntaxin 1, Galpha(o), and N-type calcium channel complex at a presynaptic nerve terminal: analysis by quantitative immunocolocalization.Q47717695
GABAA receptor subtypes expressed in cerebellar granule cells: a developmental studyQ48127724
Distribution of Clostridium perfringens epsilon toxin in the brains of acutely intoxicated mice and its effect upon glial cells.Q48134712
Synaptotagmin I and II are present in distinct subsets of central synapses.Q48173416
Neuronal damage produced in rat brains by Clostridium perfringens type D epsilon toxinQ48234011
Alzheimer's disease proteins in cerebellar and hippocampal synapses during postnatal development and aging of the rat.Q48239128
Effect of drugs acting on the central nervous system on the lethality in mice of Clostridium perfringens epsilon toxinQ48316116
Synaptic organization of the mouse cerebellar cortex in organotypic slice culturesQ48353134
Neurological disorders produced by Clostridium perfringens type D epsilon toxinQ48539176
Histopathological changes in the brain of mice given Clostridium perfringens type D epsilon toxinQ48655147
Differences in the cellular distributions of two microtubule-associated proteins, MAP1 and MAP2, in rat brainQ48694483
Clostridium perfringens prototoxin-induced alteration of endothelial barrier antigen (EBA) immunoreactivity at the blood-brain barrier (BBB).Q48907607
The potassium channel subunit KV3.1b is localized to somatic and axonal membranes of specific populations of CNS neuronsQ49049978
Organotypic monolayer cultures of nervous tissueQ49146386
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectcerebellumQ130983
Clostridium perfringensQ309465
P304page(s)e13046
P577publication date2010-09-30
P1433published inPLOS OneQ564954
P1476titleClostridium perfringens epsilon toxin targets granule cells in the mouse cerebellum and stimulates glutamate release
P478volume5

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cites work (P2860)
Q41335191Acute Effect of Pore-Forming Clostridium perfringens ε-Toxin on Compound Action Potentials of Optic Nerve of Mouse.
Q39075039Bacterial Signaling to the Nervous System through Toxins and Metabolites
Q35801837Clostridium Perfringens Epsilon Toxin Binds to Membrane Lipids and Its Cytotoxic Action Depends on Sulfatide
Q35753667Clostridium perfringens Epsilon Toxin Causes Selective Death of Mature Oligodendrocytes and Central Nervous System Demyelination
Q64055465Clostridium perfringens Epsilon Toxin Compromises the Blood-Brain Barrier in a Humanized Zebrafish Model
Q26859117Clostridium perfringens epsilon toxin: a malevolent molecule for animals and man?
Q27676861Clostridium perfringensepsilon toxin H149A mutant as a platform for receptor binding studies
Q35205240Correlation between in vitro cytotoxicity and in vivo lethal activity in mice of epsilon toxin mutants from Clostridium perfringens
Q36314027Does the Gut Microbiota Influence Immunity and Inflammation in Multiple Sclerosis Pathophysiology?
Q92631085Epsilon Toxin from Clostridium perfringens Causes Inhibition of Potassium inward Rectifier (Kir) Channels in Oligodendrocytes
Q48495233Epsilon toxin from Clostridium perfringens acts on oligodendrocytes without forming pores, and causes demyelination
Q30155565Epsilon toxin: a fascinating pore-forming toxin
Q33981454Evidence for a prepore stage in the action of Clostridium perfringens epsilon toxin
Q64330488Evidence of Clostridium perfringens epsilon toxin associated with multiple sclerosis
Q38901609F199E substitution reduced toxicity of Clostridium perfringens epsilon toxin by depriving the receptor binding capability
Q93080054Fusaricidin-Type Compounds Create Pores in Mitochondrial and Plasma Membranes of Mammalian Cells
Q35245013Gut microbiome and multiple sclerosis.
Q48287722Host response to intravenous injection of epsilon toxin in mouse model: a proteomic view
Q47102802Immunological and Clinical Effect of Diet Modulation of the Gut Microbiome in Multiple Sclerosis Patients: A Pilot Study
Q57823983Internalization of staphylococcal leukotoxins that bind and divert the C5a receptor is required for intracellular Ca2+mobilization by human neutrophils
Q54203079Mechanisms of Action and Cell Death Associated with Clostridium perfringens Toxins.
Q37868758Molecular basis of toxicity of Clostridium perfringens epsilon toxin
Q37907307Multifaceted interactions of bacterial toxins with the gastrointestinal mucosa
Q33992094Prevention and treatment of Clostridium perfringens epsilon toxin intoxication in mice with a neutralizing monoclonal antibody (c4D7) produced in Nicotiana benthamiana.
Q34346202Role of pore-forming toxins in bacterial infectious diseases
Q28703620Staphylococcal leukotoxins trigger free intracellular Ca(2+) rise in neurones, signalling through acidic stores and activation of store-operated channels
Q61965812The Cytotoxicity of Epsilon Toxin from Clostridium perfringens on Lymphocytes Is Mediated by MAL Protein Expression
Q27319992The Myelin and Lymphocyte Protein MAL Is Required for Binding and Activity of Clostridium perfringens ε-Toxin

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