The synthetic bacterial lipopeptide Pam3CSK4 modulates respiratory syncytial virus infection independent of TLR activation

scientific article (publication date: 19 August 2010)

The synthetic bacterial lipopeptide Pam3CSK4 modulates respiratory syncytial virus infection independent of TLR activation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PPAT.1001049
P932PMC publication ID2924323
P698PubMed publication ID20808895
P5875ResearchGate publication ID46108641

P50authorAb OsterhausQ354237
Martin LudlowQ50577313
Rik L. de SwartQ50577322
Teunis B H GeijtenbeekQ92124021
Selma YükselQ101974310
P2093author name stringLot de Witte
Karl-Heinz Wiesmüller
D Tien Nguyen
P2860cites workCrystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptideQ24294695
Semen-derived amyloid fibrils drastically enhance HIV infectionQ24303668
Charged polymers modulate retrovirus transduction via membrane charge neutralization and virus aggregationQ24537755
Bovine respiratory syncytial virus infection of bovine embryonic lung cultures: Enhancement of infectivity with diethylaminoethyl-dextran and virus-infected cellsQ45890578
Functional T-cell responses generated by dendritic cells expressing the early HIV-1 proteins Tat, Rev and Nef.Q46301219
Toll-like receptor 2 is expressed by alveolar epithelial cells type II and macrophages in the human lungQ47565059
Ménage à trois of bacterial and viral pulmonary pathogens delivers coup de grace to the lungQ47968886
A novel method for isolating dendritic cells from human bronchoalveolar lavage fluidQ57920525
Seasonal Invasive Pneumococcal Disease in Children: Role of Preceding Respiratory Viral InfectionQ59201102
DEAE-dextran and polybrene cation enhancement and dextran sulfate anion inhibition of immune cytolysisQ68650242
Interaction of the lymphoid cell line BCL1 with lipopeptide analogues of bacterial lipoprotein: electron energy loss spectroscopy (EELS) as a novel method to detect the distribution of the activator within the cellsQ69447982
Mammalian Toll-like receptorsQ78699977
Toll-like receptor 2 agonist Pam3CSK4 enhances the induction of antigen-specific tolerance via the sublingual routeQ81678378
Neisseria gonorrhoeae enhances infection of dendritic cells by HIV type 1Q81827397
Toll-like receptors and innate immunityQ84418644
Structural basis of viral invasion: lessons from paramyxovirus FQ27481675
Iduronic acid-containing glycosaminoglycans on target cells are required for efficient respiratory syncytial virus infectionQ28138786
Respiratory syncytial virus infectionQ33732334
Respiratory viral infection predisposing for bacterial disease: a concise reviewQ33780896
Glycosaminoglycan sulfation requirements for respiratory syncytial virus infectionQ33787265
The role of respiratory viruses in otitis mediaQ34133026
SLAM (CD150)-independent measles virus entry as revealed by recombinant virus expressing green fluorescent proteinQ34340783
Respiratory syncytial virus: reverse genetics and vaccine strategiesQ34690910
Gram-positive bacteria enhance HIV-1 susceptibility in Langerhans cells, but not in dendritic cells, via Toll-like receptor activationQ34961152
Innate sensing of viruses by toll-like receptorsQ35836607
Human metapneumovirus and severity of respiratory syncytial virus diseaseQ35880975
Interaction between respiratory syncytial virus and glycosaminoglycans, including heparan sulfateQ36821865
TNF-alpha and TLR agonists increase susceptibility to HIV-1 transmission by human Langerhans cells ex vivoQ36861237
The contribution of toll-like receptors to the pathogenesis of asthmaQ36902820
The cationic properties of SEVI underlie its ability to enhance human immunodeficiency virus infectionQ37033246
TLR2 and TLR4 triggering exerts contrasting effects with regard to HIV-1 infection of human dendritic cells and subsequent virus transfer to CD4+ T cellsQ37215125
Respiratory syncytial virus-induced dysregulation of expression of a mucosal beta-defensin augments colonization of the upper airway by non-typeable Haemophilus influenzaeQ37340656
The CC-chemokine RANTES increases the attachment of human immunodeficiency virus type 1 to target cells via glycosaminoglycans and also activates a signal transduction pathway that enhances viral infectivityQ39595163
Chirality of TLR-2 ligand Pam3CysSK4 in fully synthetic peptide conjugates critically influences the induction of specific CD8+ T-cellsQ39913089
Klebsiella pneumoniae increases the levels of Toll-like receptors 2 and 4 in human airway epithelial cellsQ39915508
Staphylococcus aureus-induced plasmacytoid dendritic cell activation is based on an IgG-mediated memory responseQ39943911
TLR2 signaling renders quiescent naive and memory CD4+ T cells more susceptible to productive infection with X4 and R5 HIV-type 1.Q40079013
Respiratory viruses augment the adhesion of bacterial pathogens to respiratory epithelium in a viral species- and cell type-dependent manner.Q40324555
In vivo tropism of attenuated and pathogenic measles virus expressing green fluorescent protein in macaques.Q40339180
Antagonistic antibody prevents toll-like receptor 2-driven lethal shock-like syndromesQ40555496
Inhibition of respiratory syncytial virus infection with the CC chemokine RANTES (CCL5).Q40560128
Enhanced adherence of Streptococcus pneumoniae to human epithelial cells infected with respiratory syncytial virusQ40563862
Enhancement of human immunodeficiency virus type 1 infection by cationic liposomes: the role of CD4, serum and liposome-cell interactionsQ41657413
The predominance of CD8+ T cells after infection with measles virus suggests a role for CD8+ class I MHC-restricted cytotoxic T lymphocytes (CTL) in recovery from measles. Clonal analyses of human CD8+ class I MHC-restricted CTL.Q41944154
Distinct uptake mechanisms but similar intracellular processing of two different toll-like receptor ligand-peptide conjugates in dendritic cellsQ42618400
Pulmonary and systemic bacterial co-infections in severe RSV bronchiolitisQ43099663
Severe pneumococcal pneumonia in previously healthy children: the role of preceding influenza infectionQ43812278
Association of respiratory virus activity and environmental factors with the incidence of invasive pneumococcal diseaseQ44050066
Direct binding of respiratory syncytial virus to pneumococci: a phenomenon that enhances both pneumococcal adherence to human epithelial cells and pneumococcal invasiveness in a murine modelQ45140053
Toll-like receptor 6-independent signaling by diacylated lipopeptidesQ45174439
Invasive pneumococcal and meningococcal disease: association with influenza virus and respiratory syncytial virus activity?Q45397635
An improved plaque reduction virus neutralization assay for human metapneumovirusQ45405370
Dual infection of infants by human metapneumovirus and human respiratory syncytial virus is strongly associated with severe bronchiolitis.Q45528390
A role for Streptococcus pneumoniae in virus-associated pneumoniaQ45615871
Recovery from infants with respiratory illness of a virus related to chimpanzee coryza agent (CCA). II. Epidemiologic aspects of infection in infants and young children.Q45719599
Recovery from infants with respiratory illness of a virus related to chimpanzee coryza agent (CCA). I. Isolation, properties and characterization.Q45719601
Association of respiratory syncytial virus and Streptococcus pneumoniae infection in young infants.Q45831689
Demonstration of Respiratory Syncytial Virus in an Autopsy SeriesQ45860216
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue8
P407language of work or nameEnglishQ1860
P921main subjecttoll-like receptorQ408004
P304page(s)e1001049
P577publication date2010-08-19
P1433published inPLOS PathogensQ283209
P1476titleThe synthetic bacterial lipopeptide Pam3CSK4 modulates respiratory syncytial virus infection independent of TLR activation
P478volume6

Reverse relations

cites work (P2860)
Q34669410Activation of human macrophages by bacterial components relieves the restriction on replication of an interferon-inducing parainfluenza virus 5 (PIV5) P/V mutant
Q91656519Anti-Respiratory Syncytial Virus Activity of Plantago asiatica and Clerodendrum trichotomum Extracts In Vitro and In Vivo
Q64359245Bacterial flagellin promotes viral entry via an NF-kB and Toll Like Receptor 5 dependent pathway
Q35592017Bovine immunoglobulin/protein isolate binds pro-inflammatory bacterial compounds and prevents immune activation in an intestinal co-culture model
Q39512759CLEC-2 signaling via Syk in myeloid cells can regulate inflammatory responses
Q38702032Coptidis Rhizoma extract inhibits replication of respiratory syncytial virus in vitro and in vivo by inducing antiviral state.
Q36365747Delineating morbillivirus entry, dissemination and airborne transmission by studying in vivo competition of multicolor canine distemper viruses in ferrets.
Q91554678Effectiveness of the ten-valent pneumococcal Haemophilus influenzae protein D conjugate vaccine (PHiD-CV10) against all respiratory tract infections in children under two years of age
Q34452601Effects of over-expression of TLR2 in transgenic goats on pathogen clearance and role of up-regulation of lysozyme secretion and infiltration of inflammatory cells
Q34674831Evaluation of an intranasal virosomal vaccine against respiratory syncytial virus in mice: effect of TLR2 and NOD2 ligands on induction of systemic and mucosal immune responses
Q45356817Evaluation of synthetic infection-enhancing lipopeptides as adjuvants for a live-attenuated canine distemper virus vaccine administered intra-nasally to ferrets
Q38160006Evolving Bacterial Envelopes and Plasticity of TLR2-Dependent Responses: Basic Research and Translational Opportunities
Q35959972High pneumococcal density correlates with more mucosal inflammation and reduced respiratory syncytial virus disease severity in infants
Q50043340In Vitro Measles Virus Infection of Human Lymphocyte Subsets Demonstrates High Susceptibility and Permissiveness of both Naive and Memory B Cells
Q34170117Infection-enhancing lipopeptides do not improve intranasal immunization of cotton rats with a delta-G candidate live-attenuated human respiratory syncytial virus vaccine
Q38008471Interactions between Streptococcus pneumoniae and influenza virus: a mutually beneficial relationship?
Q47227261Lipopeptide Pam3Cys4 Synergizes N-Formyl-Met-Leu-Phe (Fmlp)-Induced Calcium Transients in Mouse Neutrophils.
Q92867203Lipoproteins: Structure, Function, Biosynthesis
Q27342799Measles immune suppression: lessons from the macaque model
Q37712684Molecular mechanisms of TLR2-mediated antigen cross-presentation in dendritic cells
Q46220993Multifactorial Experimental Design to Optimize the Anti-Inflammatory and Proangiogenic Potential of Mesenchymal Stem Cell Spheroids
Q35039520Severe viral respiratory infections: are bugs bugging?
Q35603103Streptococcus pneumoniae Enhances Human Respiratory Syncytial Virus Infection In Vitro and In Vivo
Q39539750Structure-activity relationships in toll-like receptor 2-agonists leading to simplified monoacyl lipopeptides
Q38422679Viral bacterial co-infection of the respiratory tract during early childhood

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