Disruption of the A-kinase anchoring domain in flagellar radial spoke protein 3 results in unregulated axonemal cAMP-dependent protein kinase activity and abnormal flagellar motility

scientific article (publication date: June 2006)

Disruption of the A-kinase anchoring domain in flagellar radial spoke protein 3 results in unregulated axonemal cAMP-dependent protein kinase activity and abnormal flagellar motility is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1091/MBC.E06-02-0095
P932PMC publication ID1474798
P698PubMed publication ID16571668

P2093author name stringWinfield S Sale
Jeanne M Rhea
Branch Craige
Anne R Gaillard
Laura A Fox
P2860cites workSMART, a simple modular architecture research tool: identification of signaling domainsQ24597380
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Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease geneQ28590359
IC138 is a WD-repeat dynein intermediate chain required for light chain assembly and regulation of flagellar bendingQ28770082
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Stimulation of in vitro motility of Chlamydomonas axonemes by inhibition of cAMP-dependent phosphorylationQ69813878
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Casein kinase I is anchored on axonemal doublet microtubules and regulates flagellar dynein phosphorylation and activityQ73905834
Regulation of flagellar dynein by the axonemal central apparatusQ78010806
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Two anti-radial spoke monoclonal antibodies inhibit Chlamydomonas axonemal motility by different mechanismsQ81306385
The flagellar motility of Chlamydomonas pf25 mutant lacking an AKAP-binding protein is overtly sensitive to medium conditionsQ30476625
Cyclical interactions between two outer doublet microtubules in split flagellar axonemesQ30476788
Characterization of an A-kinase anchoring protein in human ciliary axonemesQ30873792
High-frequency nuclear transformation of Chlamydomonas reinhardtiiQ30991722
Identification of a novel leucine-rich repeat protein as a component of flagellar radial spoke in the Ascidian Ciona intestinalisQ31131809
The catalytic subunit of the cAMP-dependent protein kinase of ovine sperm flagella has a unique amino-terminal sequenceQ32023549
Cilia are at the heart of vertebrate left-right asymmetryQ34218106
Isolation and characterization of the nitrate reductase structural gene of Chlamydomonas reinhardtiiQ34299218
Genomic organisation and nervous system expression of radial spoke protein 3.Q34330043
Functional diversity of axonemal dyneins as studied in Chlamydomonas mutantsQ34813073
Lateralization defects and ciliary dyskinesia: lessons from algaeQ35076952
The radial spokes and central apparatus: mechano-chemical transducers that regulate flagellar motilityQ35597367
Localized effects of cAMP mediated by distinct routes of protein kinase A.Q35625604
Cilia and flagella revealed: from flagellar assembly in Chlamydomonas to human obesity disordersQ35798533
Flagellar radial spoke protein 2 is a calmodulin binding protein required for motility in Chlamydomonas reinhardtiiQ35807241
Cilia-related diseasesQ35923569
Cilium-generated signaling and cilia-related disordersQ36050308
Radial spokes of Chlamydomonas flagella: polypeptide composition and phosphorylation of stalk componentsQ36204560
Analysis of the movement of Chlamydomonas flagella:" the function of the radial-spoke system is revealed by comparison of wild-type and mutant flagellaQ36205806
Assembly of flagellar radial spoke proteins in Chlamydomonas: identification of the axoneme binding domain of radial spoke protein 3Q36233350
Regulation of Chlamydomonas flagellar dynein by an axonemal protein kinaseQ36235115
Regulation of flagellar dynein by phosphorylation of a 138-kD inner arm dynein intermediate chainQ36254498
Phosphoregulation of an inner dynein arm complex in Chlamydomonas reinhardtii is altered in phototactic mutant strainsQ36254512
Characterization of a Chlamydomonas insertional mutant that disrupts flagellar central pair microtubule-associated structuresQ36255719
Microtubule sliding in swimming sperm flagella: direct and indirect measurements on sea urchin and tunicate spermatozoaQ36530263
cAMP-stimulated phosphorylation of an axonemal polypeptide that copurifies with the 22S dynein arm regulates microtubule translocation velocity and swimming speed in ParameciumQ37591027
Regulation of sperm flagellar motility by calcium and cAMP-dependent phosphorylationQ39164449
Flagellar radial spoke: a model molecular genetic system for studying organelle assemblyQ40898899
Studies on cilia. 3. Further studies on the cilium tip and a "sliding filament" model of ciliary motilityQ41103738
Flagellar radial spoke protein 3 is an A-kinase anchoring protein (AKAP).Q42142592
Both cAMP and cGMP are required for maximal ciliary beat stimulation in a cell-free model of bovine ciliary axonemesQ45149867
Bending patterns of Chlamydomonas flagella: IV. Mutants with defects in inner and outer dynein arms indicate differences in dynein arm functionQ46254183
Protein phosphatases PP1 and PP2A are located in distinct positions in the Chlamydomonas flagellar axoneme.Q47903200
Local reactivation of Triton-extracted flagella by iontophoretic application of ATPQ59095766
A rapid sensitive silver stain for polypeptides in polyacrylamide gelsQ60628142
Regulation of dynein-driven microtubule sliding by the radial spokes in flagellaQ67547523
Isolation of Chlamydomonas flagella and flagellar axonemesQ69761055
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
P304page(s)2626-35
P577publication date2006-06-01
P1433published inMolecular Biology of the CellQ2338259
P1476titleDisruption of the A-kinase anchoring domain in flagellar radial spoke protein 3 results in unregulated axonemal cAMP-dependent protein kinase activity and abnormal flagellar motility
P478volume17

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cites work (P2860)
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Q35153262An axonemal PP2A B-subunit is required for PP2A localization and flagellar motility
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Q80404673Building a radial spoke: flagellar radial spoke protein 3 (RSP3) is a dimer
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Q36132736Cryoelectron tomography reveals doublet-specific structures and unique interactions in the I1 dynein.
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Q24323127Protein kinase A RII-like (R2D2) proteins exhibit differential localization and AKAP interaction
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Q36085250The versatile molecular complex component LC8 promotes several distinct steps of flagellar assembly

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