Potential of Small Molecule-Mediated Reprogramming of Rod Photoreceptors to Treat Retinitis Pigmentosa

scientific article (publication date: November 2016)

Potential of Small Molecule-Mediated Reprogramming of Rod Photoreceptors to Treat Retinitis Pigmentosa is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1167/IOVS.16-20177
P932PMC publication ID5134355
P698PubMed publication ID27893103

P2093author name stringSheng Ding
Thomas A Reh
Shibing Tang
Paul A Nakamura
Andy A Shimchuk
P2860cites workCellular expression and siRNA-mediated interference of rhodopsin cis-acting splicing mutants associated with autosomal dominant retinitis pigmentosa.Q54254493
Rods and cones in the mouse retina. I. Structural analysis using light and electron microscopyQ66961732
Identification of a photoreceptor cell-specific nuclear receptorQ22009463
The leucine zipper of NRL interacts with the CRX homeodomain. A possible mechanism of transcriptional synergy in rhodopsin regulationQ22254574
The nuclear receptor NR2E3 plays a role in human retinal photoreceptor differentiation and degenerationQ24531333
A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome.Q24813359
Photoreceptor cell fate specification in vertebratesQ26786718
Minireview: the role of nuclear receptors in photoreceptor differentiation and diseaseQ27014125
The Crystal Structure of the Orphan Nuclear Receptor NR2E3/PNR Ligand Binding Domain Reveals a Dimeric Auto-Repressed ConformationQ27680068
Functional analysis of the rod photoreceptor cGMP phosphodiesterase alpha-subunit gene promoter: Nrl and Crx are required for full transcriptional activityQ28248451
Retinoid-related orphan nuclear receptor RORbeta is an early-acting factor in rod photoreceptor developmentQ28509786
Systematic analyses of the cytotoxic effects of compound 11a, a putative synthetic agonist of photoreceptor-specific nuclear receptor (PNR), in cancer cell linesQ28533473
Expression profiling of the developing and mature Nrl-/- mouse retina: identification of retinal disease candidates and transcriptional regulatory targets of NrlQ28591943
The photoreceptor-specific nuclear receptor Nr2e3 interacts with Crx and exerts opposing effects on the transcription of rod versus cone genesQ28593002
Nrl is required for rod photoreceptor developmentQ28595099
The orphan nuclear hormone receptor ERRbeta controls rod photoreceptor survivalQ29465542
Retinitis pigmentosaQ29616538
Photoreceptor-specific nuclear receptor NR2E3 functions as a transcriptional activator in rod photoreceptorsQ33203655
Mutations in the DNA-binding domain of NR2E3 affect in vivo dimerization and interaction with CRX.Q33510152
Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78Q33778232
Nuclear receptor Rev-erb alpha (Nr1d1) functions in concert with Nr2e3 to regulate transcriptional networks in the retinaQ33847588
Mutation of a nuclear receptor gene, NR2E3, causes enhanced S cone syndrome, a disorder of retinal cell fate.Q33888425
Excess cone cell proliferation due to lack of a functional NR2E3 causes retinal dysplasia and degeneration in rd7/rd7 miceQ34085942
Expression of photoreceptor-specific nuclear receptor NR2E3 in rod photoreceptors of fetal human retinaQ34336263
The rod photoreceptor-specific nuclear receptor Nr2e3 represses transcription of multiple cone-specific genes.Q34382038
Targeting of GFP to newborn rods by Nrl promoter and temporal expression profiling of flow-sorted photoreceptorsQ34410806
Probing mechanisms of photoreceptor degeneration in a new mouse model of the common form of autosomal dominant retinitis pigmentosa due to P23H opsin mutationsQ34695879
A transient wave of BMP signaling in the retina is necessary for Müller glial differentiationQ34999613
In vivo function of the orphan nuclear receptor NR2E3 in establishing photoreceptor identity during mammalian retinal developmentQ35070506
Excess cones in the retinal degeneration rd7 mouse, caused by the loss of function of orphan nuclear receptor Nr2e3, originate from early-born photoreceptor precursorsQ35288269
Transformation of cone precursors to functional rod photoreceptors by bZIP transcription factor NRL.Q35606996
Reprogramming of adult rod photoreceptors prevents retinal degenerationQ36583066
Rod differentiation factor NRL activates the expression of nuclear receptor NR2E3 to suppress the development of cone photoreceptorsQ37138691
Differential dimerization of variants linked to enhanced S-cone sensitivity syndrome (ESCS) located in the NR2E3 ligand-binding domainQ37238631
Nr2e3-directed transcriptional regulation of genes involved in photoreceptor development and cell-type specific phototransductionQ37288143
Transcriptional regulation of photoreceptor development and homeostasis in the mammalian retinaQ37774553
Current therapeutic strategies for P23H RHO-linked RP.Q38199038
Identification of potent agonists of photoreceptor-specific nuclear receptor (NR2E3) and preparation of a radioligandQ40249519
Long-term rescue of retinal structure and function by rhodopsin RNA replacement with a single adeno-associated viral vector in P23H RHO transgenic mice.Q42003725
P53 is required for the developmental restriction in Müller glial proliferation in mouse retinaQ42282297
Suppression of mouse rhodopsin expression in vivo by AAV mediated siRNA deliveryQ42746387
Dual role of Nr2e3 in photoreceptor development and maintenanceQ46545245
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivs 4.0 InternationalQ24082749
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue14
P407language of work or nameEnglishQ1860
P921main subjectphotoreceptor proteinQ7187894
retinitis pigmentosaQ847057
P304page(s)6407-6415
P577publication date2016-11-01
P1433published inInvestigative Ophthalmology Visual ScienceQ6060707
P1476titlePotential of Small Molecule-Mediated Reprogramming of Rod Photoreceptors to Treat Retinitis Pigmentosa
P478volume57

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cites work (P2860)
Q57789092Corneal cell therapy: with iPSCs, it is no more a far-sight
Q88257192Interest rekindles in drug cocktails that reprogram cells
Q46485872Molecular Anatomy of the Developing Human Retina.
Q89983887Nr2e3 is a genetic modifier that rescues retinal degeneration and promotes homeostasis in multiple models of retinitis pigmentosa
Q59798670Potentials of Cellular Reprogramming as a Novel Strategy for Neuroregeneration
Q46085195Small molecule Photoregulin3 prevents retinal degeneration in the RhoP23H mouse model of retinitis pigmentosa.

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