Fit for the Eye: Aptamers in Ocular Disorders

scientific article

Fit for the Eye: Aptamers in Ocular Disorders is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1089/NAT.2015.0573
P3181OpenCitations bibliographic resource ID4621083
P932PMC publication ID4900223
P698PubMed publication ID26757406

P2093author name stringNebojsa Janjic
Larry Gold
Daniel W Drolet
Louis S Green
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Ligand-dependent development of the endothelial and hemopoietic lineages from embryonic mesodermal cells expressing vascular endothelial growth factor receptor 2.Q36766439
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Imino proton exchange rates imply an induced-fit binding mechanism for the VEGF165-targeting aptamer, Macugen.Q36973203
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Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumorsQ37370535
An essential role for RPE-derived soluble VEGF in the maintenance of the choriocapillarisQ37413610
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VEGF Trap-Eye for the treatment of neovascular age-related macular degeneration.Q37582957
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Sustained elevated intraocular pressures after intravitreal injection of bevacizumab, ranibizumab, and pegaptanibQ37916088
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Pharmacokinetics and safety of an anti-vascular endothelial growth factor aptamer (NX1838) following injection into the vitreous humor of rhesus monkeysQ38301978
Inhibition of receptor binding by high-affinity RNA ligands to vascular endothelial growth factorQ38305186
Intimal hyperplasia recurs after removal of PDGF-AB and -BB inhibition in the rat carotid artery injury modelQ38306798
Characterization of an in vitro-selected RNA ligand to the HIV-1 Rev proteinQ38312216
Oligonucleotide NX1838 inhibits VEGF165-mediated cellular responses in vitroQ38318856
Derivation of RNA aptamer inhibitors of human complement C5.Q38322785
2'-Fluoropyrimidine RNA-based aptamers to the 165-amino acid form of vascular endothelial growth factor (VEGF165). Inhibition of receptor binding and VEGF-induced vascular permeability through interactions requiring the exon 7-encoded domainQ38335060
A SELEX primerQ38363376
Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells.Q39740070
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An antibody directed against PDGF receptor beta enhances the antitumor and the anti-angiogenic activities of an anti-VEGF receptor 2 antibodyQ40140583
Synthesis and properties of oligodeoxyribonucleotide-polyethylene glycol conjugatesQ40402078
Nucleoside conformation is determined by the electronegativity of the sugar substituent.Q40480998
Modified RNA sequence pools for in vitro selectionQ40523091
Platelet-derived growth factor receptor signalsQ40554673
Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawalQ40848490
Polarized vascular endothelial growth factor secretion by human retinal pigment epithelium and localization of vascular endothelial growth factor receptors on the inner choriocapillaris. Evidence for a trophic paracrine relationQ40937602
Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cellsQ41144930
Selective binding of VEGF121 to one of the three vascular endothelial growth factor receptors of vascular endothelial cellsQ41217559
Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurityQ41292409
Vascular endothelial cell growth factor-a: not just for endothelial cells anymore.Q41760990
Novel approach to specific growth factor inhibition in vivo: antagonism of platelet-derived growth factor in glomerulonephritis by aptamers.Q42021723
Intraocular injection of an aptamer that binds PDGF-B: a potential treatment for proliferative retinopathiesQ42806048
Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumorsQ43578049
Preclinical and phase 1A clinical evaluation of an anti-VEGF pegylated aptamer (EYE001) for the treatment of exudative age-related macular degenerationQ43943551
Quantification of 2'-fluoro-2'-deoxyuridine and 2'-fluoro-2'-deoxycytidine in DNA and RNA isolated from rats and woodchucks using LC/MS/MS.Q44064700
Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapyQ44164588
The carboxyl-terminal domain (111-165) of vascular endothelial growth factor is critical for its mitogenic potencyQ44317160
VEGF164Is Proinflammatory in the Diabetic RetinaQ44417311
Anti-vascular endothelial growth factor therapy for subfoveal choroidal neovascularization secondary to age-related macular degenerationQ44443130
Pericyte production of cell-associated VEGF is differentiation-dependent and is associated with endothelial survivalQ44659145
Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanismsQ44680981
A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer.Q45158856
Pegaptanib for neovascular age-related macular degenerationQ45206481
VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic deathQ45863485
Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration.Q45877621
Effect of pegaptanib sodium 0.3 mg intravitreal injections (Macugen) in intraocular pressure: posthoc analysis from V.I.S.I.O.N. studyQ46065497
Induction of a fibrin-gel investment: an early event in line 10 hepatocarcinoma growth mediated by tumor-secreted productsQ46082002
Vascular endothelial growth factor: a new member of the platelet-derived growth factor gene familyQ46135963
Ranibizumab inhibits multiple forms of biologically active vascular endothelial growth factor in vitro and in vivoQ46159585
Electrophysiologic and retinal penetration studies following intravitreal injection of bevacizumab (Avastin).Q46969340
Maintenance therapy with pegaptanib sodium for neovascular age-related macular degeneration: an exploratory study in Japanese patients (LEVEL-J study).Q47995257
Systemic complement activation in age-related macular degenerationQ28285925
Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in miceQ28504776
Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188Q28507115
Endothelium-specific ablation of PDGFB leads to pericyte loss and glomerular, cardiac and placental abnormalitiesQ28508460
Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptorQ28509882
Role of complement and complement membrane attack complex in laser-induced choroidal neovascularizationQ28513118
Purification and characterization of a naturally occurring vascular endothelial growth factor.placenta growth factor heterodimerQ28574927
Vascular endothelial growth factor-A is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injury.Q28583917
Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endotheliumQ28587604
Failure of blood-island formation and vasculogenesis in Flk-1-deficient miceQ28593600
High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesisQ28594191
Vascular endothelial growth factor is a secreted angiogenic mitogenQ28646475
Aptamer-based multiplexed proteomic technology for biomarker discoveryQ28744329
Angiogenesis in cancer, vascular, rheumatoid and other diseaseQ29547165
Heterozygous embryonic lethality induced by targeted inactivation of the VEGF geneQ29547732
Abnormal blood vessel development and lethality in embryos lacking a single VEGF alleleQ29547733
Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivoQ29614729
Pericyte loss and microaneurysm formation in PDGF-B-deficient miceQ29615196
Ranibizumab for neovascular age-related macular degenerationQ29617549
Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluidQ29617640
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesisQ29617644
Ocular drug deliveryQ30475605
Human retinal molecular weight exclusion limit and estimate of species variationQ30919500
Liposome-anchored vascular endothelial growth factor aptamersQ32022095
The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA.Q33301664
Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalitiesQ33491173
Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.Q33491174
Discovery and development of therapeutic aptamers.Q33522441
Expanding the chemistry of DNA for in vitro selectionQ33536734
Endothelial cell hyperplasia in human glioblastoma: coexpression of mRNA for platelet-derived growth factor (PDGF) B chain and PDGF receptor suggests autocrine growth stimulationQ33656940
A dual-targeting PDGFRbeta/VEGF-A molecule assembled from stable antibody fragments demonstrates anti-angiogenic activity in vitro and in vivoQ33688219
Cell-type-specific, Aptamer-functionalized Agents for Targeted Disease TherapyQ33834772
PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptorQ33945092
New insight into clinical development of nucleic acid aptamers.Q33945103
Complement and its role in innate and adaptive immune responsesQ34088142
The complement systemQ34137841
A therapeutic aptamer inhibits angiogenesis by specifically targeting the heparin binding domain of VEGF165Q34245063
Aptamers as therapeutics.Q51813594
A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF.Q52529779
Extracellular cleavage of the vascular endothelial growth factor 189-amino acid form by urokinase is required for its mitogenic effect.Q52553091
Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration.Q52886344
An evaluation of the toxicities of 2'-fluorouridine and 2'-fluorocytidine-HCl in F344 rats and woodchucks (Marmota monax).Q54177011
Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cellsQ67590241
Kinetic Characterization of Ribonuclease-Resistant 2′-Modified Hammerhead RibozymesQ67923126
Vascular permeability factor, an endothelial cell mitogen related to PDGFQ69116052
Delivery of molecular medicine to solid tumorsQ70995735
Heterodimers of placenta growth factor/vascular endothelial growth factor. Endothelial activity, tumor cell expression, and high affinity binding to Flk-1/KDRQ71058989
Identification and characterization of vascular endothelial growth factor receptor (Flt) in bovine retinal pericytesQ71215521
Possible participation of autocrine and paracrine vascular endothelial growth factors in hypoxia-induced proliferation of endothelial cells and pericytesQ71585776
PDGF and its receptors in the developing rodent retina and optic nerveQ72563337
Detection and plasma pharmacokinetics of an anti-vascular endothelial growth factor oligonucleotide-aptamer (NX1838) in rhesus monkeysQ73073460
Isolation of a nuclease-resistant decoy RNA that can protect human acetylcholine receptors from myasthenic antibodiesQ73077132
Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3'-Kinase/Akt signal transduction pathwayQ73333644
Specific antagonism of PDGF prevents renal scarring in experimental glomerulonephritisQ73794083
Vascular endothelial growth factor acts as a pericyte mitogen under hypoxic conditionsQ77352961
Role of platelet-derived growth factor in vascular remodeling during pulmonary hypertension in the ovine fetusQ78811698
VEGF/VPF: the angiogenesis factor found?Q80505577
Randomized, double-masked, sham-controlled trial of ranibizumab for neovascular age-related macular degeneration: PIER Study year 1Q80553646
Local tolerance and systemic safety of pegaptanib sodium in the dog and rabbitQ81362459
Long-term outcome of intravitreal pegaptanib sodium as maintenance therapy in Japanese patients with neovascular age-related macular degenerationQ86857727
Complement-targeted therapeuticsQ34255011
Vascular endothelial growth factor/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model.Q34292373
Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disordersQ34292807
Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived folliculo stellate cellsQ34306017
Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathyQ34324536
Pegaptanib sodium as maintenance therapy in neovascular age-related macular degeneration: the LEVEL studyQ34346463
Platelet-derived growth factor D, tissue-specific expression in the eye, and a key role in control of lens epithelial cell proliferationQ34378343
Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular diseaseQ34499843
Complement activation and inflammatory processes in Drusen formation and age related macular degenerationQ34521109
A randomized controlled clinical trial of intravitreous fomivirsen for treatment of newly diagnosed peripheral cytomegalovirus retinitis in patients with AIDS.Q34522196
Vascular endothelial growth factor: basic science and clinical progressQ34549887
The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicingQ34582371
Age-related macular degeneration: insights into inflammatory genesQ34588628
Ranibizumab versus verteporfin for neovascular age-related macular degeneration.Q34652928
Inhibition of rat corneal angiogenesis by a nuclease-resistant RNA aptamer specific for angiopoietin-2Q34981750
Suppression of drusen formation by compstatin, a peptide inhibitor of complement C3 activation, on cynomolgus monkey with early-onset macular degenerationQ35064666
Inhibition of platelet-derived growth factor B signaling enhances the efficacy of anti-vascular endothelial growth factor therapy in multiple models of ocular neovascularizationQ35088365
Nucleic Acid Ligands With Protein-like Side Chains: Modified Aptamers and Their Use as Diagnostic and Therapeutic AgentsQ35309726
Complement factor D in age-related macular degenerationQ35593260
VEGF: a critical player in neurodegenerationQ35618967
Intravitreal inhibition of complement C5a reduces choroidal neovascularization in miceQ35633511
Association of antisense oligonucleotides with lipoproteins prolongs the plasma half-life and modifies the tissue distributionQ35779820
Activation of the tie2 receptor by angiopoietin-1 enhances tumor vessel maturation and impairs squamous cell carcinoma growthQ35788937
Photoreceptor-specific expression of platelet-derived growth factor-B results in traction retinal detachmentQ35829410
Modified deoxyoligonucleotides stable to exonuclease degradation in serumQ35913882
Plasma levels of complement proteins from the alternative pathway in patients with age-related macular degeneration are independent of Complement Factor H Tyr⁴⁰²His polymorphism.Q36218190
Structural and functional specificities of PDGF-C and PDGF-D, the novel members of the platelet-derived growth factors familyQ36310102
Isolation of a nuclease-resistant decoy RNA that selectively blocks autoantibody binding to insulin receptors on human lymphocytesQ36367219
Immunogenicity of biopharmaceuticalsQ36588728
Development of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degenerationQ36619213
Molecular mechanisms of VEGF-A action during tissue repairQ36636355
Challenges and obstacles of ocular pharmacokinetics and drug deliveryQ36650427
Potent 2'-amino-2'-deoxypyrimidine RNA inhibitors of basic fibroblast growth factorQ36679836
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectophthalmologyQ161437
eye diseaseQ3041498
nucleotideQ28745
nucleotide aptamersQ49849144
biomedical investigative techniqueQ66648976
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)127-46
P577publication date2016-06-01
P1433published inNucleic Acid TherapeuticsQ19297428
P1476titleFit for the Eye: Aptamers in Ocular Disorders
P478volume26

Reverse relations

cites work (P2860)
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