Wingless ligand 5a is a critical regulator of placental growth and survival

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Wingless ligand 5a is a critical regulator of placental growth and survival is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1007880653
P356DOI10.1038/SREP28127
P3181OpenCitations bibliographic resource ID684972
P932PMC publication ID4911582
P698PubMed publication ID27311852

P50authorJürgen PollheimerQ59016509
Christian FialaQ87927522
Philipp VelickyQ42447937
P2093author name stringGudrun Meinhardt
Martin Knöfler
Leila Saleh
Sandra Haider
Gerlinde R Otti
P2860cites workThe Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulationQ24315249
A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placentaQ24338902
Activation of the canonical wingless/T-cell factor signaling pathway promotes invasive differentiation of human trophoblastQ24674988
Endometrial glands as a source of nutrients, growth factors and cytokines during the first trimester of human pregnancy: a morphological and immunohistochemical studyQ24795515
Wnt/beta-catenin signaling in development and diseaseQ27860784
Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factorsQ28247928
Wnt5a is required for proper epithelial-mesenchymal interactions in the uterusQ28255597
WNTs in the neonatal mouse uterus: potential regulation of endometrial gland developmentQ28296217
A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryoQ28505232
Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor contextQ28510950
Notch2 controls prolactin and insulin-like growth factor binding protein-1 expression in decidualizing human stromal cells of early pregnancyQ28544967
Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesisQ28587352
Reversal of gene dysregulation in cultured cytotrophoblasts reveals possible causes of preeclampsiaQ30576991
Polarizing intestinal epithelial cells electrically through Ror2Q30585483
Wnt5a promotes inflammatory responses via nuclear factor κB (NF-κB) and mitogen-activated protein kinase (MAPK) pathways in human dental pulp cellsQ33947233
Appropriate crypt formation in the uterus for embryo homing and implantation requires Wnt5a-ROR signalingQ33995495
Development of the human placenta in the first three months of gestationQ34066895
Decidual NK cells regulate key developmental processes at the human fetal-maternal interface.Q52010655
Macrophages at the fetal-maternal interface express markers of alternative activation and are induced by M-CSF and IL-10.Q54350706
Failure of physiologic transformation of the spiral arteries in the placental bed in preterm premature rupture of membranesQ58778333
Dynamic changes in maternal decidual leukocyte populations from first to second trimester gestationQ60793578
Inadequate maternal vascular response to placentation in pregnancies complicated by pre-eclampsia and by small-for-gestational age infantsQ69685000
Characterization of human villous and extravillous trophoblasts isolated from first trimester placentaQ74509509
Tumor necrosis factor-alpha inhibits trophoblast migration through elevation of plasminogen activator inhibitor-1 in first-trimester villous explant culturesQ75425145
Efficient siRNA-mediated prolonged gene silencing in human amniotic fluid stem cellsQ84387301
Macrophage-derived IL-33 is a critical factor for placental growthQ87346197
Wnt1 and Wnt5a induce cyclin D1 expression through ErbB1 transactivation in HC11 mammary epithelial cells.Q34227971
Complex expression pattern of Wnt ligands and frizzled receptors in human placenta and its trophoblast subtypesQ34235433
Wnt signalling in implantation, decidualisation and placental differentiation--reviewQ34235439
Critical growth factors and signalling pathways controlling human trophoblast invasionQ34280644
Wnt 5a signaling is critical for macrophage-induced invasion of breast cancer cell linesQ34600262
Identification of novel trophoblast invasion-related genes: heme oxygenase-1 controls motility via peroxisome proliferator-activated receptor gammaQ34725207
Genome-wide expression profile of first trimester villous and extravillous human trophoblast cellsQ34727740
Evaluation of human first trimester decidual and telomerase-transformed endometrial stromal cells as model systems of in vitro decidualizationQ35704144
IFPA Award in Placentology lecture: molecular regulation of human trophoblast invasion.Q35737097
Preeclampsia is associated with widespread apoptosis of placental cytotrophoblasts within the uterine wallQ35787199
Human early placental development: potential roles of the endometrial glandsQ35813722
The role of interleukin-1β in human trophoblast motility.Q36205605
Wnt and calcium signaling: beta-catenin-independent pathwaysQ36228742
The uterine spiral arteries in human pregnancy: facts and controversiesQ36401771
Expression and hormone regulation of Wnt2, 3, 4, 5a, 7a, 7b and 10b in normal human endometrium and endometrial carcinomaQ36420147
WNT5A-NFAT signaling mediates resistance to apoptosis in pancreatic cancerQ36567558
Branching morphogenesis during development of placental villiQ36568788
Human placental trophoblast invasion and differentiation: a particular focus on Wnt signaling.Q37199588
The influence of the intrauterine environment on human placental development.Q37598153
Cell/tissue-tropic functions of Wnt5a signaling in normal and cancer cellsQ37723044
Wnt5a: its signalling, functions and implication in diseasesQ37868763
Endometrial secretions: creating a stimulatory microenvironment within the human early placenta and implications for the aetiopathogenesis of preeclampsiaQ37870476
Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT.Q38319485
Insight into the role of Wnt5a-induced signaling in normal and cancer cellsQ38331676
Wnt-dependent T-cell factor-4 controls human etravillous trophoblast motilityQ39017692
Wnt5a induces a tolerogenic phenotype of macrophages in sepsis and breast cancer patientsQ39355876
Identification of a link between Wnt/β-catenin signalling and the cell fusion pathwayQ39438577
Effects of Wnt5a protein on proliferation and apoptosis in JAR choriocarcinoma cellsQ39565233
Efficient, rapid and reliable establishment of human trophoblast cell lines using poly-L-ornithine.Q40766462
Gestational age-dependent dual action of epidermal growth factor on human placenta early in gestationQ41790416
Wnt5a-dopamine D2 receptor interactions regulate dopamine neuron development via extracellular signal-regulated kinase (ERK) activationQ41821907
Identification, characterization, and regulation of the canonical Wnt signaling pathway in human endometriumQ46832679
Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse developmentQ48841883
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P407language of work or nameEnglishQ1860
P304page(s)28127
P577publication date2016-06-17
P1433published inScientific ReportsQ2261792
P1476titleWingless ligand 5a is a critical regulator of placental growth and survival
P478volume6

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cites work (P2860)
Q47159835Deciphering transcriptional regulation in human embryonic stem cells specified towards a trophoblast fate
Q90445485Intrauterine Inflammation Damages Placental Angiogenesis via Wnt5a-Flt1 Activation
Q92884855Physiological profile of undifferentiated bovine blastocyst-derived trophoblasts
Q59329268Regulation of Placental Extravillous Trophoblasts by the Maternal Uterine Environment
Q96816256Tracking placental development in health and disease
Q49896523Vangl2 Is Essential for Myocardial Remodeling Activated by Wnt/JNK Signaling.

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