Candidate Genes Involved in the Biosynthesis of Triterpenoid Saponins in Platycodon grandiflorum Identified by Transcriptome Analysis

scientific article (publication date: 2016)

Candidate Genes Involved in the Biosynthesis of Triterpenoid Saponins in Platycodon grandiflorum Identified by Transcriptome Analysis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FPLS.2016.00673
P3181OpenCitations bibliographic resource ID1490795
P932PMC publication ID4871891
P698PubMed publication ID27242873

P2093author name stringWei Zhang
Chun-Hua Ma
Guang-Hui Zhang
Sheng-Chao Yang
Jia-Jin Zhang
Jun-Wen Chen
Jian-Hui Shao
Mei-Rong Hai
Zheng-Jie Gao
P2860cites workFrom genomics to chemical genomics: new developments in KEGGQ24538628
Full-length transcriptome assembly from RNA-Seq data without a reference genomeQ24620766
Licorice beta-amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizinQ24653492
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Combinatorial biosynthesis of sapogenins and saponins in Saccharomyces cerevisiae using a C-16α hydroxylase from Bupleurum falcatumQ30570482
The Cyt P450 enzyme CYP716A47 catalyzes the formation of protopanaxadiol from dammarenediol-II during ginsenoside biosynthesis in Panax ginsengQ33452283
Cytochrome P450 CYP716A53v2 catalyzes the formation of protopanaxatriol from protopanaxadiol during ginsenoside biosynthesis in Panax ginsengQ33455444
De novo sequencing and analysis of the American ginseng root transcriptome using a GS FLX Titanium platform to discover putative genes involved in ginsenoside biosynthesisQ33563326
454 EST analysis detects genes putatively involved in ginsenoside biosynthesis in Panax ginsengQ33869954
CYP716A subfamily members are multifunctional oxidases in triterpenoid biosynthesisQ34029243
Molecular activities, biosynthesis and evolution of triterpenoid saponinsQ34165568
Analysis of the transcriptome of Panax notoginseng root uncovers putative triterpene saponin-biosynthetic genes and genetic markersQ34173380
Formation of plant metabolic gene clusters within dynamic chromosomal regions.Q34211703
UDP-glycosyltransferases from the UGT73C subfamily in Barbarea vulgaris catalyze sapogenin 3-O-glucosylation in saponin-mediated insect resistanceQ34426154
Metabolic and functional diversity of saponins, biosynthetic intermediates and semi-synthetic derivativesQ34441998
Biosynthesis of triterpenoid saponins in plants.Q34488618
Identification of beta-amyrin and sophoradiol 24-hydroxylase by expressed sequence tag mining and functional expression assayQ34494510
Transcriptome analysis reveals ginsenosides biosynthetic genes, microRNAs and simple sequence repeats in Panax ginseng C. A. MeyerQ34664756
Platycodin D induces apoptosis, and inhibits adhesion, migration and invasion in HepG2 hepatocellular carcinoma cellsQ35123568
A different function for a member of an ancient and highly conserved cytochrome P450 family: from essential sterols to plant defense.Q35161327
Transcriptome analysis of Panax vietnamensis var. fuscidicus discovers putative ocotillol-type ginsenosides biosynthesis genes and genetic markers.Q35166519
Analysis of the transcriptome of Erigeron breviscapus uncovers putative scutellarin and chlorogenic acids biosynthetic genes and genetic markersQ35193345
Biochemical analysis of a multifunctional cytochrome P450 (CYP51) enzyme required for synthesis of antimicrobial triterpenes in plants.Q37143437
Producing aglycons of ginsenosides in bakers' yeastQ37482270
Triterpenoid Saponins Isolated from Platycodon grandiflorum Inhibit Hepatitis C Virus ReplicationQ37486646
Production of plant bioactive triterpenoid saponins: elicitation strategies and target genes to improve yields.Q37702929
Platycodin D induces apoptosis and decreases telomerase activity in human leukemia cellsQ38503011
Platycodin D inhibits migration, invasion, and growth of MDA-MB-231 human breast cancer cells via suppression of EGFR-mediated Akt and MAPK pathwaysQ39123866
Antiproliferative and apoptotic activities of triterpenoid saponins from the roots of Platycodon grandiflorum and their structure-activity relationships.Q39168314
Genome-wide identification and characterization of putative cytochrome P450 genes in the model legume Medicago truncatulaQ39784826
Implication of intracellular ROS formation, caspase-3 activation and Egr-1 induction in platycodon D-induced apoptosis of U937 human leukemia cellsQ39937884
Saponins, especially platycodin D, from Platycodon grandiflorum modulate hepatic lipogenesis in high-fat diet-fed rats and high glucose-exposed HepG2 cells.Q42713386
Platycodin D and D3 increase airway mucin release in vivo and in vitro in rats and hamstersQ43933822
Protective effect of saponins derived from roots of Platycodon grandiflorum on tert-butyl hydroperoxide-induced oxidative hepatotoxicity.Q44855600
Medicago truncatula CYP716A12 is a multifunctional oxidase involved in the biosynthesis of hemolytic saponinsQ45816243
Saponins isolated from the root of Platycodon grandiflorum protect against acute ethanol-induced hepatotoxicity in mice.Q46169659
Protective effect of saponins derived from the roots of Platycodon grandiflorum against carbon tetrachloride induced hepatotoxicity in mice.Q46740477
The involvement of β-amyrin 28-oxidase (CYP716A52v2) in oleanane-type ginsenoside biosynthesis in Panax ginsengQ46987253
Two ginseng UDP-glycosyltransferases synthesize ginsenoside Rg3 and Rd.Q47975687
Protective effect of the aqueous extract from the root of Platycodon grandiflorum on cholestasis-induced hepatic injury in miceQ48125999
Enhanced accumulation of phytosterol and triterpene in hairy root cultures of Platycodon grandiflorum by overexpression of Panax ginseng 3-hydroxy-3-methylglutaryl-coenzyme A reductase.Q53346439
Platycodin D, a triterpenoid sapoinin from Platycodon grandiflorum, ameliorates cisplatin-induced nephrotoxicity in mice.Q53375429
Saponin biosynthesis in Saponaria vaccaria. cDNAs encoding beta-amyrin synthase and a triterpene carboxylic acid glucosyltransferase.Q54450246
Combinatorial Biosynthesis of Legume Natural and Rare Triterpenoids in Engineered YeastQ63640585
Pharmacological Studies on Platycodon grandiflorum A. DC. III. Activities of Crude Platycodin on Respiratory and Circulatory Systems and Its Other Pharmacological ActivitiesQ69454654
Effects of Platycodon grandiflorum feeding on serum and liver lipid concentrations in rats with diet-induced hyperlipidemiaQ71175867
Platycodin D is a potent adjuvant of specific cellular and humoral immune responses against recombinant hepatitis B antigenQ82763079
β-Amyrin oxidation by oat CYP51H10 expressed heterologously in yeast cells: the first example of CYP51-dependent metabolism other than the 14-demethylation of sterol precursorsQ84353393
P407language of work or nameEnglishQ1860
P921main subjectTriterpenoid saponinQ7844281
Platycodon grandiflorumQ104386792
P304page(s)673
P577publication date2016-01-01
P1433published inFrontiers in Plant ScienceQ27723840
P1476titleCandidate Genes Involved in the Biosynthesis of Triterpenoid Saponins in Platycodon grandiflorum Identified by Transcriptome Analysis
P478volume7

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cites work (P2860)
Q59792945De novo sequencing and transcriptome assembly of Arisaema heterophyllum Blume and identification of genes involved in isoflavonoid biosynthesis
Q89927291NAA and 6-BA promote accumulation of oleanolic acid by JA regulation in Achyranthes bidentata Bl
Q92446278Role of Saponins in Plant Defense Against Specialist Herbivores
Q97422383Whole-genome, transcriptome, and methylome analyses provide insights into the evolution of platycoside biosynthesis in Platycodon grandiflorus, a medicinal plant

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