Molecular and biochemical characterization of the human trk proto-oncogene

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Molecular and biochemical characterization of the human trk proto-oncogene is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.9.1.24
P932PMC publication ID362141
P698PubMed publication ID2927393
P5875ResearchGate publication ID20229652

P2093author name stringM. Barbacid
D. Martin-Zanca
T. Copeland
G. Mitra
R. Oskam
P2860cites workAn analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAsQ22066003
DNA sequencing with chain-terminating inhibitorsQ22066207
Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminusQ24339526
Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptorsQ24339620
Structure and expression of the human haptoglobin locusQ24555818
Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligandQ24555963
Activation of the receptor kinase domain of the trk oncogene by recombination with two different cellular sequencesQ24564358
Tumor-promoting phorbol diesters cause the phosphorylation of epidermal growth factor receptors in normal human fibroblasts at threonine-654Q24568057
Human c-ros-1 gene homologous to the v-ros sequence of UR2 sarcoma virus encodes for a transmembrane receptorlike moleculeQ24613757
Molecular characterization of the human trk oncogeneQ68760028
Bifunctional messenger RNAs in eukaryotesQ69660482
ret transforming gene encodes a fusion protein homologous to tyrosine kinasesQ24628687
A comprehensive set of sequence analysis programs for the VAXQ26778432
Rapid and efficient site-specific mutagenesis without phenotypic selectionQ27860608
Rapid and efficient site-specific mutagenesis without phenotypic selectionQ27860628
A new technique for the assay of infectivity of human adenovirus 5 DNAQ27860797
Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencingQ27860941
Oncogenes in solid human tumoursQ28279392
A novel putative tyrosine kinase receptor encoded by the eph geneQ28280591
A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequencesQ28282360
Activation of a novel human transforming gene, ret, by DNA rearrangementQ28286635
Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogeneQ28286890
A non-AUG translational initiation in c-myc exon 1 generates an N-terminally distinct protein whose synthesis is disrupted in Burkitt's lymphomasQ28294528
The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1Q28299663
The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signallingQ28615445
Human insulin receptor and its relationship to the tyrosine kinase family of oncogenesQ28615460
Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoterQ29614259
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cellsQ29616544
Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptorsQ29616545
Protein-tyrosine kinasesQ29616546
Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificityQ33880454
Receptors for epidermal growth factor and other polypeptide mitogensQ34163558
The human met oncogene is related to the tyrosine kinase oncogenesQ34201032
Identification and biochemical characterization of p70TRK, product of the human TRK oncogeneQ34348845
Tyr527 is phosphorylated in pp60c-src: implications for regulationQ34383180
Genetic structure and transforming sequence of avian sarcoma virus UR2Q36939258
A thousand and one protein kinasesQ39596528
Biosynthetic protein transport and sorting by the endoplasmic reticulum and GolgiQ39664981
Surface-specific iodination of membrane proteins of viruses and eucaryotic cells using 1,3,4,6-tetrachloro-3α,6α-diphenylglycolurilQ40196106
Transfer of proteins across membranesQ40313007
Transforming potential of the c-fms proto-oncogene (CSF-1 receptor).Q42808913
Sevenless, a cell-specific homeotic gene of Drosophila, encodes a putative transmembrane receptor with a tyrosine kinase domainQ44689071
Molecular cloning of a new transforming gene from a chemically transformed human cell line.Q45345810
Evidence that the phosphorylation of tyrosine is essential for cellular transformation by Rous sarcoma virusQ45803202
A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene familyQ48366626
Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptorQ48369441
The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigenQ52827123
Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences.Q53554133
Protein kinase C phosphorylation at Thr 654 of the unoccupied EGF receptor and EGF binding regulate functional receptor loss by independent mechanismsQ56911539
Fused transcript of abl and bcr genes in chronic myelogenous leukaemiaQ59064021
Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membraneQ59070337
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectNeurotrophic receptor tyrosine kinase 1Q4051790
peptidyl-tyrosine phosphorylationQ14330986
P304page(s)24–33
P577publication date1989-01-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleMolecular and biochemical characterization of the human trk proto-oncogene
P478volume9

Reverse relations

cites work (P2860)
Q347636051 Protein kinase classification
Q40792892A C-terminal domain in FosB, absent in FosB/SF and Fra-1, which is able to interact with the TATA binding protein, is required for altered cell growth.
Q42026320A Comprehensive Functional Analysis of NTRK1 Missense Mutations Causing Hereditary Sensory and Autonomic Neuropathy Type IV (HSAN IV)
Q42647984A carboxyl-terminal domain in fibroblast growth factor (FGF)-2 inhibits FGF-1 release in response to heat shock in vitro
Q24568236A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain
Q41182768A metastatic neuroblastoma model in SCID mice
Q22253207A non-transmembrane form of Jagged-1 regulates the formation of matrix-dependent chord-like structures
Q38346153A novel Drosophila receptor tyrosine kinase expressed specifically in the nervous system. Unique structural features and implication in developmental signaling
Q54380745A novel role of suppressor of cytokine signaling-2 in the regulation of TrkA neurotrophin receptor biology.
Q24562632A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain
Q33943860A short in-frame deletion in NTRK1 tyrosine kinase domain caused by a novel splice site mutation in a patient with congenital insensitivity to pain with anhidrosis
Q36578603A signaling organelle containing the nerve growth factor-activated receptor tyrosine kinase, TrkA.
Q24648317A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype
Q24532216Aberrant axonal projections in mice lacking EphA8 (Eek) tyrosine protein kinase receptors
Q55240171Abundant but inactive-state gp140proto-trk is expressed in neuroblastomas of patients with good prognosis.
Q40780192Acidic substitution of the activation loop tyrosines in TrkA supports nerve growth factor-independent cell survival and neuronal differentiation
Q43717552Adenovirus vector-directed expression of the neurotrophin-3 receptor (TrkC) in mouse astrocytes
Q36429595Alternative TrkAIII splicing: a potential regulated tumor-promoting switch and therapeutic target in neuroblastoma.
Q44306021Alternatively spliced FGFR-1 isoform signaling differentially modulates endothelial cell responses to peroxynitrite
Q22004002An alternatively spliced fibroblast growth factor (FGF)-5 mRNA is abundant in brain and translates into a partial agonist/antagonist for FGF-5 neurotrophic activity
Q35897889An alternatively spliced form of the nerve growth factor receptor TrkA confers an enhanced response to neurotrophin 3.
Q37698490An immunoglobulin-like domain determines the specificity of neurotrophin receptors.
Q42814674Analysis of endogenous and exogenous nuclear translocation of fibroblast growth factor-1 in NIH 3T3 cells
Q46421786Analytical purification of the slow, high affinity NGF receptor: Identification of a novel 135 kd polypeptide
Q73215420Autophosphorylation of activation loop tyrosines regulates signaling by the TRK nerve growth factor receptor
Q48973255Axotomy alters neurotrophin and neurotrophin receptor mRNAs in the vagus nerve and nodose ganglion of the rat.
Q38331685Biogenesis and function of the NGF/TrkA signaling endosome
Q24606830Both N- and C-terminal domains of RelB are required for full transactivation: role of the N-terminal leucine zipper-like motif
Q38332525Both products of the fosB gene, FosB and its short form, FosB/SF, are transcriptional activators in fibroblasts
Q34065279Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease
Q40951689Brain-derived neurotrophic factor promotes survival and chemoprotection of human neuroblastoma cells
Q61684994CD34-positive cells in human umbilical cord blood express nerve growth factor and its specific receptor TrkA
Q42797896CEP-751 inhibits TRK receptor tyrosine kinase activity in vitro exhibits anti-tumor activity
Q48421205Cells Expressing mRNA for Neurotrophins and their Receptors During Embryonic Rat Development.
Q33638611Cellular aspects of trophic actions in the nervous system.
Q42556384Change in neurotrophins and their receptor mRNAs in the rat forebrain after status epilepticus induced by pilocarpine
Q28581032Characterization of densin-180, a new brain-specific synaptic protein of the O-sialoglycoprotein family
Q36280921Characterization of the recombinant extracellular domain of the neurotrophin receptor TrkA and its interaction with nerve growth factor (NGF)
Q37304874Circulating nerve growth factor levels are increased in humans with allergic diseases and asthma
Q34464521Competitive signaling between TrkA and p75 nerve growth factor receptors determines cell survival.
Q42587781Concentration-dependent regulation of neuronal gene expression by nerve growth factor
Q33906447Congenital insensitivity to pain with anhidrosis (CIPA) in Israeli-Bedouins: genetic heterogeneity, novel mutations in the TRKA/NGF receptor gene, clinical findings, and results of nerve conduction studies
Q40594499Congenital insensitivity to pain with anhidrosis (CIPA): novel mutations of the TRKA (NTRK1) gene, a putative uniparental disomy, and a linkage of the mutant TRKA and PKLR genes in a family with CIPA and pyruvate kinase deficiency
Q34389720Congenital insensitivity to pain with anhidrosis: novel mutations in the TRKA (NTRK1) gene encoding a high-affinity receptor for nerve growth factor
Q41925640Defining a mechanistic link between pigment epithelium-derived factor, docosahexaenoic acid and corneal nerve regeneration
Q48393512Development of survival responsiveness to brain-derived neurotrophic factor, neurotrophin 3 and neurotrophin 4/5, but not to nerve growth factor, in cultured motoneurons from chick embryo spinal cord.
Q71893219Development of the primary afferent projection in human spinal cord
Q52211644Developmentally regulated expression of mRNA for neurotrophin high-affinity (trk) receptors within chick trigeminal sensory neurons.
Q36493889Differential expression of nerve growth factor receptors leads to altered binding affinity and neurotrophin responsiveness.
Q40793381Differential interactions of Rel-NF-kappa B complexes with I kappa B alpha determine pools of constitutive and inducible NF-kappa B activity
Q58112780Dimerization of the Trk receptors in the plasma membrane: effects of their cognate ligands
Q41628475Disruption of the low affinity receptor-binding site in NGF allows neuronal survival and differentiation by binding to the trk gene product
Q35005769Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neurons
Q73589609Distribution of NGF receptors in normal and pathologic human lymphoid tissues
Q36451039Dror, a potential neurotrophic receptor gene, encodes a Drosophila homolog of the vertebrate Ror family of Trk-related receptor tyrosine kinases
Q33937330Dtrk, a Drosophila gene related to the trk family of neurotrophin receptors, encodes a novel class of neural cell adhesion molecule
Q22007989EDF-1, a novel gene product down-regulated in human endothelial cell differentiation
Q67487956Effects of NGF and glucocorticoid on NGF receptor immunolabeling of cultured rhesus adrenal chromaffin cells
Q47138460Effects of cerebrolysin on nerve growth factor system in the aging rat brain.
Q43456828Effects of insulin and insulin-like growth factors on neurofilament mRNA and tubulin mRNA content in human neuroblastoma SH-SY5Y cells
Q71955066Endocytosis of activated TrkA: evidence that nerve growth factor induces formation of signaling endosomes
Q42602466Endogenous interleukin 1 alpha must be transported to the nucleus to exert its activity in human endothelial cells
Q52190717Endogenous nerve growth factor and neurotrophin-3 act simultaneously to ensure the survival of postnatal sympathetic neurons in vivo.
Q36594251Endoplasmic reticulum quality control of asialoglycoprotein receptor H2a involves a determinant for retention and not retrieval
Q47846225Eradication of cerebellar granular cells alters the developmental expression of trk receptors in the rat inferior olive
Q40557195Estrogen and nerve growth factor-related systems in brain. Effects on basal forebrain cholinergic neurons and implications for learning and memory processes and aging
Q36644617Expression and function of TRK-B and BDNF in human neuroblastomas
Q41078653Expression and function of TrkB variants in developing sensory neurons.
Q47973679Expression of NGF receptors in normal and pathological human thymus
Q35199818Expression of TrkA confers neuron-like responsiveness to nerve growth factor on an immortalized hypothalamic cell line
Q73109117Expression of TrkA, TrkB and TrkC in human neuroblastomas
Q41873962Expression of beta-nerve growth factor and its receptor in rat seminiferous epithelium: specific function at the onset of meiosis
Q36356073Expression of functional trk protooncogene in human monocytes
Q48794963Expression of mRNA for brain-derived neurotrophic factor in the dorsal root ganglion following peripheral inflammation.
Q36136048Expression of mRNA for the neurotrophin receptor trkC in neuroblastomas with favourable tumour stage and good prognosis
Q28295025Expression of mRNAs for neurotrophic factors (NGF, BDNF, NT-3, and GDNF) and their receptors (p75NGFR, trkA, trkB, and trkC) in the adult human peripheral nervous system and nonneural tissues
Q48477752Expression of mRNAs for neurotrophins (NGF, BDNF, and NT-3) and their receptors (p75NGFR, trk, trkB, and trkC) in human peripheral neuropathies.
Q40988990Expression of mRNAs of multiple growth factors and receptors by astrocytes and glioma cells: detection with reverse transcription-polymerase chain reaction.
Q52204283Expression of mRNAs of multiple growth factors and receptors by neuronal cell lines: detection with RT-PCR.
Q36684141Expression of nerve growth factor and nerve growth factor receptor tyrosine kinase Trk in activated CD4-positive T-cell clones
Q49130270Expression of neurotrophin trk and p75 receptors in quail embryos undergoing gastrulation and neurulation.
Q73835346Expression of neurotrophins and their receptors (TRK) during fracture healing
Q40673214Expression of polycystin-1 C-terminal fragment enhances the ATP-induced Ca2+ release in human kidney cells
Q42819405Expression of the naturally occurring truncated trkB neurotrophin receptor induces outgrowth of filopodia and processes in neuroblastoma cells
Q24613828Expression of the v-crk oncogene product in PC12 cells results in rapid differentiation by both nerve growth factor- and epidermal growth factor-dependent pathways
Q35207002Expression of trk in MAH cells lacking the p75 low-affinity nerve growth factor receptor is sufficient to permit nerve growth factor-induced differentiation to postmitotic neurons
Q36827332Expression of trkA cDNA in neuroblastomas mediates differentiation in vitro and in vivo
Q92731061Extracellular Juxtamembrane Motif Critical for TrkB Preformed Dimer and Activation
Q44407276Farnesyltransferase inhibitor FTI-277 prevents autocrine growth stimulation of neuroblastoma by BDNF.
Q71830006Frequent expression of genes for receptor tyrosine kinases and their ligands in human pancreatic cancer cells
Q31122268Fte-1, a v-fos transformation effector gene, encodes the mammalian homologue of a yeast gene involved in protein import into mitochondria
Q22003807Functional analysis of H-Ryk, an atypical member of the receptor tyrosine kinase family
Q40994436Functional expression of TrkA receptors in hippocampal neurons
Q40846828Fusions to members of fibroblast growth factor gene family to study nuclear translocation and nonclassic exocytosis
Q34289656Ganglioside GM1 binds to the Trk protein and regulates receptor function
Q47792189Gestational exposure to methylmercury alters neurotrophin- and carbachol-stimulated phosphatidylinositide hydrolysis in cerebral cortex of neonatal rats
Q37293193Heat shock induces the release of fibroblast growth factor 1 from NIH 3T3 cells
Q48222648High affinity neurotrophin receptors in the human pre-term newborn, infant, and adult cerebellum
Q28263675High resolution mapping of the binding site of TrkA for nerve growth factor and TrkC for neurotrophin-3 on the second immunoglobulin-like domain of the Trk receptors
Q41687095High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor
Q34440795Human CD4+ T cell clones produce and release nerve growth factor and express high-affinity nerve growth factor receptors
Q41085580Human mast cells express functional TrkA and are a source of nerve growth factor.
Q24310691Human platelet glycoprotein V: characterization of the polypeptide and the related Ib-V-IX receptor system of adhesive, leucine-rich glycoproteins
Q28115087Human trk oncogenes activated by point mutation, in-frame deletion, and duplication of the tyrosine kinase domain
Q30959617Identification and characterization of an activating TrkA deletion mutation in acute myeloid leukemia
Q24324648Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine-zipper domains
Q73784367Identification of novel trkA variants with deletions in leucine-rich motifs of the extracellular domain
Q36444009Identification of tyrosine kinase Trk as a nerve growth factor receptor
Q41538094Immunocytochemical analysis of phosphatidylinositol-specific phospholipase C in PC12 cells: predominance of the delta isoform during neural differentiation.
Q48673316Immunoglobulin-like domains define the nerve growth factor binding site of the TrkA receptor.
Q58980339Immunohistochemical Distribution of Neurotrophins and their Receptors in the Rat Retina and the Effects of Ischemia and Reperfusion*
Q73109123Immunohistochemical detection of p140trkA and p75LNGFR neurotrophin receptors in neuroblastoma
Q35833678Immunohistochemical localization of Trk receptor protein in pediatric small round blue cell tumors.
Q42501361In situ hybridization detection of trkA mRNA in brain: distribution, colocalization with p75NGFR and up-regulation by nerve growth factor
Q41552489Increased neurite outgrowth induced by inhibition of protein tyrosine kinase activity in PC12 pheochromocytoma cells
Q41439139Induction of nerve growth factor responsiveness in C6-2B glioma cells by expression of trkA proto-oncogene
Q57154788Insights into Current Tropomyosin Receptor Kinase (TRK) Inhibitors: Development and Clinical Application
Q24313399Interaction in vitro of the product of the c-Crk-II proto-oncogene with the insulin-like growth factor I receptor
Q28249975Interactions between brain-derived neurotrophic factor and the TRKB receptor. Identification of two ligand binding domains in soluble TRKB by affinity separation and chemical cross-linking
Q41452155Involvement of S100-related calcium-binding protein pEL98 (or mts1) in cell motility and tumor cell invasion
Q40861605Ion channels and early development of neural cells
Q33997030Is bone a target-tissue for the nervous system? New advances on the understanding of their interactions
Q42461925K-252b selectively potentiates cellular actions and trk tyrosine phosphorylation mediated by neurotrophin-3.
Q36388074Keeping track of neurotrophin receptors
Q48014156Lampetra fluviatilis neurotrophin homolog, descendant of a neurotrophin ancestor, discloses the early molecular evolution of neurotrophins in the vertebrate subphylum.
Q47988662Level of p75 receptor expression in sensory ganglia is modulated by NGF level in the target tissue.
Q42450586Localization of nerve growth factor, trkA and P75 immunoreactivity in the hippocampal formation and basal forebrain of adult rats
Q48237185Localization of trkB mRNA in postnatal brain development
Q48475486Long-term dietary restriction differentially affects the expression of BDNF and its receptors in the cortex and hippocampus of middle-aged and aged male rats.
Q55006667Low frequency of rearrangements of the ret and trk proto-oncogenes in Japanese thyroid papillary carcinomas
Q39367969MYCN and ALKF1174L are sufficient to drive neuroblastoma development from neural crest progenitor cells
Q35094654Measurements in the Blood of BDNF for RA Patients and in Response to Anti-TNF Treatment Help Us to Clarify the Magnitude of Centrally Related Pain and to Explain the Relief of This Pain upon Treatment
Q24594163Mechanism of activation of the human trk oncogene
Q40788669Membrane-bound LERK2 ligand can signal through three different Eph-related receptor tyrosine kinases
Q48361736Methylmercury decreases NGF-induced TrkA autophosphorylation and neurite outgrowth in PC12 cells
Q40772666Mitogenesis in glioblastoma multiforme cell lines: a role for NGF and its TrkA receptors
Q47631068Modeling of the three-dimensional structure of proteins with the typical leucine-rich repeats
Q73896593Molecular analysis of trkC in the cat visual cortex
Q34465802Molecular basis of congenital insensitivity to pain with anhidrosis (CIPA): mutations and polymorphisms in TRKA (NTRK1) gene encoding the receptor tyrosine kinase for nerve growth factor
Q73088407Molecular cloning and characterization of the 5' region of the mouse trkA proto-oncogene
Q70470550Molecular cloning and expression of a novel truncated form of chicken trkC
Q28579759Molecular cloning of a novel membrane glycoprotein, pal, specifically expressed in photoreceptor cells of the retina and containing leucine-rich repeat
Q28592605Molecular cloning of the mouse grb2 gene: differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptors
Q37218752Molecular kinetics of nerve growth factor receptor trafficking and activation
Q47752292Mutational analysis of the TrkA gene in prostate cancer
Q34733805Mutations in the TRKA/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis
Q28265064N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling
Q42795746NF1 modulates the effects of Ras oncogenes: evidence of other NF1 function besides its GAP activity
Q67810476NGF and EGF rapidly activate p21ras in PC12 cells by distinct, convergent pathways involving tyrosine phosphorylation
Q36235736NGF-stimulated retrograde transport of trkA in the mammalian nervous system
Q92924197NTRK Fusions in Central Nervous System Tumors: A Rare, but Worthy Target
Q58547264NTRK fusion-positive cancers and TRK inhibitor therapy
Q36759079Nerve growth factor acutely reduces chemical transmission by means of postsynaptic TrkA-like receptors in squid giant synapse.
Q38033634Nerve growth factor and the physiology of pain: lessons from congenital insensitivity to pain with anhidrosis
Q40677352Nerve growth factor and the skin
Q35932924Nerve growth factor displays stimulatory effects on human skin and lung fibroblasts, demonstrating a direct role for this factor in tissue repair
Q36706107Nerve growth factor is an autocrine factor essential for the survival of macrophages infected with HIV
Q37541110Nerve growth factor rapidly stimulates tyrosine phosphorylation of phospholipase C-gamma 1 by a kinase activity associated with the product of the trk protooncogene
Q37694590Nerve growth factor signaling in prostate health and disease.
Q36501758Nerve growth factor suppresses the transforming phenotype of human prolactinomas
Q33670627Nerve growth factor: a neurotrophin with activity on cells of the immune system
Q36908290Neurite extension occurs in the absence of regulated exocytosis in PC12 subclones.
Q72150036Neuronal and nonneuronal expression of neurotrophins and their receptors in sensory and sympathetic ganglia suggest new intercellular trophic interactions
Q36412788Neuronal colocalization of mRNAs for neurotrophins and their receptors in the developing central nervous system suggests a potential for autocrine interactions.
Q40875490Neuronal differentiation in human neuroblastoma cells by nerve growth factor following TrkA up-regulation by interferon-gamma
Q33952005Neurotrophic factors in the primary olfactory pathway.
Q42619312Neurotrophin receptors in the somatosensory cortex of the mature rat: co-localization of p75, trk, isoforms and c-neu
Q57009636Neurotrophin-3 and neurotrophin receptor immunoreactivity in peptidergic enteric neurons
Q48338447Neurotrophin-3 receptors in the developing chicken retina
Q46124149Neurotrophin-4/5 treatment reduces infarct size in rats with middle cerebral artery occlusion
Q35145450Neurotrophins and neurodegeneration.
Q36232695Neurotrophins and their receptors in rat peripheral trigeminal system during maxillary nerve growth.
Q48287267Neurotrophins and their receptors in the tench retina during optic nerve regeneration
Q71660730Neurotrophins and their trk receptors in cultured cells of the glial lineage and in white matter of the central nervous system
Q48374445Neurotrophins regulate the function of cultured microglia
Q35845700Novel transcripts reveal a complex structure of the human TRKA gene and imply the presence of multiple protein isoforms
Q73134382On the role of the low-affinity neurotrophin receptor p75LNTR in nerve growth factor induction of differentiation and AP 1 binding activity in PC12 cells
Q30194476Oncogenes, Protein Tyrosine Kinases, and Signal Transduction
Q24556565Oncogenic activation of the human trk proto-oncogene by recombination with the ribosomal large subunit protein L7a
Q41306757PC12-E2 cells: a stable variant with altered responses to growth factor stimulation
Q41472183Participation of nerve growth factor in the regulation of ovarian function.
Q40912774Pharmacology of nerve growth factor in the brain
Q64982906Prevention of apoptotic neuronal death by GM1 ganglioside. Involvement of Trk neurotrophin receptors.
Q30675835Prolonged exposure to elevated levels of endogenous nerve growth factor affects the morphological and neurochemical features of sympathetic neurons of postnatal and adult mice
Q40867771Protein tyrosine kinase growth factor receptors and their ligands in development, differentiation, and cancer
Q35229328Protein tyrosine kinases in nervous system development
Q46597824Protein tyrosine phosphatase receptor type Z dephosphorylates TrkA receptors and attenuates NGF-dependent neurite outgrowth of PC12 cells
Q73995819Proximal promoter sequences mediate cell-specific and elevated expression of the favorable prognosis marker TrkA in human neuroblastoma cells
Q46744440Rapid phosphorylation of phospholipase C gamma 1 by brain-derived neurotrophic factor and neurotrophin-3 in cultures of embryonic rat cortical neurons
Q24564404Receptor protein tyrosine phosphatase alpha activates pp60c-src and is involved in neuronal differentiation
Q59067674Recombinant fibroblast growth factor-1 promotes intimal hyperplasia and angiogenesis in arteries in vivo
Q43640121Regulation of the Y1 neuropeptide Y receptor gene expression in PC12 cells
Q36812702RelB, a new Rel family transcription activator that can interact with p50-NF-kappa B.
Q28771479Retrolinkin, a membrane protein, plays an important role in retrograde axonal transport
Q42166582Role of AKT/PKB signaling in fibroblast growth factor-1 (FGF-1)-induced angiogenesis in the chicken chorioallantoic membrane (CAM).
Q47146770Role of BDNF/TrkB pathway in the visual system: Therapeutic implications for glaucoma
Q41792400Role of p75 neurotrophin receptor in the neurotoxicity by beta-amyloid peptides and synergistic effect of inflammatory cytokines
Q35131575Roles of trk family neurotrophin receptors in medullary thyroid carcinoma development and progression
Q36621089Search for NTRK1 proto-oncogene rearrangements in human thyroid tumours originated after therapeutic radiation
Q70901850Seizures increase trkC mRNA expression in the dentate gyrus of rat hippocampus. Role of glutamate receptor activation
Q52205343Selective regulation of TrkA and TrkB receptors by retinoic acid and interferon-gamma in human neuroblastoma cell lines.
Q34338664Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene.
Q35228909Signal Transduction by the Colony-Stimulating Factor-1 Receptor; Comparison to Other Receptor Tyrosine Kinases
Q42796164Simultaneous downregulation of CDK inhibitors p18(Ink4c) and p27(Kip1) is required for MEN2A-RET-mediated mitogenesis
Q24307989Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling
Q28591215Spatiotemporal patterns of expression of neurotrophins and neurotrophin receptors in mice suggest functional roles in testicular and epididymal morphogenesis
Q71816063Specific neurotrophin binding to leucine‐rich motif peptides of TrkA and TrkB
Q24291977Specificity in Trk receptor:neurotrophin interactions: the crystal structure of TrkB-d5 in complex with neurotrophin-4/5
Q31084932Sputa nerve growth factor forms a preferable substitute to mouse 7S-beta nerve growth factor
Q40374660Structural and functional properties of the TRK family of neurotrophin receptors
Q37599025Structural characterization of nonactive site, TrkA-selective kinase inhibitors.
Q24310833Structure and organization of the human TRKA gene encoding a high affinity receptor for nerve growth factor
Q36698072Structure, mapping, and expression of erp, a growth factor-inducible gene encoding a nontransmembrane protein tyrosine phosphatase, and effect of ERP on cell growth
Q24554215Structure-function analysis of SUV39H1 reveals a dominant role in heterochromatin organization, chromosome segregation, and mitotic progression
Q42434702TRK-A, HER-2/neu, and KIT Expression/Activation Profiles in Salivary Gland Carcinoma
Q28591473Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death
Q37322267Targeting nerve growth factor in pain: what is the therapeutic potential?
Q30002320Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation
Q28144152The Csk homologous kinase associates with TrkA receptors and is involved in neurite outgrowth of PC12 cells
Q24311495The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain
Q38297918The Drosophila insulin receptor contains a novel carboxyl-terminal extension likely to play an important role in signal transduction
Q28288204The HIV-1 TAT protein induces the expression and extracellular appearance of acidic fibroblast growth factor
Q41563732The Met receptor tyrosine kinase transduces motility, proliferation, and morphogenic signals of scatter factor/hepatocyte growth factor in epithelial cells
Q42623357The N-terminal globular domain of Eph receptors is sufficient for ligand binding and receptor signaling
Q71795873The Neurotrophin Receptors TrkA and TrkB are Inhibitory for Neurite Outgrowth
Q50315358The Protein Tyrosine Phosphatase MEG2 Regulates the Transport and Signal Transduction of Tropomyosin Receptor Kinase A.
Q40874607The Rgr oncogene (homologous to RalGDS) induces transformation and gene expression by activating Ras, Ral and Rho mediated pathways
Q37639840The binding epitopes of neurotrophin-3 to its receptors trkC and gp75 and the design of a multifunctional human neurotrophin.
Q73169905The coexistence of TrkA with putative transmitter agents and calcium-binding proteins in the vagal and glossopharyngeal sensory neurons of the adult rat
Q42819354The cysteine residue responsible for the release of fibroblast growth factor-1 residues in a domain independent of the domain for phosphatidylserine binding
Q28571207The death receptor antagonist FAIM promotes neurite outgrowth by a mechanism that depends on ERK and NF-kapp B signaling
Q28580900The death receptor antagonist FLIP-L interacts with Trk and is necessary for neurite outgrowth induced by neurotrophins
Q41594504The expanding role of nerve growth factor: from neurotrophic activity to immunologic diseases
Q35227908The nerve growth factor receptor: a multicomponent system that mediates the actions of the neurotrophin family of proteins
Q39948991The neuroblastoma tumour-suppressor TrkAI and its oncogenic alternative TrkAIII splice variant exhibit geldanamycin-sensitive interactions with Hsp90 in human neuroblastoma cells
Q28295368The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor
Q42805592The noncatalytic TrkCNC2 receptor is cleaved by metalloproteases upon neurotrophin-3 stimulation
Q41191822The nuclear trafficking of extracellular fibroblast growth factor (FGF)-1 correlates with the perinuclear association of the FGF receptor-1alpha isoforms but not the FGF receptor-1beta isoforms
Q38297803The orphan mouse receptor interleukin (IL)-8R beta binds N51. Structure-function analysis using N51/IL-8 chimeric molecules
Q42833929The precursor but not the mature form of IL1alpha blocks the release of FGF1 in response to heat shock
Q46494894The pro-fibrogenic effect of nerve growth factor on conjunctival fibroblasts is mediated by transforming growth factor-beta
Q42805482The protein kinase mos activates MAP kinase kinase in vitro and stimulates the MAP kinase pathway in mammalian somatic cells in vivo
Q36898497The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor
Q38299909The release of fibroblast growth factor-1 from NIH 3T3 cells in response to temperature involves the function of cysteine residues
Q41656246The ret oncogene products are membrane-bound glycoproteins phosphorylated on tyrosine residues in vivo
Q30176292The role of the linker between the SH2 domain and catalytic domain in the regulation and function of Src.
Q34190204The trk family of receptors mediates nerve growth factor and neurotrophin-3 effects in melanocytes.
Q28609788The trk proto-oncogene encodes a receptor for nerve growth factor
Q41674996The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3.
Q34497200The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3
Q30450983The tyrosine kinase receptors Ron and Sea control "scattering" and morphogenesis of liver progenitor cells in vitro
Q39902669Trafficking of TrkA-green fluorescent protein chimerae during nerve growth factor-induced differentiation
Q41552629Transformation of mouse fibroblasts with the oncogenes H-ras OR trk is associated with pronounced changes in drug sensitivity and metabolism
Q48464687Transient ischemia-induced expression and changes of tyrosine kinase A in the hippocampal dentate gyrus of the gerbil.
Q48880171Trk receptor alterations in Alzheimer's disease.
Q41341486TrkA Tyrosine Residues Involved in NGF‐induced Neurite Outgrowth of PC12 Cells
Q37376155TrkA activation is sufficient to rescue axotomized cholinergic neurons
Q24307374TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma
Q41724436TrkA amino acids controlling specificity for nerve growth factor.
Q34442757TrkA cross-linking mimics neuronal responses to nerve growth factor
Q33965019TrkA immunoglobulin-like ligand binding domains inhibit spontaneous activation of the receptor
Q41216085TrkA mediates the nerve growth factor-induced intracellular calcium accumulation.
Q41233767TrkA receptor ectodomain cleavage generates a tyrosine-phosphorylated cell-associated fragment
Q37582910TrkB as a therapeutic target for ovarian cancer.
Q38940598TrkB inhibition by GNF-4256 slows growth and enhances chemotherapeutic efficacy in neuroblastoma xenografts
Q43259331Tunicamycin-induced cell death in the trigeminal ganglion is suppressed by nerve growth factor in the mouse embryo
Q36534828Two pathways for the degradation of the H2 subunit of the asialoglycoprotein receptor in the endoplasmic reticulum
Q46824443Tyr-701 is a new regulatory site for neurotrophin receptor TrkA trafficking and function.
Q40872205Tyrosine 785 is a major determinant of Trk--substrate interaction
Q34576586Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF.
Q24310364axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase
Q53596015beta-Nerve growth factor participates in an auto/paracrine pathway of regulation of the meiotic differentiation of rat spermatocytes.
Q34396259cDNA cloning of a novel membrane glycoprotein that is expressed specifically in glial cells in the mouse brain. LIG-1, a protein with leucine-rich repeats and immunoglobulin-like domains
Q24555683cdc2 family kinases phosphorylate a human cell DNA replication factor, RPA, and activate DNA replication
Q24313468p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins
Q42489003trk-immunoreactivity in the monkey central nervous system: forebrain
Q28273781trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor
Q47734647trkB messenger RNA expression in normal human brain and in the substantia nigra of parkinsonian patients: an in situ hybridization study
Q33332038trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors
Q40822237trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development.
Q24564488trkC encodes multiple neurotrophin-3 receptors with distinct biological properties and substrate specificities
Q28301898trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3

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