scholarly article | Q13442814 |
P2093 | author name string | M. Barbacid | |
D. Martin-Zanca | |||
T. Copeland | |||
G. Mitra | |||
R. Oskam | |||
P2860 | cites work | An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs | Q22066003 |
DNA sequencing with chain-terminating inhibitors | Q22066207 | ||
Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus | Q24339526 | ||
Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors | Q24339620 | ||
Structure and expression of the human haptoglobin locus | Q24555818 | ||
Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand | Q24555963 | ||
Activation of the receptor kinase domain of the trk oncogene by recombination with two different cellular sequences | Q24564358 | ||
Tumor-promoting phorbol diesters cause the phosphorylation of epidermal growth factor receptors in normal human fibroblasts at threonine-654 | Q24568057 | ||
Human c-ros-1 gene homologous to the v-ros sequence of UR2 sarcoma virus encodes for a transmembrane receptorlike molecule | Q24613757 | ||
Molecular characterization of the human trk oncogene | Q68760028 | ||
Bifunctional messenger RNAs in eukaryotes | Q69660482 | ||
ret transforming gene encodes a fusion protein homologous to tyrosine kinases | Q24628687 | ||
A comprehensive set of sequence analysis programs for the VAX | Q26778432 | ||
Rapid and efficient site-specific mutagenesis without phenotypic selection | Q27860608 | ||
Rapid and efficient site-specific mutagenesis without phenotypic selection | Q27860628 | ||
A new technique for the assay of infectivity of human adenovirus 5 DNA | Q27860797 | ||
Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing | Q27860941 | ||
Oncogenes in solid human tumours | Q28279392 | ||
A novel putative tyrosine kinase receptor encoded by the eph gene | Q28280591 | ||
A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences | Q28282360 | ||
Activation of a novel human transforming gene, ret, by DNA rearrangement | Q28286635 | ||
Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene | Q28286890 | ||
A non-AUG translational initiation in c-myc exon 1 generates an N-terminally distinct protein whose synthesis is disrupted in Burkitt's lymphomas | Q28294528 | ||
The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1 | Q28299663 | ||
The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling | Q28615445 | ||
Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes | Q28615460 | ||
Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter | Q29614259 | ||
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells | Q29616544 | ||
Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors | Q29616545 | ||
Protein-tyrosine kinases | Q29616546 | ||
Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity | Q33880454 | ||
Receptors for epidermal growth factor and other polypeptide mitogens | Q34163558 | ||
The human met oncogene is related to the tyrosine kinase oncogenes | Q34201032 | ||
Identification and biochemical characterization of p70TRK, product of the human TRK oncogene | Q34348845 | ||
Tyr527 is phosphorylated in pp60c-src: implications for regulation | Q34383180 | ||
Genetic structure and transforming sequence of avian sarcoma virus UR2 | Q36939258 | ||
A thousand and one protein kinases | Q39596528 | ||
Biosynthetic protein transport and sorting by the endoplasmic reticulum and Golgi | Q39664981 | ||
Surface-specific iodination of membrane proteins of viruses and eucaryotic cells using 1,3,4,6-tetrachloro-3α,6α-diphenylglycoluril | Q40196106 | ||
Transfer of proteins across membranes | Q40313007 | ||
Transforming potential of the c-fms proto-oncogene (CSF-1 receptor). | Q42808913 | ||
Sevenless, a cell-specific homeotic gene of Drosophila, encodes a putative transmembrane receptor with a tyrosine kinase domain | Q44689071 | ||
Molecular cloning of a new transforming gene from a chemically transformed human cell line. | Q45345810 | ||
Evidence that the phosphorylation of tyrosine is essential for cellular transformation by Rous sarcoma virus | Q45803202 | ||
A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family | Q48366626 | ||
Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor | Q48369441 | ||
The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen | Q52827123 | ||
Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences. | Q53554133 | ||
Protein kinase C phosphorylation at Thr 654 of the unoccupied EGF receptor and EGF binding regulate functional receptor loss by independent mechanisms | Q56911539 | ||
Fused transcript of abl and bcr genes in chronic myelogenous leukaemia | Q59064021 | ||
Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane | Q59070337 | ||
P433 | issue | 1 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | Neurotrophic receptor tyrosine kinase 1 | Q4051790 |
peptidyl-tyrosine phosphorylation | Q14330986 | ||
P304 | page(s) | 24–33 | |
P577 | publication date | 1989-01-01 | |
P1433 | published in | Molecular and Cellular Biology | Q3319478 |
P1476 | title | Molecular and biochemical characterization of the human trk proto-oncogene | |
P478 | volume | 9 |
Q34763605 | 1 Protein kinase classification |
Q40792892 | A C-terminal domain in FosB, absent in FosB/SF and Fra-1, which is able to interact with the TATA binding protein, is required for altered cell growth. |
Q42026320 | A Comprehensive Functional Analysis of NTRK1 Missense Mutations Causing Hereditary Sensory and Autonomic Neuropathy Type IV (HSAN IV) |
Q42647984 | A carboxyl-terminal domain in fibroblast growth factor (FGF)-2 inhibits FGF-1 release in response to heat shock in vitro |
Q24568236 | A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain |
Q41182768 | A metastatic neuroblastoma model in SCID mice |
Q22253207 | A non-transmembrane form of Jagged-1 regulates the formation of matrix-dependent chord-like structures |
Q38346153 | A novel Drosophila receptor tyrosine kinase expressed specifically in the nervous system. Unique structural features and implication in developmental signaling |
Q54380745 | A novel role of suppressor of cytokine signaling-2 in the regulation of TrkA neurotrophin receptor biology. |
Q24562632 | A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain |
Q33943860 | A short in-frame deletion in NTRK1 tyrosine kinase domain caused by a novel splice site mutation in a patient with congenital insensitivity to pain with anhidrosis |
Q36578603 | A signaling organelle containing the nerve growth factor-activated receptor tyrosine kinase, TrkA. |
Q24648317 | A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype |
Q24532216 | Aberrant axonal projections in mice lacking EphA8 (Eek) tyrosine protein kinase receptors |
Q55240171 | Abundant but inactive-state gp140proto-trk is expressed in neuroblastomas of patients with good prognosis. |
Q40780192 | Acidic substitution of the activation loop tyrosines in TrkA supports nerve growth factor-independent cell survival and neuronal differentiation |
Q43717552 | Adenovirus vector-directed expression of the neurotrophin-3 receptor (TrkC) in mouse astrocytes |
Q36429595 | Alternative TrkAIII splicing: a potential regulated tumor-promoting switch and therapeutic target in neuroblastoma. |
Q44306021 | Alternatively spliced FGFR-1 isoform signaling differentially modulates endothelial cell responses to peroxynitrite |
Q22004002 | An alternatively spliced fibroblast growth factor (FGF)-5 mRNA is abundant in brain and translates into a partial agonist/antagonist for FGF-5 neurotrophic activity |
Q35897889 | An alternatively spliced form of the nerve growth factor receptor TrkA confers an enhanced response to neurotrophin 3. |
Q37698490 | An immunoglobulin-like domain determines the specificity of neurotrophin receptors. |
Q42814674 | Analysis of endogenous and exogenous nuclear translocation of fibroblast growth factor-1 in NIH 3T3 cells |
Q46421786 | Analytical purification of the slow, high affinity NGF receptor: Identification of a novel 135 kd polypeptide |
Q73215420 | Autophosphorylation of activation loop tyrosines regulates signaling by the TRK nerve growth factor receptor |
Q48973255 | Axotomy alters neurotrophin and neurotrophin receptor mRNAs in the vagus nerve and nodose ganglion of the rat. |
Q38331685 | Biogenesis and function of the NGF/TrkA signaling endosome |
Q24606830 | Both N- and C-terminal domains of RelB are required for full transactivation: role of the N-terminal leucine zipper-like motif |
Q38332525 | Both products of the fosB gene, FosB and its short form, FosB/SF, are transcriptional activators in fibroblasts |
Q34065279 | Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease |
Q40951689 | Brain-derived neurotrophic factor promotes survival and chemoprotection of human neuroblastoma cells |
Q61684994 | CD34-positive cells in human umbilical cord blood express nerve growth factor and its specific receptor TrkA |
Q42797896 | CEP-751 inhibits TRK receptor tyrosine kinase activity in vitro exhibits anti-tumor activity |
Q48421205 | Cells Expressing mRNA for Neurotrophins and their Receptors During Embryonic Rat Development. |
Q33638611 | Cellular aspects of trophic actions in the nervous system. |
Q42556384 | Change in neurotrophins and their receptor mRNAs in the rat forebrain after status epilepticus induced by pilocarpine |
Q28581032 | Characterization of densin-180, a new brain-specific synaptic protein of the O-sialoglycoprotein family |
Q36280921 | Characterization of the recombinant extracellular domain of the neurotrophin receptor TrkA and its interaction with nerve growth factor (NGF) |
Q37304874 | Circulating nerve growth factor levels are increased in humans with allergic diseases and asthma |
Q34464521 | Competitive signaling between TrkA and p75 nerve growth factor receptors determines cell survival. |
Q42587781 | Concentration-dependent regulation of neuronal gene expression by nerve growth factor |
Q33906447 | Congenital insensitivity to pain with anhidrosis (CIPA) in Israeli-Bedouins: genetic heterogeneity, novel mutations in the TRKA/NGF receptor gene, clinical findings, and results of nerve conduction studies |
Q40594499 | Congenital insensitivity to pain with anhidrosis (CIPA): novel mutations of the TRKA (NTRK1) gene, a putative uniparental disomy, and a linkage of the mutant TRKA and PKLR genes in a family with CIPA and pyruvate kinase deficiency |
Q34389720 | Congenital insensitivity to pain with anhidrosis: novel mutations in the TRKA (NTRK1) gene encoding a high-affinity receptor for nerve growth factor |
Q41925640 | Defining a mechanistic link between pigment epithelium-derived factor, docosahexaenoic acid and corneal nerve regeneration |
Q48393512 | Development of survival responsiveness to brain-derived neurotrophic factor, neurotrophin 3 and neurotrophin 4/5, but not to nerve growth factor, in cultured motoneurons from chick embryo spinal cord. |
Q71893219 | Development of the primary afferent projection in human spinal cord |
Q52211644 | Developmentally regulated expression of mRNA for neurotrophin high-affinity (trk) receptors within chick trigeminal sensory neurons. |
Q36493889 | Differential expression of nerve growth factor receptors leads to altered binding affinity and neurotrophin responsiveness. |
Q40793381 | Differential interactions of Rel-NF-kappa B complexes with I kappa B alpha determine pools of constitutive and inducible NF-kappa B activity |
Q58112780 | Dimerization of the Trk receptors in the plasma membrane: effects of their cognate ligands |
Q41628475 | Disruption of the low affinity receptor-binding site in NGF allows neuronal survival and differentiation by binding to the trk gene product |
Q35005769 | Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neurons |
Q73589609 | Distribution of NGF receptors in normal and pathologic human lymphoid tissues |
Q36451039 | Dror, a potential neurotrophic receptor gene, encodes a Drosophila homolog of the vertebrate Ror family of Trk-related receptor tyrosine kinases |
Q33937330 | Dtrk, a Drosophila gene related to the trk family of neurotrophin receptors, encodes a novel class of neural cell adhesion molecule |
Q22007989 | EDF-1, a novel gene product down-regulated in human endothelial cell differentiation |
Q67487956 | Effects of NGF and glucocorticoid on NGF receptor immunolabeling of cultured rhesus adrenal chromaffin cells |
Q47138460 | Effects of cerebrolysin on nerve growth factor system in the aging rat brain. |
Q43456828 | Effects of insulin and insulin-like growth factors on neurofilament mRNA and tubulin mRNA content in human neuroblastoma SH-SY5Y cells |
Q71955066 | Endocytosis of activated TrkA: evidence that nerve growth factor induces formation of signaling endosomes |
Q42602466 | Endogenous interleukin 1 alpha must be transported to the nucleus to exert its activity in human endothelial cells |
Q52190717 | Endogenous nerve growth factor and neurotrophin-3 act simultaneously to ensure the survival of postnatal sympathetic neurons in vivo. |
Q36594251 | Endoplasmic reticulum quality control of asialoglycoprotein receptor H2a involves a determinant for retention and not retrieval |
Q47846225 | Eradication of cerebellar granular cells alters the developmental expression of trk receptors in the rat inferior olive |
Q40557195 | Estrogen and nerve growth factor-related systems in brain. Effects on basal forebrain cholinergic neurons and implications for learning and memory processes and aging |
Q36644617 | Expression and function of TRK-B and BDNF in human neuroblastomas |
Q41078653 | Expression and function of TrkB variants in developing sensory neurons. |
Q47973679 | Expression of NGF receptors in normal and pathological human thymus |
Q35199818 | Expression of TrkA confers neuron-like responsiveness to nerve growth factor on an immortalized hypothalamic cell line |
Q73109117 | Expression of TrkA, TrkB and TrkC in human neuroblastomas |
Q41873962 | Expression of beta-nerve growth factor and its receptor in rat seminiferous epithelium: specific function at the onset of meiosis |
Q36356073 | Expression of functional trk protooncogene in human monocytes |
Q48794963 | Expression of mRNA for brain-derived neurotrophic factor in the dorsal root ganglion following peripheral inflammation. |
Q36136048 | Expression of mRNA for the neurotrophin receptor trkC in neuroblastomas with favourable tumour stage and good prognosis |
Q28295025 | Expression of mRNAs for neurotrophic factors (NGF, BDNF, NT-3, and GDNF) and their receptors (p75NGFR, trkA, trkB, and trkC) in the adult human peripheral nervous system and nonneural tissues |
Q48477752 | Expression of mRNAs for neurotrophins (NGF, BDNF, and NT-3) and their receptors (p75NGFR, trk, trkB, and trkC) in human peripheral neuropathies. |
Q40988990 | Expression of mRNAs of multiple growth factors and receptors by astrocytes and glioma cells: detection with reverse transcription-polymerase chain reaction. |
Q52204283 | Expression of mRNAs of multiple growth factors and receptors by neuronal cell lines: detection with RT-PCR. |
Q36684141 | Expression of nerve growth factor and nerve growth factor receptor tyrosine kinase Trk in activated CD4-positive T-cell clones |
Q49130270 | Expression of neurotrophin trk and p75 receptors in quail embryos undergoing gastrulation and neurulation. |
Q73835346 | Expression of neurotrophins and their receptors (TRK) during fracture healing |
Q40673214 | Expression of polycystin-1 C-terminal fragment enhances the ATP-induced Ca2+ release in human kidney cells |
Q42819405 | Expression of the naturally occurring truncated trkB neurotrophin receptor induces outgrowth of filopodia and processes in neuroblastoma cells |
Q24613828 | Expression of the v-crk oncogene product in PC12 cells results in rapid differentiation by both nerve growth factor- and epidermal growth factor-dependent pathways |
Q35207002 | Expression of trk in MAH cells lacking the p75 low-affinity nerve growth factor receptor is sufficient to permit nerve growth factor-induced differentiation to postmitotic neurons |
Q36827332 | Expression of trkA cDNA in neuroblastomas mediates differentiation in vitro and in vivo |
Q92731061 | Extracellular Juxtamembrane Motif Critical for TrkB Preformed Dimer and Activation |
Q44407276 | Farnesyltransferase inhibitor FTI-277 prevents autocrine growth stimulation of neuroblastoma by BDNF. |
Q71830006 | Frequent expression of genes for receptor tyrosine kinases and their ligands in human pancreatic cancer cells |
Q31122268 | Fte-1, a v-fos transformation effector gene, encodes the mammalian homologue of a yeast gene involved in protein import into mitochondria |
Q22003807 | Functional analysis of H-Ryk, an atypical member of the receptor tyrosine kinase family |
Q40994436 | Functional expression of TrkA receptors in hippocampal neurons |
Q40846828 | Fusions to members of fibroblast growth factor gene family to study nuclear translocation and nonclassic exocytosis |
Q34289656 | Ganglioside GM1 binds to the Trk protein and regulates receptor function |
Q47792189 | Gestational exposure to methylmercury alters neurotrophin- and carbachol-stimulated phosphatidylinositide hydrolysis in cerebral cortex of neonatal rats |
Q37293193 | Heat shock induces the release of fibroblast growth factor 1 from NIH 3T3 cells |
Q48222648 | High affinity neurotrophin receptors in the human pre-term newborn, infant, and adult cerebellum |
Q28263675 | High resolution mapping of the binding site of TrkA for nerve growth factor and TrkC for neurotrophin-3 on the second immunoglobulin-like domain of the Trk receptors |
Q41687095 | High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor |
Q34440795 | Human CD4+ T cell clones produce and release nerve growth factor and express high-affinity nerve growth factor receptors |
Q41085580 | Human mast cells express functional TrkA and are a source of nerve growth factor. |
Q24310691 | Human platelet glycoprotein V: characterization of the polypeptide and the related Ib-V-IX receptor system of adhesive, leucine-rich glycoproteins |
Q28115087 | Human trk oncogenes activated by point mutation, in-frame deletion, and duplication of the tyrosine kinase domain |
Q30959617 | Identification and characterization of an activating TrkA deletion mutation in acute myeloid leukemia |
Q24324648 | Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine-zipper domains |
Q73784367 | Identification of novel trkA variants with deletions in leucine-rich motifs of the extracellular domain |
Q36444009 | Identification of tyrosine kinase Trk as a nerve growth factor receptor |
Q41538094 | Immunocytochemical analysis of phosphatidylinositol-specific phospholipase C in PC12 cells: predominance of the delta isoform during neural differentiation. |
Q48673316 | Immunoglobulin-like domains define the nerve growth factor binding site of the TrkA receptor. |
Q58980339 | Immunohistochemical Distribution of Neurotrophins and their Receptors in the Rat Retina and the Effects of Ischemia and Reperfusion* |
Q73109123 | Immunohistochemical detection of p140trkA and p75LNGFR neurotrophin receptors in neuroblastoma |
Q35833678 | Immunohistochemical localization of Trk receptor protein in pediatric small round blue cell tumors. |
Q42501361 | In situ hybridization detection of trkA mRNA in brain: distribution, colocalization with p75NGFR and up-regulation by nerve growth factor |
Q41552489 | Increased neurite outgrowth induced by inhibition of protein tyrosine kinase activity in PC12 pheochromocytoma cells |
Q41439139 | Induction of nerve growth factor responsiveness in C6-2B glioma cells by expression of trkA proto-oncogene |
Q57154788 | Insights into Current Tropomyosin Receptor Kinase (TRK) Inhibitors: Development and Clinical Application |
Q24313399 | Interaction in vitro of the product of the c-Crk-II proto-oncogene with the insulin-like growth factor I receptor |
Q28249975 | Interactions between brain-derived neurotrophic factor and the TRKB receptor. Identification of two ligand binding domains in soluble TRKB by affinity separation and chemical cross-linking |
Q41452155 | Involvement of S100-related calcium-binding protein pEL98 (or mts1) in cell motility and tumor cell invasion |
Q40861605 | Ion channels and early development of neural cells |
Q33997030 | Is bone a target-tissue for the nervous system? New advances on the understanding of their interactions |
Q42461925 | K-252b selectively potentiates cellular actions and trk tyrosine phosphorylation mediated by neurotrophin-3. |
Q36388074 | Keeping track of neurotrophin receptors |
Q48014156 | Lampetra fluviatilis neurotrophin homolog, descendant of a neurotrophin ancestor, discloses the early molecular evolution of neurotrophins in the vertebrate subphylum. |
Q47988662 | Level of p75 receptor expression in sensory ganglia is modulated by NGF level in the target tissue. |
Q42450586 | Localization of nerve growth factor, trkA and P75 immunoreactivity in the hippocampal formation and basal forebrain of adult rats |
Q48237185 | Localization of trkB mRNA in postnatal brain development |
Q48475486 | Long-term dietary restriction differentially affects the expression of BDNF and its receptors in the cortex and hippocampus of middle-aged and aged male rats. |
Q55006667 | Low frequency of rearrangements of the ret and trk proto-oncogenes in Japanese thyroid papillary carcinomas |
Q39367969 | MYCN and ALKF1174L are sufficient to drive neuroblastoma development from neural crest progenitor cells |
Q35094654 | Measurements in the Blood of BDNF for RA Patients and in Response to Anti-TNF Treatment Help Us to Clarify the Magnitude of Centrally Related Pain and to Explain the Relief of This Pain upon Treatment |
Q24594163 | Mechanism of activation of the human trk oncogene |
Q40788669 | Membrane-bound LERK2 ligand can signal through three different Eph-related receptor tyrosine kinases |
Q48361736 | Methylmercury decreases NGF-induced TrkA autophosphorylation and neurite outgrowth in PC12 cells |
Q40772666 | Mitogenesis in glioblastoma multiforme cell lines: a role for NGF and its TrkA receptors |
Q47631068 | Modeling of the three-dimensional structure of proteins with the typical leucine-rich repeats |
Q73896593 | Molecular analysis of trkC in the cat visual cortex |
Q34465802 | Molecular basis of congenital insensitivity to pain with anhidrosis (CIPA): mutations and polymorphisms in TRKA (NTRK1) gene encoding the receptor tyrosine kinase for nerve growth factor |
Q73088407 | Molecular cloning and characterization of the 5' region of the mouse trkA proto-oncogene |
Q70470550 | Molecular cloning and expression of a novel truncated form of chicken trkC |
Q28579759 | Molecular cloning of a novel membrane glycoprotein, pal, specifically expressed in photoreceptor cells of the retina and containing leucine-rich repeat |
Q28592605 | Molecular cloning of the mouse grb2 gene: differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptors |
Q37218752 | Molecular kinetics of nerve growth factor receptor trafficking and activation |
Q47752292 | Mutational analysis of the TrkA gene in prostate cancer |
Q34733805 | Mutations in the TRKA/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis |
Q28265064 | N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling |
Q42795746 | NF1 modulates the effects of Ras oncogenes: evidence of other NF1 function besides its GAP activity |
Q67810476 | NGF and EGF rapidly activate p21ras in PC12 cells by distinct, convergent pathways involving tyrosine phosphorylation |
Q36235736 | NGF-stimulated retrograde transport of trkA in the mammalian nervous system |
Q92924197 | NTRK Fusions in Central Nervous System Tumors: A Rare, but Worthy Target |
Q58547264 | NTRK fusion-positive cancers and TRK inhibitor therapy |
Q36759079 | Nerve growth factor acutely reduces chemical transmission by means of postsynaptic TrkA-like receptors in squid giant synapse. |
Q38033634 | Nerve growth factor and the physiology of pain: lessons from congenital insensitivity to pain with anhidrosis |
Q40677352 | Nerve growth factor and the skin |
Q35932924 | Nerve growth factor displays stimulatory effects on human skin and lung fibroblasts, demonstrating a direct role for this factor in tissue repair |
Q36706107 | Nerve growth factor is an autocrine factor essential for the survival of macrophages infected with HIV |
Q37541110 | Nerve growth factor rapidly stimulates tyrosine phosphorylation of phospholipase C-gamma 1 by a kinase activity associated with the product of the trk protooncogene |
Q37694590 | Nerve growth factor signaling in prostate health and disease. |
Q36501758 | Nerve growth factor suppresses the transforming phenotype of human prolactinomas |
Q33670627 | Nerve growth factor: a neurotrophin with activity on cells of the immune system |
Q36908290 | Neurite extension occurs in the absence of regulated exocytosis in PC12 subclones. |
Q72150036 | Neuronal and nonneuronal expression of neurotrophins and their receptors in sensory and sympathetic ganglia suggest new intercellular trophic interactions |
Q36412788 | Neuronal colocalization of mRNAs for neurotrophins and their receptors in the developing central nervous system suggests a potential for autocrine interactions. |
Q40875490 | Neuronal differentiation in human neuroblastoma cells by nerve growth factor following TrkA up-regulation by interferon-gamma |
Q33952005 | Neurotrophic factors in the primary olfactory pathway. |
Q42619312 | Neurotrophin receptors in the somatosensory cortex of the mature rat: co-localization of p75, trk, isoforms and c-neu |
Q57009636 | Neurotrophin-3 and neurotrophin receptor immunoreactivity in peptidergic enteric neurons |
Q48338447 | Neurotrophin-3 receptors in the developing chicken retina |
Q46124149 | Neurotrophin-4/5 treatment reduces infarct size in rats with middle cerebral artery occlusion |
Q35145450 | Neurotrophins and neurodegeneration. |
Q36232695 | Neurotrophins and their receptors in rat peripheral trigeminal system during maxillary nerve growth. |
Q48287267 | Neurotrophins and their receptors in the tench retina during optic nerve regeneration |
Q71660730 | Neurotrophins and their trk receptors in cultured cells of the glial lineage and in white matter of the central nervous system |
Q48374445 | Neurotrophins regulate the function of cultured microglia |
Q35845700 | Novel transcripts reveal a complex structure of the human TRKA gene and imply the presence of multiple protein isoforms |
Q73134382 | On the role of the low-affinity neurotrophin receptor p75LNTR in nerve growth factor induction of differentiation and AP 1 binding activity in PC12 cells |
Q30194476 | Oncogenes, Protein Tyrosine Kinases, and Signal Transduction |
Q24556565 | Oncogenic activation of the human trk proto-oncogene by recombination with the ribosomal large subunit protein L7a |
Q41306757 | PC12-E2 cells: a stable variant with altered responses to growth factor stimulation |
Q41472183 | Participation of nerve growth factor in the regulation of ovarian function. |
Q40912774 | Pharmacology of nerve growth factor in the brain |
Q64982906 | Prevention of apoptotic neuronal death by GM1 ganglioside. Involvement of Trk neurotrophin receptors. |
Q30675835 | Prolonged exposure to elevated levels of endogenous nerve growth factor affects the morphological and neurochemical features of sympathetic neurons of postnatal and adult mice |
Q40867771 | Protein tyrosine kinase growth factor receptors and their ligands in development, differentiation, and cancer |
Q35229328 | Protein tyrosine kinases in nervous system development |
Q46597824 | Protein tyrosine phosphatase receptor type Z dephosphorylates TrkA receptors and attenuates NGF-dependent neurite outgrowth of PC12 cells |
Q73995819 | Proximal promoter sequences mediate cell-specific and elevated expression of the favorable prognosis marker TrkA in human neuroblastoma cells |
Q46744440 | Rapid phosphorylation of phospholipase C gamma 1 by brain-derived neurotrophic factor and neurotrophin-3 in cultures of embryonic rat cortical neurons |
Q24564404 | Receptor protein tyrosine phosphatase alpha activates pp60c-src and is involved in neuronal differentiation |
Q59067674 | Recombinant fibroblast growth factor-1 promotes intimal hyperplasia and angiogenesis in arteries in vivo |
Q43640121 | Regulation of the Y1 neuropeptide Y receptor gene expression in PC12 cells |
Q36812702 | RelB, a new Rel family transcription activator that can interact with p50-NF-kappa B. |
Q28771479 | Retrolinkin, a membrane protein, plays an important role in retrograde axonal transport |
Q42166582 | Role of AKT/PKB signaling in fibroblast growth factor-1 (FGF-1)-induced angiogenesis in the chicken chorioallantoic membrane (CAM). |
Q47146770 | Role of BDNF/TrkB pathway in the visual system: Therapeutic implications for glaucoma |
Q41792400 | Role of p75 neurotrophin receptor in the neurotoxicity by beta-amyloid peptides and synergistic effect of inflammatory cytokines |
Q35131575 | Roles of trk family neurotrophin receptors in medullary thyroid carcinoma development and progression |
Q36621089 | Search for NTRK1 proto-oncogene rearrangements in human thyroid tumours originated after therapeutic radiation |
Q70901850 | Seizures increase trkC mRNA expression in the dentate gyrus of rat hippocampus. Role of glutamate receptor activation |
Q52205343 | Selective regulation of TrkA and TrkB receptors by retinoic acid and interferon-gamma in human neuroblastoma cell lines. |
Q34338664 | Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene. |
Q35228909 | Signal Transduction by the Colony-Stimulating Factor-1 Receptor; Comparison to Other Receptor Tyrosine Kinases |
Q42796164 | Simultaneous downregulation of CDK inhibitors p18(Ink4c) and p27(Kip1) is required for MEN2A-RET-mediated mitogenesis |
Q24307989 | Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling |
Q28591215 | Spatiotemporal patterns of expression of neurotrophins and neurotrophin receptors in mice suggest functional roles in testicular and epididymal morphogenesis |
Q71816063 | Specific neurotrophin binding to leucine‐rich motif peptides of TrkA and TrkB |
Q24291977 | Specificity in Trk receptor:neurotrophin interactions: the crystal structure of TrkB-d5 in complex with neurotrophin-4/5 |
Q31084932 | Sputa nerve growth factor forms a preferable substitute to mouse 7S-beta nerve growth factor |
Q40374660 | Structural and functional properties of the TRK family of neurotrophin receptors |
Q37599025 | Structural characterization of nonactive site, TrkA-selective kinase inhibitors. |
Q24310833 | Structure and organization of the human TRKA gene encoding a high affinity receptor for nerve growth factor |
Q36698072 | Structure, mapping, and expression of erp, a growth factor-inducible gene encoding a nontransmembrane protein tyrosine phosphatase, and effect of ERP on cell growth |
Q24554215 | Structure-function analysis of SUV39H1 reveals a dominant role in heterochromatin organization, chromosome segregation, and mitotic progression |
Q42434702 | TRK-A, HER-2/neu, and KIT Expression/Activation Profiles in Salivary Gland Carcinoma |
Q28591473 | Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death |
Q37322267 | Targeting nerve growth factor in pain: what is the therapeutic potential? |
Q30002320 | Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation |
Q28144152 | The Csk homologous kinase associates with TrkA receptors and is involved in neurite outgrowth of PC12 cells |
Q24311495 | The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain |
Q38297918 | The Drosophila insulin receptor contains a novel carboxyl-terminal extension likely to play an important role in signal transduction |
Q28288204 | The HIV-1 TAT protein induces the expression and extracellular appearance of acidic fibroblast growth factor |
Q41563732 | The Met receptor tyrosine kinase transduces motility, proliferation, and morphogenic signals of scatter factor/hepatocyte growth factor in epithelial cells |
Q42623357 | The N-terminal globular domain of Eph receptors is sufficient for ligand binding and receptor signaling |
Q71795873 | The Neurotrophin Receptors TrkA and TrkB are Inhibitory for Neurite Outgrowth |
Q50315358 | The Protein Tyrosine Phosphatase MEG2 Regulates the Transport and Signal Transduction of Tropomyosin Receptor Kinase A. |
Q40874607 | The Rgr oncogene (homologous to RalGDS) induces transformation and gene expression by activating Ras, Ral and Rho mediated pathways |
Q37639840 | The binding epitopes of neurotrophin-3 to its receptors trkC and gp75 and the design of a multifunctional human neurotrophin. |
Q73169905 | The coexistence of TrkA with putative transmitter agents and calcium-binding proteins in the vagal and glossopharyngeal sensory neurons of the adult rat |
Q42819354 | The cysteine residue responsible for the release of fibroblast growth factor-1 residues in a domain independent of the domain for phosphatidylserine binding |
Q28571207 | The death receptor antagonist FAIM promotes neurite outgrowth by a mechanism that depends on ERK and NF-kapp B signaling |
Q28580900 | The death receptor antagonist FLIP-L interacts with Trk and is necessary for neurite outgrowth induced by neurotrophins |
Q41594504 | The expanding role of nerve growth factor: from neurotrophic activity to immunologic diseases |
Q35227908 | The nerve growth factor receptor: a multicomponent system that mediates the actions of the neurotrophin family of proteins |
Q39948991 | The neuroblastoma tumour-suppressor TrkAI and its oncogenic alternative TrkAIII splice variant exhibit geldanamycin-sensitive interactions with Hsp90 in human neuroblastoma cells |
Q28295368 | The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor |
Q42805592 | The noncatalytic TrkCNC2 receptor is cleaved by metalloproteases upon neurotrophin-3 stimulation |
Q41191822 | The nuclear trafficking of extracellular fibroblast growth factor (FGF)-1 correlates with the perinuclear association of the FGF receptor-1alpha isoforms but not the FGF receptor-1beta isoforms |
Q38297803 | The orphan mouse receptor interleukin (IL)-8R beta binds N51. Structure-function analysis using N51/IL-8 chimeric molecules |
Q42833929 | The precursor but not the mature form of IL1alpha blocks the release of FGF1 in response to heat shock |
Q46494894 | The pro-fibrogenic effect of nerve growth factor on conjunctival fibroblasts is mediated by transforming growth factor-beta |
Q42805482 | The protein kinase mos activates MAP kinase kinase in vitro and stimulates the MAP kinase pathway in mammalian somatic cells in vivo |
Q36898497 | The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor |
Q38299909 | The release of fibroblast growth factor-1 from NIH 3T3 cells in response to temperature involves the function of cysteine residues |
Q41656246 | The ret oncogene products are membrane-bound glycoproteins phosphorylated on tyrosine residues in vivo |
Q30176292 | The role of the linker between the SH2 domain and catalytic domain in the regulation and function of Src. |
Q34190204 | The trk family of receptors mediates nerve growth factor and neurotrophin-3 effects in melanocytes. |
Q28609788 | The trk proto-oncogene encodes a receptor for nerve growth factor |
Q41674996 | The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3. |
Q34497200 | The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3 |
Q30450983 | The tyrosine kinase receptors Ron and Sea control "scattering" and morphogenesis of liver progenitor cells in vitro |
Q39902669 | Trafficking of TrkA-green fluorescent protein chimerae during nerve growth factor-induced differentiation |
Q41552629 | Transformation of mouse fibroblasts with the oncogenes H-ras OR trk is associated with pronounced changes in drug sensitivity and metabolism |
Q48464687 | Transient ischemia-induced expression and changes of tyrosine kinase A in the hippocampal dentate gyrus of the gerbil. |
Q48880171 | Trk receptor alterations in Alzheimer's disease. |
Q41341486 | TrkA Tyrosine Residues Involved in NGF‐induced Neurite Outgrowth of PC12 Cells |
Q37376155 | TrkA activation is sufficient to rescue axotomized cholinergic neurons |
Q24307374 | TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma |
Q41724436 | TrkA amino acids controlling specificity for nerve growth factor. |
Q34442757 | TrkA cross-linking mimics neuronal responses to nerve growth factor |
Q33965019 | TrkA immunoglobulin-like ligand binding domains inhibit spontaneous activation of the receptor |
Q41216085 | TrkA mediates the nerve growth factor-induced intracellular calcium accumulation. |
Q41233767 | TrkA receptor ectodomain cleavage generates a tyrosine-phosphorylated cell-associated fragment |
Q37582910 | TrkB as a therapeutic target for ovarian cancer. |
Q38940598 | TrkB inhibition by GNF-4256 slows growth and enhances chemotherapeutic efficacy in neuroblastoma xenografts |
Q43259331 | Tunicamycin-induced cell death in the trigeminal ganglion is suppressed by nerve growth factor in the mouse embryo |
Q36534828 | Two pathways for the degradation of the H2 subunit of the asialoglycoprotein receptor in the endoplasmic reticulum |
Q46824443 | Tyr-701 is a new regulatory site for neurotrophin receptor TrkA trafficking and function. |
Q40872205 | Tyrosine 785 is a major determinant of Trk--substrate interaction |
Q34576586 | Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF. |
Q24310364 | axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase |
Q53596015 | beta-Nerve growth factor participates in an auto/paracrine pathway of regulation of the meiotic differentiation of rat spermatocytes. |
Q34396259 | cDNA cloning of a novel membrane glycoprotein that is expressed specifically in glial cells in the mouse brain. LIG-1, a protein with leucine-rich repeats and immunoglobulin-like domains |
Q24555683 | cdc2 family kinases phosphorylate a human cell DNA replication factor, RPA, and activate DNA replication |
Q24313468 | p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins |
Q42489003 | trk-immunoreactivity in the monkey central nervous system: forebrain |
Q28273781 | trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor |
Q47734647 | trkB messenger RNA expression in normal human brain and in the substantia nigra of parkinsonian patients: an in situ hybridization study |
Q33332038 | trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors |
Q40822237 | trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development. |
Q24564488 | trkC encodes multiple neurotrophin-3 receptors with distinct biological properties and substrate specificities |
Q28301898 | trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3 |
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