Winner's Curse Correction and Variable Thresholding Improve Performance of Polygenic Risk Modeling Based on Genome-Wide Association Study Summary-Level Data

scientific article (publication date: December 2016)

Winner's Curse Correction and Variable Thresholding Improve Performance of Polygenic Risk Modeling Based on Genome-Wide Association Study Summary-Level Data is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PGEN.1006493
P8608Fatcat IDrelease_c24gi3hanjckjc6y6gd5tfw3fe
P932PMC publication ID5201242
P698PubMed publication ID28036406

P50authorNilanjan ChatterjeeQ21526241
Paolo VineisQ25999450
Stephen ChanockQ27662321
Nathaniel RothmanQ28050622
Montserrat García-ClosasQ28356305
Nuria MalatsQ28360608
Maria Teresa LandiQ28606990
Hermann BrennerQ28958315
Victoria CortessisQ46581470
Douglas F LevinsonQ59748818
Alan R. SandersQ67652837
Jonine FigueroaQ71778357
Eric JacobsQ85550629
Yun-Chul HongQ85715844
Margaret KaragasQ88162936
Alison P KleinQ89907184
Jubao DuanQ90172397
Gloria M PetersenQ95972100
Harvey A. RischQ97531829
Debra T. SilvermanQ103839499
Neil CaporasoQ107095573
Brian M. WolpinQ110920101
Pablo V GejmanQ114270584
Adeline SeowQ114328035
Baosen ZhouQ114328051
Winton MoyQ114441101
Rachael Z. Stolzenberg-SolomonQ30002268
Laufey T. AmundadottirQ30093106
Keitaro MatsuoQ30506416
P2093author name stringKai Yu
William Wheeler
Donghui Li
Jianxin Shi
Ju-Hyun Park
Qing Lan
Lei Song
Dongxin Lin
Robert E Schoen
Chao Agnes Hsiung
Li Hsu
Xing Hua
I-Shou Chang
Sonja T Berndt
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Common SNPs explain a large proportion of the heritability for human heightQ29547221
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Genome-wide association study identifies multiple susceptibility loci for pancreatic cancerQ34314018
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Lung eQTLs to help reveal the molecular underpinnings of asthmaQ34499419
All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPsQ34699776
Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorderQ35059381
A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancerQ35248192
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancerQ35996692
Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk ScoresQ36133352
Estimation of effect size distribution from genome-wide association studies and implications for future discoveriesQ36191121
Partitioning heritability by functional annotation using genome-wide association summary statisticsQ36225291
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Global analysis of DNA methylation variation in adipose tissue from twins reveals links to disease-associated variants in distal regulatory elementsQ37298169
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P275copyright licenseCreative Commons CC0 LicenseQ6938433
P6216copyright statuscopyrighted, dedicated to the public domain by copyright holderQ88088423
P4510describes a project that usesgenome-wide association studyQ1098876
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectgenome-wide association studyQ1098876
P304page(s)e1006493
P577publication date2016-12-01
P1433published inPLOS GeneticsQ1893441
P1476titleWinner's Curse Correction and Variable Thresholding Improve Performance of Polygenic Risk Modeling Based on Genome-Wide Association Study Summary-Level Data
P478volume12

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