Vaccines against bovine babesiosis: where we are now and possible roads ahead

scientific article (publication date: 28 July 2014)

Vaccines against bovine babesiosis: where we are now and possible roads ahead is …
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scholarly articleQ13442814

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P356DOI10.1017/S0031182014000961
P3181OpenCitations bibliographic resource ID2573662
P698PubMed publication ID25068315

P50authorCarlos E SuarezQ91657659
Anabel RodriguezQ83140092
Monica Florin-ChristensenQ84748486
P2093author name stringLeonhard Schnittger
Daniela A Flores
P2860cites workThe Revised Classification of EukaryotesQ17792525
Advances and challenges in malaria vaccine developmentQ21032463
Genome sequence of Babesia bovis and comparative analysis of apicomplexan hemoprotozoaQ21090529
The New Higher Level Classification of Eukaryotes with Emphasis on the Taxonomy of ProtistsQ22065654
Genome Sequence of Theileria parva, a Bovine Pathogen That Transforms LymphocytesQ22065800
Genome of the Host-Cell Transforming Parasite Theileria annulata Compared with T. parvaQ22065801
BabesiosisQ24550713
Sequencing of the smallest Apicomplexan genome from the human pathogen Babesia microtiQ24630337
Babesia divergens, a bovine blood parasite of veterinary and zoonotic importanceQ24681513
Successful vaccines for naturally occurring protozoal diseases of animals should guide human vaccine research. A review of protozoal vaccines and their designsQ26825650
Gliding motility of Babesia bovis merozoites visualized by time-lapse video microscopyQ27304632
The solution structure of the adhesion protein Bd37 from Babesia divergens reveals structural homology with eukaryotic proteins involved in membrane traffickingQ27649133
A multidomain adhesion protein family expressed in Plasmodium falciparum is essential for transmission to the mosquitoQ27974493
Piroplasmids and ticks: a long-lasting intimate relationshipQ28237708
Comparative genomic analysis and phylogenetic position of Theileria equiQ28278882
Babesia divergens and Plasmodium falciparum use common receptors, glycophorins A and B, to invade the human red blood cellQ28299885
Babesia--a historical overviewQ28300030
Induction of proinflammatory responses in macrophages by the glycosylphosphatidylinositols of Plasmodium falciparum: cell signaling receptors, glycosylphosphatidylinositol (GPI) structural requirement, and regulation of GPI activityQ28579420
One Health approach to identify research needs in bovine and human babesioses: workshop reportQ30396980
Babesia divergens: cloning and biochemical characterization of Bd37.Q30752933
A unique Babesia bovis spherical body protein is conserved among geographic isolates and localizes to the infected erythrocyte membraneQ30829640
A novel 20-kilodalton protein conserved in Babesia bovis and B. bigemina stimulates memory CD4(+) T lymphocyte responses in B. bovis-immune cattle.Q31029653
The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interactionQ31160341
A novel 78-kDa fatty acyl-CoA synthetase (ACS1) of Babesia bovis stimulates memory CD4+ T lymphocyte responses in B. bovis-immune cattleQ33233562
Erythrocyte invasion by Babesia bovis merozoites is inhibited by polyclonal antisera directed against peptides derived from a homologue of Plasmodium falciparum apical membrane antigen 1.Q37427474
Control of tick infestations and pathogen prevalence in cattle and sheep farms vaccinated with the recombinant Subolesin-Major Surface Protein 1a chimeric antigenQ37497109
The P domain of the P0 protein of Plasmodium falciparum protects against challenge with malaria parasitesQ37521643
Plasmodial heat shock proteins: targets for chemotherapyQ37664895
Recent insights into alteration of red blood cells by Babesia bovis: moovin' forward.Q37769676
The bovine spleen: interactions among splenic cell populations in the innate immunologic control of hemoparasitic infections.Q37778520
The moving junction of apicomplexan parasites: a key structure for invasionQ37871026
Proteases as regulators of pathogenesis: examples from the Apicomplexa.Q37891227
Emerging perspectives in the research of bovine babesiosis and anaplasmosisQ37891415
Australian frozen vaccines for the control of babesiosis and anaplasmosis in cattle--a reviewQ37911848
Babesia and red cell invasionQ38001324
Malaria vaccine development: persistent challengesQ38004323
The quest for a universal vaccine against ticks: cross-immunity insights.Q38024197
Babesia: a world emerging.Q38032685
In vitro culture systems for the study of apicomplexan parasites in farm animals.Q38045711
Combination of adjuvants: the future of vaccine designQ38124060
Vaccinomics, the new road to tick vaccinesQ38176372
The path of malaria vaccine development: challenges and perspectivesQ38196455
Genome-wide analysis of peptidase content and expression in a virulent and attenuated Babesia bovis strain pairQ38312393
A systematic, functional genomics, and reverse vaccinology approach to the identification of vaccine candidates in the cattle tick, Rhipicephalus microplusQ38325994
Whole-genome sequencing of Theileria parva strains provides insight into parasite migration and diversification in the African continent.Q38866018
A quantitative PCR assay for the detection and quantification of Babesia bovis and B. bigeminaQ38925446
Genotypic diversity in Babesia bovis field isolates and vaccine strains from South AfricaQ38951293
Validation and field evaluation of a competitive enzyme-linked immunosorbent assay for diagnosis of Babesia bovis infections in ArgentinaQ38975676
Evidence for extensive genetic diversity and substructuring of the Babesia bovis metapopulation.Q39006697
A Babesia bovis merozoite protein with a domain architecture highly similar to the thrombospondin-related anonymous protein (TRAP) present in Plasmodium sporozoitesQ39015313
Babesia bovis merozoites invade human, ovine, equine, porcine and caprine erythrocytes by a sialic acid-dependent mechanism followed by developmental arrest after a single round of cell fissionQ39015319
Anti-babesial activity of a potent peptide fragment derived from longicin of Haemaphysalis longicornisQ39015736
Babesia bovis: immunity induced by vaccination with a lipid enriched fractionQ39028426
Multi-locus typing scheme for Babesia bovis and Babesia bigemina reveals high levels of genetic variability in strains from Northern Argentina.Q39035959
Expression and characterization of the Babesia bigemina cysteine protease BbiCPL1.Q39220129
Immunization of cattle with an inactivated polyvalent vaccine against anaplasmosis and babesiosisQ39264054
Molecular and antigenic characterisation of ribosomal phosphoprotein P0 from Babesia bovisQ39381802
In vitro responsiveness of Babesia bovis to imidocarb dipropionate and the selection of a drug-adapted lineQ39404391
Population genetic analysis and sub-structuring in Babesia bovisQ39465594
Loss of neurovirulence is associated with reduction of cerebral capillary sequestration during acute Babesia bovis infectionQ37004193
Protection of Babesia bigemina-immune animals against subsequent challenge with virulent Babesia bovisQ37016219
Productivity and health effects of anaplasmosis and babesiosis on Bos indicus cattle and their crosses, and the effects of differing intensity of tick control in Australia.Q37160072
An overview of the Babesia, Plasmodium and Theileria genomes: a comparative perspective.Q37358597
Evaluation of the growth-inhibitory effect of trifluralin analogues on in vitro cultured Babesia bovis parasitesQ37390606
Babesia divergens apical membrane antigen 1 and its interaction with the human red blood cell.Q37410331
A conserved subtilisin protease identified in Babesia divergens merozoites.Q33257947
Babesia divergens: identification and characterization of BdHSP-20, a small heat shock proteinQ33324187
Babesia equi-induced anemia in a Quarter Horse and subsequent regulatory responseQ33406572
Redescription of Babesia capreoli (Enigk and Friedhoff, 1962) from roe deer (Capreolus capreolus): isolation, cultivation, host specificity, molecular characterisation and differentiation from Babesia divergensQ33500476
Fine mapping of Plasmodium falciparum ribosomal phosphoprotein PfP0 revealed sequences with highly specific binding activity to human red blood cellsQ33505350
Subolesin expression in response to pathogen infection in ticks.Q33532772
Designing blood-stage vaccines against Babesia bovis and B. bigeminaQ33666101
In vitro evaluation of drug susceptibilities of Babesia divergens isolatesQ33692508
Modulation of host immune responses by protozoal DNA.Q33805664
Detection of Theileria and Babesia in brown brocket deer (Mazama gouazoubira) and marsh deer (Blastocerus dichotomus) in the State of Minas Gerais, BrazilQ33830538
Secretion of a new spherical body protein of Babesia bovis into the cytoplasm of infected erythrocytesQ33846774
Cultivation of Babesia and Babesia-like blood parasites: agents of an emerging zoonotic diseaseQ33906933
Attenuation of virulence in an apicomplexan hemoparasite results in reduced genome diversity at the population level.Q33992054
Identity of the causal agents of human babesiosis in EuropeQ33993990
DNA from protozoan parasites Babesia bovis, Trypanosoma cruzi, and T. brucei is mitogenic for B lymphocytes and stimulates macrophage expression of interleukin-12, tumor necrosis factor alpha, and nitric oxideQ34006725
Comparative genome analysis of three eukaryotic parasites with differing abilities to transform leukocytes reveals key mediators of Theileria-induced leukocyte transformationQ34033489
Targeting cattle-borne zoonoses and cattle pathogens using a novel trypanosomatid-based delivery systemQ34064231
Babesia bovis merozoite surface antigen 1 and rhoptry-associated protein 1 are expressed in sporozoites, and specific antibodies inhibit sporozoite attachment to erythrocytesQ34120190
Immunodominant epitopes in Babesia bovis rhoptry-associated protein 1 that elicit memory CD4(+)-T-lymphocyte responses in B. bovis-immune individuals are located in the amino-terminal domainQ34120976
Cellular localization of Babesia bovis merozoite rhoptry-associated protein 1 and its erythrocyte-binding activityQ34132730
Functional genomics studies of Rhipicephalus (Boophilus) annulatus ticks in response to infection with the cattle protozoan parasite, Babesia bigeminaQ34135069
Babesia bovis: comparison of culture-derived parasites, non-living antigen and conventional vaccine in the protection of cattle against heterologous challengeQ34256588
Live vaccine against hemoparasitic disease in livestockQ34298813
EuPathDB: the eukaryotic pathogen databaseQ34313331
The Rhipicephalus (Boophilus) microplus Bm86 gene plays a critical role in the fitness of ticks fed on cattle during acute Babesia bovis infectionQ34366764
Analysis of Babesia bovis infection-induced gene expression changes in larvae from the cattle tick, Rhipicephalus (Boophilus) microplusQ34370247
Bovipain-2, the falcipain-2 ortholog, is expressed in intraerythrocytic stages of the tick-transmitted hemoparasite Babesia bovisQ34413796
The productivity effects of cattle tick (Boophilus microplus) infestation on cattle, with particular reference to Bos indicus cattle and their crosses.Q34493697
Evaluating high-throughput ab initio gene finders to discover proteins encoded in eukaryotic pathogen genomes missed by laboratory techniquesQ34505603
Immunity following use of Australian tick fever vaccine: a review of the evidenceQ34524121
Threat of foreign arthropod-borne pathogens to livestock in the United StatesQ34682094
Shared features in the pathobiology of babesiosis and malariaQ34711551
Stimulation of B lymphocytes, macrophages, and dendritic cells by protozoan DNA.Q34727445
Stable expression of a GFP-BSD fusion protein in Babesia bovis merozoitesQ44227275
Organization, transcription, and expression of rhoptry associated protein genes in the Babesia bigemina rap-1 locusQ44276288
Selection of Babesia bovis-infected erythrocytes for adhesion to endothelial cells coselects for altered variant erythrocyte surface antigen isoformsQ44362810
Ankyrin peptide blocks falcipain-2-mediated malaria parasite release from red blood cellsQ44459212
Organophosphorus pesticide residues in Mexican commercial pasteurized milkQ44505011
Induction of protective immunity to Babesia divergens in Mongolian gerbils, Meriones unguiculatus, using culture-derived immunogensQ44661311
Expressed sequence tag (EST) analysis of the erythrocytic stages of Babesia bovisQ44890427
Babesia bovis: lipids from virulent S2P and attenuated R1A strains trigger differential signalling and inflammatory responses in bovine macrophagesQ44995336
Development of a microtitre-based spectrophotometric method to monitor Babesia divergens growth in vitroQ44997279
Acute and persistent infection by a transfected Mo7 strain of Babesia bovis.Q45020542
Phosphatidylcholine formation is the predominant lipid biosynthetic event in the hemoparasite Babesia bovisQ45223150
Involvement of mitochondrial genes of Babesia gibsoni in resistance to diminazene aceturateQ45381974
The novel protein BboRhop68 is expressed by intraerythrocytic stages of Babesia bovisQ45807801
Molecular characterization of Babesia bovis merozoite surface proteins bearing epitopes immunodominant in protected cattle.Q45905758
Delivery of recombinant vaccines against bovine herpesvirus type 1 gD and Babesia bovis MSA-2c to mice using liposomes derived from egg yolk lipids.Q46018372
Genetic diversity of Babesia bovis in virulent and attenuated strainsQ46069580
Babesia bovis: effect of Albumax II and orotic acid in a low-serum in vitro culture.Q46184809
Prevention by polyamines of the curative effect of amicarbalide and imidocarb for Trypanosoma brucei infections in miceQ46362550
Proteomic profiling of Rhipicephalus (Boophilus) microplus midgut responses to infection with Babesia bovisQ46775980
Molecular characterization and immunogenicity of neutralization-sensitive Babesia bigemina merozoite surface proteinsQ46780566
Ca(2+) -mediated exocytosis of subtilisin-like protease 1: a key step in egress of Plasmodium falciparum merozoitesQ46908547
Potential for recombinant Babesia bovis antigens to protect against a highly virulent isolateQ47608124
Bovine babesiosis: the immunization of cattle with killed Babesia argentinaQ47711156
Association between sequence polymorphism in an epitope of Babesia divergens Bd37 exoantigen and protection induced by passive transferQ47820399
Phylogenetic analysis with newly characterized Babesia bovis hsp70 and hsp90 provides strong support for paraphyly within the piroplasmsQ47840207
Babesia bigemina: attenuation of an Uzbek isolate for immunization of cattle with live calf- or culture-derived parasitesQ47872193
Structural alteration of the membrane of erythrocytes infected with Babesia bovis.Q47925975
The C-terminal domain of the Plasmodium falciparum acyl-CoA synthetases PfACS1 and PfACS3 functions as ligand for ankyrin.Q47931954
A mouse model for cerebral babesiosisQ47989826
Molecular detection and identification of hemoparasites in pampas deer (Ozotoceros bezoarticus Linnaeus, 1758) from the Pantanal BrazilQ48039953
Molecular detection of Babesia bovis and Babesia bigemina in white-tailed deer (Odocoileus virginianus) from Tom Green County in central TexasQ48060843
Identification of three CCp genes in Babesia divergens: novel markers for sexual stages parasitesQ48064143
Molecular cloning of a putative rhoptry associated protein homologue from Babesia divergensQ48065127
Immunologic and molecular identification of Babesia bovis and Babesia bigemina in free-ranging white-tailed deer in northern MexicoQ48078171
Recombinant protein Bd37 protected gerbils against heterologous challenges with isolates of Babesia divergens polymorphic for the bd37 geneQ48084115
Continuous in vitro culture of Babesia divergens in a serum-free mediumQ48745072
Stable expression of green fluorescent protein and targeted disruption of thioredoxin peroxidase-1 gene in Babesia bovis with the WR99210/dhfr selection system.Q50507256
Babesia divergens experimental infection of spleen-intact sheep results in long-lasting parasitemia despite a strong humoral response: preliminary results.Q50597026
Bovine babesiosis live vaccine production: use of gamma irradiation on the substrate.Q50713334
Host serum modifies the drug susceptibility of Babesia bovis in vitro.Q51415247
Vaccines for vector control: exciting possibilities for the future.Q51554719
Selection of native isolates of Beauveria bassiana (Ascomycetes: Clavicipitaceae) for the microbial control of Rhipicephalus (Boophilus) microplus (Acari: Ixodidae).Q51645795
Detection of Babesia bigemina in cattle of different genetic groups and in Rhipicephalus (Boophilus) microplus tick.Q51697748
Characterization of the apical membrane antigen-1 in Italian strains of Babesia bigemina.Q51767714
In silico predicted conserved B-cell epitopes in the merozoite surface antigen-2 family of B. bovis are neutralization sensitive.Q51781372
Babesia bovis: increased percentage parasitized erythrocytes in cultures and assessment of growth by incorporation of [3H]hypoxanthine.Q52260193
The glycosylphosphatidylinositol-anchored protein repertoire of Babesia bovis and its significance for erythrocyte invasion.Q53061771
Detection of Bm86 antigen in different strains of Boophilus microplus and effectiveness of immunization with recombinant Bm86.Q54167857
Differential Bos taurus cattle response to Babesia bovis infection.Q54199964
Expression and immunological characterization of the heat shock protein-70 homologue from Babesia bigemina.Q54299878
Targeting the tick protective antigen subolesin reduces vector infestations and pathogen infection by Anaplasma marginale and Babesia bigemina.Q54346383
Hydrophobic moeties in recombinant proteins are crucial to generate efficient saponin-based vaccine against Apicomplexan Babesia divergens.Q54478086
Development of fluorogenic probe-based PCR assays for the detection and quantification of bovine piroplasmids.Q54486215
Expression analysis of heat shock protein 20 and rhoptry-associated protein 1a in sexual stages and kinetes of Babesia bigemina.Q54500664
L-cysteine replaces microaerophilous culture conditions for the in vitro initiation of Theileria equi.Q54564070
Vaccination of older Bos taurus bulls against bovine babesiosis.Q54668515
Babesia bigemina: sporozoite isolation from Boophilus microplus nymphs and initial immunomolecular characterization.Q54688953
Myosins of Babesia bovis: molecular characterisation, erythrocyte invasion, and phylogenyQ56900723
Vaccination with proteins involved in tick–pathogen interactions reduces vector infestations and pathogen infectionQ57082981
Tick control: further thoughts on a research agendaQ57083006
Post-thawing viability of vaccines for bovine babesiosis and anaplasmosis cryopreserved with glycerolQ57114127
Babesia bigemina: Host Factors Affecting the Invasion of ErythrocytesQ57176707
Babesia bovis: Evidence for selection of subpopulations during attenuationQ57532774
Spherical body protein 4 is a new serological antigen for global detection of Babesia bovis infection in cattleQ34738656
Gut transcriptome of replete adult female cattle ticks, Rhipicephalus (Boophilus) microplus, feeding upon a Babesia bovis-infected bovine hostQ34763615
Type 1 and type 2 responses in regulation of Ig isotype expression in cattleQ34983652
A novel strategy for classifying the output from an in silico vaccine discovery pipeline for eukaryotic pathogens using machine learning algorithmsQ35030321
Comparative transcriptome analysis of geographically distinct virulent and attenuated Babesia bovis strains reveals similar gene expression changes through attenuationQ35032768
The invasion process of bovine erythrocyte by Babesia divergens: knowledge from an in vitro assayQ35052721
Molecular characterization of a new Babesia bovis thrombospondin-related anonymous protein (BbTRAP2).Q35070887
Targeted surface expression of an exogenous antigen in stably transfected Babesia bovisQ35170806
A 37-kilodalton glycoprotein of Babesia divergens is a major component of a protective fraction containing low-molecular-mass culture-derived exoantigens.Q35391024
The development of a recombinant Babesia vaccineQ35533144
Conservation of Babesia bovis small heat shock protein (Hsp20) among strains and definition of T helper cell epitopes recognized by cattle with diverse major histocompatibility complex class II haplotypesQ35551115
Stimulation of T-helper cell gamma interferon and immunoglobulin G responses specific for Babesia bovis rhoptry-associated protein 1 (RAP-1) or a RAP-1 protein lacking the carboxy-terminal repeat region is insufficient to provide protective immunityQ35802276
Cryptic organelle homology in apicomplexan parasites: insights from evolutionary cell biology.Q35883731
Current advances in detection and treatment of babesiosisQ35969816
Make it or take it: fatty acid metabolism of apicomplexan parasitesQ36095373
Possible mechanisms underlying age-related resistance to bovine babesiosisQ36135447
Vertical transmission of Babesia microti, United StatesQ36147969
Babesiosis of cattle.Q36153268
Tick control: an industry point of viewQ36153303
Tick control: thoughts on a research agendaQ36404590
Chemotherapy against babesiosisQ36407682
Erythrocyte invasion by Babesia parasites: current advances in the elucidation of the molecular interactions between the protozoan ligands and host receptors in the invasion stageQ36407687
Live vaccines against bovine babesiosisQ36407691
Immune control of Babesia bovis infectionQ36410689
Antigenic variation as an exploitable weakness of babesial parasites.Q36413875
Genetic basis for GPI-anchor merozoite surface antigen polymorphism of Babesia and resulting antigenic diversityQ36427535
Prospects for recombinant vaccines against Babesia bovis and related parasitesQ36536645
Unusual chromatin structure associated with monoparalogous transcription of the Babesia bovis ves multigene family.Q36586197
Evolution of apicomplexan secretory organellesQ36640728
Babesia bovis: infectivity of an attenuated strain of Brazilian origin for the tick vector, Boophilus microplusQ36734096
Attenuated vaccines for tropical theileriosis, babesiosis and heartwater: the continuing necessityQ36893127
Differential expression of three members of the multidomain adhesion CCp family in Babesia bigemina, Babesia bovis and Theileria equiQ36981177
Study of virulence and vector transmission of Babesia bovis by use of cloned parasite linesQ36985563
Rhoptries: an arsenal of secreted virulence factorsQ36998670
Bovine CD4(+) T-lymphocyte clones specific for rhoptry-associated protein 1 of Babesia bigemina stimulate enhanced immunoglobulin G1 (IgG1) and IgG2 synthesisQ39509191
Characterization of allelic variation in the Babesia bovis merozoite surface antigen 1 (MSA-1) locus and identification of a cross-reactive inhibition-sensitive MSA-1 epitopeQ39517301
Molecular basis for variable expression of merozoite surface antigen gp45 among American isolates of Babesia bigeminaQ39520592
Babesia bovis-stimulated macrophages express interleukin-1beta, interleukin-12, tumor necrosis factor alpha, and nitric oxide and inhibit parasite replication in vitroQ39538031
Commercialisation of a recombinant vaccine against Boophilus microplusQ39594516
Eradication programs for the arthropod parasites of livestockQ39645730
Babesia bovis merozoite surface antigen 2 proteins are expressed on the merozoite and sporozoite surface, and specific antibodies inhibit attachment and invasion of erythrocytesQ39663342
Validation of a competitive enzyme-linked immunosorbent assay for detection of antibodies against Babesia bovisQ39753186
Immunization of cattle with recombinant Babesia bovis merozoite surface antigen-1.Q39821090
A Babesia bovis 225-kilodalton spherical-body protein: localization to the cytoplasmic face of infected erythrocytes after merozoite invasion.Q39825396
Babesia bigemina: in vitro multiplication of sporokinetes in Ixodes scapularis (IDE8) cellsQ39867849
Development of a tandem repeat-based multilocus typing system distinguishing Babesia bovis geographic isolatesQ39938301
Babesia bovis contains an abundant parasite-specific protein-free glycerophosphatidylinositol and the genes predicted for its assemblyQ39938305
Growth inhibition of Babesia bovis in culture by secretions from bovine mononuclear phagocytesQ40170466
A Babesia bovis gene syntenic to Theileria parva p67 is expressed in blood and tick stage parasitesQ40353567
Immunization of Bos taurus steers with Babesia bovis recombinant antigens MSA-1, MSA-2c and 12D3.Q40356770
Viability assays of intra-erythrocytic organisms using fluorescent dyesQ40391921
International collaborative research: significance of tick-borne hemoparasitic diseases to world animal healthQ40436219
Detection of Babesia bigemina infection in strains of Rhipicephalus (Boophilus) microplus collected from outbreaks in south Texas.Q40461909
Overcoming constraints to meeting increased demand for Babesia bigemina vaccine in AustraliaQ40551593
Babesia bovis: culture of laboratory-adapted parasite lines and clinical isolates in a chemically defined mediumQ40588327
Attenuated trivalent vaccine against babesiosis and anaplasmosis in Colombia.Q40608151
Effect of breed of cattle on innate resistance to infection with Babesia bovis, B bigemina and Anaplasma marginaleQ40651351
The history of the cattle tick Boophilus microplus in Australia and achievements in its controlQ40660393
Exoantigens of an attenuated strain of Babesia bovis used as a vaccine against bovine babesiosisQ40679572
Investigations of breakdowns in protection provided by living Babesia bovis vaccineQ40733322
Heterologous strain immunity in bovine babesiosis using a culture-derived soluble Babesia bovis immunogenQ40813287
Characterization of acyl carrier protein and LytB in Babesia bovis apicoplastQ41081172
Impact of Babesia bovis and Babesia bigemina on the production of beef cattle in UruguayQ41134047
Transplacental transmission of Babesia equi (Theileria equi) from carrier mares to foalsQ41447530
Identification of binding domains on red blood cell glycophorins for Babesia divergensQ41850373
Validation of a competitive enzyme-linked immunosorbent assay for detection of Babesia bigemina antibodies in cattleQ41889654
Specific antibody to a conserved region of Babesia apical membrane antigen-1 inhibited the invasion of B. bovis into the erythrocyte.Q42245651
Neutralization-sensitive merozoite surface antigens of Babesia bovis encoded by members of a polymorphic gene familyQ42597874
A shared antigen among Babesia species: ribosomal phosphoprotein P0 as a universal babesial vaccine candidateQ42630953
Intergenic regions in the rhoptry associated protein-1 (rap-1) locus promote exogenous gene expression in Babesia bovisQ42636395
Babesia bovis expresses a neutralization-sensitive antigen that contains a microneme adhesive repeat (MAR) domain.Q42653577
Molecular and serologic evidence for Babesia bovis-like parasites in white-tailed deer (Odocoileus virginianus) in south TexasQ42666794
Structure, sequence, and transcriptional analysis of the Babesia bovis rap-1 multigene locusQ42680823
Characterization and gene expression of Babesia bovis elongation factor-1alphaQ42685082
Lipids from attenuated and virulent Babesia bovis strains induce differential TLR2-mediated macrophage activation.Q43243309
Babesia bovis and B. bigemina: Persistence of infection in friesian cows following vaccination with live antibabesial vaccinesQ43414818
Efficacy of rBm86 against Rhipicephalus (Boophilus) microplus (IVRI-I line) and Hyalomma anatolicum anatolicum (IVRI-II line) infestations on bovine calvesQ43615577
Infection of the Mongolian gerbil with the cattle piroplasm Babesia divergensQ43647483
Effect of imidocarb dipropionate prophylaxis on the infectivity and immunogenicity of a Babesia bovis vaccine in cattleQ43796444
Sheep as a new experimental host for Babesia divergensQ43881000
Bioinformatic prediction of the exportome of Babesia bovis and identification of novel proteins in parasite-infected red blood cellsQ43959941
Invasion, and short- and long-term survival of Babesia divergens (Phylum Apicomplexa) cultures in non-bovine sera and erythrocytesQ44064549
Chymotrypsin and neuraminidase treatment inhibits host cell invasion by Babesia divergens (Phylum Apicomplexa).Q44093024
Differential protein expression in ovaries of uninfected and Babesia-infected southern cattle ticks, Rhipicephalus (Boophilus) microplusQ44120651
Recombinant Pfs230, a Plasmodium falciparum gametocyte protein, induces antisera that reduce the infectivity of Plasmodium falciparum to mosquitoesQ44173322
The identification of a VDAC-like protein involved in the interaction of Babesia bigemina sexual stages with Rhipicephalus microplus midgut cellsQ44218619
Immune responses of cattle following vaccination with living and non-living Babesia bovis antigensQ57532811
Disposition of diminazene aceturate (Berenil) in trypanosome-infected pregnant and lactating cowsQ58843674
Mycobacterium bovis BCG as a delivery system for the RAP-1 antigen from Babesia bovisQ60696437
Plasmodium falciparum: new vector with bi-directional promoter activity to stably express transgenesQ62064964
Immunisation of smallholder dairy cattle against anaplasmosis and babesiosis in MalawiQ62490626
Is endemic stability of tick-borne disease in cattle a useful concept?Q64386689
A rapid, reliable method of evaluating growth and viability of intraerythrocytic protozoan hemoparasites using fluorescence flow cytometryQ67511874
An electron microscopic study of Babesia microti invading erythrocytesQ67523673
The adaptation of three isolates ofBabesia divergensto continuous culture in rat erythrocytesQ67767927
Heat shock response of Babesia divergens and identification of the hsp70 as an immunodominant early antigen during ox, gerbil and human babesiosisQ67789717
Bovine babesiosis: induction of protective immunity with culture-derived Babesia bovis and Babesia bigemina immunogensQ68226652
Efficacy, toxicity and metabolism of imidocarb dipropionate in the treatment of Babesia ovis infection in sheepQ69628489
A strain of Babesia divergens, attenuated after long term cultureQ69958145
A flow cytometric method for assessing viability of intraerythrocytic hemoparasitesQ70214522
Babesia divergens infections in the Mongolian gerbil: characteristics of a human strainQ70738478
Development of a highly infective Babesia bigemina vaccine of reduced virulenceQ70786231
Reactive oxygen and nitrogen intermediates and products from polyamine degradation are Babesiacidal in vitroQ71478388
Evaluation of the infectivity of a vaccinal and a pathogenic Babesia bovis strain from Argentina to Boophilus microplusQ72293883
Live and soluble antigens for cattle protection to Babesia bigeminaQ72293896
Babesia bigemina: immunization with purified rhoptries induces protection against acute parasitemiaQ73031691
Babesia bovis merozoite surface protein-2c (MSA-2c) contains highly immunogenic, conserved B-cell epitopes that elicit neutralization-sensitive antibodies in cattleQ73208310
Vaccination against ticks (Boophilus spp.): the experience with the Bm86-based vaccine GavacQ73269696
Elevated anti-parasitic activity in peripheral blood monocytes and neutrophils of cattle infected with Babesia bovisQ73411054
The innate immune response in calves to Boophilus microplus tick transmitted Babesia bovis involves type-1 cytokine induction and NK-like cells in the spleenQ73861395
Vaccines against hemoparasitic diseases in Israel with special reference to quality assuranceQ74345717
Improved disease resistance after Babesia divergens vaccinationQ74375342
The age-related immunity in cattle to Babesia bovis infection involves the rapid induction of interleukin-12, interferon-gamma and inducible nitric oxide synthase mRNA expression in the spleenQ74598815
Apical organelles and host-cell invasion by ApicomplexaQ77184156
IL-4 and IL-10 inhibition of IFN-gamma- and TNF-alpha-dependent nitric oxide production from bovine mononuclear phagocytes exposed to Babesia bovis merozoitesQ77451260
Age-related innate immune response in calves to Babesia bovis involves IL-12 induction and IL-10 modulationQ78377768
Transient transfection of purified Babesia bovis merozoitesQ80190650
Babesia bigemina sexual stages are induced in vitro and are specifically recognized by antibodies in the midgut of infected Boophilus microplus ticksQ80877927
Expression of Babesia bovis rhoptry-associated protein 1 (RAP1) in Brucella abortus S19Q81232459
Bovine NK cells acquire cytotoxic activity and produce IFN-gamma after stimulation by Mycobacterium bovis BCG- or Babesia bovis-exposed splenic dendritic cellsQ81364619
Dynamics of bovine spleen cell populations during the acute response to Babesia bovis infection: an immunohistological studyQ82876038
Enhancement of the Mexican bovine babesiosis vaccine efficacy by using Lactobacillus caseiQ83140080
Water Buffalos as carriers of Babesia bovis in ArgentinaQ83140095
Bovine splenic NK cells synthesize IFN-gamma in response to IL-12-containing supernatants from Babesia bovis-exposed monocyte culturesQ83184932
Vaccination of cattle against B. bovis infection with live attenuated parasites and non-viable immunogensQ83262652
Babesia bovis biological clones and the inter-strain allelic diversity of the Bv80 gene support subpopulation selection as a mechanism involved in the attenuation of two virulent isolatesQ84595903
First report of fluazuron resistance in Rhipicephalus microplus: a field tick population resistant to six classes of acaricidesQ87341262
P433issue12
P921main subjectbovine babesiosisQ9274702
P304page(s)1-30
P577publication date2014-07-28
P1433published inParasitologyQ15753259
P1476titleVaccines against bovine babesiosis: where we are now and possible roads ahead
P478volume141