The mouse Spo11 gene is required for meiotic chromosome synapsis

scientific article (publication date: November 2000)

The mouse Spo11 gene is required for meiotic chromosome synapsis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S1097-2765(00)00097-6
P3181OpenCitations bibliographic resource ID359261
P698PubMed publication ID11106738

P2093author name stringCamerini-Otero RD
Romanienko PJ
P2860cites workCloning, characterization, and localization of mouse and human SPO11Q22010714
Fibroblast growth factor receptor 3 is a negative regulator of bone growthQ24322706
An alternative splicing event which occurs in mouse pachytene spermatocytes generates a form of DNA ligase III with distinct biochemical properties that may function in meiotic recombinationQ24647280
Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein familyQ27930009
Meiotic chromosomes: it takes two to tangoQ27930023
RecA homologs Dmc1 and Rad51 interact to form multiple nuclear complexes prior to meiotic chromosome synapsis.Q27932144
Saccharomyces cerevisiae recA homologues RAD51 and DMC1 have both distinct and overlapping roles in meiotic recombinationQ27936736
The transcriptional program of sporulation in budding yeastQ27938344
New gene family defined by MORC, a nuclear protein required for mouse spermatogenesisQ28115778
Meiotic recombination in C. elegans initiates by a conserved mechanism and is dispensable for homologous chromosome synapsisQ28279936
Mammalian MutS homologue 5 is required for chromosome pairing in meiosisQ28295022
The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertilityQ28505195
Identification of morc (microrchidia), a mutation that results in arrest of spermatogenesis at an early meiotic stage in the mouseQ28513262
Mouse mutants from chemically mutagenized embryonic stem cellsQ28593735
An atypical topoisomerase II from Archaea with implications for meiotic recombinationQ29618230
Meiotic prophase arrest with failure of chromosome synapsis in mice deficient for Dmc1, a germline-specific RecA homologQ29618405
Atm-deficient mice: a paradigm of ataxia telangiectasiaQ29619532
The association of ATR protein with mouse meiotic chromosome coresQ30724277
Toprim--a conserved catalytic domain in type IA and II topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteinsQ32030823
Hanging on to your homolog: the roles of pairing, synapsis and recombination in the maintenance of homolog adhesionQ33943969
High rate of recombination and double crossovers in the mouse pseudoautosomal region during male meiosisQ34354262
Isolation, DNA sequence, and regulation of a meiosis-specific eukaryotic recombination geneQ34365937
Mouse MutS-like protein Msh5 is required for proper chromosome synapsis in male and female meiosisQ35190411
The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in miceQ36008239
Multiple roles of Spo11 in meiotic chromosome behaviorQ36246137
Cisplatin increases meiotic crossing-over in miceQ36554672
Evidence for close contact between recombination nodules and the central element of the synaptonemal complexQ38551724
Identification and characterization of an SPO11 homolog in the mouseQ40873645
Synaptonemal complexes: structure and functionQ41066968
RAD51 and DMC1 form mixed complexes associated with mouse meiotic chromosome cores and synaptonemal complexesQ42918693
Meiotic synapsis in the absence of recombination.Q46794994
Evidence for the evolution of bdelloid rotifers without sexual reproduction or genetic exchangeQ47673378
Meiotic DNA breaks associated with recombination in S. pombeQ47847394
The mouse RecA-like gene Dmc1 is required for homologous chromosome synapsis during meiosisQ47858327
Differential gene expression of mammalian SPO11/TOP6A homologs during meiosisQ47895242
A mouse homolog of the Saccharomyces cerevisiae meiotic recombination DNA transesterase Spo11p.Q47917592
Chromosome synapsis defects and sexually dimorphic meiotic progression in mice lacking Spo11.Q50720785
THE LEPTOTENE-ZYGOTENE TRANSITION OF MEIOSISQ56136641
Genetic control of chromosome synapsis in yeast meiosisQ69557796
The differential expression of the actins and tubulins during spermatogenesis in the mouseQ71390702
Chromosome pairing via multiple interstitial interactions before and during meiosis in yeastQ72034931
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)975-87
P577publication date2000-11-01
P1433published inMolecular CellQ3319468
P1476titleThe mouse Spo11 gene is required for meiotic chromosome synapsis
P478volume6

Reverse relations

cites work (P2860)
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Q35079862Meiotic cohesin SMC1β provides prophase I centromeric cohesion and is required for multiple synapsis-associated functions.
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Q28512386Mouse HFM1/Mer3 is required for crossover formation and complete synapsis of homologous chromosomes during meiosis
Q28586590Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPase
Q33826136Mouse HORMAD1 is a meiosis i checkpoint protein that modulates DNA double- strand break repair during female meiosis
Q60045774Mouse REC114 is essential for meiotic DNA double-strand break formation and forms a complex with MEI4
Q28512197Mouse TEX15 is essential for DNA double-strand break repair and chromosomal synapsis during male meiosis
Q28504811Mouse maelstrom, a component of nuage, is essential for spermatogenesis and transposon repression in meiosis
Q36391036Mouse models for genes involved in impaired spermatogenesis.
Q34932076Mouse models of male infertility.
Q28591450Mouse pachytene checkpoint 2 (trip13) is required for completing meiotic recombination but not synapsis
Q36233041Mouse strains with an active H2-Ea meiotic recombination hot spot exhibit increased levels of H2-Ea-specific DNA breaks in testicular germ cells
Q34558046Multiple opposing constraints govern chromosome interactions during meiosis
Q33324168MutL homologs in restriction-modification systems and the origin of eukaryotic MORC ATPases
Q28594464Mutation in mouse hei10, an e3 ubiquitin ligase, disrupts meiotic crossing over
Q64387363Mutation of the ATPase Domain of MutS Homolog-5 (MSH5) Reveals a Requirement for a Functional MutSγ Complex for All Crossovers in Mammalian Meiosis
Q28474807Mutation of the mouse Syce1 gene disrupts synapsis and suggests a link between synaptonemal complex structural components and DNA repair
Q28506028Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages
Q92825425NBS1 is required for SPO11-linked DNA double-strand break repair in male meiosis
Q61450769Narya, a RING finger domain-containing protein, is required for meiotic DNA double-strand break formation and crossover maturation in Drosophila melanogaster
Q64065581Noncanonical Contributions of MutLγ to VDE-Initiated Crossovers During Meiosis
Q34617124Nonrandom homolog segregation at meiosis I in Schizosaccharomyces pombe mutants lacking recombination
Q24543577Normal Synaptonemal Complex and Abnormal Recombination Nodules in Two Alleles of the Drosophila Meiotic Mutant mei-W68
Q35998496Nuclear localization of PRDM9 and its role in meiotic chromatin modifications and homologous synapsis
Q36832176Numerical constraints and feedback control of double-strand breaks in mouse meiosis
Q34351172Oocyte differentiation is genetically dissociable from meiosis in mice
Q21129203OsRAD51C is essential for double-strand break repair in rice meiosis
Q35042146OsSDS is essential for DSB formation in rice meiosis
Q53312961OsSPO11-1 is essential for both homologous chromosome pairing and crossover formation in rice.
Q37217307Patterns of meiotic recombination in human fetal oocytes
Q47100071Periodic production of retinoic acid by meiotic and somatic cells coordinates four transitions in mouse spermatogenesis.
Q33629187Phenotyping male infertility in the mouse: how to get the most out of a 'non-performer'
Q34162317Phosphorylation of chromosome core components may serve as axis marks for the status of chromosomal events during mammalian meiosis
Q47108181Physiological Roles of DNA Double-Strand Breaks
Q57673146Point-of-care whole-exome sequencing of idiopathic male infertility
Q33653455Polo-like kinase-dependent phosphorylation of the synaptonemal complex protein SYP-4 regulates double-strand break formation through a negative feedback loop
Q28507685Polycomb protein SCML2 associates with USP7 and counteracts histone H2A ubiquitination in the XY chromatin during male meiosis
Q34523227Polymorphic alleles of the human MEI1 gene are associated with human azoospermia by meiotic arrest.
Q28512598Positional cloning and characterization of Mei1, a vertebrate-specific gene required for normal meiotic chromosome synapsis in mice
Q47358994Positive role of the mammalian TBPIP/HOP2 protein in DMC1-mediated homologous pairing.
Q64387595Prdm9 and Meiotic Cohesin Proteins Cooperatively Promote DNA Double-Strand Break Formation in Mammalian Spermatocytes
Q35020831Predicting human minisatellite polymorphism
Q35619405Prelude to a division
Q39155608Prophase I: Preparing Chromosomes for Segregation in the Developing Oocyte
Q37150956Proteins involved in meiotic recombination: a role in male infertility?
Q33779559Pseudosynapsis and decreased stringency of meiotic repair pathway choice on the hemizygous sex chromosome of Caenorhabditis elegans males
Q35080034Purification, folding, and characterization of Rec12 (Spo11) meiotic recombinase of fission yeast
Q36780816Quantitative analysis of male germline stem cell differentiation reveals a role for the p53-mTORC1 pathway in spermatogonial maintenance
Q28589265RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females
Q28509598RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis
Q36542150Rad50S alleles of the Mre11 complex: questions answered and questions raised
Q38071442RanBPM, a scaffolding protein for gametogenesis
Q35094244Rap1-independent telomere attachment and bouquet formation in mammalian meiosis
Q35058333Rec25 and Rec27, novel linear-element components, link cohesin to meiotic DNA breakage and recombination.
Q29618790Recombinational DNA double-strand breaks in mice precede synapsis
Q28505990Regulated CPEB phosphorylation during meiotic progression suggests a mechanism for temporal control of maternal mRNA translation
Q38824610Regulating the construction and demolition of the synaptonemal complex.
Q34464620Regulation of meiotic recombination and prophase I progression in mammals
Q51803054Relationship between incomplete synapsis and chiasma localization.
Q27012688Repair of strand breaks by homologous recombination
Q37096201Repeat expansion by homologous recombination in the mouse germ line at palindromic sequences
Q34015261Retinoic acid activates two pathways required for meiosis in mice
Q45808311Retinoic acid derived from the fetal ovary initiates meiosis in mouse germ cells.
Q36535367Retinol dehydrogenase 10 is indispensible for spermatogenesis in juvenile males
Q37769457Role of ubiquitination in meiotic recombination repair
Q55186299SHOC1 is a ERCC4-(HhH)2-like protein, integral to the formation of crossover recombination intermediates during mammalian meiosis.
Q39447587SOHLH1 and SOHLH2 coordinate spermatogonial differentiation
Q36758273SPO11-C631T Gene Polymorphism: Association With Male Infertility and an in Silico-Analysis
Q27322567SPO11-independent DNA repair foci and their role in meiotic silencing
Q36217378Saccharomyces cerevisiae Dmc1 and Rad51 proteins preferentially function with Tid1 and Rad54 proteins, respectively, to promote DNA strand invasion during genetic recombination
Q34786779Seeking new meiotic genes
Q34672035Senataxin plays an essential role with DNA damage response proteins in meiotic recombination and gene silencing
Q37098468Sex chromosome inactivation in germ cells: emerging roles of DNA damage response pathways
Q35205846Single nucleotide polymorphism in the UBR2 gene may be a genetic risk factor for Japanese patients with azoospermia by meiotic arrest.
Q24614084Single nucleotide polymorphisms in the SEPTIN12 gene may be associated with azoospermia by meiotic arrest in Japanese men
Q57162910Single-cell RNA-seq uncovers dynamic processes and critical regulators in mouse spermatogenesis
Q42589701Sister cohesion and structural axis components mediate homolog bias of meiotic recombination
Q28588839Spata22, a novel vertebrate-specific gene, is required for meiotic progress in mouse germ cells
Q35212439Spo11 and the Formation of DNA Double-Strand Breaks in Meiosis
Q35829344Stimulation of fission yeast and mouse Hop2-Mnd1 of the Dmc1 and Rad51 recombinases
Q36889785Stra8 and its inducer, retinoic acid, regulate meiotic initiation in both spermatogenesis and oogenesis in mice.
Q27933080Support for a meiotic recombination initiation complex: interactions among Rec102p, Rec104p, and Spo11p
Q34840536Suppression of genetic recombination in the pseudoautosomal region and at subtelomeres in mice with a hypomorphic Spo11 allele
Q24529923Surveillance of different recombination defects in mouse spermatocytes yields distinct responses despite elimination at an identical developmental stage
Q89857158Sycp2 is essential for synaptonemal complex assembly, early meiotic recombination and homologous pairing in zebrafish spermatocytes
Q104747937Synaptonemal Complex Formation Produces a Particular Arrangement of the Lateral Element-Associated DNA
Q45951757Synaptonemal complex assembly and H3K4Me3 demethylation determine DIDO3 localization in meiosis.
Q47069553Synaptonemal complex assembly in C. elegans is dispensable for loading strand-exchange proteins but critical for proper completion of recombination
Q36061063TAF4b Regulates Oocyte-Specific Genes Essential for Meiosis
Q28589015TOPAZ1, a germ cell specific factor, is essential for male meiotic progression
Q34403318Targeted JAM-C deletion in germ cells by Spo11-controlled Cre recombinase.
Q37493438Targeted gene knockout reveals a role in meiotic recombination for ZHP-3, a Zip3-related protein in Caenorhabditis elegans
Q36607600Targeting the Gdnf Gene in peritubular myoid cells disrupts undifferentiated spermatogonial cell development
Q38622778Telomere homeostasis in mammalian germ cells: a review.
Q33424478Temporally regulated traffic of HuR and its associated ARE-containing mRNAs from the chromatoid body to polysomes during mouse spermatogenesis
Q38678873Tex19.1 promotes Spo11-dependent meiotic recombination in mouse spermatocytes
Q35174765The ATM signaling cascade promotes recombination-dependent pachytene arrest in mouse spermatocytes.
Q24535915The Arabidopsis homologue of Xrcc3 plays an essential role in meiosis
Q34084136The Arabidopsis synaptonemal complex protein ZYP1 is required for chromosome synapsis and normal fidelity of crossing over.
Q95831637The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes
Q34282575The Hop2 protein has a direct role in promoting interhomolog interactions during mouse meiosis
Q27308664The Meiotic Recombination Activator PRDM9 Trimethylates Both H3K36 and H3K4 at Recombination Hotspots In Vivo
Q33939457The RNA-binding specificity of the mouse Dazl protein
Q28592802The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation
Q36574666The cellular control of DNA double-strand breaks
Q37384277The consequences of asynapsis for mammalian meiosis
Q35781510The conserved transcriptome in human and rodent male gametogenesis
Q40952548The control of Spo11's interaction with meiotic recombination hotspots.
Q34613621The distribution of early recombination nodules on zygotene bivalents from plants
Q36416265The diverse roles of transverse filaments of synaptonemal complexes in meiosis
Q90728910The ectopic expression of meiCT genes promotes meiomitosis and may facilitate carcinogenesis
Q36013651The enigmatic meiotic dense body and its newly discovered component, SCML1, are dispensable for fertility and gametogenesis in mice.
Q34119672The expression profile of the major mouse SPO11 isoforms indicates that SPO11beta introduces double strand breaks and suggests that SPO11alpha has an additional role in prophase in both spermatocytes and oocytes
Q36429056The many facets of SC function during C. elegans meiosis
Q47446592The mouse X chromosome is enriched for sex-biased genes not subject to selection by meiotic sex chromosome inactivation
Q92529023The pericentromeric heterochromatin of homologous chromosomes remains associated after centromere pairing dissolves in mouse spermatocyte meiosis
Q36900929The role of spermatogonially expressed germ cell-specific genes in mammalian meiosis
Q61814681The telomere bouquet is a hub where meiotic double-strand breaks, synapsis, and stable homolog juxtaposition are coordinated in the zebrafish, Danio rerio
Q36781174The tricky path to recombining X and Y chromosomes in meiosis
Q37763943The use of transgenic mouse models in the study of male infertility
Q63344850Theatspo11-1 mutation rescues atxrcc3 meiotic chromosome fragmentation
Q37192086Thoc1 deficiency compromises gene expression necessary for normal testis development in the mouse
Q43259698Tid1/Rdh54 promotes dissociation of Dmc1 from nonrecombinogenic sites on meiotic chromatin
Q28508190TopBP1 and ATR colocalization at meiotic chromosomes: role of TopBP1/Cut5 in the meiotic recombination checkpoint
Q61812011Transition from a meiotic to a somatic-like DNA damage response during the pachytene stage in mouse meiosis
Q30438766Tuberoinfundibular Peptide of 39 residues is required for germ cell development
Q24650847Two single nucleotide polymorphisms in PRDM9 (MEISETZ) gene may be a genetic risk factor for Japanese patients with azoospermia by meiotic arrest
Q37358029Tying synaptonemal complex initiation to the formation and programmed repair of DNA double-strand breaks
Q34278026UBR2 of the N-end rule pathway is required for chromosome stability via histone ubiquitylation in spermatocytes and somatic cells
Q29615266Un ménage à quatre: the molecular biology of chromosome segregation in meiosis
Q90259369Variable Patterning of Chromatin Remodeling, Telomere Positioning, Synapsis, and Chiasma Formation of Individual Rye Chromosomes in Meiosis of Wheat-Rye Additions
Q35018030Variation in patterns of human meiotic recombination
Q36435635Vilya, a component of the recombination nodule, is required for meiotic double-strand break formation in Drosophila
Q35778662Where the crossovers are: recombination distributions in mammals.
Q62609015White-cap mutants and meiotic apoptosis in the basidiomycete Coprinus cinereus
Q90451189XRCC2 mutation causes meiotic arrest, azoospermia and infertility
Q33641006Zfy genes are required for efficient meiotic sex chromosome inactivation (MSCI) in spermatocytes
Q48185934ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2.
Q33853843p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes

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