SH3 domains: complexity in moderation

scientific article (publication date: April 2001)

SH3 domains: complexity in moderation is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P3181OpenCitations bibliographic resource ID1437140
P698PubMed publication ID11256992

P2093author name stringMayer BJ
P433issuePt 7
P407language of work or nameEnglishQ1860
P921main subjectSH3 domainQ24771787
P304page(s)1253-63
P577publication date2001-04-01
P1433published inJournal of Cell ScienceQ1524177
P1476titleSH3 domains: complexity in moderation
P478volume114

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cites work (P2860)
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Q36215945Dopamine transporter phosphorylation site threonine 53 regulates substrate reuptake and amphetamine-stimulated efflux
Q30009032Dynamics of the Tec-family tyrosine kinase SH3 domains
Q37661944EKPD: a hierarchical database of eukaryotic protein kinases and protein phosphatases.
Q43290410Early low-temperature responsive mitogen activated protein kinases RaMPK1 and RaMPK2 from Rheum australe D. Don respond differentially to diverse stresses
Q24293524Efficient T-cell receptor signaling requires a high-affinity interaction between the Gads C-SH3 domain and the SLP-76 RxxK motif
Q30009332Electrostatic interactions in the binding pathway of a transient protein complex studied by NMR and isothermal titration calorimetry
Q36845865Epstein-Barr virus latent membrane protein 2A preferentially signals through the Src family kinase Lyn
Q34023653Evolution of breast cancer therapeutics: Breast tumour kinase's role in breast cancer and hope for breast tumour kinase targeted therapy
Q30009154Evolution of the SH3 Domain Specificity Landscape in Yeasts
Q34333590Evolution of the ferric reductase domain (FRD) superfamily: modularity, functional diversification, and signature motifs
Q28334390Evolutionary analysis of selective constraints identifies ameloblastin (AMBN) as a potential candidate for amelogenesis imperfecta
Q92719884Excitation-contraction coupling in skeletal muscle: recent progress and unanswered questions
Q30008743Exhaustive search of linear information encoding protein-peptide recognition
Q33870265Exophilin-8 assembles secretory granules for exocytosis in the actin cortex via interaction with RIM-BP2 and myosin-VIIa.
Q24555819Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities
Q30157676Expression of aquaporin 5 (AQP5) promotes tumor invasion in human non small cell lung cancer
Q30009477Expression, purification and preliminary crystallographic studies of the C-terminal SH3 domain of human Tks4.
Q30157309Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the SH3 domain of human AHI1
Q24296333FAM83A confers EGFR-TKI resistance in breast cancer cells and in mice
Q90697272FAM83A is amplified and promotes tumorigenicity in non-small cell lung cancer via ERK and PI3K/Akt/mTOR pathways
Q30419039Feed-forward regulation of phagocytosis by Entamoeba histolytica
Q37253121FeoA and FeoC are essential components of the Vibrio cholerae ferrous iron uptake system, and FeoC interacts with FeoB.
Q30008906From Binding-Induced Dynamic Effects in SH3 Structures to Evolutionary Conserved Sectors
Q30008807Functional and structural characterization of a novel putative cysteine protease cell wall-modifying multi-domain enzyme selected from a microbial metagenome.
Q30010077Functional mechanisms and roles of adaptor proteins in abl-regulated cytoskeletal actin dynamics
Q24337649GAREM, a novel adaptor protein for growth factor receptor-bound protein 2, contributes to cellular transformation through the activation of extracellular signal-regulated kinase signaling
Q33320137Genome-wide inference of protein interaction sites: lessons from the yeast high-quality negative protein-protein interaction dataset
Q58199697Grb2 signaling in cell motility and cancer
Q30010274HIV-1 Tat binds to SH3 domains: cellular and viral outcome of Tat/Grb2 interaction
Q30009188Hepatitis C virus NS5A protein blocks epidermal growth factor receptor degradation via a proline motif- dependent interaction
Q30009145Highly homologous proteins exert opposite biological activities by using different interaction interfaces
Q30155579Homodimerization of the Src homology 3 domain of the calcium channel β-subunit drives dynamin-dependent endocytosis.
Q43159984Host endoplasmic reticulum COPII proteins control cell-to-cell spread of the bacterial pathogen Listeria monocytogenes
Q46259543Human accelerated regions and other human-specific sequence variations in the context of evolution and their relevance for brain development
Q37406748Huntingtin associated protein 1 and its functions
Q28587677Huntingtin-associated protein 1 interacts with Ahi1 to regulate cerebellar and brainstem development in mice
Q41576978Identification and characterization of Rvs162/Rvs167-3, a novel N-BAR heterodimer in the human fungal pathogen Candida albicans
Q24322679Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening
Q30009534Inhibition of CIN85-mediated invasion by a novel SH3 domain binding motif in the lysyl oxidase propeptide
Q30008772Inhibition of N1-Src kinase by a specific SH3 peptide ligand reveals a role for N1-Src in neurite elongation by L1-CAM.
Q28471978Insights into protein aggregation by NMR characterization of insoluble SH3 mutants solubilized in salt-free water
Q35021562Integration by design
Q38124217Integration of signaling and cytoskeletal remodeling by Nck in directional cell migration
Q24299038Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase II
Q27930589Interaction of the Saccharomyces cerevisiae cortical actin patch protein Rvs167p with proteins involved in ER to Golgi vesicle trafficking
Q27937518Interaction with the SH3 domain protein Bem1 regulates signaling by the Saccharomyces cerevisiae p21-activated kinase Ste20
Q30160364Interactions between Cdc42 and the scaffold protein Scd2: requirement of SH3 domains for GTPase binding
Q33860875Intermolecular steric inhibition of Ephexin4 is relieved by Elmo1.
Q30159493Intramolecular interaction in the tail of Acanthamoeba myosin IC between the SH3 domain and a putative pleckstrin homology domain
Q30538071Investigating lasp-2 in cell adhesion: new binding partners and roles in motility
Q30010192Isolation of monobodies that bind specifically to the SH3 domain of the Fyn tyrosine protein kinase
Q34056461KAP-1 promotes resection of broken DNA ends not protected by γ-H2AX and 53BP1 in G₁-phase lymphocytes.
Q33974355Knockdown of mu-calpain in Fanconi anemia, FA-A, cells by siRNA restores alphaII spectrin levels and corrects chromosomal instability and defective DNA interstrand cross-link repair
Q30008891Large-Scale Screening of Preferred Interactions of Human Src Homology-3 (SH3) Domains Using Native Target Proteins as Affinity Ligands
Q27660480Limitations of Peptide Retro-inverso Isomerization in Molecular Mimicry
Q36245150MET meet adaptors: functional and structural implications in downstream signalling mediated by the Met receptor
Q24607812MUSI: an integrated system for identifying multiple specificity from very large peptide or nucleic acid data sets
Q90440360Mapping low-affinity/high-specificity peptide-protein interactions using ligand-footprinting mass spectrometry
Q37310343Marshalin, a microtubule minus-end binding protein, regulates cytoskeletal structure in the organ of Corti
Q24298329Mechanism of aldolase control of sorting nexin 9 function in endocytosis
Q26778952Membrane Binding and Modulation of the PDZ Domain of PICK1
Q47096120Minimotif Miner 4: a million peptide minimotifs and counting
Q52013389Molecular cloning of a novel gene ZAhi-1 and its expression analysis during zebrafish gametogenesis.
Q37420126Molecular machines or pleiomorphic ensembles: signaling complexes revisited
Q52690155Most yeast SH3 domains bind peptide targets with high intrinsic specificity.
Q26775592Motif co-regulation and co-operativity are common mechanisms in transcriptional, post-transcriptional and post-translational regulation
Q56881320Multiple Host Factors Interact with Hypervariable Domain of Chikungunya Virus nsP3 and Determine Viral Replication in Cell-Specific Mode
Q35096124Multipose binding in molecular docking.
Q38928277Multivalent binding of formin-binding protein 21 (FBP21)-tandem-WW domains fosters protein recognition in the pre-spliceosome
Q30157648NMR evidence for forming highly populated helical conformations in the partially folded hNck2 SH3 domain
Q35885933Natural variability of minimotifs in 1092 people indicates that minimotifs are targets of evolution
Q36320882Nebulin regulates the assembly and lengths of the thin filaments in striated muscle
Q30010152Network evolution: rewiring and signatures of conservation in signaling
Q30159844New approaches to high-throughput structure characterization of SH3 complexes: the example of Myosin-3 and Myosin-5 SH3 domains from S. cerevisiae
Q35947098Noise in cellular signaling pathways: causes and effects
Q37408896Novel genetic risk variants for pediatric celiac disease
Q37208542Nuclear alpha spectrin: Critical roles in DNA interstrand cross-link repair and genomic stability
Q27028029On the Teneurin track: a new synaptic organization molecule emerges
Q30368988Overview of protein structural and functional folds.
Q36144859PCAF regulates the stability of the transcriptional regulator and cyclin-dependent kinase inhibitor p27 Kip1.
Q30008797PRMT2 interacts with splicing factors and regulates the alternative splicing of BCL-X.
Q30157072Partially-supervised protein subclass discovery with simultaneous annotation of functional residues
Q36217320Peptide motifs: building the clathrin machinery
Q41075690Phylogenetic analysis of the teneurins: conserved features and premetazoan ancestry
Q30156919Pleiotropic function of intersectin homologue Cin1 in Cryptococcus neoformans
Q57730950Polymorphisms in AHI1 are not associated with type 2 diabetes or related phenotypes in Danes: non-replication of a genome-wide association result
Q64078233Potential Oncogenic Role of the Papillary Renal Cell Carcinoma Gene in Non-Small Cell Lung Cancers
Q30009023Predicting physiologically relevant SH3 domain mediated protein-protein interactions in yeast
Q42385886Presynaptic calcium channels and α3-integrins are complexed with synaptic cleft laminins, cytoskeletal elements and active zone components
Q30158067Proline cis-trans isomerization controls autoinhibition of a signaling protein
Q30157301Proline isomerization preorganizes the Itk SH2 domain for binding to the Itk SH3 domain
Q24804216Protein interaction networks by proteome peptide scanning
Q37237774Protein partners of deubiquitinating enzymes
Q28533779Putative bioactive motif of tritrpticin revealed by an antibody with biological receptor-like properties
Q42861890RIM binding proteins (RBPs) couple Rab3-interacting molecules (RIMs) to voltage-gated Ca(2+) channels
Q24307857Recognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assembly
Q27655498Redox-Linked Conformational Dynamics in Apoptosis-Inducing Factor
Q30009286Regulating dynamin dynamics during endocytosis
Q24561373Regulation of Bin1 SH3 domain binding by phosphoinositides
Q38746454Regulation of L-type Ca2+ Channel Activity and Insulin Secretion by Huntingtin-associated Protein 1.
Q30009038Resolution of Site-Specific Conformational Heterogeneity in Proline-Rich Molecular Recognition by Src Homology 3 Domains
Q37249768Rewiring MAP kinases in Saccharomyces cerevisiae to regulate novel targets through ubiquitination
Q27658130Role of Interfacial Water Molecules in Proline-rich Ligand Recognition by the Src Homology 3 Domain of Abl
Q38500274Role of human aquaporin 5 in colorectal carcinogenesis
Q92596369Roles of Myosin-Mediated Membrane Trafficking in TGF-β Signaling
Q30009300SH2-catalytic domain linker heterogeneity influences allosteric coupling across the SFK family.
Q30010096SH3 domain tyrosine phosphorylation--sites, role and evolution.
Q30010197SH3 domain-based phototrapping in living cells reveals Rho family GAP signaling complexes
Q30010201SH3 domain-mediated recruitment of host cell amphiphysins by alphavirus nsP3 promotes viral RNA replication
Q24309634SH3 domains of Grb2 adaptor bind to PXpsiPXR motifs within the Sos1 nucleotide exchange factor in a discriminate manner
Q30008731SH3 domains: modules of protein-protein interactions
Q30157984SH3-Hunter: discovery of SH3 domain interaction sites in proteins
Q27938698SLAC, a complex between Sla1 and Las17, regulates actin polymerization during clathrin-mediated endocytosis
Q36443406SRC points the way to biomarkers and chemotherapeutic targets
Q27931652Saccharomyces cerevisiae Bzz1p is implicated with type I myosins in actin patch polarization and is able to recruit actin-polymerizing machinery in vitro
Q30009128Selection of recombinant anti-SH3 domain antibodies by high-throughput phage display
Q38004951Selenoprotein N in skeletal muscle: from diseases to function.
Q30010165Single-domain antibody-SH3 fusions for efficient neutralization of HIV-1 Nef functions
Q30009081Site-selective Characterization of Src Homology 3 Domain Molecular Recognition with Cyanophenylalanine Infrared Probes
Q24304437Small proline-rich proteins (SPRR) function as SH3 domain ligands, increase resistance to injury and are associated with epithelial-mesenchymal transition (EMT) in cholangiocytes
Q27660743Solution Structure of a Novel Cdc42 Binding Module of Bem1 and Its Interaction with Ste20 and Cdc42
Q30155573Solution structure, dynamics and thermodynamics of the three SH3 domains of CD2AP.
Q34827442Sorting nexin 9 recruits clathrin heavy chain to the mitotic spindle for chromosome alignment and segregation
Q30014849Specificity and versatility of SH3 and other proline-recognition domains: structural basis and implications for cellular signal transduction
Q52349345Spectrin and its interacting partners in nuclear structure and function.
Q30157893Src kinase activity and SH2 domain regulate the dynamics of Src association with lipid and protein targets
Q30009426Stac3 inhibits myoblast differentiation into myotubes.
Q28504953Stac3 is a novel regulator of skeletal muscle development in mice
Q30159875State and role of SRC family kinases in replication of herpes simplex virus 1.
Q27647733Structural Basis for Ubiquitin Recognition by SH3 Domains
Q27650842Structural and Functional Evidence that Nck Interaction with CD3ε Regulates T-Cell Receptor Activity
Q27641338Structural basis for SH3 domain-mediated high-affinity binding between Mona/Gads and SLP-76
Q27677251Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms
Q30159713Structural basis of Robo proline-rich motif recognition by the srGAP1 Src homology 3 domain in the Slit-Robo signaling pathway
Q41387960Structural characterization of CAS SH3 domain selectivity and regulation reveals new CAS interaction partners.
Q30009595Structural insights into the recognition of β3 integrin cytoplasmic tail by the SH3 domain of Src kinase
Q30159569Structural modeling of protein interactions by analogy: application to PSD-95
Q27656356Structural, Functional, and Bioinformatic Studies Demonstrate the Crucial Role of an Extended Peptide Binding Site for the SH3 Domain of Yeast Abp1p
Q24311589Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide
Q24306688Structure of the Eps15-stonin2 complex provides a molecular explanation for EH-domain ligand specificity
Q30157708Structure of the SH3 domain of rat endophilin A2.
Q60912946Structure of the SLy1 SAM homodimer reveals a new interface for SAM domain self-association
Q30009462Structure of the kidney slit diaphragm adapter protein CD2-associated protein as determined with electron microscopy.
Q27662083Structure ofStenotrophomonas maltophiliaFeoA complexed with zinc: a unique prokaryotic SH3-domain protein that possibly acts as a bacterial ferrous iron-transport activating factor
Q30157258Structure, stability, and flexibility of ribosomal protein L14e from Sulfolobus solfataricus
Q30155843Structures of Anabaena calcium-binding protein CcbP: insights into Ca2+ signaling during heterocyst differentiation
Q33632022Swiprosin-1 Regulates Cytokine Expression of Human Mast Cell Line HMC-1 through Actin Remodeling
Q24614506Synaptic targeting of N-type calcium channels in hippocampal neurons
Q26774428Synthetic Protein Scaffolds Based on Peptide Motifs and Cognate Adaptor Domains for Improving Metabolic Productivity
Q35611762T-cell control by human T-cell leukemia/lymphoma virus type 1.
Q24320165Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis
Q28591182The AHNAKs are a class of giant propeller-like proteins that associate with calcium channel proteins of cardiomyocytes and other cells
Q37190462The Bif-1-Dynamin 2 membrane fission machinery regulates Atg9-containing vesicle generation at the Rab11-positive reservoirs
Q30009309The Cdc15 and Imp2 SH3 domains cooperatively scaffold a network of proteins that redundantly ensure efficient cell division in fission yeast
Q37292195The EGFR-GEP100-Arf6-AMAP1 signaling pathway specific to breast cancer invasion and metastasis
Q42363836The EspF N-Terminal of Enterohemorrhagic Escherichia coli O157:H7 EDL933w Imparts Stronger Toxicity Effects on HT-29 Cells than the C-Terminal
Q37777278The EspF effector, a bacterial pathogen's Swiss army knife
Q34000660The Fanconi anemia protein, FANCG, binds to the ERCC1-XPF endonuclease via its tetratricopeptide repeats and the central domain of ERCC1.
Q27935043The Glc7p-interacting protein Bud14p attenuates polarized growth, pheromone response, and filamentous growth in Saccharomyces cerevisiae
Q34571628The N-terminal domain of EspF induces host cell apoptosis after infection with enterohaemorrhagic Escherichia coli O157:H7.
Q35995896The PDZ domain as a complex adaptive system
Q30156109The SH3 domain, but not the catalytic domain, is required for phospholipase C-gamma1 to mediate epidermal growth factor-induced mitogenesis
Q30157402The SH3 domains of two PCH family members cooperate in assembly of the Schizosaccharomyces pombe contractile ring
Q28767218The SH3/PH domain protein AgBoi1/2 collaborates with the Rho-type GTPase AgRho3 to prevent nonpolar growth at hyphal tips of Ashbya gossypii
Q30008930The SH3BGR/STAT3 Pathway Regulates Cell Migration and Angiogenesis Induced by a Gammaherpesvirus MicroRNA.
Q33991863The Unfinished Story of Cytochrome f.
Q27938721The WASP/Las17p-interacting protein Bzz1p functions with Myo5p in an early stage of endocytosis.
Q34308157The application of modular protein domains in proteomics
Q27930919The biologically relevant targets and binding affinity requirements for the function of the yeast actin-binding protein 1 Src-homology 3 domain vary with genetic context
Q39957451The challenge of increasing Pfam coverage of the human proteome
Q35111678The cyclin-dependent kinase inhibitor p57Kip2 regulates cell cycle exit, differentiation, and migration of embryonic cerebral cortical precursors
Q34193015The dopamine D4receptor, the ultimate disordered protein
Q37708020The dual role of zonula occludens (ZO) proteins
Q37831362The endocytic adaptor proteins of pathogenic fungi: charting new and familiar pathways
Q90462509The functional importance of lamins, actin, myosin, spectrin and the LINC complex in DNA repair
Q27648726The high resolution NMR structure of the third SH3 domain of CD2AP
Q27644350The high-resolution NMR structure of the R21A Spc-SH3:P41 complex: Understanding the determinants of binding affinity by comparison with Abl-SH3
Q30008794The intrinsically disordered linker of E. coli SSB is critical for the release from single-stranded DNA
Q34262069The linker region of NS3 plays a critical role in the replication and infectivity of hepatitis C virus
Q47588518The molecular structure of the glycoside hydrolase domain of Cwp19 from Clostridium difficile
Q28115307The multiple-specificity landscape of modular peptide recognition domains
Q30009559The nebulin SH3 domain is dispensable for normal skeletal muscle structure but is required for effective active load bearing in mouse.
Q30009295The proline-rich region of 18.5 kDa myelin basic protein binds to the SH3-domain of Fyn tyrosine kinase with the aid of an upstream segment to form a dynamic complex in vitro.
Q47369077The structure of the S-layer of Clostridium difficile.
Q30155988The β Subunit of Voltage-Gated Ca2+Channels
Q27640026Topography for independent binding of alpha-helical and PPII-helical ligands to a peroxisomal SH3 domain
Q35088242Transcriptomics and identification of the chemoreceptor superfamily of the pupal parasitoid of the oriental fruit fly, Spalangia endius Walker (Hymenoptera: Pteromalidae).
Q30010150Transient protein-protein interaction of the SH3-peptide complex via closely located multiple binding sites
Q37134404Transmembrane form agrin-induced process formation requires lipid rafts and the activation of Fyn and MAPK.
Q37344623Tuberculosis-induced variant IL-4 mRNA encodes a cytokine functioning as growth factor for (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate-specific Vgamma2Vdelta2 T cells
Q35946296Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium
Q30010083Ubiquitin and its binding domains.
Q27930138Ubiquitin binds to and regulates a subset of SH3 domains
Q33531737Unexpected tolerance of alpha-cleavage of the prion protein to sequence variations
Q47100851VEGFR1 promotes cell migration and proliferation through PLCγ and PI3K pathways.
Q37226190Vascular smooth muscle cell motility is mediated by a physical and functional interaction of Ca2+/calmodulin-dependent protein kinase IIδ2 and Fyn.
Q27933802Yeast Nap1-Binding Protein Nbp2p Is Required for Mitotic Growth at High Temperatures and for Cell Wall Integrity
Q54979831c-Src kinase is involved in the tyrosine phosphorylation and activity of SLC11A1 in differentiating macrophages.
Q30157946o-Nitrotyrosine and p-iodophenylalanine as spectroscopic probes for structural characterization of SH3 complexes

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