Identification of nitric oxide synthase as a protective locus against tuberculosis

scientific article (publication date: 13 May 1997)

Identification of nitric oxide synthase as a protective locus against tuberculosis is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode1997PNAS...94.5243M
P356DOI10.1073/PNAS.94.10.5243
P3181OpenCitations bibliographic resource ID201212
P932PMC publication ID24663
P698PubMed publication ID9144222
P5875ResearchGate publication ID14074672

P50authorCarl F. NathanQ1037710
P2093author name stringNorth RJ
MacMicking JD
Shah SK
Mudgett JS
LaCourse R
P2860cites workLipoarabinomannan, a possible virulence factor involved in persistence of Mycobacterium tuberculosis within macrophagesQ24644376
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A direct effect of glucocorticoid hormones on the ability of human and murine macrophages to control the growth of M. tuberculosisQ70370072
Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthaseQ71694221
Multiple defects of immune cell function in mice with disrupted interferon-gamma genesQ28267397
Natural resistance to infection with intracellular parasites: isolation of a candidate for BcgQ28269092
Automatable radiometric detection of growth of Mycobacterium tuberculosis in selective mediaQ28319361
Effects of nitric oxide synthase inhibitors on murine infection with Mycobacterium tuberculosisQ28367637
The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 geneQ28589797
Nitric oxide and macrophage functionQ29615327
An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infectionQ29616521
Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophagesQ29617356
Simplified mammalian DNA isolation procedureQ29618648
Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in miceQ29622922
Interaction with extracellular matrix proteins influences Lsh/Ity/Bcg (candidate Nramp) gene regulation of macrophage priming/activation for tumour necrosis factor-alpha and nitrite release.Q30194385
Molecular mechanisms of dexamethasone inhibition of nitric oxide synthase expression in interleukin 1 beta-stimulated mesangial cells: evidence for the involvement of transcriptional and posttranscriptional regulationQ33614403
Genetic and redox determinants of nitric oxide cytotoxicity in a Salmonella typhimurium modelQ34123367
Mechanisms of recrudescence of Mycobacterium bovis BCG infection in miceQ35096828
Roles of nitric oxide in inducible resistance of Escherichia coli to activated murine macrophagesQ35390580
Growth of Mycobacterium tuberculosis in BCG-resistant and -susceptible mice: establishment of latency and reactivationQ35417336
The influence of corticotrophin and certain corticosteroids on populations of Mycobacterium tuberculosis in tissues of miceQ36152649
Microbial persistence. I. The capacity of tubercle bacilli to survive sterilization in mouse tissuesQ36268025
Mice that lack the interferon-gamma receptor have profoundly altered responses to infection with Bacillus Calmette-Guérin and subsequent challenge with lipopolysaccharide.Q36362408
Nitric oxide potentiates hydrogen peroxide-induced killing of Escherichia coli.Q36365394
Evidence inconsistent with a role for the Bcg gene (Nramp1) in resistance of mice to infection with virulent Mycobacterium tuberculosisQ36365796
Reactivation of latent leishmaniasis by inhibition of inducible nitric oxide synthaseQ36366480
Inducible nitric oxide synthase in pulmonary alveolar macrophages from patients with tuberculosisQ36366661
Mechanisms involved in mycobacterial growth inhibition by gamma interferon-activated bone marrow macrophages: role of reactive nitrogen intermediatesQ36968357
Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infectionQ37347705
Cloning and characterization of inducible nitric oxide synthase from mouse macrophagesQ38329463
Anti-inflammatory actions of steroids: molecular mechanismsQ40386939
Carboxyl terminus of inducible nitric oxide synthase. Contribution to NADPH binding and enzymatic activityQ41429540
Glucocorticoids inhibit the induction of nitric oxide synthase in macrophagesQ41714852
Mycobacterial virulence. Virulent strains of Mycobacteria tuberculosis have faster in vivo doubling times and are better equipped to resist growth-inhibiting functions of macrophages in the presence and absence of specific immunityQ41780161
Apoptosis, but not necrosis, of infected monocytes is coupled with killing of intracellular bacillus Calmette-GuérinQ41867941
L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase.Q42275426
L-N6-(1-iminoethyl)-lysine potently inhibits inducible nitric oxide synthase and is superior to NG-monomethyl-arginine in vitro and in vivo.Q43926524
The Nramp1 antimicrobial resistance gene segregates independently of resistance to virulent Mycobacterium tuberculosisQ44151130
Haplotype mapping and sequence analysis of the mouse Nramp gene predict susceptibility to infection with intracellular parasites.Q44615539
Altered immune responses in mice lacking inducible nitric oxide synthaseQ44662136
Interferon-gamma-treated murine macrophages inhibit growth of tubercle bacilli via the generation of reactive nitrogen intermediatesQ44828688
Tumor necrosis factor and granulocyte macrophage-colony stimulating factor stimulate human macrophages to restrict growth of virulent Mycobacterium avium and to kill avirulent M. avium: killing effector mechanism depends on the generation of reactivQ44904847
Global epidemiology of tuberculosis. Morbidity and mortality of a worldwide epidemicQ46228076
Homocysteine antagonism of nitric oxide-related cytostasis in Salmonella typhimuriumQ50139335
The kinetics of emergence and loss of mediator T lymphocytes acquired in response to infection with Mycobacterium tuberculosis.Q52135468
Requirement for transcription factor IRF-1 in NO synthase induction in macrophages.Q52507356
Nitrosative stress: activation of the transcription factor OxyR.Q54580956
P433issue10
P407language of work or nameEnglishQ1860
P921main subjecttuberculosisQ12204
P304page(s)5243-8
P577publication date1997-05-13
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleIdentification of nitric oxide synthase as a protective locus against tuberculosis
P478volume94

Reverse relations

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Q90135468Interleukin 10 knock-down in bovine monocyte-derived macrophages has distinct effects during infection with two divergent strains of Mycobacterium bovis
Q37309538Interleukin-10 promotes Mycobacterium tuberculosis disease progression in CBA/J mice
Q61313267Interleukin-12p40 overexpression promotes interleukin-12p70 and interleukin-23 formation but does not affect bacille Calmette-Guérin and Mycobacterium tuberculosis clearance
Q40634545Intracellular expression of Mycobacterium tuberculosis-specific 10-kDa antigen down-regulates macrophage B7.1 expression and nitric oxide release.
Q44163367Investigation of chromosome 17 candidate genes in susceptibility to TB in a South African population
Q38055958In vitro infection of human cells with Mycobacterium tuberculosis.
Q92163260Iron Supplementation Therapy, A Friend and Foe of Mycobacterial Infections?
Q37778480Is Mycobacterium tuberculosis stressed out? A critical assessment of the genetic evidence
Q54976471Is Receptor-Interacting Protein Kinase 3 a Viable Therapeutic Target for Mycobacterium tuberculosis Infection?
Q56469515Is Total Serum Nitrite and Nitrate (NOx) Level in Dengue Patients a Potential Prognostic Marker of Dengue Hemorrhagic Fever?
Q34463493Is nitric oxide overproduction the target of choice for the management of septic shock?
Q38756763Lack of IL-1 Receptor-Associated Kinase-4 Leads to Defective Th1 Cell Responses and Renders Mice Susceptible to Mycobacterial Infection
Q45733743Lack of nitric oxide synthase type 2 (NOS2) results in reduced neuronal apoptosis and mortality following mouse hepatitis virus infection of the central nervous system
Q40065379Lactoferricin Peptides Increase Macrophages' Capacity To Kill Mycobacterium avium.
Q34297816Latent tuberculosis infection: myths, models, and molecular mechanisms
Q35211295Latent tuberculosis: mechanisms of host and bacillus that contribute to persistent infection
Q37421310Lazy, dynamic or minimally recrudescent? On the elusive nature and location of the mycobacterium responsible for latent tuberculosis
Q73002017Lethal Mycobacterium bovis Bacillus Calmette Guérin infection in nitric oxide synthase 2-deficient mice: cell-mediated immunity requires nitric oxide synthase 2
Q36703585Life and death in the granuloma: immunopathology of tuberculosis
Q79243126Life on the inside for Mycobacterium tuberculosis
Q48165177Lipid droplet formation in Mycobacterium tuberculosis infected macrophages requires IFN-γ/HIF-1α signaling and supports host defense
Q28140459Lipoarabinomannan from Mycobacterium tuberculosis promotes macrophage survival by phosphorylating Bad through a phosphatidylinositol 3-kinase/Akt pathway
Q53908549Lung cell responses to M. tuberculosis in genetically susceptible and resistant mice following intratracheal challenge.
Q35605917M. tuberculosis persistence, latency, and drug tolerance
Q34280835Macrophage arginase-1 controls bacterial growth and pathology in hypoxic tuberculosis granulomas
Q38363796Macrophage defense mechanisms against intracellular bacteria.
Q35039679Macrophage immunoregulatory pathways in tuberculosis
Q38497801Macrophage takeover and the host-bacilli interplay during tuberculosis.
Q36959378Macrophage-mediated inflammatory response decreases mycobacterial survival in mouse MSCs by augmenting NO production
Q37856707Macrophages and control of granulomatous inflammation in tuberculosis
Q27319471Mechanism of inducible nitric oxide synthase exclusion from mycobacterial phagosomes
Q37118101Mechanisms and consequences of persistence of intracellular pathogens: leishmaniasis as an example.
Q30398195Metabolic Perspectives on Persistence
Q28590692Mice lacking inducible nitric oxide synthase demonstrate impaired killing of Porphyromonas gingivalis
Q37103066Microenvironments in tuberculous granulomas are delineated by distinct populations of macrophage subsets and expression of nitric oxide synthase and arginase isoforms
Q28362977Modulation of Mycobacterium bovis-specific responses of bovine peripheral blood mononuclear cells by 1,25-dihydroxyvitamin D(3)
Q80818732Modulation of immune responses in mice to recombinant antigens from PE and PPE families of proteins of Mycobacterium tuberculosis by the Ribi adjuvant
Q45829514Molecular Mechanisms Modulating the Phenotype of Macrophages and Microglia
Q36688480Molecular immunologic correlates of spontaneous latency in a rabbit model of pulmonary tuberculosis
Q35622988Molecular mechanisms of host-pathogen interaction: entry and survival of mycobacteria in macrophages.
Q91904779Mucosal-associated invariant T cells and disease
Q28540070Mycobacteria counteract a TLR-mediated nitrosative defense mechanism in a zebrafish infection model
Q37426403Mycobacteria inhibit nitric oxide synthase recruitment to phagosomes during macrophage infection
Q54520033Mycobacteria-induced granuloma necrosis depends on IRF-1.
Q28552338Mycobacterial Metabolic Syndrome: LprG and Rv1410 Regulate Triacylglyceride Levels, Growth Rate and Virulence in Mycobacterium tuberculosis
Q28083739Mycobacterial genes essential for the pathogen's survival in the host
Q35671416Mycobacterial glycolipids di-O-acylated trehalose and tri-O-acylated trehalose downregulate inducible nitric oxide synthase and nitric oxide production in macrophages
Q34426515Mycobacterium marinum causes a latent infection that can be reactivated by gamma irradiation in adult zebrafish
Q35598609Mycobacterium smegmatis RoxY is a repressor of oxyS and contributes to resistance to oxidative stress and bactericidal ubiquitin-derived peptides
Q39655566Mycobacterium tuberculosis CDC1551 is resistant to reactive nitrogen and oxygen intermediates in vitro
Q28486511Mycobacterium tuberculosis DosS is a redox sensor and DosT is a hypoxia sensor
Q93220808Mycobacterium tuberculosis Requires Regulation of ESX-5 Secretion for Virulence in Irgm1-Deficient Mice
Q91720786Mycobacterium tuberculosis Rv2700 Contributes to Cell Envelope Integrity and Virulence
Q28552573Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense
Q52722200Mycobacterium tuberculosis Transfer RNA Induces IL-12p70 via Synergistic Activation of Pattern Recognition Receptors within a Cell Network.
Q89997913Mycobacterium tuberculosis WhiB3 maintains redox homeostasis and survival in response to reactive oxygen and nitrogen species
Q36223232Mycobacterium tuberculosis WhiB4 regulates oxidative stress response to modulate survival and dissemination in vivo.
Q36938592Mycobacterium tuberculosis and the environment within the phagosome
Q35216595Mycobacterium tuberculosis and the intimate discourse of a chronic infection
Q64964405Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes.
Q28486947Mycobacterium tuberculosis conserved hypothetical protein rRv2626c modulates macrophage effector functions
Q28486777Mycobacterium tuberculosis expresses methionine sulphoxide reductases A and B that protect from killing by nitrite and hypochlorite
Q34945420Mycobacterium tuberculosis growth at the cavity surface: a microenvironment with failed immunity
Q41374063Mycobacterium tuberculosis has diminished capacity to counteract redox stress induced by elevated levels of endogenous superoxide.
Q27633806Mycobacterium tuberculosis hemoglobin N displays a protein tunnel suited for O2 diffusion to the heme
Q45000171Mycobacterium tuberculosis induces high production of nitric oxide in coordination with production of tumour necrosis factor-alpha in patients with fresh active tuberculosis but not in MDR tuberculosis
Q34213787Mycobacterium tuberculosis pathogenesis and molecular determinants of virulence
Q33982151Mycobacterium tuberculosis persistence mutants identified by screening in isoniazid-treated mice
Q28486412Mycobacterium tuberculosis prcBA genes encode a gated proteasome with broad oligopeptide specificity
Q34747029Mycobacterium tuberculosis protein kinase K confers survival advantage during early infection in mice and regulates growth in culture and during persistent infection: implications for immune modulation
Q36506132Mycobacterium tuberculosis requires phosphate-responsive gene regulation to resist host immunity.
Q38268279Mycobacterium tuberculosis response to stress from reactive oxygen and nitrogen species
Q34089860Mycobacterium tuberculosis wears what it eats
Q29619735Mycobacterium tuberculosis: here today, and here tomorrow
Q38686660Mycobacterium tuberculosis: what is the role of PPE2 during infection?
Q91321395Mycoplasma bovis delay in apoptosis of macrophages is accompanied by increased expression of anti-apoptotic genes, reduced cytochrome C translocation and inhibition of DNA fragmentation
Q61755441Mycothiol-dependent mycobacterial response to oxidative stress
Q90674170Myeloid HIF-1α regulates pulmonary inflammation during experimental Mycobacterium tuberculosis infection
Q41969521N,C-Capped dipeptides with selectivity for mycobacterial proteasome over human proteasomes: role of S3 and S1 binding pockets
Q38937950NOD-2 and TLR-4 Signaling Reinforces the Efficacy of Dendritic Cells and Reduces the Dose of TB Drugs against Mycobacterium tuberculosis.
Q40087530NOS2-deficient mice with hypoxic necrotizing lung lesions predict outcomes of tuberculosis chemotherapy in humans
Q44558306NOS2-derived nitric oxide regulates the size, quantity and quality of granuloma formation in Mycobacterium avium-infected mice without affecting bacterial loads
Q39304314NOS2A promoter (CCTTT)n association with TB lacks independent functional correlation amongst Indians
Q33896845NOS2A, TLR4, and IFNGR1 interactions influence pulmonary tuberculosis susceptibility in African-Americans
Q34460946Natural transmission of Plasmodium berghei exacerbates chronic tuberculosis in an experimental co-infection model
Q40868823Naturally produced opsonizing antibodies restrict the survival of Mycobacterium tuberculosis in human macrophages by augmenting phagosome maturation
Q48138531Necroptotic signaling is primed in Mycobacterium tuberculosis-infected macrophages, but its pathophysiological consequence in disease is restricted
Q42908536Neuroinflammation, Oxidative Stress and the Pathogenesis of Parkinson's Disease
Q28388477New insights into TB physiology suggest untapped therapeutic opportunities
Q35095367New targets and inhibitors of mycobacterial sulfur metabolism.
Q90468452Nitric Oxide Engages an Anti-inflammatory Feedback Loop Mediated by Peroxiredoxin 5 in Phagocytes
Q40115065Nitric Oxide Modulates Macrophage Responses to Mycobacterium tuberculosis Infection through Activation of HIF-1α and Repression of NF-κB.
Q33734476Nitric oxide and infectious diseases
Q29617591Nitric oxide and the immune response
Q27485884Nitric oxide and virus infection
Q34941147Nitric oxide as an inflammatory mediator in autoimmune MRL-lpr/lpr mice
Q37040409Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1β.
Q37400186Nitric oxide in dengue and dengue haemorrhagic fever: necessity or nuisance?
Q77802828Nitric oxide in the failing myocardium
Q34984498Nitric oxide inhibits exocytosis of cytolytic granules from lymphokine-activated killer cells
Q36875493Nitric oxide inhibits the accumulation of CD4+CD44hiTbet+CD69lo T cells in mycobacterial infection
Q48022256Nitric oxide participation in granulomatous response induced by Paracoccidioides brasiliensis infection in mice
Q34932787Nitric oxide protects bacteria from aminoglycosides by blocking the energy-dependent phases of drug uptake
Q28486473Nitric oxide scavenging and detoxification by the Mycobacterium tuberculosis haemoglobin, HbN in Escherichia coli
Q35061791Nitric oxide synthase activity has limited influence on the control of Coccidioides infection in mice
Q35558464Nitric oxide, inflammation and acute burn injury
Q48379508Nitric oxide: from a mysterious labile factor to the molecule of the Nobel Prize. Recent progress in nitric oxide research
Q37318269Nitrite produced by Mycobacterium tuberculosis in human macrophages in physiologic oxygen impacts bacterial ATP consumption and gene expression
Q38253107Nitrogen metabolism in Mycobacterium tuberculosis physiology and virulence
Q34381833Nitrosylation. the prototypic redox-based signaling mechanism.
Q58846273No evidence for association of the inducible nitric oxide synthase promoter polymorphism with Trypanosoma cruzi infection
Q36342789Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials
Q37101494Novel Cephalosporins Selectively Active on Nonreplicating Mycobacterium tuberculosis
Q27757495Novel non-heme iron center of nitrile hydratase with a claw setting of oxygen atoms
Q47136699Nucleotide-Binding Oligomerization Domain 2 Contributes to Limiting Growth of Mycobacterium abscessus in the Lung of Mice by Regulating Cytokines and Nitric Oxide Production
Q43985483On the killing of mycobacteria by macrophages
Q36580383One Episode of Self-Resolving Plasmodium yoelii Infection Transiently Exacerbates Chronic Mycobacterium tuberculosis Infection
Q38672958Oxidative Phosphorylation as a Target Space for Tuberculosis: Success, Caution, and Future Directions
Q39567733Oxidative stress response and characterization of the oxyR-ahpC and furA-katG loci in Mycobacterium marinum.
Q34543665Oxygen binding and NO scavenging properties of truncated hemoglobin, HbN, of Mycobacterium smegmatis
Q24654913PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release
Q38085418PPE2 protein of Mycobacterium tuberculosis may inhibit nitric oxide in activated macrophages
Q35150831Patients with tuberculosis disease have Mycobacterium tuberculosis-specific CD8 T cells with a pro-apoptotic phenotype and impaired proliferative capacity, which is not restored following treatment
Q40548422Peroxiredoxin 1 Contributes to Host Defenses against Mycobacterium tuberculosis.
Q35889600Persistent bacterial infections: the interface of the pathogen and the host immune system
Q37368468Perspectives series: host/pathogen interactions. Mechanisms of nitric oxide-related antimicrobial activity
Q37945715Pharmacogenetics of the lipodystrophy syndrome associated with HIV infection and combination antiretroviral therapy.
Q33793673Pharmacological modulation of nitric oxide synthesis by mechanism-based inactivators and related inhibitors
Q45274479Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase.
Q36914816Phthiocerol dimycocerosate transport is required for resisting interferon-gamma-independent immunity
Q38484210Phylogenomics of Mycobacterium Nitrate Reductase Operon
Q36163097Polyclonal mucosa-associated invariant T cells have unique innate functions in bacterial infection
Q35208353Preexisting helminth infection induces inhibition of innate pulmonary anti-tuberculosis defense by engaging the IL-4 receptor pathway
Q58553806Presence of Infected Gr-1CD11bCD11c Monocytic Myeloid Derived Suppressor Cells Subverts T Cell Response and Is Associated With Impaired Dendritic Cell Function in -Infected Mice
Q37282737Progress and new directions in genetics of tuberculosis: an NHLBI working group report
Q39076238Prokaryotic expression and functional analysis of the Mb1514 gene in Mycobacterium bovis
Q37502693Prokaryotic ubiquitin-like protein (Pup), proteasomes and pathogenesis
Q28487570Proteasomal control of cytokinin synthesis protects Mycobacterium tuberculosis against nitric oxide
Q37204436Protection of Mycobacterium tuberculosis from reactive oxygen species conferred by the mel2 locus impacts persistence and dissemination
Q38247209Protective immune responses to fungal infections
Q37033735Protective role of membrane tumour necrosis factor in the host's resistance to mycobacterial infection
Q33751428Protective role of nitric oxide in Staphylococcus aureus infection in mice
Q91966785Protein-protein interaction of Rv0148 with Htdy and its predicted role towards drug resistance in Mycobacterium tuberculosis
Q38321484Pulmonary Mycobacterium tuberculosis infection in leptin-deficient ob/ob mice
Q36404225Rapid interferon gamma-dependent clearance of influenza A virus and protection from consolidating pneumonitis in nitric oxide synthase 2-deficient mice
Q43245570Rapid, Semiquantitative Assay To Discriminate among Compounds with Activity against Replicating or Nonreplicating Mycobacterium tuberculosis.
Q37190166Reaction of Mycobacterium tuberculosis cytochrome P450 enzymes with nitric oxide
Q34001719Reactivation of latent tuberculosis: variations on the Cornell murine model
Q33840580Reactive nitrogen intermediates and the pathogenesis of Salmonella and mycobacteria
Q39664494Reactive nitrogen intermediates have a bacteriostatic effect on Mycobacterium tuberculosis in vitro
Q24630289Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens
Q33840513Reactive oxygen and reactive nitrogen intermediates in innate and specific immunity
Q34851055Recombinant gamma interferon stimulates signal transduction and gene expression in alveolar macrophages in vitro and in tuberculosis patients
Q27012879Redox homeostasis in mycobacteria: the key to tuberculosis control?
Q35356550Reduced oxidative and nitrosative damage in murine experimental colitis in the absence of inducible nitric oxide synthase
Q40136119Reduced susceptibility of clinical strains of Mycobacterium tuberculosis to reactive nitrogen species promotes survival in activated macrophages
Q28539327Reengineering redox sensitive GFP to measure mycothiol redox potential of Mycobacterium tuberculosis during infection
Q58461876Regulation of granuloma fibrosis by nitric oxide during Mycobacterium avium experimental infection
Q36040945Regulation of innate immunity by NADPH oxidase
Q60300625Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin
Q35441389Regulation of neutrophils by interferon-γ limits lung inflammation during tuberculosis infection
Q28487527Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding α-crystallin
Q34445693Regulation of the ahpC gene encoding alkyl hydroperoxide reductase in Mycobacterium smegmatis
Q50319373Reinforcing the Functionality of Mononuclear Phagocyte System to Control Tuberculosis
Q36669873Relationship of bovine NOS2 gene polymorphisms to the risk of bovine tuberculosis in Holstein cattle.
Q33943840Replication of Yersinia pestis in interferon gamma-activated macrophages requires ripA, a gene encoded in the pigmentation locus
Q36369581Reprogramming of the macrophage transcriptome in response to interferon-gamma and Mycobacterium tuberculosis: signaling roles of nitric oxide synthase-2 and phagocyte oxidase
Q28487034Response to reactive nitrogen intermediates in Mycobacterium tuberculosis: induction of the 16-kilodalton alpha-crystallin homolog by exposure to nitric oxide donors
Q38003929Revisiting the role of the granuloma in tuberculosis
Q62488588Rifampicin and dexamethasone have similar effects on macrophage phagocytosis of zymosan, but differ in their effects on nitrite and TNF-α production
Q42237169Rifampin augments cytokine-induced nitric oxide production in human alveolar epithelial cells
Q35627704Role for NOD2 in Mycobacterium tuberculosis-induced iNOS expression and NO production in human macrophages
Q41946149Role for nucleotide excision repair in virulence of Mycobacterium tuberculosis
Q28486437Role of Mycobacterium tuberculosis copper-zinc superoxide dismutase
Q43126200Role of Pre-A motif in nitric oxide scavenging by truncated hemoglobin, HbN, of Mycobacterium tuberculosis.
Q34191797Role of free radicals in viral pathogenesis and mutation
Q33600697Role of inducible nitric oxide synthase in resistance to Mycobacterium leprae in mice
Q34418998Role of nitric oxide in inflammation
Q34714207Role of the NF-kappaB signaling pathway and kappaB cis-regulatory elements on the IRF-1 and iNOS promoter regions in mycobacterial lipoarabinomannan induction of nitric oxide
Q37099497Role of the dosR-dosS two-component regulatory system in Mycobacterium tuberculosis virulence in three animal models.
Q24546207S-Nitrosogluthathione reductase activity of amphioxus ADH3: insights into the nitric oxide metabolism
Q33722881S-nitroso proteome of Mycobacterium tuberculosis: Enzymes of intermediary metabolism and antioxidant defense
Q35119656S-nitrosylation in health and disease
Q52728434S-nitrosylation of NADPH oxidase regulates cell death in plant immunity.
Q57471957S-nitrosylation of the zinc finger protein SRG1 regulates plant immunity
Q40623428STAT3 Represses Nitric Oxide Synthesis in Human Macrophages upon Mycobacterium tuberculosis Infection
Q90521129Salmonella Persist in Activated Macrophages in T Cell-Sparse Granulomas but Are Contained by Surrounding CXCR3 Ligand-Positioned Th1 Cells
Q28505858Serine protease activity contributes to control of Mycobacterium tuberculosis in hypoxic lung granulomas in mice
Q34009146Silencing of oxidative stress response in Mycobacterium tuberculosis: expression patterns of ahpC in virulent and avirulent strains and effect of ahpC inactivation
Q64097469Spatial and temporal localization of immune transcripts defines hallmarks and diversity in the tuberculosis granuloma
Q58889002Species-Specific Transcriptional Regulation of Genes Involved in Nitric Oxide Production and Arginine Metabolism in Macrophages
Q27694770Spotlights on immunological effects of reactive nitrogen species: When inflammation says nitric oxide
Q39437320Striking the right immunological balance prevents progression of tuberculosis
Q47259350Structure of a Wbl protein and implications for NO sensing by M. tuberculosis.
Q45066836Study on myeloperoxidase role in antituberculous defense in the context of cytokine activation
Q45952650Suppression of IFNgamma+mycobacterial lipoarabinomannan-induced NO by IL-4 is due to decreased IRF-1 expression.
Q28397253Suppression of the NF-κB pathway by diesel exhaust particles impairs human antimycobacterial immunity
Q47109680Suppressor of Cytokine Signaling 3 in Macrophages Prevents Exacerbated Interleukin-6-Dependent Arginase-1 Activity and Early Permissiveness to Experimental Tuberculosis.
Q51655159Surfactant protein A enhances Mycobacterium avium ingestion but not killing by rat macrophages.
Q33842618Surfactant protein A suppresses reactive nitrogen intermediates by alveolar macrophages in response to Mycobacterium tuberculosis
Q33876178Survival of Mycobacterium avium and Mycobacterium tuberculosis in acidified vacuoles of murine macrophages
Q51984727Susceptibility and resistance to monocytic ehrlichiosis in the mouse.
Q53854589Susceptibility of brushtail possums (Trichosurus vulpecula) infected with Mycobacterium bovis is associated with a transient macrophage activation profile.
Q98224728Susceptibility to Intracellular Infections: Contributions of TNF to Immune Defense
Q36241272Sustained generation of nitric oxide and control of mycobacterial infection requires argininosuccinate synthase 1.
Q38742184T Cell-Derived IL-10 Impairs Host Resistance to Mycobacterium tuberculosis Infection
Q33536568T cell mediated immunity to Mycobacterium tuberculosis
Q45948289T-cell release of granulysin contributes to host defense in leprosy.
Q28083600TB drug development: immunology at the table
Q38166990TB or not TB: that is no longer the question
Q37435926TB vaccines: current status and future perspectives
Q36666348TGF beta 1 and TNF alpha potentiate nitric oxide production in astrocyte cultures by recruiting distinct subpopulations of cells to express NOS-2.
Q40178443TLR2 but not TLR4 signalling is critically involved in the inhibition of IFN-gamma-induced killing of mycobacteria by murine macrophages
Q36403076TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis.
Q41816750TNF dually mediates resistance and susceptibility to mycobacteria via mitochondrial reactive oxygen species
Q55287141TNF-α blockade impairs in vitro tuberculous granuloma formation and down modulate Th1, Th17 and Treg cytokines.
Q37891774Taking Out TB-Lysosomal Trafficking and Mycobactericidal Ubiquitin-Derived Peptides
Q39149038Targeting Phenotypically Tolerant Mycobacterium tuberculosis
Q24644997Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes immunity to mycobacteria
Q52692190Targeting the Proteostasis Network for Mycobacterial Drug Discovery.
Q26774207Th1 and Th17 Cells in Tuberculosis: Protection, Pathology, and Biomarkers
Q49900955Th1 cytokines, true functional signatures for protective immunity against TB?
Q38314435The BER necessities: the repair of DNA damage in human-adapted bacterial pathogens.
Q39727290The CFP-10/ESAT-6 complex of Mycobacterium tuberculosis potentiates the activation of murine macrophages involvement of IFN-gamma signaling
Q43082287The IL-13/IL-4Rα axis is involved in tuberculosis-associated pathology
Q37594360The Minimal Unit of Infection: Mycobacterium tuberculosis in the Macrophage
Q35628763The Mycobacterium marinum mel2 locus displays similarity to bacterial bioluminescence systems and plays a role in defense against reactive oxygen and nitrogen species
Q42600002The Mycobacterium tuberculosis SecA2 system subverts phagosome maturation to promote growth in macrophages.
Q33658714The Mycobacterium tuberculosis proteasome active site threonine is essential for persistence yet dispensable for replication and resistance to nitric oxide
Q37578057The Mycobacterium tuberculosis proteasome: more than just a barrel-shaped protease
Q54286145The Mycobacterium tuberculosis recombinant LprN protein of mce4 operon induces Th-1 type response deleterious to protection in mice.
Q27702517The N-terminal pre-A region of Mycobacterium tuberculosis 2/2HbN promotes NO-dioxygenase activity
Q26825089The Pup-Proteasome System of Mycobacteria
Q27490787The Role of Nitric Oxide in Mycobacterial Infections
Q34026690The SPRY domain-containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation
Q34888988The Sculpting of the Mycobacterium tuberculosis Genome by Host Cell-Derived Pressures
Q28487596The SecA2 secretion factor of Mycobacterium tuberculosis promotes growth in macrophages and inhibits the host immune response
Q30402360The Tyrosine Kinase Inhibitor Gefitinib Restricts Mycobacterium tuberculosis Growth through Increased Lysosomal Biogenesis and Modulation of Cytokine Signaling.
Q39613066The capsule supports survival but not traversal of Escherichia coli K1 across the blood-brain barrier.
Q26744038The emerging role of gasotransmitters in the pathogenesis of tuberculosis
Q34595822The endothelin system has a significant role in the pathogenesis and progression of Mycobacterium tuberculosis infection.
Q38872142The fibroblast growth factor-2 arrests Mycobacterium avium sp. paratuberculosis growth and immunomodulates host response in macrophages
Q55653568The functional interplay of low molecular weight thiols in Mycobacterium tuberculosis.
Q41727902The host immune response to tuberculosis
Q35676581The immunological aspects of latency in tuberculosis
Q33777367The immunology of tuberculosis: from bench to bedside
Q34009836The inducible nitric oxide synthase locus confers protection against aerogenic challenge of both clinical and laboratory strains of Mycobacterium tuberculosis in mice
Q37123814The intracellular environment of human macrophages that produce nitric oxide promotes growth of mycobacteria.
Q36838527The iron export protein ferroportin 1 is differentially expressed in mouse macrophage populations and is present in the mycobacterial-containing phagosome.
Q37419579The macrophage marches on its phagosome: dynamic assays of phagosome function.
Q34266438The many faces of host responses to tuberculosis
Q28487623The multifunctional histone-like protein Lsr2 protects mycobacteria against reactive oxygen intermediates
Q36075177The pathogenesis of tuberculosis: the first one hundred (and twenty-three) years
Q36376221The relative importance of T cell subsets in immunity and immunopathology of airborne Mycobacterium tuberculosis infection in mice
Q37859621The role of IL-10 in immune regulation during M. tuberculosis infection
Q37374958The role of cytokines in the initiation, expansion, and control of cellular immunity to tuberculosis
Q34265039The role of gamma interferon in antimicrobial immunity
Q44891712The role of nitric oxide in lung innate immunity: modulation by surfactant protein-A.
Q47286732The role of nitric oxide in metabolic regulation of Dendritic cell immune function
Q26863204The role of pro-resolution lipid mediators in infectious disease
Q41965764The toll-like receptor 2/6 ligand MALP-2 reduces the viability of Mycobacterium tuberculosis in murine macrophages
Q58746346Tolerating the Unwelcome Guest; How the Host Withstands Persistent
Q35609316Toll-like receptor 2-dependent extracellular signal-regulated kinase signaling in Mycobacterium tuberculosis-infected macrophages drives anti-inflammatory responses and inhibits Th1 polarization of responding T cells
Q40104128Toll-like receptor genes are differentially expressed at the sites of infection during the progression of Johne's disease in outbred sheep.
Q34049969Toll-like receptors: molecular mechanisms of the mammalian immune response
Q37228738Toll-like receptors: their roles in bacterial recognition and respiratory infections
Q96435430Topologically correct synthetic reconstruction of pathogen social behavior found during Yersinia growth in deep tissue sites
Q35117081Trans-species communication in the Mycobacterium tuberculosis-infected macrophage
Q37248992Transcriptional characterization of the antioxidant response of Mycobacterium tuberculosis in vivo and during adaptation to hypoxia in vitro
Q54224374Transcriptional landscape of Mycobacterium tuberculosis infection in macrophages.
Q41570545Transcriptome changes upon in vitro challenge with Mycobacterium bovis in monocyte-derived macrophages from bovine tuberculosis-infected and healthy cows
Q28593510Transient loss of resistance to pulmonary tuberculosis in p47(phox-/-) mice
Q27658975Triazaspirodimethoxybenzoyls as Selective Inhibitors of Mycobacterial Lipoamide Dehydrogenase,
Q36970544Triggering through NOD-2 Differentiates Bone Marrow Precursors to Dendritic Cells with Potent Bactericidal activity
Q28486863Truncated hemoglobin HbN protects Mycobacterium bovis from nitric oxide
Q35988766Tuberculosis - metabolism and respiration in the absence of growth
Q47720001Tuberculosis Infectiousness and Host Susceptibility
Q37270954Tuberculosis Susceptibility and Vaccine Protection Are Independently Controlled by Host Genotype
Q21131403Tuberculosis and HIV co-infection
Q34974987Tuberculosis chemotherapy: the influence of bacillary stress and damage response pathways on drug efficacy
Q28201426Tuberculosis: latency and reactivation
Q35094378Tuberculosis: new aspects of an old disease.
Q45929497Tumor Necrosis Factor-Alpha Targeting Can Protect against Arthritis with Low Sensitization to Infection.
Q33315753Tumor necrosis factor blockade in chronic murine tuberculosis enhances granulomatous inflammation and disorganizes granulomas in the lungs
Q44248030Type 1 interferon (IFNalpha/beta) and type 2 nitric oxide synthase regulate the innate immune response to a protozoan parasite
Q37465000Type I IFN Inhibits Alternative Macrophage Activation during Mycobacterium tuberculosis Infection and Leads to Enhanced Protection in the Absence of IFN-γ Signaling
Q34222028Type I IFN induces IL-10 production in an IL-27-independent manner and blocks responsiveness to IFN-γ for production of IL-12 and bacterial killing in Mycobacterium tuberculosis-infected macrophages
Q35851626Understanding latent tuberculosis: a moving target
Q39010964Violent suicidal behaviour in bipolar disorder is associated with nitric oxide synthase 3 gene polymorphism.
Q35097591Virulence factor SenX3 is the oxygen-controlled replication switch of Mycobacterium tuberculosis
Q36371162Virulent but not avirulent Mycobacterium tuberculosis can evade the growth inhibitory action of a T helper 1-dependent, nitric oxide Synthase 2-independent defense in mice
Q34442443What is the role of nitric oxide in murine and human host defense against tuberculosis?Current knowledge
Q36044574Widespread bronchogenic dissemination makes DBA/2 mice more susceptible than C57BL/6 mice to experimental aerosol infection with Mycobacterium tuberculosis
Q49956938c-Abl-TWIST1 Epigenetically Dysregulate Inflammatory Responses during Mycobacterial Infection by Co-Regulating Bone Morphogenesis Protein and miR27a
Q36741352microRNA-146a promotes mycobacterial survival in macrophages through suppressing nitric oxide production
Q30720627noxR3, a novel gene from Mycobacterium tuberculosis, protects Salmonella typhimurium from nitrosative and oxidative stress.
Q35709631p47 GTPases: regulators of immunity to intracellular pathogens

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