Mechanism and functional significance of Itk autophosphorylation

scientific article

Mechanism and functional significance of Itk autophosphorylation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.JMB.2007.08.060
P932PMC publication ID2753204
P698PubMed publication ID17897671
P5875ResearchGate publication ID5946420

P50authorAmy H. AndreottiQ88093154
P2093author name stringD Bruce Fulton
Raji E Joseph
P2860cites workLAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activationQ24315021
BAP-135, a target for Bruton's tyrosine kinase in response to B cell receptor engagementQ24316165
The solution structure and intramolecular associations of the Tec kinase SRC homology 3 domainQ27635775
Structure of the carboxyl-terminal Src kinase, CskQ27638251
Structural characterization of a proline-driven conformational switch within the Itk SH2 domainQ27639877
Crystal structures of interleukin-2 tyrosine kinase and their implications for the design of selective inhibitorsQ27643098
Regulatory intramolecular association in a tyrosine kinase of the Tec familyQ27734282
Three-dimensional structure of the tyrosine kinase c-SrcQ27734749
Solution structure of the SH3 domain from Bruton's tyrosine kinaseQ27748889
Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascadeQ28142714
Tec family of protein-tyrosine kinases: an overview of their structure and functionQ28143299
Itk/Emt/Tsk activation in response to CD3 cross-linking in Jurkat T cells requires ZAP-70 and Lat and is independent of membrane recruitmentQ28145381
Characterization of Itk tyrosine kinase: contribution of noncatalytic domains to enzymatic activityQ28204624
Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activityQ28249985
Regulation of Btk function by a major autophosphorylation site within the SH3 domainQ28278818
Competing modes of self-association in the regulatory domains of Bruton's tyrosine kinase: intramolecular contact versus asymmetric homodimerizationQ28366182
Defective Fas ligand expression and activation-induced cell death in the absence of IL-2-inducible T cell kinaseQ28589905
Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analogQ29616450
Improved sensitivity of HSQC spectra of exchanging protons at short interscan delays using a new fast HSQC (FHSQC) detection scheme that avoids water saturationQ29619727
A remote substrate docking mechanism for the tec family tyrosine kinasesQ30157996
Tec kinase Itk forms membrane clusters specifically in the vicinity of recruiting receptorsQ30159596
Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinaseQ30159870
Ligand specificity modulated by prolyl imide bond Cis/Trans isomerization in the Itk SH2 domain: a quantitative NMR studyQ30164342
Conformation of full-length Bruton tyrosine kinase (Btk) from synchrotron X-ray solution scattering.Q30164519
Itk phosphorylation sites are required for functional activity in primary T cellsQ30164638
Determinants of intra versus intermolecular self-association within the regulatory domains of Rlk and Itk.Q30164691
Intermolecular interactions between the SH3 domain and the proline-rich TH region of Bruton's tyrosine kinase.Q30168418
A specific intermolecular association between the regulatory domains of a Tec family kinaseQ30168752
The SH3 domain of Bruton's tyrosine kinase displays altered ligand binding properties when auto-phosphorylated in vitroQ30175389
SH3 domains and drug design: ligands, structure, and biological functionQ30176672
Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutationsQ34317446
New insights into the regulation and functions of Tec family tyrosine kinases in the immune systemQ34612520
T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cellsQ36400875
Key role of Ser562/661 in Snf1-dependent regulation of Cat8p in Saccharomyces cerevisiae and Kluyveromyces lactis.Q40815510
Multiple modes of activation of the stress-responsive MAP kinase pathway in fission yeastQ41006877
Solution structure of the ubiquitin-associated domain of human BMSC-UbP and its complex with ubiquitinQ41768339
Phosphorylation of tyrosine 319 of the angiotensin II type 1 receptor mediates angiotensin II-induced trans-activation of the epidermal growth factor receptorQ44274577
Transphosphorylation of Bruton's tyrosine kinase on tyrosine 551 is critical for B cell antigen receptor functionQ73427450
The linker between SH2 and kinase domains positively regulates catalysis of the Tec family kinasesQ80138581
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)1281-1292
P577publication date2007-08-31
P1433published inJournal of Molecular BiologyQ925779
P1476titleMechanism and functional significance of Itk autophosphorylation
P478volume373

Reverse relations

cites work (P2860)
Q37416259Conformational snapshots of Tec kinases during signaling
Q34731639Disrupting the intermolecular self-association of Itk enhances T cell signaling
Q37581866ITK inhibitors in inflammation and immune-mediated disorders
Q37452660Itk tyrosine kinase substrate docking is mediated by a nonclassical SH2 domain surface of PLCgamma1.
Q37375071Phylogeny of Tec family kinases identification of a premetazoan origin of Btk, Bmx, Itk, Tec, Txk, and the Btk regulator SH3BP5.
Q30157301Proline isomerization preorganizes the Itk SH2 domain for binding to the Itk SH3 domain
Q30157228SH2-dependent autophosphorylation within the Tec family kinase Itk.
Q30010096SH3 domain tyrosine phosphorylation--sites, role and evolution.
Q35967631Scaffold Protein SLP-76 Primes PLCγ1 for Activation by ITK-Mediated Phosphorylation
Q38472559Structure and function of Tec family kinase Itk.
Q33931933T-cell signaling regulated by the Tec family kinase, Itk.
Q39629321TEC protein tyrosine kinase is involved in the Erk signaling pathway induced by HGF
Q37468293Targeting Interleukin-2-Inducible T-cell Kinase (ITK) in T-Cell Related Diseases.
Q57752422The Src module: an ancient scaffold in the evolution of cytoplasmic tyrosine kinases
Q30010235Tyrosine phosphorylation within the SH3 domain regulates CAS subcellular localization, cell migration, and invasiveness

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