Deletions in the SH2 domain of p60v-src prevent association with the detergent-insoluble cellular matrix

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Deletions in the SH2 domain of p60v-src prevent association with the detergent-insoluble cellular matrix is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.11.3.1207
P932PMC publication ID369391
P698PubMed publication ID1705002

P2093author name stringH Hanafusa
Y Fukui
M C O'Brien
P2860cites workA noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fpsQ24616538
Homology of a yeast actin-binding protein to signal transduction proteins and myosin-I.Q27936873
A novel viral oncogene with structural similarity to phospholipase CQ28307371
Binding of Transforming Protein, P47 gag-crk , to a Broad Range of Phosphotyrosine-containing ProteinsQ30195844
Site-directed mutagenesis of the SH2- and SH3-coding domains of c-src produces varied phenotypes, including oncogenic activation of p60c-srcQ30195875
Regulation of cellular morphology by the Rous sarcoma virus src gene: analysis of fusiform mutantsQ30449967
Association of p60src with Triton X-100-resistant cellular structure correlates with morphological transformationQ30450902
Site-directed mutagenesis of the src gene of Rous sarcoma virus: construction and characterization of a deletion mutant temperature sensitive for transformation.Q30452305
A conserved domain regulates interactions of the v-fps protein-tyrosine kinase with the host cellQ34378948
Rous sarcoma virus variants that carry the cellular src gene instead of the viral src gene cannot transform chicken embryo fibroblastsQ36272657
Association of the src gene product of Rous sarcoma virus with cytoskeletal structures of chicken embryo fibroblastsQ36393988
Rapid transformation of cells by Rous sarcoma virusQ36449148
Activation of the proto-oncogene p60c-src by point mutations in the SH2 domainQ36710757
The common src homology region 2 domain of cytoplasmic signaling proteins is a positive effector of v-fps tyrosine kinase functionQ36761454
Phosphatidylinositol kinase activity associates with viral p60src proteinQ36764186
A mutation in v-src that removes a single conserved residue in the SH-2 domain of pp60v-src restricts transformation in a host-dependent mannerQ36780279
Linker insertion-deletion mutagenesis of the v-src gene: isolation of host- and temperature-dependent mutantsQ36780520
Phosphorylation of cellular proteins in Rous sarcoma virus-infected cells: analysis by use of anti-phosphotyrosine antibodiesQ36792507
N-terminal deletions in Rous sarcoma virus p60src: effects on tyrosine kinase and biological activities and on recombination in tissue culture with the cellular src geneQ36895142
A mutation at the ATP-binding site of pp60v-src abolishes kinase activity, transformation, and tumorigenicityQ36903823
Isolation of monoclonal antibodies that recognize the transforming proteins of avian sarcoma virusesQ36909345
Transformation of chicken embryo fibroblasts and tumor induction by the middle T antigen of polyomavirus carried in an avian retroviral vectorQ36913622
pp60c-src has less affinity for the detergent-insoluble cellular matrix than do pp60v-src and other viral protein-tyrosine kinases.Q36915794
DNA sequence of the viral and cellular src gene of chickens. II. Comparison of the src genes of two strains of avian sarcoma virus and of the cellular homologQ36924864
Cell transformation by the viral src oncogeneQ38182098
Small deletion in src of Rous sarcoma virus modifying transformation phenotypes: identification of 207-nucleotide deletion and its smaller product with protein kinase activityQ40144115
Amino acid substitutions sufficient to convert the nontransforming p60c-src protein to a transforming proteinQ40667798
The outer boundary of the cytoskeleton: a lamina derived from plasma membrane proteinsQ41963121
Altered phosphorylation and activation of pp60c-src during fibroblast mitosisQ42804505
Localization of major potential substrates of p60v-src kinase in the plasma membrane matrix fraction.Q43917603
ANALYSIS OF THE DEFECTIVENESS OF ROUS SARCOMA VIRUS. 3. DETERMINING INFLUENCE OF A NEW HELPER VIRUS ON THE HOST RANGE AND SUSCEPTIBILITY TO INTERFERENCE OF RSV.Q45713280
Local mutagenesis of Rous sarcoma virus: The major sites of tyrosine and serine phosphorylation of p60src are dispensable for transformationQ45797801
Nucleotide sequence of Fujinami sarcoma virus: evolutionary relationship of its transforming gene with transforming genes of other sarcoma virusesQ45799526
Avian sarcoma virus Y73 genome sequence and structural similarity of its transforming gene product to that of Rous sarcoma virusQ45800368
Viral and cellular src genes contribute to the structure of recovered avian sarcoma virus transforming proteinQ45802102
Sequence similarity of phospholipase C with the non-catalytic region of src.Q48099424
Cloning of bovine GAP and its interaction with oncogenic ras p21.Q48316676
Src homology 2 domain deletion mutants of p60v-src do not phosphorylate cellular proteins of 120-150 kDa.Q53517122
Similarity in membrane proteinsQ59002438
Transforming and membrane proteinsQ59045132
Enzymatically inactive p60c-src mutant with altered ATP-binding site is fully phosphorylated in its carboxy-terminal regulatory regionQ69001655
In vivo phosphorylation states and kinase activities of transforming p60c-src mutantsQ69100963
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)1207-1213
P577publication date1991-03-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleDeletions in the SH2 domain of p60v-src prevent association with the detergent-insoluble cellular matrix
P478volume11

Reverse relations

cites work (P2860)
Q35875878A novel nuclear Src and p300 signaling axis controls migratory and invasive behavior in pancreatic cancer
Q30194494Aberrant protein phosphorylation at tyrosine is responsible for the growth-inhibitory action of pp60v-src expressed in the yeast Saccharomyces cerevisiae
Q30194001Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527.
Q24655034CDC37 is required for p60v-src activity in yeast
Q30176626Complexes of focal adhesion kinase (FAK) and Crk-associated substrate (p130(Cas)) are elevated in cytoskeleton-associated fractions following adhesion and Src transformation. Requirements for Src kinase activity and FAK proline-rich motifs
Q30194179Csk suppression of Src involves movement of Csk to sites of Src activity
Q73851245Differential activation and redistribution of c-Src and Fyn in platelets, assessed by MoAb specific for C-terminal tyrosine-dephosphorylated c-Src and Fyn
Q30193485Disease specificity of kinase domains: the src-encoded catalytic domain converts erbB into a sarcoma oncogene
Q30195430Effects of SH2 and SH3 deletions on the functional activities of wild-type and transforming variants of c-Src
Q42833147Epidermal growth factor-induced activation and translocation of c-Src to the cytoskeleton depends on the actin binding domain of the EGF-receptor.
Q42157369Evidence for secretion-like coupling involving pp60src in the activation and maintenance of store-mediated Ca2+ entry in mouse pancreatic acinar cells.
Q40727590Fc receptor-mediated signal transduction
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Q44545603Lipid-dependent recruitment of neuronal Src to lipid rafts in the brain
Q28279411Mechanical strain induces pp60src activation and translocation to cytoskeleton in fetal rat lung cells
Q40043365Modulating effects of the extracellular sequence of the human insulinlike growth factor I receptor on its transforming and tumorigenic potential.
Q24596400Molecular features of the viral and cellular Src kinases involved in interactions with the GTPase-activating protein
Q24606832Multiple SH2-mediated interactions in v-src-transformed cells
Q30194111Physical and functional interactions between SH2 and SH3 domains of the Src family protein tyrosine kinase p59fyn
Q36812664Point mutations in the abl SH2 domain coordinately impair phosphotyrosine binding in vitro and transforming activity in vivo
Q41540183Polyamines are essential for cell transformation by pp60v-src: delineation of molecular events relevant for the transformed phenotype
Q34581878Progress towards the development of SH2 domain inhibitors
Q50681563Rapid trafficking of c-Src, a non-palmitoylated Src-family kinase, between the plasma membrane and late endosomes/lysosomes.
Q36676794Redistribution of activated pp60c-src to integrin-dependent cytoskeletal complexes in thrombin-stimulated platelets
Q36688195Requirement of phosphatidylinositol-3 kinase modification for its association with p60src
Q30195311SH3--an abundant protein domain in search of a function
Q30195559Selective binding of activated pp60c-src by an immobilized synthetic phosphopeptide modeled on the carboxyl terminus of pp60c-src
Q37212669Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases
Q36274033Substrate recognition by osteoclast precursors induces C-src/microtubule association.
Q30194837Suppression of c-Src Activity by C-Terminal Src Kinase Involves the c-Src SH2 and SH3 Domains: Analysis with Saccharomyces cerevisiae
Q57261418Synthesis of the Src SH2 domain and its application in bioassays for mirror-image screening
Q24304668The SH3 domain of p56lck is involved in binding to phosphatidylinositol 3'-kinase from T lymphocytes
Q30167852The actin filament-associated protein AFAP-110 is an adaptor protein that modulates changes in actin filament integrity
Q52509555The lethality of p60v-src in Saccharomyces cerevisiae and the activation of p34CDC28 kinase are dependent on the integrity of the SH2 domain
Q71619854Translocation of an SH2-containing protein tyrosine phosphatase (SH-PTP1) to the cytoskeleton of thrombin-activated platelets
Q41518119Translocation of pp60c-src to the cytoskeleton during platelet aggregation
Q42136904Tyrosine kinases activate store-mediated Ca2+ entry in human platelets through the reorganization of the actin cytoskeleton.
Q42828816UCS15A, a non-kinase inhibitor of Src signal transduction
Q40774867c-Src and HSP72 interact in ATP-depleted renal epithelial cells.