Understanding the alphaviruses: recent research on important emerging pathogens and progress towards their control.

scientific article

Understanding the alphaviruses: recent research on important emerging pathogens and progress towards their control. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.ANTIVIRAL.2009.07.007
P932PMC publication ID7114216
P698PubMed publication ID19616028
P5875ResearchGate publication ID26679878

P50authorAlexander E. GorbalenyaQ47451293
Maxim KhasnatinovQ54438314
Naomi L ForresterQ88670736
Tamara S. GritsunQ110674288
Ernest A. GouldQ24701585
Bruno CanardQ28039067
Hélène MaletQ28039103
P2093author name stringX de Lamballerie
S Weaver
S Jamal
I Delogu
B Morin
B Coutard
C Baronti
G Moureau
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A highly specific phosphatase that acts on ADP-ribose 1''-phosphate, a metabolite of tRNA splicing in Saccharomyces cerevisiaeQ24802001
Pegylated alpha interferon is an effective treatment for virulent venezuelan equine encephalitis virus and has profound effects on the host immune response to infectionQ27469593
Effects of palmitoylation of replicase protein nsP1 on alphavirus infectionQ27469680
Modification of the 5' terminus of Sindbis virus genomic RNA allows nsP4 RNA polymerases with nonaromatic amino acids at the N terminus to function in RNA replicationQ27473100
Global traffic and disease vector dispersalQ27473134
Catalytic Core of Alphavirus Nonstructural Protein nsP4 Possesses Terminal Adenylyltransferase ActivityQ27477547
Effects of chloroquine and cytochalasin B on the infection of cells by Sindbis virus and vesicular stomatitis virusQ27477806
Role of the Amphipathic Peptide of Semliki Forest Virus Replicase Protein nsP1 in Membrane Association and Virus ReplicationQ27478041
Enzymatic Defects of the nsP2 Proteins of Semliki Forest Virus Temperature-Sensitive MutantsQ27478372
Seco-pregnane steroids target the subgenomic RNA of alphavirus-like RNA virusesQ27478419
Recombinational history and molecular evolution of western equine encephalomyelitis complex alphavirusesQ27480774
Proteolytic activation of tick-borne encephalitis virus by furinQ27480892
Regulation of Sindbis virus RNA replication: uncleaved P123 and nsP4 function in minus-strand RNA synthesis, whereas cleaved products from P123 are required for efficient plus-strand RNA synthesisQ27485961
ATPase and GTPase activities associated with Semliki Forest virus nonstructural protein nsP2Q27485993
Expression of Semliki Forest virus nsP1-specific methyltransferase in insect cells and in Escherichia coliQ27486003
Inhibition of alphavirus infection in cell culture and in mice with antisense morpholino oligomersQ27486413
Mutagenesis of the in-frame opal termination codon preceding nsP4 of Sindbis virus: studies of translational readthrough and its effect on virus replicationQ27486486
Increased Mortality Rate Associated with Chikungunya Epidemic, Ahmedabad, IndiaQ27487078
Chimeric alphavirus vaccine candidates for chikungunyaQ27487105
Susceptibility of Florida mosquitoes to infection with chikungunya virusQ27487145
Immunogenicity of novel consensus-based DNA vaccines against Chikungunya virusQ27487330
Treatment of Venezuelan equine encephalitis virus infection with (−)-carbodineQ27487534
Chikungunya Virus and Central Nervous System Infections in Children, IndiaQ27488268
The nsP3 macro domain is important for Sindbis virus replication in neurons and neurovirulence in miceQ27488409
The Crystal Structures of Chikungunya and Venezuelan Equine Encephalitis Virus nsP3 Macro Domains Define a Conserved Adenosine Binding PocketQ27488798
Molecular cloning, overproduction, purification and biochemical characterization of the p39 nsp2 protease domains encoded by three alphavirusesQ27488874
Mapping the Structure and Function of the E1 and E2 Glycoproteins in AlphavirusesQ27489867
Western equine encephalitis virus is a recombinant virusQ27490908
Membrane binding mechanism of an RNA virus-capping enzymeQ27627017
The Fusion glycoprotein shell of Semliki Forest virus: an icosahedral assembly primed for fusogenic activation at endosomal pHQ27631190
Crystal structures of the X-domains of a Group-1 and a Group-3 coronavirus reveal that ADP-ribose-binding may not be a conserved propertyQ27653582
The alphaviruses: gene expression, replication, and evolutionQ27860954
Structure and mechanism of ADP-ribose-1''-monophosphatase (Appr-1''-pase), a ubiquitous cellular processing enzymeQ27937235
A comparison of the nucleotide sequences of eastern and western equine encephalomyelitis viruses with those of other alphaviruses and related RNA virusesQ28249445
Broad-spectrum antiviral activity of carbodine, the carbocyclic analogue of cytidineQ28323208
Inhibitory effect of selected antiviral compounds on arenavirus replication in vitroQ28328863
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Antigenic variants of Venezuelan equine encephalitis virus: their geographic distribution and epidemiologic significanceQ29354416
Transmission cycles, host range, evolution and emergence of arboviral diseaseQ29616258
Primary structural comparison of RNA-dependent polymerases from plant, animal and bacterial virusesQ29617489
Changing patterns of chikungunya virus: re-emergence of a zoonotic arbovirusQ29620003
Structure and mechanism of helicases and nucleic acid translocasesQ29620151
The VIZIER project: preparedness against pathogenic RNA virusesQ30229225
Molecular phylogenetics of the RrmJ/fibrillarin superfamily of ribose 2'-O-methyltransferases.Q30332409
Elimination of phosphorylation sites of Semliki Forest virus replicase protein nsP3.Q31649623
In vitro inhibition of Chikungunya and Semliki Forest viruses replication by antiviral compounds: synergistic effect of interferon-alpha and ribavirin combinationQ33195882
Identification of compounds with anti-West Nile Virus activityQ33236579
Impact of climate change and other factors on emerging arbovirus diseasesQ33370244
Replicase complex genes of Semliki Forest virus confer lethal neurovirulenceQ33804386
RNA helicase activity of Semliki Forest virus replicase protein NSP2.Q33859798
Complete sequence of the genomic RNA of O'nyong-nyong virus and its use in the construction of alphavirus phylogenetic treesQ33893536
Cleavage-site preferences of Sindbis virus polyproteins containing the non-structural proteinase. Evidence for temporal regulation of polyprotein processing in vivoQ33924220
Phase II safety and immunogenicity study of live chikungunya virus vaccine TSI-GSD-218.Q33942533
Host range, amplification and arboviral disease emergence.Q33992289
Chikungunya outbreaks--the globalization of vectorborne diseasesQ34002554
On chikungunya acute infection and chloroquine treatmentQ34012738
Functional analysis of nsP3 phosphoprotein mutants of Sindbis virusQ34227437
Identification of the active site residues in the nsP2 proteinase of Sindbis virusQ34263496
Origins, evolution, and vector/host coadaptations within the genus FlavivirusQ34286382
Evolution, epidemiology, and dispersal of flaviviruses revealed by molecular phylogeniesQ34419822
Replication and clearance of Venezuelan equine encephalitis virus from the brains of animals vaccinated with chimeric SIN/VEE virusesQ34434918
Invasions by insect vectors of human diseaseQ34453718
Mayaro virus: complete nucleotide sequence and phylogenetic relationships with other alphavirusesQ34475206
The anti-yellow fever virus activity of ribavirin is independent of error-prone replicationQ34485851
Conservation of the putative methyltransferase domain: a hallmark of the 'Sindbis-like' supergroup of positive-strand RNA virusesQ34490438
Evolutionary conservation of histone macroH2A subtypes and domainsQ34668581
Reaction in alphavirus mRNA capping: formation of a covalent complex of nonstructural protein nsP1 with 7-methyl-GMP.Q34775056
L-nucleosides: antiviral activity and molecular mechanismQ34779807
Nucleotide triphosphatase/helicase of hepatitis C virus as a target for antiviral therapyQ34807255
Characterization of purified Sindbis virus nsP4 RNA-dependent RNA polymerase activity in vitroQ35023244
Venezuelan equine encephalitisQ35598701
Alphavirus nsP3 functions to form replication complexes transcribing negative-strand RNAQ36636147
Chloroquine enhances replication of Semliki Forest virus and encephalomyocarditis virus in miceQ36680744
Role for conserved residues of sindbis virus nonstructural protein 2 methyltransferase-like domain in regulation of minus-strand synthesis and development of cytopathic infectionQ36804640
Genetic stability among temporally and geographically diverse isolates of Barmah Forest virusQ36881507
Effects of lysosomotropic weak bases on infection of BHK-21 cells by Sindbis virus.Q36896646
Cross-neutralization studies with group A arthropod-borne viruses.Q36913324
Molecular strategies to inhibit the replication of RNA virusesQ37099776
Selective inhibitors of picornavirus replicationQ37125475
Venezuelan equine encephalitis emergence: enhanced vector infection from a single amino acid substitution in the envelope glycoproteinQ37388695
A novel superfamily of nucleoside triphosphate-binding motif containing proteins which are probably involved in duplex unwinding in DNA and RNA replication and recombinationQ39243948
Antigenic Relationships of Alphaviruses by a Simple Micro-culture Cross-neutralization MethodQ39423135
Template-dependent initiation of Sindbis virus RNA replication in vitroQ39579511
Re-emergence of epidemic Venezuelan equine encephalomyelitis in South America. VEE Study GroupQ39582642
Ribavirin causes error catastrophe during Hantaan virus replication.Q39698441
A new role for ns polyprotein cleavage in Sindbis virus replicationQ39767616
Substitutions of 169Lys and 173Thr in nonstructural protein 1 influence the infectivity and pathogenicity of XJ-160 virusQ39899505
A mutant of Sindbis virus which is able to replicate in cells with reduced CTP makes a replicase/transcriptase with a decreased Km for CTP.Q39961147
Inhibition of Chikungunya virus infection in cultured human muscle cells by furin inhibitors: impairment of the maturation of the E2 surface glycoproteinQ39971773
Expression and biochemical characterization of nsP2 cysteine protease of Chikungunya virusQ40160382
Inhibition of multiple strains of Venezuelan equine encephalitis virus by a pool of four short interfering RNAsQ40198668
Sindbis virus nonstructural protein nsP2 is cytotoxic and inhibits cellular transcriptionQ40274399
Deletions in the hypervariable domain of the nsP3 gene attenuate Semliki Forest virus virulenceQ40306678
The predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of IMP dehydrogenaseQ40517134
Direct fluorometric measurement of hepatitis C virus helicase activityQ40549110
Tolerability of modified tick-borne encephalitis vaccine FSME-IMMUN "NEW" in children: results of post-marketing surveillanceQ40567459
The effect of ribavirin and IMPDH inhibitors on hepatitis C virus subgenomic replicon RNA.Q40643235
Use of the yellow fever virus vaccine strain 17D for the study of strategies for the treatment of yellow fever virus infections.Q40668883
Alphavirus positive and negative strand RNA synthesis and the role of polyproteins in formation of viral replication complexes.Q40672583
Chikungunya Virus Vaccine Prepared by Tween-Ether ExtractionQ40712673
Polypeptide requirements for assembly of functional Sindbis virus replication complexes: a model for the temporal regulation of minus- and plus-strand RNA synthesisQ40792314
Deletion and duplication mutations in the C-terminal nonconserved region of Sindbis virus nsP3: effects on phosphorylation and on virus replication in vertebrate and invertebrate cellsQ41459294
Phosphorylation of Sindbis virus nsP3 in vivo and in vitroQ41716721
SVLM21, a Sindbis virus mutant resistant to methionine deprivation, encodes an altered methyltransferaseQ41759394
In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquineQ41913526
Chloroquine phosphate treatment of chronic Chikungunya arthritis. An open pilot studyQ41918756
Inhibition of Semliki forest virus penetration by lysosomotropic weak basesQ41923695
Effect of chloroquine on the growth of animal virusesQ41936128
Comparison of the antiviral activity in vitro of some non-steroidal anti-inflammatory drugsQ41939418
Semliki Forest virus mRNA capping enzyme requires association with anionic membrane phospholipids for activityQ42034834
Chikungunya disease outbreak, Reunion Island.Q42616934
Aura virus is a New World representative of Sindbis-like virusesQ42684044
Activity of ribavirin against Hantaan virus correlates with production of ribavirin-5'-triphosphate, not with inhibition of IMP dehydrogenase.Q42718871
Identification of a ribavirin-resistant NS5B mutation of hepatitis C virus during ribavirin monotherapyQ42980354
Epidemic Venezuelan equine encephalitis in La Guajira, Colombia, 1995.Q42981954
High-throughput screening assay of hepatitis C virus helicase inhibitors using fluorescence-quenching phenomenon.Q42984520
Mutations that confer resistance to mycophenolic acid and ribavirin on sindbis virus map to the nonstructural protein nsP1Q42986339
Vectors vs. humans in Australia--who is on top down under? An update on vector-borne disease and research on vectors in Australia.Q42989209
Association of the Sindbis virus RNA methyltransferase activity with the nonstructural protein nsP1.Q42990081
Sindbis virus mutants resistant to mycophenolic acid and ribavirinQ42992087
Persistence in humans of antibody to subtypes of Venezuelan equine encephalomyelitis (VEE) virus after immunization with attenuated (TC-83) VEE virus vaccineQ43514367
Expression of sindbis virus nsP1 and methyltransferase activity inEscherichia coliQ43571353
The crystal structure of the Venezuelan equine encephalitis alphavirus nsP2 proteaseQ43589065
Guanosine nucleotide analogs as inhibitors of alphavirus mRNA capping enzymeQ43624139
Site-specific protease activity of the carboxyl-terminal domain of Semliki Forest virus replicase protein nsP2.Q43643522
The effects of palmitoylation on membrane association of Semliki forest virus RNA capping enzymeQ43828148
On the use of chloroquine for chikungunya.Q43973239
Inhibition of replication of Venezuelan equine encephalomyelitis with polyclonal antibodies to laminin-binding proteinQ44055458
Neurologic manifestations of pediatric chikungunya infectionQ44140290
Attenuated Mutants of Venezuelan Equine Encephalitis Virus Containing Lethal Mutations in the PE2 Cleavage Signal Combined with a Second-Site Suppressor Mutation in E1Q44169045
Sequelae of Venezuelan equine encephalitis in humans: a four year follow-upQ44252532
Regulation of the sequential processing of Semliki Forest virus replicase polyproteinQ44548826
Putative papain-related thiol proteases of positive-strand RNA viruses. Identification of rubi- and aphthovirus proteases and delineation of a novel conserved domain associated with proteases of rubi-, alpha- and coronavirusesQ44808922
An animal model for studying the pathogenesis of chikungunya virus infectionQ44851012
Improved mucosal protection against Venezuelan equine encephalitis virus is induced by the molecularly defined, live-attenuated V3526 vaccine candidateQ45742226
Mutagenesis of the Sindbis virus nsP1 protein: effects on methyltransferase activity and viral infectivityQ45771191
Live, attenuated Venezuelan equine encephalomyelitis virus vaccine. I. Clinical effects in man.Q45808070
P433issue2
P921main subjectalphavirus infectionsQ4735280
Chikungunya virusQ15794049
emerging pathogenQ108429945
P304page(s)111-124
P577publication date2009-07-16
2010-08-01
P1433published inAntiviral ResearchQ4775352
P1476titleUnderstanding the alphaviruses: recent research on important emerging pathogens and progress towards their control
P478volume87

Reverse relations

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