Epigenetics in Kidney Transplantation: Current Evidence, Predictions, and Future Research Directions.

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Epigenetics in Kidney Transplantation: Current Evidence, Predictions, and Future Research Directions. is …
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scholarly articleQ13442814

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P356DOI10.1097/TP.0000000000000878
P932PMC publication ID6843994
P698PubMed publication ID26356174

P2093author name stringDaniel G Maluf
Valeria R Mas
Thu H Le
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Microarray analysis of MicroRNA expression in acute rejection after renal transplantationQ80887475
Induction of transplantation tolerance by allogeneic donor-derived CD4(+)CD25(+)Foxp3(+) regulatory T cellsQ81338247
DNA methylation profiling identifies epigenetic differences between diabetes patients with ESRD and diabetes patients without nephropathyQ82848506
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Miles to go…Q84284647
Improving long-term outcomes for transplant patients: making the case for long-term disease-specific and multidisciplinary researchQ85013471
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Circulating long noncoding RNATapSaki is a predictor of mortality in critically ill patients with acute kidney injuryQ85710754
MicroRNA-21 attenuates renal ischemia reperfusion injury via targeting caspase signaling in miceQ85813125
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New loci associated with kidney function and chronic kidney diseaseQ24630646
MicroRNA profiling: approaches and considerationsQ26861675
Fibroblasts in fibrosis: novel roles and mediatorsQ26998508
Histone deacetylases as targets for treatment of multiple diseasesQ27000389
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Epigenetics of progression of chronic kidney disease: fact or fantasy?Q27005788
Treg functional stability and its responsiveness to the microenvironmentQ27008946
Dynamic nature of noncoding RNA regulation of adaptive immune responseQ27012604
Proteomics and metabolomics in renal transplantation-quo vadis?Q27024418
miR-127 protects proximal tubule cells against ischemia/reperfusion: identification of kinesin family member 3B as miR-127 targetQ27320810
MicroRNA expression data reveals a signature of kidney damage following ischemia reperfusion injuryQ27327194
Treatment of chronic kidney diseaseQ27694623
Long-term prognosis after acute kidney injury (AKI): what is the role of baseline kidney function and recovery? A systematic reviewQ28652412
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The urine microRNA profile may help monitor post-transplant renal graft functionQ30411597
Identification of biomarkers to assess organ quality and predict posttransplantation outcomes.Q30414752
Reduced expression of inflammatory genes in deceased donor kidneys undergoing pulsatile pump preservationQ30427250
The microRNA-processing enzyme dicer maintains juxtaglomerular cellsQ30433053
Hematopoietic microRNA-126 protects against renal ischemia/reperfusion injury by promoting vascular integrity.Q30585385
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Cellular and molecular mechanisms in kidney fibrosisQ33685938
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miR-200b precursor can ameliorate renal tubulointerstitial fibrosisQ33737756
DNA hypermethylation and DNA hypomethylation is present at different loci in chronic kidney diseaseQ33740666
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Targeted deletion of Dicer from proximal tubules protects against renal ischemia-reperfusion injury.Q33834320
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Identification of a microRNA signature of renal ischemia reperfusion injuryQ34069581
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MicroRNA profiles in allograft tissues and paired urines associate with chronic allograft dysfunction with IF/TA.Q34203975
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Histone deacetylase: a potential therapeutic target for fibrotic disordersQ34257607
Role of transforming growth factor-beta1 in the progression of chronic allograft nephropathyQ34259063
Recent advances in renal interstitial fibrosis and tubular atrophy after kidney transplantationQ34289498
On the intraoperative molecular status of renal allografts after vascular reperfusion and clinical outcomes.Q34312520
Analytical approaches to metabolomics and applications to systems biologyQ34340503
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The primary glomerulonephritides: a systems biology approachQ34462626
MicroRNA sequence profiles of human kidney allografts with or without tubulointerstitial fibrosisQ34468508
Epigenetic regulation of pluripotency and differentiationQ34498966
MicroRNA-24 antagonism prevents renal ischemia reperfusion injuryQ34568822
DNA methylation dynamics in blood after hematopoietic cell transplantQ34602752
Long non-coding RNAs and control of gene expression in the immune systemQ34616243
Long non-coding RNAs: modulators of nuclear structure and functionQ37589709
The complexities of microRNA regulation: mirandering around the rulesQ37607457
The role of procurement biopsies in acceptance decisions for kidneys retrieved for transplantQ37621568
Preimplant histologic acute tubular necrosis and allograft outcomesQ37621573
Epigenetic events during B lymphocyte development.Q37624372
A PTBA small molecule enhances recovery and reduces postinjury fibrosis after aristolochic acid-induced kidney injuryQ37629173
Noninvasive diagnosis of acute rejection of renal allograftsQ37637948
DNA methylation profile associated with rapid decline in kidney function: findings from the CRIC studyQ37668895
Molecular pathways involved in loss of graft function in kidney transplant recipients.Q37724869
Improved transplantation outcome by epigenetic changesQ37752924
Infection and chronic allograft dysfunctionQ37813410
Consequences of transplant quality on chronic allograft nephropathyQ37813412
Assessment of kidney organ quality and prediction of outcome at time of transplantationQ37832966
Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?Q37849269
MicroRNAs and epigeneticsQ37852129
The role of natural killer cells in human solid organ and tissue transplantationQ37853788
Brain death induced renal injury.Q37854398
Epigenetic mechanisms and kidney diseases.Q37861834
Signals and combinatorial functions of histone modificationsQ37870190
Local and global epigenetic regulation of V(D)J recombinationQ37893054
Regulatory T cell therapy for the induction of clinical organ transplantation toleranceQ37932810
The coin toss of B cells in rejection and tolerance: danger versus defenseQ37950550
Mutational determinants of epigenetic instablity in myeloid malignanciesQ37979960
Epigenetics: time to translate into transplantationQ37995936
Protein and peptide biomarkers in organ transplantationQ38021513
Relevance of regulatory T cell promotion of donor-specific tolerance in solid organ transplantation.Q38027504
Chronic renal allograft injury: early detection, accurate diagnosis and management.Q38035660
Developing microRNA therapeutics: approaching the unique complexities.Q38036732
Biomarker discovery in transplantation--proteomic adventure or mission impossible?Q38054291
NADPH oxidases as a source of oxidative stress and molecular target in ischemia/reperfusion injuryQ38054458
The role of promoter hypermethylation in fibroblast activation and fibrogenesisQ38055432
miRNA-transcription factor interactions: a combinatorial regulation of gene expressionQ38075480
T-cell memory differentiation: insights from transcriptional signatures and epigenetics.Q38076478
Has the survival of the graft improved after renal transplantation in the era of modern immunosuppression?Q38077924
Long non-coding RNAs: challenges for diagnosis and therapiesQ38079887
Development and maintenance of regulatory T cellsQ38092234
Summary of FDA workshop on ischemia reperfusion injury in kidney transplantationQ38097126
Genetic and epigenetic studies for determining molecular targets of natural product anticancer agentsQ38099873
Histone modifications for human epigenome analysisQ38112246
Epigenetic modulation of the immune function: a potential target for toleranceQ38117237
Regulatory T cells in the immunodiagnosis and outcome of kidney allograft rejectionQ38120752
Intragenic DNA methylation in transcriptional regulation, normal differentiation and cancerQ38128454
Contribution of genetics and epigenetics to progression of kidney fibrosisQ38131466
Urine microRNAs as potential noninvasive biomarkers in urologic cancers.Q38137530
Acute kidney injury in kidney transplantationQ38146486
Clinical significance of the interaction between non-coding RNAs and the epigenetics machinery: challenges and opportunities in oncologyQ38152226
MicroRNAs with a role in gene regulation and in human diseasesQ38160370
Modulation of epigenetic regulators and cell fate decisions by miRNAsQ38166839
FibromiRs: translating molecular discoveries into new anti-fibrotic drugsQ38190254
Targeting cardiac fibroblasts to treat fibrosis of the heart: focus on HDACs.Q38196176
Chromatin dynamics in kidney development and function.Q38210944
Epigenetics: the neglected key to minimize learning and memory deficits in Down syndrome.Q38214416
Molecular biology of brain metastasisQ38216231
Complement as a multifaceted modulator of kidney transplant injuryQ38217273
The effect of ischemia/reperfusion on the kidney graftQ38218153
Innate and adaptive immune responses subsequent to ischemia-reperfusion injury in the kidneyQ38221985
Diabetic nephropathy--emerging epigenetic mechanismsQ38227252
Epigenetics of hematopoietic stem cell aging and diseaseQ38235887
The role of genetics and epigenetics in the pathogenesis of systemic sclerosisQ38241234
An update on epigenetics and childhood respiratory diseasesQ38242704
Advances in the profiling of DNA modifications: cytosine methylation and beyondQ38243577
Ischemic epigenetics and the transplanted kidneyQ38306439
Inhibition of histone deacetylase activity suppresses epithelial-to-mesenchymal transition induced by TGF-beta1 in human renal epithelial cellsQ38307188
Update on epigenetics in allergic disease.Q38310584
Smad3-mediated upregulation of miR-21 promotes renal fibrosisQ38388639
Gene expression patterns in deceased donor kidneys developing delayed graft function after kidney transplantation.Q38514211
MicroRNA‑21 inhibits SMAD7 expression through a target sequence in the 3' untranslated region and inhibits proliferation of renal tubular epithelial cellsQ38986403
Robust global microRNA expression profiling using next-generation sequencing technologiesQ39032588
The microRNA miR-433 promotes renal fibrosis by amplifying the TGF-β/Smad3-Azin1 pathwayQ39123810
Gender-specific role of HDAC11 in kidney ischemia- and reperfusion-induced PAI-1 expression and injuryQ39154615
Ischaemia-reperfusion injury: a major protagonist in kidney transplantationQ39295523
Cytosine methylation changes in enhancer regions of core pro-fibrotic genes characterize kidney fibrosis developmentQ39338522
Histone deacetylase inhibitors suppress natural killer cell cytolytic activityQ40161252
Risk factors of long-term graft loss in renal transplant recipients with chronic allograft dysfunctionQ42782232
Histone deacetylase modulates the proinflammatory and -fibrotic changes in tubulointerstitial injuryQ43244113
TGF-β-induced signaling circuit loops mediated by microRNAs as new therapeutic targets for renal fibrosis?Q43423735
Urinary miR-210 as a mediator of acute T-cell mediated rejection in renal allograft recipientsQ44164490
Impact of inflammation on epigenetic DNA methylation - a novel risk factor for cardiovascular disease?Q44573200
Establishing the molecular pathways involved in chronic allograft nephropathy for testing new noninvasive diagnostic markersQ44927347
Gene expression changes are associated with loss of kidney graft function and interstitial fibrosis and tubular atrophy: diagnosis versus prediction.Q44962520
Novel markers in zero-hour kidney biopsies indicate graft quality and clinical outcomeQ45142240
New opportunities for organ transplantation research: epigenetics is likely to be an important determinant of the host immune responseQ45382914
Solid organ allograft survival improvement in the United States: the long-term does not mirror the dramatic short-term success.Q45964495
Markers of cellular senescence in zero hour biopsies predict outcome in renal transplantationQ46608101
Ischemia- reperfusion injury and its influence on the epigenetic modification of the donor kidney genomeQ46897225
Protection of NAD(P)H:quinone oxidoreductase 1 against renal ischemia/reperfusion injury in miceQ46975578
The complex world of kidney microRNAs.Q48821153
Epigenetic mechanisms in development and disease.Q50743330
Demethylation of the RORC2 and IL17A in human CD4+ T lymphocytes defines Th17 origin of nonclassic Th1 cells.Q50850916
Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells.Q50968365
Molecular dysfunctions in acute rejection after renal transplantation revealed by integrated analysis of transcription factor, microRNA and long noncoding RNA.Q50984036
Epigenetic reprogramming of the RORC locus during in vitro expansion is a distinctive feature of human memory but not naïve Treg.Q51013890
Epigenetic modification of the human CCR6 gene is associated with stable CCR6 expression in T cells.Q51024074
High-throughput approaches for microRNA expression analysis.Q51770581
DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells.Q52924279
TGF-beta1 mRNA upregulation influences chronic renal allograft dysfunction.Q54608975
The Transcriptome of the Implant Biopsy Identifies Donor Kidneys at Increased Risk of Delayed Graft FunctionQ57014398
Early activation of fibrogenesis in transplanted kidneys: A study on serial renal biopsiesQ58004292
Microvesicles derived from endothelial progenitor cells protect the kidney from ischemia–reperfusion injury by microRNA-dependent reprogramming of resident renal cellsQ58831473
Intragraft Regulatory T Cells in Protocol Biopsies Retain Foxp3 Demethylation and Are Protective Biomarkers for Kidney Graft OutcomeQ59491274
MicroRNA expression profiles predictive of human renal allograft statusQ37146807
Delayed ischemic preconditioning contributes to renal protection by upregulation of miR-21Q37184698
Genomic analysis in nephrology--towards systems biology and systematic medicine?Q37202423
MicroRNA and nephropathy: emerging conceptsQ37221074
From microRNA functions to microRNA therapeutics: novel targets and novel drugs in breast cancer research and treatment (Review).Q37313310
Chronic allograft dysfunction: can we use mammalian target of rapamycin inhibitors to replace calcineurin inhibitors to preserve graft function?Q37342577
Epigenetic reprogramming: is deamination key to active DNA demethylation?Q37393053
Epigenetic regulation of killer immunoglobulin-like receptor expression in T cellsQ37396074
Beyond genetics: epigenetic code in chronic kidney diseaseQ37402757
Epigenetic mechanisms of regulation of Foxp3 expressionQ37412329
Inhibition of histone deacetylase activity attenuates renal fibroblast activation and interstitial fibrosis in obstructive nephropathy.Q37417291
Pathway modulations and epigenetic alterations in ovarian tumorbiogenesisQ37420213
Essential concept of transplant immunology for clinical practiceQ37428551
Ischemia and reperfusion--from mechanism to translationQ37455225
Chronic allograft nephropathy--a clinical syndrome: early detection and the potential role of proliferation signal inhibitorsQ37589673
Epigenetics in kidney development and renal diseaseQ34633331
Expression of miR-142-5p in peripheral blood mononuclear cells from renal transplant patients with chronic antibody-mediated rejectionQ34663943
miR-21 in ischemia/reperfusion injury: a double-edged sword?Q34790075
Advances of genomic science and systems biology in renal transplantation: a reviewQ34862535
TGF-beta signaling in renal diseaseQ34869314
Quantitative DNA methylation analysis of FOXP3 as a new method for counting regulatory T cells in peripheral blood and solid tissueQ34922714
A comprehensive overview of Infinium HumanMethylation450 data processingQ34976889
An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transitionQ34977307
Methylation determines fibroblast activation and fibrogenesis in the kidneyQ35019643
Identifying biomarkers as diagnostic tools in kidney transplantationQ35049801
Dynamic regulation of transcriptional states by chromatin and transcription factors.Q35068557
Epigenetics: deciphering its role in diabetes and its chronic complicationsQ35068854
Activation-induced cytidine deaminase mediates central tolerance in B cellsQ35105238
Late kidney allograft loss: what we know about it, and what we can do about itQ35153318
DNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiationQ35266180
Identification of a microRNA signature in renal fibrosis: role of miR-21.Q35326035
Sodium valproate ameliorates diabetes-induced fibrosis and renal damage by the inhibition of histone deacetylases in diabetic rat.Q35541039
Noncoding RNA as therapeutic targets for hepatocellular carcinoma.Q35592207
Systems biology of kidney diseasesQ35619034
Suppression of microRNA-29 expression by TGF-β1 promotes collagen expression and renal fibrosisQ35715738
Demethylation of the TSDR is a marker of squamous cell carcinoma in transplant recipientsQ35834994
Upregulation of miR-142-3p in peripheral blood mononuclear cells of operationally tolerant patients with a renal transplantQ35853304
Pretransplant transcriptome profiles identify among kidneys with delayed graft function those with poorer quality and outcomeQ35876866
A microRNA circuit mediates transforming growth factor-β1 autoregulation in renal glomerular mesangial cellsQ35915947
Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft toleranceQ36024233
Quantitative detection of promoter hypermethylation as a biomarker of acute kidney injury during transplantation.Q36102469
MicroRNAs and fibrosisQ36103009
Protocol biopsy of donor kidney in renal transplantation.Q36122303
MicroRNA circuits in transforming growth factor-β actions and diabetic nephropathy.Q36124250
The molecular basis of the memory T cell response: differential gene expression and its epigenetic regulationQ36390497
A global DNA methylation and gene expression analysis of early human B-cell development reveals a demethylation signature and transcription factor networkQ36478003
Kidney transplantation as primary therapy for end-stage renal disease: a National Kidney Foundation/Kidney Disease Outcomes Quality Initiative (NKF/KDOQITM) conferenceQ36666806
Epigenetic regulation of BMP7 in the regenerative response to ischemiaQ36736738
miR-17~92 miRNA cluster promotes kidney cyst growth in polycystic kidney diseaseQ36967821
HDAC inhibitors in kidney development and diseaseQ37115414
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectkidney transplantationQ740909
epigeneticsQ26939
P304page(s)23-38
P577publication date2016-01-01
P1433published inTransplantationQ15730500
P1476titleEpigenetics in Kidney Transplantation: Current Evidence, Predictions, and Future Research Directions
P478volume100

Reverse relations

cites work (P2860)
Q104289866Advances of miRNAs in kidney graft injury
Q38683990Application of Ultrasound Elastography for Chronic Allograft Dysfunction in Kidney Transplantation.
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Q47822802Using omics to explore complications of kidney transplantation.
Q37419464Variations in DNA methylation of interferon gamma and programmed death 1 in allograft rejection after kidney transplantation

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