Pathophysiology of hyperinsulinemia following pancreas transplantation: altered pulsatile versus Basal insulin secretion and the role of specific transplant anatomy in dogs

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Pathophysiology of hyperinsulinemia following pancreas transplantation: altered pulsatile versus Basal insulin secretion and the role of specific transplant anatomy in dogs is …
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scholarly articleQ13442814

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P356DOI10.1097/00000658-200210000-00011
P698PubMed publication ID12368677

P50authorJohannes D VeldhuisQ64495473
P2093author name stringJohn B Hanks
Greg Cornett
Richard C Earnhardt
P2860cites workPancreatic endocrine responses to stimulation of the peripheral ends of the splanchnic nerves in the conscious adrenalectomized calfQ70767685
Endocrine function of the heterotopic pancreatic allotransplant in dogsQ71548986
Deconvolution analysis of hormone dataQ30436599
Glucose metabolism after pancreas autotransplantation. The effect of open duct versus urinary bladder drainage techniqueQ30449508
The pituitary gland secretes in bursts: appraising the nature of glandular secretory impulses by simultaneous multiple-parameter deconvolution of plasma hormone concentrationsQ30450888
Amplitude modulation of a burstlike mode of cortisol secretion subserves the circadian glucocorticoid rhythmQ30460262
Peripheral insulin release after pancreatic resection: the effect of decreased beta-cell mass with systemic or portal drainageQ30462252
Hyperinsulinemia after pancreatic transplantation. Prediction by a novel computer model and in vivo verificationQ30466678
Amplitude modulation of pulsatile insulin secretion by intrapancreatic ganglion neuronsQ31809747
Signaling underlying pulsatile insulin secretionQ34091869
Low- and high-frequency insulin secretion pulses in normal subjects and pancreas transplant recipients: role of extrinsic innervationQ35605434
An in vivo and in vitro study of the mechanism of prednisone-induced insulin resistance in healthy subjectsQ36992538
Influence of the vagus and splanchnic nerves on insulin secretion and glycemiaQ41203390
Temporal profiles and clinical significance of pulsatile insulin secretionQ41742055
Systemic venous drainage of pancreas allografts as independent cause of hyperinsulinemia in type I diabetic recipientsQ42481168
Concordant induction of rapid in vivo pulsatile insulin secretion by recurrent punctuated glucose infusionsQ42482655
Acute and short-term administration of a sulfonylurea (gliclazide) increases pulsatile insulin secretion in type 2 diabetesQ43687837
Decrease in beta-cell mass leads to impaired pulsatile insulin secretion, reduced postprandial hepatic insulin clearance, and relative hyperglucagonemia in the minipigQ43719948
Pulsatile insulin secretion accounts for 70% of total insulin secretion during fasting.Q51586230
Contribution of partial pancreatectomy, systemic hormone delivery, and duct obliteration to glucose regulation in canine pancreas. Importance in pancreas transplantation.Q51619785
Decreased insulin- and glucagon-pulse amplitude accompanying beta-cell deficiency induced by streptozocin in baboons.Q51620528
Efficacy of pulsatile versus continuous insulin administration on hepatic glucose production and glucose utilization in type I diabetic humans.Q51633153
Modeling the insulin-glucose feedback system: the significance of pulsatile insulin secretion.Q52096319
Oscillatory insulin secretion after pancreas transplant.Q52395179
Effects of pancreas transplantation on postprandial glucose metabolism.Q54286407
Effects of prolonged pulsatile hyperinsulinemia in humans. Enhancement of insulin sensitivityQ68499378
Pattern of postprandial carbohydrate metabolism and effects of portal and peripheral insulin deliveryQ68582519
Splanchnic neural regulation of insulin and glucagon secretion in the isolated perfused human pancreasQ68926656
In vivo pulsatility of pancreatic islet peptidesQ69885448
Rapid reduction and return of surface insulin receptors after exposure to brief pulses of insulin in perifused rat hepatocytesQ70210977
Experience with simultaneous pancreas-kidney transplantationQ70219390
Splanchnic and renal metabolism of insulin in human subjects: a dose-response studyQ70261209
Ultradian oscillations of plasma glucose, insulin, and C-peptide in man during continuous enteral nutritionQ70328317
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectpathophysiologyQ1135939
pancreasQ9618
P304page(s)480-90; discussion 490-1
P577publication date2002-10-01
P1433published inAnnals of SurgeryQ4767866
P1476titlePathophysiology of hyperinsulinemia following pancreas transplantation: altered pulsatile versus Basal insulin secretion and the role of specific transplant anatomy in dogs
P478volume236

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Q51359653A prospective study of basal insulin concentrations in dogs with congenital portosystemic shunts.cites workP2860

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