Morphometric Characterization of Rat and Human Alveolar Macrophage Cell Models and their Response to Amiodarone using High Content Image Analysis

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Morphometric Characterization of Rat and Human Alveolar Macrophage Cell Models and their Response to Amiodarone using High Content Image Analysis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S11095-017-2176-5
P8608Fatcat IDrelease_25tyaf6furbixlqrxhpt57637y
P932PMC publication ID5736774
P698PubMed publication ID28540501

P2093author name stringAateka Patel
Abhinav Kumar
Abigail Martin
Ben Forbes
Doug Ball
Ewelina Hoffman
Jan Klapwijk
Lea Ann Dailey
Rhamiya Mahendran
Val Millar
Victoria Hutter
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Drug-induced phospholipidosis: are there functional consequences?Q34377656
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Anionic pulmonary surfactant phospholipids inhibit inflammatory responses from alveolar macrophages and U937 cells by binding the lipopolysaccharide-interacting proteins CD14 and MD-2.Q37377588
Amiodarone pulmonary toxicity: morphologic and biochemical featuresQ37618098
Amiodarone: review of pulmonary effects and toxicityQ37765549
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Regulatory toxicology considerations for the development of inhaled pharmaceuticalsQ37978447
Challenges for inhaled drug discovery and development: Induced alveolar macrophage responses.Q53295465
High-throughput multi-parameter profiling of electrophysiological drug effects in human embryonic stem cell derived cardiomyocytes using multi-electrode arrays.Q53555497
Elevation of heat shock protein synthesis and hsp gene transcription during monocyte to macrophage differentiation of U937 cells.Q64915166
Interspecies differences in the phagocytic activity of pulmonary macrophages subjected to acidic challengeQ67576424
TPA-induced differentiation and adhesion of U937 cells: changes in ultrastructure, cytoskeletal organization and expression of cell surface antigensQ69649812
Morphometric characteristics of cells in the alveolar region of mammalian lungsQ71817608
Monitoring the accumulation of fluorescently labeled phospholipids in cell cultures provides an accurate screen for drugs that induce phospholipidosisQ82272533
Interpretation and prediction of inhaled drug particle accumulation in the lung and its associated toxicityQ82627326
A decade of changeQ83164214
Foamy macrophage responses in the rat lung following exposure to inhaled pharmaceuticals: a simple, pragmatic approach for inhaled drug developmentQ38182903
Kinetics of chemotaxis, cytokine, and chemokine release of NR8383 macrophages after exposure to inflammatory and inert granular insoluble particles.Q38736185
An in vitro alveolar macrophage assay for the assessment of inflammatory cytokine expression induced by atmospheric particulate matterQ39027110
In vitro detection of drug-induced phospholipidosis using gene expression and fluorescent phospholipid based methodologiesQ40120219
A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening systemQ40519669
Bridging Functional and Structural Cardiotoxicity Assays Using Human Embryonic Stem Cell-Derived Cardiomyocytes for a More Comprehensive Risk AssessmentQ40640593
Participation of various kinases in staurosporine induced apoptosis of RAW 264.7 cellsQ40682010
Biodegradation of polycarbonate-based polyurethanes by the human monocytes-derived macrophage and U937 cell systemsQ40717289
Actinobacillus actinomycetemcomitans induces lethal effects on the macrophage-like human cell line U937.Q40780848
An evaluation of possible mechanisms underlying amiodarone-induced pulmonary toxicityQ41073684
Interleukin-4 inhibits the gene expression and biosyntheis of cytosolic phospholipase A2 in lipopolysaccharide stimulated U937 macrophage cell line and freshly prepared adherent rheumatoid synovial cellsQ41135163
In Vitro Multiparameter Assay Development Strategy toward Differentiating Macrophage Responses to Inhaled Medicines.Q41258849
Intracellular sequestration of amiodarone: role of vacuolar ATPase and macroautophagic transition of the resulting vacuolar cytopathology.Q41973216
Amiodarone attenuates apoptosis, but induces phospholipidosis in rat alveolar epithelial cellsQ42759137
Amiodarone pulmonary toxicityQ42936697
Amiodarone-induced pulmonary toxicity in rats: biochemical and pharmacological characteristicsQ45005219
Amiodarone-induced phospholipidosis in rat alveolar macrophagesQ45054885
Effects of amiodarone-induced phospholipidosis on pulmonary host defense functions in ratsQ45096418
STP position paper: interpreting the significance of increased alveolar macrophages in rodents following inhalation of pharmaceutical materialsQ45105757
Inhaled cationic amphiphilic drug-induced pulmonary phospholipidosis in rats and dogs: time-course and dose-response of biomarkers of exposure and effectQ47882213
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectamiodaroneQ410061
image analysisQ860755
P304page(s)2466-2476
P577publication date2017-05-24
P1433published inPharmaceutical ResearchQ7180737
P1476titleMorphometric Characterization of Rat and Human Alveolar Macrophage Cell Models and their Response to Amiodarone using High Content Image Analysis
P478volume34

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cites work (P2860)
Q91994368Comparison of Oral, Intranasal and Aerosol Administration of Amiodarone in Rats as a Model of Pulmonary Phospholipidosis
Q89049080Fate of inhaled Nano-CeO2 revisited: Predicting the unpredictable
Q90397120Investigating the Suitability of High Content Image Analysis as a Tool to Assess the Reversibility of Foamy Alveolar Macrophage Phenotypes In Vitro

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