The interactions in the carboxyl terminus of human 4-hydroxyphenylpyruvate dioxygenase are critical to mediate the conformation of the final helix and the tail to shield the active site for catalysis.

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The interactions in the carboxyl terminus of human 4-hydroxyphenylpyruvate dioxygenase are critical to mediate the conformation of the final helix and the tail to shield the active site for catalysis. is …
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scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...869733L
P356DOI10.1371/JOURNAL.PONE.0069733
P932PMC publication ID3739788
P698PubMed publication ID23950902
P5875ResearchGate publication ID255959525

P2093author name stringChiung-Wen Chang
Hwei-Jen Lee
Tsu-Chung Chang
Chia-Pei Shen
Jang-Foung Lin
Ni-Yuan Chang
Yung-Lin Sheih
P2860cites workThe crystal structures of Zea mays and Arabidopsis 4-hydroxyphenylpyruvate dioxygenaseQ24562009
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Crystal structure of Pseudomonas fluorescens 4-hydroxyphenylpyruvate dioxygenase: an enzyme involved in the tyrosine degradation pathwayQ27619512
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Two roads diverged: the structure of hydroxymandelate synthase from Amycolatopsis orientalis in complex with 4-hydroxymandelateQ27649652
Crystal structure of the biphenyl-cleaving extradiol dioxygenase from a PCB-degrading pseudomonadQ27729302
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Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activityQ28118969
Mutations in the 4-hydroxyphenylpyruvic acid dioxygenase gene are responsible for tyrosinemia type III and hawkinsinuriaQ28143604
Engineering p-hydroxyphenylpyruvate dioxygenase to a p-hydroxymandelate synthase and evidence for the proposed benzene oxide intermediate in homogentisate formationQ28239537
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Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum diseaseQ28274080
Structural basis for herbicidal inhibitor selectivity revealed by comparison of crystal structures of plant and mammalian 4-hydroxyphenylpyruvate dioxygenasesQ28276259
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4-Hydroxyphenylpyruvate dioxygenaseQ28296819
The C-terminal of rat 4-hydroxyphenylpyruvate dioxygenase is indispensable for enzyme activityQ28577879
4-hydroxyphenylpyruvate dioxygenase catalysis: identification of catalytic residues and production of a hydroxylated intermediate shared with a structurally unrelated enzymeQ30502554
The 2-His-1-carboxylate facial triad: a versatile platform for dioxygen activation by mononuclear non-heme iron(II) enzymes.Q33212392
Ascorbate is consumed stoichiometrically in the uncoupled reactions catalyzed by prolyl 4-hydroxylase and lysyl hydroxylaseQ34255642
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SC-0051, a 2-benzoyl-cyclohexane-1,3-dione bleaching herbicide, is a potent inhibitor of the enzyme p-hydroxyphenylpyruvate dioxygenaseQ36770682
Human 4-hydroxyphenylpyruvate dioxygenase. Primary structure and chromosomal localization of the geneQ36784197
A Streptomyces avermitilis gene encoding a 4-hydroxyphenylpyruvic acid dioxygenase-like protein that directs the production of homogentisic acid and an ochronotic pigment in Escherichia coliQ39897766
The 2-His-1-carboxylate facial triad--an emerging structural motif in mononuclear non-heme iron(II) enzymesQ41699906
Characterization and subcellular compartmentation of recombinant 4-hydroxyphenylpyruvate dioxygenase from Arabidopsis in transgenic tobaccoQ42599046
Probing the penicillin sidechain selectivity of recombinant deacetoxycephalosporin C synthaseQ43661694
Mesotrione: a new selective herbicide for use in maizeQ43676128
Structure of the ferrous form of (4-hydroxyphenyl)pyruvate dioxygenase from Streptomyces avermitilis in complex with the therapeutic herbicide, NTBC.Q44905628
Accumulation of multiple intermediates in the catalytic cycle of (4-hydroxyphenyl)pyruvate dioxygenase from Streptomyces avermitilisQ46480179
Inhibition of p-hydroxyphenylpyruvate dioxygenase by the diketonitrile of isoxaflutole: a case of half-site reactivity.Q54195768
The 2-oxoglutarate binding site of prolyl 4-hydroxylase. Identification of distinct subsites and evidence for 2-oxoglutarate decarboxylation in a ligand reaction at the enzyme-bound ferrous ionQ70190658
Subcellular distribution and partial characterization of an alpha-ketoisocaproate oxidase of rat liver: formation of beta-hydroxyisovaleric acidQ70717621
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)e69733
P577publication date2013-08-09
P1433published inPLOS OneQ564954
P1476titleThe interactions in the carboxyl terminus of human 4-hydroxyphenylpyruvate dioxygenase are critical to mediate the conformation of the final helix and the tail to shield the active site for catalysis.
P478volume8

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cites work (P2860)
Q90441150A robust bacterial assay for high-throughput screening of human 4-hydroxyphenylpyruvate dioxygenase inhibitors
Q50333870Combination of Virtual Screening Protocol by in Silico toward the Discovery of Novel 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors
Q78946256Crystal Structure of 4-Hydroxyphenylpyruvate Dioxygenase in Complex with Substrate Reveals a New Starting Point for Herbicide Discovery
Q46464746Structurally diverse dehydroshikimate dehydratase variants participate in microbial quinate catabolism

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