Specific residues of PB2 and PA influenza virus polymerase subunits confer the ability for RNA polymerase II degradation and virus pathogenicity in mice

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Specific residues of PB2 and PA influenza virus polymerase subunits confer the ability for RNA polymerase II degradation and virus pathogenicity in mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.02263-13
P932PMC publication ID3957926
P698PubMed publication ID24403580

P50authorAriel RodriguezQ42865549
P2093author name stringA Nieto
C M Llompart
P2860cites workInfluenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3'-end processing machineryQ24534097
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Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAsQ28609836
Generation of influenza A viruses entirely from cloned cDNAsQ29616768
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Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humansQ29619059
Factors associated with death or hospitalization due to pandemic 2009 influenza A(H1N1) infection in California.Q30382272
Alternative live-attenuated influenza vaccines based on modifications in the polymerase genes protect against epidemic and pandemic flu.Q30385987
Virulence determinants of pandemic influenza virusesQ30398168
Differential contribution of PB1-F2 to the virulence of highly pathogenic H5N1 influenza A virus in mammalian and avian speciesQ30406151
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1918 Influenza virus hemagglutinin (HA) and the viral RNA polymerase complex enhance viral pathogenicity, but only HA induces aberrant host responses in miceQ30427717
Analysis of the interaction of influenza virus polymerase complex with human cell factorsQ33336123
Detection of mammalian virulence determinants in highly pathogenic avian influenza H5N1 viruses: multivariate analysis of published dataQ33485679
The HA and NS Genes of Human H5N1 Influenza A Virus Contribute to High Virulence in FerretsQ33700611
Molecular basis of live-attenuated influenza virusQ34653879
The PA protein directly contributes to the virulence of H5N1 avian influenza viruses in domestic ducksQ34741631
Replication fitness determines high virulence of influenza A virus in mice carrying functional Mx1 resistance geneQ35800387
A new generation of modified live-attenuated avian influenza viruses using a two-strategy combination as potential vaccine candidatesQ35947906
An overlapping protein-coding region in influenza A virus segment 3 modulates the host responseQ36554219
Identification of novel influenza A virus proteins translated from PA mRNAQ36607099
Four viral genes independently contribute to attenuation of live influenza A/Ann Arbor/6/60 (H2N2) cold-adapted reassortant virus vaccinesQ36826849
Cellular mRNA translation is blocked at both initiation and elongation after infection by influenza virus or adenovirusQ36870618
Pathogenicity of highly pathogenic avian influenza virus in mammalsQ37020877
Attenuated strains of influenza A viruses do not induce degradation of RNA polymerase II.Q37410776
Influenza virus mRNA translation revisited: is the eIF4E cap-binding factor required for viral mRNA translation?Q38298302
CHD6, a cellular repressor of influenza virus replication, is degraded in human alveolar epithelial cells and mice lungs during infectionQ39194807
The replication activity of influenza virus polymerase is linked to the capacity of the PA subunit to induce proteolysis.Q39588256
Correlation between polymerase activity and pathogenicity in two duck H5N1 influenza viruses suggests that the polymerase contributes to pathogenicityQ39730929
Threonine 157 of influenza virus PA polymerase subunit modulates RNA replication in infectious virusesQ39748856
Mechanisms and functional implications of the degradation of host RNA polymerase II in influenza virus infected cellsQ39781908
Monoclonal antibodies against influenza virus PB2 and NP polypeptides interfere with the initiation step of viral mRNA synthesis in vitroQ40042184
Influenza virus infection causes specific degradation of the largest subunit of cellular RNA polymerase II.Q40162019
Pneumonia and respiratory failure from swine-origin influenza A (H1N1) in MexicoQ40385742
Inhibition of Host Protein Synthesis and Degradation of Cellular mRNAs During Infection by Influenza and Herpes Simplex VirusQ40680141
Adaptive mutations resulting in enhanced polymerase activity contribute to high virulence of influenza A virus in miceQ41359819
Detection and characterization of influenza A virus PA-PB2 interaction through a bimolecular fluorescence complementation assayQ42107951
Distinct regions of influenza virus PB1 polymerase subunit recognize vRNA and cRNA templates.Q42604950
Are the 5' ends of influenza viral mRNAs synthesized in vivo donated by host mRNAs?Q44631823
Degradation of cellular mRNA during influenza virus infection: its possible role in protein synthesis shutoffQ45867899
P4510describes a project that usesImageJQ1659584
P433issue6
P304page(s)3455-3463
P577publication date2014-01-08
P1433published inJournal of VirologyQ1251128
P1476titleSpecific residues of PB2 and PA influenza virus polymerase subunits confer the ability for RNA polymerase II degradation and virus pathogenicity in mice
P478volume88

Reverse relations

cites work (P2860)
Q38270617At the centre: influenza A virus ribonucleoproteins
Q38234789Crucial role of PA in virus life cycle and host adaptation of influenza A virus
Q39174662Differential nucleocytoplasmic shuttling of the nucleoprotein of influenza a viruses and association with host tropism
Q47551113Epigenetic control of influenza virus: role of H3K79 methylation in interferon-induced antiviral response.
Q33611449Generation and Comprehensive Analysis of Host Cell Interactome of the PA Protein of the Highly Pathogenic H5N1 Avian Influenza Virus in Mammalian Cells
Q58762417Host Shutoff in Influenza A Virus: Many Means to an End
Q92638354Identifying genetic determinants of complex phenotypes from whole genome sequence data
Q34615966Influenza A viruses with different amino acid residues at PB2-627 display distinct replication properties in vitro and in vivo: revealing the sequence plasticity of PB2-627 position
Q38801154Influenza Virus and Chromatin: Role of the CHD1 Chromatin Remodeler in the Virus Life Cycle
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Q38959160PB2-E627K and PA-T97I substitutions enhance polymerase activity and confer a virulent phenotype to an H6N1 avian influenza virus in mice.
Q40705551RNA-Free and Ribonucleoprotein-Associated Influenza Virus Polymerases Directly Bind the Serine-5-Phosphorylated Carboxyl-Terminal Domain of Host RNA Polymerase II.
Q26752361Shutoff of Host Gene Expression in Influenza A Virus and Herpesviruses: Similar Mechanisms and Common Themes
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Q39099407Structural insights into RNA synthesis by the influenza virus transcription-replication machine
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Q38364349hCLE/C14orf166, a cellular protein required for viral replication, is incorporated into influenza virus particles.

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