Scaffold proteins LACK and TRACK as potential drug targets in kinetoplastid parasites: Development of inhibitors

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Scaffold proteins LACK and TRACK as potential drug targets in kinetoplastid parasites: Development of inhibitors is …
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scholarly articleQ13442814

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P356DOI10.1016/J.IJPDDR.2016.02.003
P932PMC publication ID4805777
P698PubMed publication ID27054066
P5875ResearchGate publication ID294576985

P50authorEric DumonteilQ37370310
Ana Claudia TorrecilhasQ41839175
Maria Júlia Manso AlvesQ41839194
Daria Mochly-RosenQ56073232
Nir QvitQ58873393
Pedro Martinez-VegaQ64633983
P2093author name stringNancy A Federspiel
Deborah Schechtman
Qianqian Miao
Armando Jardim
Darlene Aparecida Pena
Maria Jesus Ramirez-Sierra
Fabio Cesar Gozzo
Andrey V Malkovskiy
Ndao Momar
Eric Churchill
Christian Teh-Poot
Denise Aparecida Berti
Anna D Cunningham
Chrislaine Oliveira Soares
Lauren A Baron
Liying Annie Liang
P2860cites workChagas disease: "the new HIV/AIDS of the Americas"Q21144502
Treatment with benznidazole during the chronic phase of experimental Chagas' disease decreases cardiac alterationsQ24520510
Chagas disease in the 21st century: a public health success or an emerging threat?Q24594371
Improved tools for biological sequence comparisonQ24652199
Miltefosine for visceral and cutaneous leishmaniasis: drug characteristics and evidence-based treatment recommendationsQ28088410
Visceral leishmaniasis: what are the needs for diagnosis, treatment and control?Q29038941
Control of neglected tropical diseasesQ29547285
PANTHER: a library of protein families and subfamilies indexed by functionQ29547480
Drug resistance in leishmaniasisQ29616242
The RACK1 homologue from Trypanosoma brucei is required for the onset and progression of cytokinesisQ30480155
Synthesis of a novel macrocyclic library: discovery of an IGF-1R inhibitorQ33319607
Trypanosomatid RACK1 orthologs show functional differences associated with translation despite similar roles in Leishmania pathogenesisQ33934065
Adaptor proteins in protein kinase C-mediated signal transductionQ34095764
A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi.Q34228426
Highly Specific Modulators of Protein Kinase C Localization: Applications to Heart FailureQ34386778
Mode of action of natural and synthetic drugs against Trypanosoma cruzi and their interaction with the mammalian host.Q34515509
Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasisQ34645824
Topical treatment for cutaneous leishmaniasis.Q34714228
Selective inhibitors of methionyl-tRNA synthetase have potent activity against Trypanosoma brucei Infection in MiceQ34933050
Leishmania amazonensis promastigotes induce and are killed by neutrophil extracellular trapsQ34974266
The RACK1 scaffold protein: a dynamic cog in cell response mechanismsQ34999716
Phosphodiesterase inhibitors as a new generation of antiprotozoan drugs: exploiting the benefit of enzymes that are highly conserved between host and parasiteQ35189546
Microwave-assisted synthesis of cyclic phosphopeptide on solid supportQ35209746
Leishmaniasis--current chemotherapy and recent advances in the search for novel drugsQ35569073
Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave IrradiationQ35919791
Leishmania major LACK antigen is required for efficient vertebrate parasitizationQ36371532
Drug discovery and development for neglected parasitic diseasesQ36654913
Expression cloning of a protective Leishmania antigenQ36701227
Centrosomal PKCbetaII and pericentrin are critical for human prostate cancer growth and angiogenesisQ37003631
Protein kinase C, an elusive therapeutic target?Q37141320
Rationally designed peptide regulators of protein kinase C.Q37271445
Side effects of benznidazole as treatment in chronic Chagas disease: fears and realitiesQ37404837
Untargeted metabolomic analysis of miltefosine action in Leishmania infantum reveals changes to the internal lipid metabolismQ37613357
Targeting Trypanothione Metabolism in Trypanosomatid Human ParasitesQ37782110
Nanoparticles as multifunctional devices for the topical treatment of cutaneous leishmaniasisQ38195310
Therapeutic applications of the cell-penetrating HIV-1 Tat peptideQ38256208
Peptide therapeutics: current status and future directionsQ38275750
Cationic PTD/CPP-mediated macromolecular delivery: charging into the cellQ38494545
Leishmaniasis: treatment updates and clinical practice guidelines reviewQ38574783
A BODIPY-embedding miltefosine analog linked to cell-penetrating Tat(48-60) peptide favors intracellular delivery and visualization of the antiparasitic drugQ39032576
Effect of a combination DNA vaccine for the prevention and therapy of Trypanosoma cruzi infection in mice: role of CD4+ and CD8+ T cellsQ39836484
Novel peptide inhibitors of Leishmania gp63 based on the cleavage site of MARCKS (myristoylated alanine-rich C kinase substrate)-related proteinQ41825252
Randomized trial of posaconazole and benznidazole for chronic Chagas' disease.Q42215365
Preventive and therapeutic DNA vaccination partially protect dogs against an infectious challenge with Trypanosoma cruziQ42270726
Adhesion and interiorization of Trypanosoma cruzi in mammalian cellsQ42825388
In vitro sensitivity of Leishmania (Viannia) braziliensis and Leishmania (Leishmania) amazonensis Brazilian isolates to meglumine antimoniate and amphotericin B.Q43252625
Ankyrin peptide blocks falcipain-2-mediated malaria parasite release from red blood cellsQ44459212
Azasterols as inhibitors of sterol 24-methyltransferase in Leishmania species and Trypanosoma cruzi.Q44618895
Inhibition of delta-protein kinase C protects against reperfusion injury of the ischemic heart in vivoQ44642004
Raman spectroscopic characterization of secondary structure in natively unfolded proteins: alpha-synucleinQ44775680
Biodistribution of intracellularly acting peptides conjugated reversibly to Tat.Q44899521
Antitrypanosomal, antileishmanial, and antimalarial activities of quaternary arylalkylammonium 2-amino-4-chlorophenyl phenyl sulfides, a new class of trypanothione reductase inhibitor, and of N-acyl derivatives of 2-amino-4-chlorophenyl phenyl sulfiQ46841203
Intracoronary KAI-9803 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction.Q50647596
Leishmania mexicana: LACK (Leishmania homolog of receptors for activated C-kinase) is a plasminogen binding protein.Q54617027
Color test for detection of free terminal amino groups in the solid-phase synthesis of peptidesQ56390180
Activity and stability of human kallikrein-2-specific linear and cyclic peptide inhibitorsQ56894313
Backbone cyclization: A new method for conferring conformational constraint on peptidesQ67702601
Preparation of the very acid‐sensitive Fmoc‐Lys(Mtt)‐OH Application in the synthesis of side‐chain to side‐chain cyclic peptides and oligolysine cores suitable for the solid‐phase assembly of MAPs and TASPsQ71820607
P433issue1
P304page(s)74-84
P577publication date2016-02-12
P1433published inInternational Journal for Parasitology: Drugs and Drug ResistanceQ20181953
P1476titleScaffold proteins LACK and TRACK as potential drug targets in kinetoplastid parasites: Development of inhibitors
P478volume6

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cites work (P2860)
Q88719341Conversion of Protein Active Regions into Peptidomimetic Therapeutic Leads Using Backbone Cyclization and Cycloscan - How to Do it Yourself!
Q39072845Peptides and peptidomimetics as regulators of protein-protein interactions

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