Combined Microsatellite Instability, MLH1 Methylation Analysis, and Immunohistochemistry for Lynch Syndrome Screening in Endometrial Cancers From GOG210: An NRG Oncology and Gynecologic Oncology Group Study

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Combined Microsatellite Instability, MLH1 Methylation Analysis, and Immunohistochemistry for Lynch Syndrome Screening in Endometrial Cancers From GOG210: An NRG Oncology and Gynecologic Oncology Group Study is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1200/JCO.2015.63.9518
P932PMC publication ID4678181
P698PubMed publication ID26552419

P50authorFloor BackesQ38643301
David E. CohnQ39381089
Feng GaoQ43276868
Louise A. BrintonQ58623846
P2093author name stringRichard J Zaino
Colin C Pritchard
Heather A Lankes
Paul A DiSilvestro
Heather Hampel
Matthew A Powell
Lisa M Landrum
Shamshad Ali
Paul J Goodfellow
Amy P Schmidt
Melissa A Geller
Shashikant B Lele
Michael L Pearl
Caroline C Billingsley
David Mutch
Nilsa Ramirez
Russell J Broaddus
Alexis S Chassen
Luke V Simmons
P2860cites workATR mutation in endometrioid endometrial cancer is associated with poor clinical outcomesQ27851472
Society of Gynecologic Oncology statement on risk assessment for inherited gynecologic cancer predispositionsQ28248318
Molecular Analysis of Familial Endometrial Carcinoma: A Manifestation of Hereditary Nonpolyposis Colorectal Cancer or a Separate Syndrome?Q59244843
Screening for Lynch syndrome (hereditary nonpolyposis colorectal cancer) among endometrial cancer patientsQ80050907
Are prediction models for Lynch syndrome valid for probands with endometrial cancer?Q84316559
Immunohistochemical analysis reveals high frequency of PMS2 defects in colorectal cancerQ28249924
A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancerQ28289377
Etiologic heterogeneity in endometrial cancer: evidence from a Gynecologic Oncology Group trial.Q30413346
Risks of Lynch syndrome cancers for MSH6 mutation carriersQ30492977
The PREMM(1,2,6) model predicts risk of MLH1, MSH2, and MSH6 germline mutations based on cancer historyQ30501708
Improving identification of lynch syndrome patients: a comparison of research data with clinical recordsQ30580847
Does risk of endometrial cancer for women without a germline mutation in a DNA mismatch repair gene depend on family history of endometrial cancer or colorectal cancer?Q33593851
Endometrial cancer and a family history of cancer.Q33737568
Evaluation of clinical criteria for the identification of Lynch syndrome among unselected patients with endometrial cancerQ33874719
Cost-effectiveness and diagnostic effectiveness analyses of multiple algorithms for the diagnosis of Lynch syndromeQ34543387
Prevalence of defective DNA mismatch repair and MSH6 mutation in an unselected series of endometrial cancersQ35022384
Tumor mismatch repair immunohistochemistry and DNA MLH1 methylation testing of patients with endometrial cancer diagnosed at age younger than 60 years optimizes triage for population-level germline mismatch repair gene mutation testing.Q35063442
A frame-shift mutation of PMS2 is a widespread cause of Lynch syndromeQ35119757
Comparative effectiveness of screening strategies for Lynch syndrome.Q35474031
Aberrant methylation of the X-linked ribosomal S6 kinase RPS6KA6 (RSK4) in endometrial cancersQ35623021
ColoSeq provides comprehensive lynch and polyposis syndrome mutational analysis using massively parallel sequencingQ36081155
Performance of PREMM(1,2,6), MMRpredict, and MMRpro in detecting Lynch syndrome among endometrial cancer casesQ36094483
MLH1 methylation screening is effective in identifying epimutation carriersQ36403949
Relationship between PTEN, DNA mismatch repair, and tumor histotype in endometrial carcinoma: retained positive expression of PTEN preferentially identifies sporadic non-endometrioid carcinomasQ37038863
Endometrial and ovarian cancer in women with Lynch syndrome: update in screening and preventionQ37288004
Prevalence of Lynch syndrome among patients with newly diagnosed endometrial cancersQ37288374
Identification of constitutional MLH1 epimutations and promoter variants in colorectal cancer patients from the Colon Cancer Family RegistryQ37537200
Hereditary colorectal cancer syndromes: American Society of Clinical Oncology Clinical Practice Guideline endorsement of the familial risk-colorectal cancer: European Society for Medical Oncology Clinical Practice GuidelinesQ37659105
Frequent HOXA11 and THBS2 promoter methylation, and a methylator phenotype in endometrial adenocarcinomaQ40641250
Lynch syndrome caused by germline PMS2 mutations: delineating the cancer riskQ41685035
Milestones of Lynch syndrome: 1895-2015.Q43864989
One to 2-year surveillance intervals reduce risk of colorectal cancer in families with Lynch syndromeQ46565810
One size may not fit all: the debate of universal tumor testing for Lynch syndromeQ47397560
Gynecologic cancer as a "sentinel cancer" for women with hereditary nonpolyposis colorectal cancer syndromeQ50776571
Performance characteristics of screening strategies for Lynch syndrome in unselected women with newly diagnosed endometrial cancer who have undergone universal germline mutation testing.Q51065192
Prospective evaluation of molecular screening for Lynch syndrome in patients with endometrial cancer ≤ 70 years.Q54532022
P433issue36
P407language of work or nameEnglishQ1860
P921main subjectmicrosatelliteQ265193
Lynch syndromeQ783644
immunohistochemistryQ899285
gynecologic oncologyQ5625186
P304page(s)4301-4308
P577publication date2015-11-09
P1433published inJournal of Clinical OncologyQ400292
P1476titleCombined Microsatellite Instability, MLH1 Methylation Analysis, and Immunohistochemistry for Lynch Syndrome Screening in Endometrial Cancers From GOG210: An NRG Oncology and Gynecologic Oncology Group Study
P478volume33

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