Novel delivery approaches for cancer therapeutics.

scientific article

Novel delivery approaches for cancer therapeutics. is …
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scholarly articleQ13442814

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P356DOI10.1016/J.JCONREL.2015.09.067
P932PMC publication ID4656058
P698PubMed publication ID26456750
P5875ResearchGate publication ID282812068

P50authorDhananjay PalQ96247254
P2093author name stringAshim K Mitra
Yi Hao
Xiaoyan Yang
Ravi Vaishya
Kishore Cholkar
Hoang M Trinh
Vibhuti Agrahari
Abhirup Mandal
Varun Khurana
Mary Joseph
Sujay Shah
Chandramouli Natarajan
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Poly(L-lysine)-modified iron oxide nanoparticles for stem cell labelingQ46742712
Resistance to cytarabine and gemcitabine and in vitro selection of transduced cells after retroviral expression of cytidine deaminase in human hematopoietic progenitor cellsQ46817260
Ado-trastuzumab emtansine approved for advanced breast cancerQ46845281
Acid pH-activated glycol chitosan/fullerene nanogels for efficient tumor therapyQ46931536
Hyperthermia enables tumor-specific nanoparticle delivery: effect of particle sizeQ47230491
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Sonoporation mediated transduction of pDNA/siRNA into joint synovium in vivo.Q50679500
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Ultrasound-mediated destruction of paclitaxel and oxygen loaded lipid microbubbles for combination therapy in ovarian cancer xenografts.Q51000509
Induced phenotype targeted therapy: radiation-induced apoptosis-targeted chemotherapy.Q51025137
A reusable magnetic graphene oxide-modified biosensor for vascular endothelial growth factor detection in cancer diagnosis.Q51053553
Oxidative quenching of quinone methide adducts reveals transient products of reversible alkylation in duplex DNA.Q51076842
An activatable theranostic for targeted cancer therapy and imaging.Q51747526
The prodrug platin-A: simultaneous release of cisplatin and aspirin.Q51757111
Postherpetic neuralgia: a workable treatment plan.Q51801146
LHRH-conjugated magnetic iron oxide nanoparticles for detection of breast cancer metastases.Q51807114
Short oligonucleotide prodrug having 5-fluoro and 5-iodouracil inhibits the proliferation of cancer cells in a photo-responsive manner.Q53058177
Substituent effects on oxidation-induced formation of quinone methides from arylboronic ester precursors.Q53107301
Doxorubicin-DNA adducts induce a non-topoisomerase II-mediated form of cell death.Q53624957
Brentuximab vedotin demonstrates objective responses in a phase 2 study of relapsed/refractory DLBCL with variable CD30 expression.Q53648839
A dose-finding and pharmacokinetic study of reversal of multidrug resistance with SDZ PSC 833 in combination with doxorubicin in patients with solid tumors.Q54116953
N-Acyl-phosphoramidates as potential novel form of gemcitabine prodrugs.Q54293128
The promise of antibody-drug conjugates.Q54472969
Design and biological evaluation of cell-penetrating peptide-doxorubicin conjugates as prodrugsQ57117289
A pH-sensitive doxorubicin prodrug based on folate-conjugated BSA for tumor-targeted drug deliveryQ57273318
Multifunctional squalene-based prodrug nanoparticles for targeted cancer therapyQ57676482
Research Spotlight: Applications of ultrasound for image-guided drug delivery in cancer chemotherapyQ62565441
Enhancement of the activity of immunotoxins by analogues of verapamilQ69742341
Treatment of solid L1210 murine tumors with local hyperthermia and temperature-sensitive liposomes containing methotrexateQ71848159
Extracellular pH distribution in human tumoursQ72334607
Preliminary investigations of ultrasound induced acoustic streaming using particle image velocimetryQ73875813
Ultrasound-facilitated transport of silver chloride (AgCl) particles in fish skinQ74107784
Heat-sensitive liposomes containing cisplatin and localized hyperthermia in treatment of murine tumorQ77621526
Cancer immunotherapyQ80066933
Phase I/II trial of a P-glycoprotein inhibitor, Zosuquidar.3HCl trihydrochloride (LY335979), given orally in combination with the CHOP regimen in patients with non-Hodgkin's lymphomaQ80206172
Aptamer-functionalized magnetic nanoparticle-based bioassay for the detection of ochratoxin A using upconversion nanoparticles as labelsQ83820126
Influence of ultrasound induced cavitation on magnetic resonance imaging contrast in the rat liver in the presence of macromolecular contrast agentQ84020292
Molecular targeted enhanced ultrasound imaging of flk1 reveals diagnosis and prognosis potential in a genetically engineered mouse prostate cancer modelQ84512825
Brentuximab vedotinQ85706779
[Antibody-drug conjugates in oncology: from the concept to trastuzumab emtansine (T-DM1)]Q85714525
Designing a gold nanoparticle-based nanocarrier for microRNA transfection into the prostate and breast cancer cellsQ85832800
A nitrophenyl-based prodrug type for colorectal targeting of prednisolone, budesonide and celecoxibQ86138562
Novel isoprenoyl nanoassembled prodrug for paclitaxel deliveryQ86545920
Enhanced cytotoxicity to cancer cells by mitochondria-targeting MWCNTs containing platinum(IV) prodrug of cisplatinQ86555025
Novel cleavable cell-penetrating peptide-drug conjugates: synthesis and characterizationQ87543613
Precise engineering of siRNA delivery vehicles to tumors using polyion complexes and gold nanoparticlesQ87607521
Cell-penetrable lysine dendrimers for anti-cancer drug delivery: synthesis and preliminary biological evaluationQ87698817
Interfacial behavior of PEGylated lipids and their effect on the stability of squalenoyl-drug nanoassembliesQ87841796
Targeted delivery of nanoparticles bearing fibroblast growth factor-2 by ultrasonic microbubble destruction for therapeutic arteriogenesisQ30438396
Microbubbles in ultrasound-triggered drug and gene deliveryQ30438994
Overview of therapeutic ultrasound applications and safety considerationsQ30447970
Microbubble-mediated ultrasound therapy: a review of its potential in cancer treatmentQ30454718
Ultrasound-mediated tumor imaging and nanotherapy using drug loaded, block copolymer stabilized perfluorocarbon nanoemulsionsQ30465710
Ultrasonic nanotherapy of pancreatic cancer: lessons from ultrasound imagingQ30477363
Controlled and targeted tumor chemotherapy by ultrasound-activated nanoemulsions/microbubblesQ30479575
ECHOGENIC LIPSOMES FOR TARGETED DRUG DELIVERY.Q30480915
Driving delivery vehicles with ultrasoundQ30483826
In vivo effects of cavitation alone or in combination with chemotherapy in a peritoneal carcinomatosis in the rat.Q30486862
Progress and problems in the application of focused ultrasound for blood-brain barrier disruptionQ30487878
Ultrasound mediated delivery of drugs and genes to solid tumorsQ30488681
Effects of acoustic parameters and ultrasound contrast agent dose on focused-ultrasound induced blood-brain barrier disruptionQ30489416
Pulsed-high intensity focused ultrasound and low temperature-sensitive liposomes for enhanced targeted drug delivery and antitumor effect.Q30493238
Ultrasound radiation force enables targeted deposition of model drug carriers loaded on microbubblesQ30499622
Application of ultrasound to selectively localize nanodroplets for targeted imaging and therapyQ30501162
Investigation of HIFU-induced anti-tumor immunity in a murine tumor modelQ30502120
Development and bioorthogonal activation of palladium-labile prodrugs of gemcitabineQ30582495
Disulfide cross-linked phosphorylcholine micelles for triggered release of camptothecinQ30641959
Self-assembling doxorubicin-tocopherol succinate prodrug as a new drug delivery system: synthesis, characterization, and in vitro and in vivo anticancer activityQ30712774
CD44-targeted docetaxel conjugate for cancer cells and cancer stem-like cells: a novel hyaluronic acid-based drug delivery systemQ30738016
pH and hydrogen peroxide dual responsive supramolecular prodrug system for controlled release of bioactive moleculesQ30834427
Intracellular trafficking of nuclear localization signal conjugated nanoparticles for cancer therapyQ30955663
Ultrasound-enhanced drug delivery in prostate cancer xenografts by nanoparticles stabilizing microbubblesQ31161580
Reversal of multidrug resistance by the P-glycoprotein modulator, LY335979, from the bench to the clinicQ31923033
Aptamers: an emerging class of therapeuticsQ33211036
Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriersQ33235069
A DNA transporter based on mesoporous silica nanospheres mediated with polycation poly(allylamine hydrochloride) coating on mesopore surfaceQ33338346
A Phase I trial of a potent P-glycoprotein inhibitor, zosuquidar trihydrochloride (LY335979), administered intravenously in combination with doxorubicin in patients with advanced malignancyQ33360952
Brentuximab vedotin (SGN-35) in patients with relapsed or refractory systemic anaplastic large-cell lymphoma: results of a phase II studyQ33401346
Gene medicine for cancer treatment: commercially available medicine and accumulated clinical data in ChinaQ33516121
Temperature-sensitive magnetic drug carriers for concurrent gemcitabine chemohyperthermiaQ33561078
Tumor heterogeneity: causes and consequencesQ33624298
Increased delivery of doxorubicin into tumor cells using extracellularly activated TAT functionalized liposomes: in vitro and in vivo study.Q38976009
Synthesis and inclusion study of a novel γ-cyclodextrin derivative as a potential thermo-sensitive carrier for doxorubicin.Q38978573
Chitosan-based hybrid nanocomplex for siRNA delivery and its application for cancer therapyQ38991978
Design of a paclitaxel prodrug conjugate for active targeting of an enzyme upregulated in breast cancer cellsQ38993094
Preparation, optimization and in vitro characterization of stearoyl-gemcitabine polymeric micelles: a comparison with its self-assembled nanoparticlesQ39004327
13F-1, a novel 5-fluorouracil prodrug containing an Asn-Gly-Arg (NO2) COOCH3 tripeptide, inhibits human colonic carcinoma growth by targeting Aminopeptidase N (APN/CD13).Q39004875
Uptake and cytotoxicity of docetaxel-loaded hyaluronic acid-grafted oily core nanocapsules in MDA-MB 231 cancer cells.Q39014066
Photosensitive Pt(IV)-azide prodrug-loaded nanoparticles exhibit controlled drug release and enhanced efficacy in vivoQ39025502
Application of ProTide technology to gemcitabine: a successful approach to overcome the key cancer resistance mechanisms leads to a new agent (NUC-1031) in clinical development.Q39029664
Synthesis and optimization of a bifunctional hyaluronan-based camptothecin prodrugQ39036296
Co-delivery of small interfering RNA using a camptothecin prodrug as the carrierQ39042837
Rational design of polyion complex nanoparticles to overcome cisplatin resistance in cancer therapy.Q39043200
Near-infrared light-mediated photoactivation of a platinum antitumor prodrug and simultaneous cellular apoptosis imaging by upconversion-luminescent nanoparticles.Q39047691
Reversal of multidrug resistance phenotype in human breast cancer cells using doxorubicin-liposome-microbubble complexes assisted by ultrasoundQ39052614
Oncolytic viral therapy with a combination of HF10, a herpes simplex virus type 1 variant and granulocyte-macrophage colony-stimulating factor for murine ovarian cancerQ39058604
Targeted polysaccharide nanoparticle for adamplatin prodrug deliveryQ39061436
Selective cancer targeting with prodrugs activated by histone deacetylases and a tumour-associated proteaseQ39066800
Preparation of a camptothecin prodrug with glutathione-responsive disulfide linker for anticancer drug deliveryQ39077133
Tailored doxorubicin-hyaluronan conjugate as a potent anticancer glyco-drug: an alternative to prodrug approachQ39077970
Active targeting of block copolymer micelles with trastuzumab Fab fragments and nuclear localization signal leads to increased tumor uptake and nuclear localization in HER2-overexpressing xenograftsQ39091930
Aptamer-conjugated Mn3O4@SiO2 core-shell nanoprobes for targeted magnetic resonance imagingQ39093063
Nanoassemblies containing a fluorouracil/zidovudine glyceryl prodrug with phospholipase A2-triggered drug release for cancer treatment.Q39095964
Novel peptide-doxorubucin conjugates for targeting breast cancer cells including the multidrug resistant cellsQ39096797
Lipophilic prodrugs of a triazole-containing colchicine analogue in liposomes: biological effects on human tumor cellsQ39102678
Cell uptake enhancement of folate targeted polymer coated magnetic nanoparticlesQ39125334
Self-assemblies of pH-activatable PEGylated multiarm poly(lactic acid-co-glycolic acid)-doxorubicin prodrugs with improved long-term antitumor efficaciesQ39125982
Synthesis and in vitro cytostatic activity of 1,2- and 1,3-diacylglycerophosphates of clofarabineQ39131492
Acyloxymethyl esters of isophosphoramide mustard as new anticancer prodrugsQ39140737
Knockdown of protein phosphatase magnesium-dependent 1 (PPM1D) through lentivirus-mediated RNA silencing inhibits colorectal carcinoma cell proliferationQ39142682
Tumor redox heterogeneity-responsive prodrug nanocapsules for cancer chemotherapy.Q39143452
Novel epithelial cell adhesion molecule antibody conjugated polyethyleneimine-capped gold nanoparticles for enhanced and targeted small interfering RNA delivery to retinoblastoma cellsQ39149758
Biological properties of melanoma and endothelial cells after plasmid AMEP gene electrotransfer depend on integrin quantity on cells.Q39155558
Synthesis and biological evaluation of fluoro analogues of antimitotic phenstatinQ39160451
Increased cellular uptake of biocompatible superparamagnetic iron oxide nanoparticles into malignant cells by an external magnetic fieldQ33625192
HER2/neu Antibody Conjugated Poly(amino acid)-Coated Iron Oxide Nanoparticles for Breast Cancer MR ImagingQ33713063
Charge-reversal polyamidoamine dendrimer for cascade nuclear drug delivery.Q33734954
Tumor site-specific silencing of NF-kappaB p65 by targeted hollow gold nanosphere-mediated photothermal transfectionQ33795417
Purification, synthesis and characterization of AaCtx, the first chlorotoxin-like peptide from Androctonus australis scorpion venom.Q33801818
An optical and microPET assessment of thermally-sensitive liposome biodistribution in the Met-1 tumor model: Importance of formulationQ33818246
Causes and consequences of tumour acidity and implications for treatmentQ33818730
Pt(IV) prodrugs designed to bind non-covalently to human serum albumin for drug deliveryQ33825880
Breathing new life into immunotherapy: review of melanoma, lung and kidney cancerQ33862861
Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells.Q33896810
The nuclear pore complex: a protein machine bridging the nucleus and cytoplasmQ33912881
Trastuzumab-conjugated liposome-coated fluorescent magnetic nanoparticles to target breast cancerQ33929273
Kinetic analysis of translocation through nuclear pore complexesQ33938174
Adeno-associated virus type 2 infection of nude mouse human breast cancer xenograft induces necrotic death and inhibits tumor growthQ33989913
Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI-guided focused ultrasoundQ34003611
Adenoviral vector-mediated gene therapy for gliomas: coming of age.Q34022048
Reactive oxygen species (ROS) inducible DNA cross-linking agents and their effect on cancer cells and normal lymphocytesQ34049655
Conjugates of cisplatin and cyclooxygenase inhibitors as potent antitumor agents overcoming cisplatin resistance.Q34060461
Toward hypoxia-selective DNA-alkylating agents built by grafting nitrogen mustards onto the bioreductively activated, hypoxia-selective DNA-oxidizing agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).Q34061361
Contrast agents for MR imaging of the liverQ34127781
PPM1D silencing by RNA interference inhibits the proliferation of lung cancer cellsQ34136105
Magnetic nanomaterials for hyperthermia-based therapy and controlled drug deliveryQ34174125
P-glycoprotein: from genomics to mechanism.Q34272173
NF-κB-inducing kinase is a key regulator of inflammation-induced and tumour-associated angiogenesis.Q34324711
The novel alkylating prodrug melflufen (J1) inhibits angiogenesis in vitro and in vivoQ34363166
Human anti-CCR4 minibody gene transfer for the treatment of cutaneous T-cell lymphoma.Q34413695
Non-viral vectors for gene-based therapyQ34429032
Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology.Q34447986
Multifunctional core/shell nanoparticles cross-linked polyetherimide-folic acid as efficient Notch-1 siRNA carrier for targeted killing of breast cancerQ34519604
A DNA aptamer with high affinity and specificity for molecular recognition and targeting therapy of gastric cancerQ34565529
Copper-doxorubicin as a nanoparticle cargo retains efficacy with minimal toxicityQ34566961
Targeting PPM1D by lentivirus-mediated RNA interference inhibits the tumorigenicity of bladder cancer cellsQ34574266
Chemotherapeutic drug delivery to cancer cells using a combination of folate targeting and tumor microenvironment-sensitive polypeptides.Q34604822
pH-triggered intracellular release from actively targeting polymer micellesQ34627898
Understanding and targeting cancer stem cells: therapeutic implications and challengesQ36907405
Efficacious cyclic N-acyl O-amino phenol duocarmycin prodrugsQ36943532
Super pH-sensitive multifunctional polymeric micelle for tumor pH(e) specific TAT exposure and multidrug resistanceQ37016869
Development and application of a dual-purpose nanoparticle platform for delivery and imaging of siRNA in tumorsQ37081569
Factors affecting the clearance and biodistribution of polymeric nanoparticles.Q37146591
Targeting therapy of hepatocellular carcinoma with doxorubicin prodrug PDOX increases anti-metastatic effect and reduces toxicity: a preclinical studyQ37153412
Synthesis and evaluation of diaryl sulfides and diaryl selenide compounds for antitubulin and cytotoxic activity.Q37174354
Enhancing cell nucleus accumulation and DNA cleavage activity of anti-cancer drug via graphene quantum dotsQ37214403
In vivo MRI detection of gliomas by chlorotoxin-conjugated superparamagnetic nanoprobes.Q37216626
Intravenous delivery of siRNA targeting CD47 effectively inhibits melanoma tumor growth and lung metastasisQ37254863
Development of a tumor-specific photoactivatable doxorubicin prodrugQ37280632
Monofunctional and higher-valent platinum anticancer agents.Q37282213
Novel membrane-permeable contrast agent for brain tumor detection by MRIQ37284164
CRM1-mediated nuclear export of proteins and drug resistance in cancerQ37320237
AAV-mediated persistent bevacizumab therapy suppresses tumor growth of ovarian cancer.Q37374843
Ultrasound triggered image-guided drug deliveryQ37409835
Peptide-mediated DNA condensation for non-viral gene therapy.Q37430562
Molecular therapeutics of cancer by means of electroporation-based transfer of siRNAs and EBV-based expression vectorsQ37501982
New strategies for cancer gene therapy: progress and opportunitiesQ37577964
Hyaluronidase-sensitive nanoparticle templates for triggered release of HIV/AIDS microbicide in vitroQ37601061
Experimental strategies in gene therapy of cancer.Q37604243
The leaving group strongly affects H₂O₂-induced DNA cross-linking by arylboronatesQ37612273
Adenovirus-mediated cancer gene therapy and virotherapy (Review).Q37643498
Emerging applications of stimuli-responsive polymer materialsQ37679697
Silicate esters of paclitaxel and docetaxel: synthesis, hydrophobicity, hydrolytic stability, cytotoxicity, and prodrug potentialQ37697357
Synthesis, identification and in vivo studies of tumor-targeting agent peptide doxorubicin (PDOX) to treat peritoneal carcinomatosis of gastric cancer with similar efficacy but reduced toxicityQ37699783
Far-red light activatable, multifunctional prodrug for fluorescence optical imaging and combinational treatmentQ37727672
Remotely triggerable drug delivery systemsQ37785501
Engineering nanocomposite materials for cancer therapyQ37794066
Hydrodynamic gene delivery and its applications in pharmaceutical researchQ37824615
Synergistic effect of ultrasound and antibiotics against Chlamydia trachomatis-infected human epithelial cells in vitroQ37852485
Nuclear drug delivery for cancer chemotherapy.Q37918608
Enzyme-responsive nanoparticles for drug release and diagnostics.Q37977773
Transformation-induced mutations in transgenic plants: analysis and biosafety implicationsQ38005167
Plasmid IL-12 electroporation in melanoma.Q38059773
Phase I trial of interleukin-12 plasmid electroporation in patients with metastatic melanomaQ34887442
Efficient siRNA delivery and tumor accumulation mediated by ionically cross-linked folic acid-poly(ethylene glycol)-chitosan oligosaccharide lactate nanoparticles: for the potential targeted ovarian cancer gene therapyQ35029953
Oligonucleotides--assembled Au nanorod-assisted cancer photothermal ablation and combination chemotherapy with targeted dual-drug delivery of Doxorubicin and Cisplatin prodrugQ35100212
Identification and characterization of a suite of tumor targeting peptides for non-small cell lung cancerQ35131992
Free radical formation induced by ultrasound and its biological implicationsQ35232001
Targeted delivery of doxorubicin into tumor cells via MMP-sensitive PEG hydrogel-coated magnetic iron oxide nanoparticles (MIONPs).Q35237180
Phase I trial of doxorubicin-containing low temperature sensitive liposomes in spontaneous canine tumorsQ44867437
Macromolecular prodrug that provides the irinotecan (CPT-11) active-metabolite SN-38 with ultralong half-life, low C(max), and low glucuronide formation.Q44913074
Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studiesQ44991784
Verapamil-mediated sensitization of doxorubicin-selected pleiotropic resistance in human sarcoma cells: selectivity for drugs which produce DNA scission.Q45019846
A randomized, placebo-controlled, double-blind phase 2 study of docetaxel compared to docetaxel plus zosuquidar (LY335979) in women with metastatic or locally recurrent breast cancer who have received one prior chemotherapy regimenQ45125373
Recombinant adeno-associated virus encoding Epstein-Barr virus latent membrane proteins fused with heat shock protein as a potential vaccine for nasopharyngeal carcinomaQ45144516
Sonophoresis. II. Examination of the mechanism(s) of ultrasound-enhanced transdermal drug deliveryQ45163090
Targeting of nanoparticles to the clathrin-mediated endocytic pathwayQ45864648
High-efficiency transfection of nucleic acids by the modified calcium phosphate precipitation method in chondrocytesQ45879695
Systemic administration of a PEGylated adenovirus vector with a cancer-specific promoter is effective in a mouse model of metastasisQ45887307
Thermoresponsive magnetic composite nanomaterials for multimodal cancer therapy.Q45930564
Multifunctional nanoparticles for combining ultrasonic tumor imaging and targeted chemotherapy.Q45940724
Hepatocellular carcinoma: regional therapy with a magnetic targeted carrier bound to doxorubicin in a dual MR imaging/ conventional angiography suite--initial experience with four patients.Q46014412
Ultrasound and microbubble-targeted delivery of macromolecules is regulated by induction of endocytosis and pore formationQ46147948
A phase I trial of continuous infusion of the multidrug resistance inhibitor zosuquidar with daunorubicin and cytarabine in acute myeloid leukemia.Q46183389
Preparation and characterization of novel poly(ethylene glycol) paclitaxel derivativesQ46187223
Recent advances in design of immunogenic and effective naked DNA vaccines against cancerQ38085021
Aptamers: molecules of great potentialQ38103145
Ultrasound and microbubble-mediated gene delivery in cancer: progress and perspectives.Q38108658
Ultrasound-mediated drug/gene delivery in solid tumor treatmentQ38115401
Mechanisms of drug resistance in cancer chemotherapy: coordinated role and regulation of efflux transporters and metabolizing enzymesQ38119518
Applications of cell-penetrating peptides for tumor targeting and future cancer therapies.Q38166533
Gene therapy and DNA delivery systemsQ38167136
pH-sensitive nano-systems for drug delivery in cancer therapyQ38169030
Orchestrating immune check-point blockade for cancer immunotherapy in combinationsQ38184138
Electroporation-based technologies for medicine: principles, applications, and challenges.Q38218252
Biosynthesis and the conjugation of magnetite nanoparticles with luteinizing hormone releasing hormone (LHRH).Q38285894
Identification of liver cancer-specific aptamers using whole live cellsQ38294792
MiRNA-21 silencing mediated by tumor-targeted nanoparticles combined with sunitinib: A new multimodal gene therapy approach for glioblastoma.Q38299859
Targeted and ultrasound-triggered drug delivery using liposomes co-modified with cancer cell-targeting aptamers and a thermosensitive polymer.Q38309779
Diazido mixed-amine platinum(IV) anticancer complexes activatable by visible-light form novel DNA adducts.Q38315077
The Pharmacokinetics of Cell-Penetrating PeptidesQ38340819
Aptamer nanomedicine for cancer therapeutics: barriers and potential for translation.Q38366753
Epithelial Plasticity in Cancer: Unmasking a MicroRNA Network for TGF-β-, Notch-, and Wnt-Mediated EMT.Q38425500
Targeting the Bone Microenvironment in Metastatic Castration-Resistant Prostate CancerQ38429067
Multifunctional magnetic nanoparticles modified with polyethylenimine and folic acid for biomedical theranosticsQ38450638
Drug/Dye-Loaded, Multifunctional PEG-Chitosan-Iron Oxide Nanocomposites for Methotraxate Synergistically Self-Targeted Cancer Therapy and Dual Model ImagingQ38874446
miRNA-221 and miRNA-222 induce apoptosis via the KIT/AKT signalling pathway in gastrointestinal stromal tumoursQ38883917
Versican silencing improves the antitumor efficacy of endostatin by alleviating its induced inflammatory and immunosuppressive changes in the tumor microenvironmentQ38887374
Co-delivery of doxorubicin and siRNA for glioma therapy by a brain targeting system: angiopep-2-modified poly(lactic-co-glycolic acid) nanoparticlesQ38889403
Synthesis and characterization of Bombesin-superparamagnetic iron oxide nanoparticles as a targeted contrast agent for imaging of breast cancer using MRI.Q38914039
Preactivated oxazaphosphorines designed for isophosphoramide mustard delivery as bulk form or nanoassemblies: synthesis and proof of concept.Q38930156
Enzyme-triggered delivery of chlorambucil from conjugates based on the cell-penetrating peptide BP16.Q38932275
Highly effective inhibition of lung cancer growth and metastasis by systemic delivery of siRNA via multimodal mesoporous silica-based nanocarrierQ38951009
Biological activity of a series of cisplatin-based aliphatic bis(carboxylato) Pt(IV) prodrugs: how long the organic chain should be?Q38961699
Annexin A2 is implicated in multi-drug-resistance in gastric cancer through p38MAPK and AKT pathwayQ38963460
Antitumor platinum(IV) derivatives of oxaliplatin with axial valproato ligands.Q38971493
ZEB1 knockdown mediated using polypeptide cationic micelles inhibits metastasis and effects sensitization to a chemotherapeutic drug for cancer therapyQ38974682
Targeted co-delivery of docetaxel, cisplatin and herceptin by vitamin E TPGS-cisplatin prodrug nanoparticles for multimodality treatment of cancer.Q39195635
Poly(ethylene glycol) shell-sheddable nanomicelle prodrug of camptothecin with enhanced cellular uptake.Q39199024
Mechanistic study of the covalent loading of paclitaxel via disulfide linkers for controlled drug release.Q39223714
Improving the antitumor activity of squalenoyl-paclitaxel conjugate nanoassemblies by manipulating the linker between paclitaxel and squaleneQ39232076
Combination of vinblastine and oncolytic herpes simplex virus vector expressing IL-12 therapy increases antitumor and antiangiogenic effects in prostate cancer modelsQ39247534
Camptothecin-7-yl-methanthiole: semisynthesis and biological evaluationQ39255471
A novel valproic acid prodrug as an anticancer agent that enhances doxorubicin anticancer activity and protects normal cells against its toxicity in vitro and in vivoQ39264284
Targeted lipid based drug conjugates: a novel strategy for drug delivery.Q39332407
CO2 gas induced drug release from pH-sensitive liposome to circumvent doxorubicin resistant cellsQ39365167
Enhanced anti-glioblastoma activity of microglia by AAV2-mediated IL-12 through TRAIL and phagocytosis in vitroQ39576819
Functionalization of iron oxide magnetic nanoparticles with targeting ligands: their physicochemical properties and in vivo behaviorQ39624333
Influence of extracellular pH on the cytotoxicity, cellular accumulation, and DNA interaction of novel pH-sensitive 2-aminoalcoholatoplatinum(II) complexesQ39625764
Efficient nuclear drug translocation and improved drug efficacy mediated by acidity-responsive boronate-linked dextran/cholesterol nanoassemblyQ39631068
Evaluation of the temporal window for drug delivery following ultrasound-mediated membrane permeability enhancementQ39697051
Reversal of P-glycoprotein-mediated multidrug resistance by XR9051, a novel diketopiperazine derivativeQ39709772
Potent pleiotropic anti-angiogenic effects of TM601, a synthetic chlorotoxin peptide.Q39740554
DC-Chol/DOPE cationic liposomes: a comparative study of the influence factors on plasmid pDNA and siRNA gene deliveryQ39746063
Mediating tumor targeting efficiency of nanoparticles through designQ39864411
Preparation of hierarchical hollow CaCO3 particles and the application as anticancer drug carrierQ39922079
Efficient gene delivery using reconstituted chromatin enhanced for nuclear targeting.Q40000002
Calcium carbonate nanoparticle delivering vascular endothelial growth factor-C siRNA effectively inhibits lymphangiogenesis and growth of gastric cancer in vivoQ40023784
Surface charge of nanoparticles determines their endocytic and transcytotic pathway in polarized MDCK cellsQ40026176
Targeted charge-reversal nanoparticles for nuclear drug deliveryQ40127866
Targeting gene therapy for prostate cancer cells by liposomes complexed with anti-prostate-specific membrane antigen monoclonal antibodyQ40221738
Hydrodynamics-based gene delivery of naked DNA encoding fetal liver kinase-1 gene effectively suppresses the growth of pre-existing tumorsQ40269728
Clinical safety of induced CTL infusion through recombinant adeno-associated virus-transfected dendritic cell vaccination in Chinese cancer patientsQ40278871
"Intelligent" polymers in medicine and biotechnology.Q40454589
MDR expression in normal tissues. Pharmacologic implications for the clinical use of P-glycoprotein inhibitors.Q40464073
Nuclear localization signal-targeted poly(ethylene glycol) conjugates as potential carriers and nuclear localizing agents for carboplatin analoguesQ40533503
Isolation and mapping of a polymorphic DNA sequence (pCMM8.1) on chromosome 1p [D1S63]Q40556209
Efficacy of liposomes and hyperthermia in a human tumor xenograft model: importance of triggered drug release.Q40609513
Targeted drug delivery to tumors: myths, reality and possibilityQ40868797
Synthesis of bombesin-functionalized iron oxide nanoparticles and their specific uptake in prostate cancer cellsQ40994215
UV-Induced DNA Interstrand Cross-Linking and Direct Strand Breaks from a New Type of Binitroimidazole AnalogueQ41112734
Reversal of P-glycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberane modulator, LY335979.Q41167886
Verapamil and adriamycin in the treatment of drug-resistant ovarian cancer patientsQ41328786
Tumor-targeted Chlorotoxin-coupled Nanoparticles for Nucleic Acid Delivery to Glioblastoma Cells: A Promising System for Glioblastoma Treatment.Q41459815
In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative.Q41522468
Gene electrotransfer clinical trialsQ41522827
SDZ PSC-833--a novel potent in vitro chemosensitizer in multiple myelomaQ41591996
Active efflux of daunorubicin and adriamycin in sensitive and resistant sublines of P388 leukemiaQ41613500
Development of Novel Magnetic Nanoparticles for Hyperthermia Cancer TherapyQ41821934
Conjugation of Monoclonal Antibodies to Super Paramagnetic Iron Oxide Nanoparticles for Detection of her2/neu Antigen on Breast Cancer Cell Lines.Q42084798
Phase I and pharmacokinetic study of the multidrug resistance modulator dexverapamil with EPOCH chemotherapyQ42277372
Endgame: glybera finally recommended for approval as the first gene therapy drug in the European unionQ42516930
Oxidative halogenation of cisplatin and carboplatin: synthesis, spectroscopy, and crystal and molecular structures of Pt(IV) prodrugsQ43051494
A core cross-linked polymeric micellar platium(IV) prodrug with enhanced anticancer efficiencyQ43411545
A facile approach for dual-responsive prodrug nanogels based on dendritic polyglycerols with minimal leachingQ43519220
Synthesis and activity of a folate targeted monodisperse PEG camptothecin conjugateQ43534141
An oncolytic herpes simplex virus vector, G47Δ, synergizes with paclitaxel in the treatment of breast cancerQ43653289
Eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan: muscle biopsy findings in 4 patientsQ43797167
P407language of work or nameEnglishQ1860
P304page(s)248-268
P577publication date2015-10-06
P1433published inJournal of Controlled ReleaseQ6295046
P1476titleNovel delivery approaches for cancer therapeutics.
P478volume219

Reverse relations

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