| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2009PLoSO...4.5658L |
| P356 | DOI | 10.1371/JOURNAL.PONE.0005658 |
| P8608 | Fatcat ID | release_dbj5wyxcjnehrpxigtvivksil4 |
| P932 | PMC publication ID | 2680953 |
| P698 | PubMed publication ID | 19462010 |
| P5875 | ResearchGate publication ID | 24446100 |
| P50 | author | Guan Yi | Q8962817 |
| Leo Lit Man Poon | Q87742312 | ||
| Olive T W Li | Q89899364 | ||
| P2093 | author name string | John M Nicholls | |
| Michael C W Chan | |||
| Renee W Y Chan | |||
| Cynthia S W Leung | |||
| P2860 | cites work | A single mutation in the PB1-F2 of H5N1 (HK/97) and 1918 influenza A viruses contributes to increased virulence | Q21089626 |
| BRCA1/BARD1 inhibition of mRNA 3' processing involves targeted degradation of RNA polymerase II. | Q24302667 | ||
| Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells | Q24535660 | ||
| Characterization of a novel influenza A virus hemagglutinin subtype (H16) obtained from black-headed gulls | Q24556678 | ||
| Sequence of the 1918 pandemic influenza virus nonstructural gene (NS) segment and characterization of recombinant viruses bearing the 1918 NS genes | Q24598177 | ||
| Role of ran binding protein 5 in nuclear import and assembly of the influenza virus RNA polymerase complex | Q24673668 | ||
| Crystal structure of the polymerase PA(C)-PB1(N) complex from an avian influenza H5N1 virus | Q27651109 | ||
| The structural basis for an essential subunit interaction in influenza virus RNA polymerase | Q27651365 | ||
| A novel influenza A virus mitochondrial protein that induces cell death. | Q27863709 | ||
| Model suggesting that replication of influenza virus is regulated by stabilization of replicative intermediates | Q27863792 | ||
| Functional association between viral and cellular transcription during influenza virus infection | Q27863933 | ||
| Identification of two separate domains in the influenza virus PB1 protein involved in the interaction with the PB2 and PA subunits: a model for the viral RNA polymerase structure. | Q27867695 | ||
| Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease? | Q28217338 | ||
| Universal primer set for the full-length amplification of all influenza A viruses | Q57202943 | ||
| The impact of influenza and influenza-like illness on productivity and healthcare resource utilization in a working population | Q74617108 | ||
| Primary isolation of influenza viruses at 33 degrees C | Q79645939 | ||
| Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia | Q28262914 | ||
| Characterization of the 1918 influenza virus polymerase genes | Q28275749 | ||
| Initial genetic characterization of the 1918 "Spanish" influenza virus | Q28305563 | ||
| Rates of evolutionary change in viruses: patterns and determinants | Q29616174 | ||
| Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses | Q29619144 | ||
| A DNA transfection system for generation of influenza A virus from eight plasmids | Q29642855 | ||
| Pathogenicity and immunogenicity of influenza viruses with genes from the 1918 pandemic virus. | Q30339011 | ||
| The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host. | Q30352150 | ||
| The polymerase complex genes contribute to the high virulence of the human H5N1 influenza virus isolate A/Vietnam/1203/04. | Q30353368 | ||
| The challenge of avian influenza to the veterinary community. | Q30354807 | ||
| Single gene reassortants identify a critical role for PB1, HA, and NA in the high virulence of the 1918 pandemic influenza virus | Q30367863 | ||
| Deviation from the random distribution pattern of influenza A virus gene segments in reassortants produced under non-selective conditions. | Q30368880 | ||
| Genetic compatibility and virulence of reassortants derived from contemporary avian H5N1 and human H3N2 influenza A viruses | Q30369536 | ||
| Progress in identifying virulence determinants of the 1918 H1N1 and the Southeast Asian H5N1 influenza A viruses. | Q30369896 | ||
| H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice. | Q30371122 | ||
| Host restriction of avian influenza viruses at the level of the ribonucleoproteins. | Q30371993 | ||
| Avian-to-human transmission of the PB1 gene of influenza A viruses in the 1957 and 1968 pandemics | Q30396327 | ||
| Interaction of polymerase subunit PB2 and NP with importin alpha1 is a determinant of host range of influenza A virus | Q33318082 | ||
| Analysis of the interaction of influenza virus polymerase complex with human cell factors | Q33336123 | ||
| Importance of both the coding and the segment-specific noncoding regions of the influenza A virus NS segment for its efficient incorporation into virions | Q33737596 | ||
| Rescue of influenza A virus from recombinant DNA. | Q33846053 | ||
| Large-scale isolation of Cajal bodies from HeLa cells | Q33960367 | ||
| Avian influenza (H5N1) viruses isolated from humans in Asia in 2004 exhibit increased virulence in mammals | Q33987458 | ||
| Lethal H5N1 influenza viruses escape host anti-viral cytokine responses | Q34146021 | ||
| Properties and dissemination of H5N1 viruses isolated during an influenza outbreak in migratory waterfowl in western China | Q34651554 | ||
| Investigating RNA polymerase II carboxyl-terminal domain (CTD) phosphorylation. | Q35544374 | ||
| Involvement of Hsp90 in assembly and nuclear import of influenza virus RNA polymerase subunits | Q35635186 | ||
| Molecular changes in the polymerase genes (PA and PB1) associated with high pathogenicity of H5N1 influenza virus in mallard ducks | Q35947765 | ||
| Biologic importance of neuraminidase stalk length in influenza A virus | Q36640894 | ||
| A single amino acid in the PB2 gene of influenza A virus is a determinant of host range. | Q36685680 | ||
| Limited compatibility between the RNA polymerase components of influenza virus type A and B. | Q36776218 | ||
| The avian influenza virus nucleoprotein gene and a specific constellation of avian and human virus polymerase genes each specify attenuation of avian-human influenza A/Pintail/79 reassortant viruses for monkeys | Q36918699 | ||
| Influenza virus susceptibility and resistance to oseltamivir. | Q36974609 | ||
| Compatibility among polymerase subunit proteins is a restricting factor in reassortment between equine H7N7 and human H3N2 influenza viruses | Q36974774 | ||
| Sabotage of antiviral signaling and effectors by influenza viruses | Q37247073 | ||
| A 48-amino-acid region of influenza A virus PB1 protein is sufficient for complex formation with PA. | Q38290017 | ||
| Molecular and antigenic evolution and geographical spread of H5N1 highly pathogenic avian influenza viruses in western Africa | Q38978988 | ||
| Residue 627 of PB2 is a determinant of cold sensitivity in RNA replication of avian influenza viruses. | Q39606273 | ||
| The PA subunit is required for efficient nuclear accumulation of the PB1 subunit of the influenza A virus RNA polymerase complex | Q39755896 | ||
| Maturation efficiency of viral glycoproteins in the ER impacts the production of influenza A virus | Q39972881 | ||
| Monoclonal antibodies against influenza virus PB2 and NP polypeptides interfere with the initiation step of viral mRNA synthesis in vitro | Q40042184 | ||
| Evidence that the C-terminal PB2-binding region of the influenza A virus PB1 protein is a discrete alpha-helical domain | Q40060750 | ||
| Differential polymerase activity in avian and mammalian cells determines host range of influenza virus | Q40120171 | ||
| Influenza virus infection causes specific degradation of the largest subunit of cellular RNA polymerase II. | Q40162019 | ||
| Host-range determinants on the PB2 protein of influenza A viruses control the interaction between the viral polymerase and nucleoprotein in human cells | Q40176000 | ||
| Cloning of the chicken RNA polymerase I promoter and use for reverse genetics of influenza A viruses in avian cells | Q40361564 | ||
| In vitro assembly of PB2 with a PB1-PA dimer supports a new model of assembly of influenza A virus polymerase subunits into a functional trimeric complex | Q40409573 | ||
| Association of the influenza A virus RNA-dependent RNA polymerase with cellular RNA polymerase II. | Q40435957 | ||
| The NS1 gene of H5N1 influenza viruses circumvents the host anti-viral cytokine responses | Q40533278 | ||
| PB2 amino acid at position 627 affects replicative efficiency, but not cell tropism, of Hong Kong H5N1 influenza A viruses in mice | Q40579478 | ||
| Differential effect of nucleotide substitutions in the 3' arm of the influenza A virus vRNA promoter on transcription/replication by avian and human polymerase complexes is related to the nature of PB2 amino acid 627. | Q40682495 | ||
| Fine mapping of the subunit binding sites of influenza virus RNA polymerase | Q40732397 | ||
| Apoptosis by influenza viruses correlates with efficiency of viral mRNA synthesis | Q40792812 | ||
| Molecular assembly of the influenza virus RNA polymerase: determination of the subunit-subunit contact sites | Q41171919 | ||
| Influenza: interspecies transmission and emergence of new pandemics | Q41624400 | ||
| NP, PB1, and PB2 viral genes contribute to altered replication of H5N1 avian influenza viruses in chickens. | Q43112417 | ||
| Polygenic virulence factors involved in pathogenesis of 1997 Hong Kong H5N1 influenza viruses in mice | Q43176186 | ||
| Highly pathogenic H5N1 influenza virus infection in migratory birds | Q43177302 | ||
| Studies on the temperature sensitivity of influenza A virus reassortants nonpathogenic for chicken | Q44160445 | ||
| Effects of single-point amino acid substitutions on the structure and function neuraminidase proteins in influenza A virus | Q45395685 | ||
| Host factor Ebp1: selective inhibitor of influenza virus transcriptase | Q45407323 | ||
| Influenza virus inhibits RNA polymerase II elongation | Q45417487 | ||
| Generation of recombinant influenza A virus without M2 ion-channel protein by introduction of a point mutation at the 5' end of the viral intron. | Q45481671 | ||
| Efficient formation of influenza virus-like particles: dependence on the expression levels of viral proteins | Q45748160 | ||
| Alterations of the stalk of the influenza virus neuraminidase: deletions and insertions | Q45777661 | ||
| Complex formation between influenza virus polymerase proteins expressed in Xenopus oocytes | Q45843373 | ||
| A single gene determines the host range of influenza virus | Q45890452 | ||
| Multiple mechanisms confining RNA polymerase II ubiquitylation to polymerases undergoing transcriptional arrest | Q46550839 | ||
| Genetic analysis of the compatibility between polymerase proteins from human and avian strains of influenza A viruses | Q47868208 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 5 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | avian influenza | Q43987 |
| P304 | page(s) | e5658 | |
| P577 | publication date | 2009-05-21 | |
| P1433 | published in | PLOS One | Q564954 |
| P1476 | title | Full factorial analysis of mammalian and avian influenza polymerase subunits suggests a role of an efficient polymerase for virus adaptation | |
| P478 | volume | 4 |
| Q30429987 | A statistical strategy to identify recombinant viral ribonucleoprotein of avian, human, and swine influenza A viruses with elevated polymerase activity |
| Q27005668 | Adaptive pathways of zoonotic influenza viruses: From exposure to establishment in humans |
| Q36164324 | Aging and Loss of Circulating 17β-Estradiol Alters the Alternative Splicing of ERβ in the Female Rat Brain |
| Q47553044 | Amino acid substitutions affecting aspartic acid 605 and valine 606 decrease the interaction strength between the influenza virus RNA polymerase PB2 '627' domain and the viral nucleoprotein |
| Q34261973 | Amino acid substitutions in PB1 of avian influenza viruses influence pathogenicity and transmissibility in chickens |
| Q40044602 | Characterization of influenza A viruses with polymorphism in PB2 residues 701 and 702. |
| Q34756478 | DNA intercalator stimulates influenza transcription and virus replication |
| Q36276551 | Entry of influenza A Virus with a α2,6-linked sialic acid binding preference requires host fibronectin |
| Q38335874 | Genetic Adaptation of Influenza A Viruses in Domestic Animals and Their Potential Role in Interspecies Transmission: A Literature Review |
| Q33677723 | Genetic content of Influenza H3N2 vaccine seeds |
| Q38330022 | Human annexin A6 interacts with influenza a virus protein M2 and negatively modulates infection. |
| Q36089952 | Identification of combinatorial host-specific signatures with a potential to affect host adaptation in influenza A H1N1 and H3N2 subtypes. |
| Q49358466 | Identification of influenza polymerase inhibitors targeting C-terminal domain of PA through surface plasmon resonance screening |
| Q34564391 | Identification of novel conserved functional motifs across most Influenza A viral strains |
| Q34615966 | Influenza A viruses with different amino acid residues at PB2-627 display distinct replication properties in vitro and in vivo: revealing the sequence plasticity of PB2-627 position |
| Q34263308 | Influenza polymerase activity correlates with the strength of interaction between nucleoprotein and PB2 through the host-specific residue K/E627. |
| Q38444279 | Influenza virus polymerase: Functions on host range, inhibition of cellular response to infection and pathogenicity. |
| Q30398740 | Nationwide molecular surveillance of pandemic H1N1 influenza A virus genomes: Canada, 2009. |
| Q30402549 | PA residues in the 2009 H1N1 pandemic influenza virus enhance avian influenza virus polymerase activity in mammalian cells |
| Q30385995 | PB2 residue 271 plays a key role in enhanced polymerase activity of influenza A viruses in mammalian host cells. |
| Q30388799 | Postreassortment amino acid substitutions in influenza A viruses |
| Q30369947 | Predicting host tropism of influenza A virus proteins using random forest. |
| Q30382876 | Recombinant influenza virus with a pandemic H2N2 polymerase complex has a higher adaptive potential than one with seasonal H2N2 polymerase complex. |
| Q30431677 | Replication and Transcription Activities of Ribonucleoprotein Complexes Reconstituted from Avian H5N1, H1N1pdm09 and H3N2 Influenza A Viruses |
| Q45358659 | Small Variations Between Species/Subtypes Attributed to Reassortment Evidenced from Polymerase Basic Protein 1 with Other Seven Proteins from Influenza A Virus |
| Q27678470 | Structural Basis for RNA Binding and Homo-Oligomer Formation by Influenza B Virus Nucleoprotein |
| Q30354127 | Switch from protective to adverse inflammation during influenza: viral determinants and hemostasis are caught as culprits. |
| Q30417293 | The 2009 Pandemic Influenza Virus: Where Did It Come from, Where Is It Now, and Where Is It Going? |
| Q30413814 | The RNA Polymerase PB2 Subunit of Influenza A/HongKong/156/1997 (H5N1) Restrict the Replication of Reassortant Ribonucleoprotein Complexes |
| Q30371201 | The avian-origin PB1 gene segment facilitated replication and transmissibility of the H3N2/1968 pandemic influenza virus. |
| Q30403251 | The influenza pandemic of 2009: lessons and implications |
| Q37640854 | Toll-like receptor 10 is involved in induction of innate immune responses to influenza virus infection |
| Q30353598 | Virus-specific factors associated with zoonotic and pandemic potential. |
| Q38364349 | hCLE/C14orf166, a cellular protein required for viral replication, is incorporated into influenza virus particles. |
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