MEKK4 Signaling Regulates Sensory Cell Development and Function in the Mouse Inner Ear.

scientific article

MEKK4 Signaling Regulates Sensory Cell Development and Function in the Mouse Inner Ear. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.1853-15.2016
P932PMC publication ID4728730
P698PubMed publication ID26818521

P50authorSaima RiazuddinQ87170801
Chandrakala PuligillaQ87170803
P2093author name stringHong-Wei Zheng
Su-Hua Sha
Khujista Haque
Atul K Pandey
P2860cites workMEKK4 is an effector of the embryonic TRAF4 for JNK activationQ24322922
Planar cell polarity links axes of spatial dynamics in neural-tube closureQ24336656
Fgf10 is required for specification of non-sensory regions of the cochlear epithelium.Q27302948
Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitorsQ27737008
Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signalQ28118955
Trophoblast stem cell maintenance by fibroblast growth factor 4 requires MEKK4 activation of Jun N-terminal kinaseQ28505246
Canal cristae growth and fiber extension to the outer hair cells of the mouse ear require Prox1 activityQ28505263
Wnt5a functions in planar cell polarity regulation in miceQ28505898
FGF/FGFR-2(IIIb) signaling is essential for inner ear morphogenesisQ28506828
Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of CortiQ28507372
Loss of Fgfr3 leads to excess hair cell development in the mouse organ of CortiQ28508562
Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathwayQ28509023
The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determinationQ28510708
Disruption of fibroblast growth factor receptor 3 signaling results in defects in cellular differentiation, neuronal patterning, and hearing impairmentQ28511525
Sprouty2, a mouse deafness gene, regulates cell fate decisions in the auditory sensory epithelium by antagonizing FGF signalingQ28513138
FGFR1 is required for the development of the auditory sensory epitheliumQ28513526
Math1: an essential gene for the generation of inner ear hair cellsQ28513764
Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell developmentQ28513897
p27(Kip1) links cell proliferation to morphogenesis in the developing organ of CortiQ28585281
Sox2 is required for sensory organ development in the mammalian inner earQ28585583
Fgf3 and Fgf10 are required for mouse otic placode inductionQ28585848
Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulationQ28587130
Fgf20 is required for sensory epithelial specification in the developing cochleaQ28592558
Identification of Vangl2 and Scrb1 as planar polarity genes in mammalsQ28593071
Fibroblast growth factor signaling regulates pillar cell development in the organ of cortiQ28594385
MAP kinasesQ28679111
Shaping sound in space: the regulation of inner ear patterningQ28741138
The molecular basis of making spiral ganglion neurons and connecting them to hair cells of the organ of CortiQ28742834
Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functionsQ29547189
Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammationQ29614227
Dishevelled controls cell polarity during Xenopus gastrulationQ29619295
Expression of activated MAP kinase in Xenopus laevis embryos: evaluating the roles of FGF and other signaling pathways in early induction and patterningQ30306433
Cochlear progenitor number is controlled through mesenchymal FGF receptor signalingQ30411351
Molecular regulation of auditory hair cell death and approaches to protect sensory receptor cells and/or stimulate repair following acoustic traumaQ30414386
Expression of LHX3 and SOX2 during mouse inner ear developmentQ30480292
Organization and regulation of mitogen-activated protein kinase signaling pathwaysQ33333640
Generation and characterization of Atoh1-Cre knock-in mouse lineQ33912847
Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development.Q33928666
Ablation of MEKK4 kinase activity causes neurulation and skeletal patterning defects in the mouse embryo.Q34097247
Expression patterns of FGF receptors in the developing mammalian cochlea.Q34104286
A novel Atoh1 "self-terminating" mouse model reveals the necessity of proper Atoh1 level and duration for hair cell differentiation and viabilityQ34141795
Analysis of FGF-dependent and FGF-independent pathways in otic placode inductionQ34565185
MAP3Ks as central regulators of cell fate during developmentQ34853182
Opportunities and limits of the one gene approach: the ability of Atoh1 to differentiate and maintain hair cells depends on the molecular contextQ35053199
Culture of embryonic mouse cochlear explants and gene transfer by electroporationQ35161901
MEKK4 signaling regulates filamin expression and neuronal migration.Q35809506
The MAPK/JNK signalling pathway offers potential therapeutic targets for the prevention of acquired deafnessQ35892679
How does Fgf signaling from the isthmic organizer induce midbrain and cerebellum development?Q35989462
Patterning of the mammalian cochleaQ36208996
Mutant mice reveal the molecular and cellular basis for specific sensory connections to inner ear epithelia and primary nuclei of the brainQ36218694
Planar cell polarity, ciliogenesis and neural tube defectsQ36599301
The Atoh1-lineage gives rise to hair cells and supporting cells within the mammalian cochlea.Q36838607
Expression and functions of FGF ligands during early otic development.Q36950101
Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochleaQ36984946
Trouble making the first move: interpreting arrested neuronal migration in the cerebral cortexQ37059375
Myosin II regulates extension, growth and patterning in the mammalian cochlear duct.Q37200935
Disruption of neural progenitors along the ventricular and subventricular zones in periventricular heterotopiaQ37292838
Control of stemness by fibroblast growth factor signaling in stem cells and cancer stem cellsQ37370536
FGFR1-Frs2/3 signalling maintains sensory progenitors during inner ear hair cell formation.Q37509595
Expression and function of FGF10 in mammalian inner ear developmentQ37524712
Early steps in inner ear development: induction and morphogenesis of the otic placodeQ38365010
Inhibition of the c-Jun N-terminal kinase signaling pathway influences neurite outgrowth of spiral ganglion neurons in vitroQ40621038
Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner earsQ41736617
Compensatory regulation of the size of the inner ear in response to excess induction of otic progenitors by fibroblast growth factor signalingQ41955252
Activity of all JNK isoforms contributes to neurite growth in spiral ganglion neurons.Q42145446
Fgf-signaling-dependent Sox9a and Atoh1a regulate otic neural development in zebrafishQ46789416
Cellular growth and rearrangement during the development of the mammalian organ of CortiQ47887091
Calbindin and S100 protein expression in the developing inner ear in mice.Q51813358
Fgf8 induces pillar cell fate and regulates cellular patterning in the mammalian cochlea.Q51980744
A morphogenetic wave of p27Kip1 transcription directs cell cycle exit during organ of Corti development.Q52014319
Localization of MAP Kinase Activity in EarlyXenopusEmbryos: Implications for Endogenous FGF SignalingQ60488632
The TAO of MEKKQ77574581
MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3betaQ80860090
P4510describes a project that usesImageJQ1659584
ImageQuantQ112270642
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)1347-1361
P577publication date2016-01-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleMEKK4 Signaling Regulates Sensory Cell Development and Function in the Mouse Inner Ear
P478volume36

Reverse relations

cites work (P2860)
Q38669117An Atoh1-S193A phospho-mutant allele causes hearing deficits and motor impairment
Q96122083Analysis of FGF20-regulated genes in organ of Corti progenitors by translating ribosome affinity purification
Q90191234Enhancer activation by FGF signalling during otic induction
Q98180791FGF20-FGFR1 signaling through MAPK and PI3K controls sensory progenitor differentiation in the organ of Corti
Q91650414Sox2 and FGF20 interact to regulate organ of Corti hair cell and supporting cell development in a spatially-graded manner
Q38826161The role of post-translational modifications in hearing and deafness