A tale of the epidermal growth factor receptor: The quest for structural resolution on cells.

scientific article

A tale of the epidermal growth factor receptor: The quest for structural resolution on cells. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YMETH.2015.10.009
P8608Fatcat IDrelease_yvwt57h4hjhdpkpp3o363r5phy
P698PubMed publication ID26484734

P50authorMichael HirschQ42831017
David T ClarkeQ43977306
Laura C Zanetti-DominguesQ56424620
Sarah R NeedhamQ56424622
Christopher TynanQ58002114
Marisa L Martin-FernandezQ58313886
Daniel J RolfeQ58313893
Dimitrios KorovesisQ88654514
P2093author name stringSelene K Roberts
Valentina Lo Schiavo
P2860cites workAn allosteric mechanism for activation of the kinase domain of epidermal growth factor receptorQ24293598
EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerizationQ24296900
Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alphaQ24307630
Crystal structure of the complex of human epidermal growth factor and receptor extracellular domainsQ24307661
Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segmentQ24309071
Conformational coupling across the plasma membrane in activation of the EGF receptorQ24313122
The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signalingQ24337017
Mobility measurement by analysis of fluorescence photobleaching recovery kineticsQ24536888
Cell signaling by receptor tyrosine kinasesQ24598357
Energy transfer: a spectroscopic rulerQ24618609
Impact of epidermal growth factor receptor and KRAS mutations on clinical outcomes in previously untreated non-small cell lung cancer patients: results of an online tumor registry of clinical trialsQ24625201
The epidermal growth factor receptor variant III (EGFRvIII): where wild things are alteredQ27015045
ADVANCED IMAGING. Extended-resolution structured illumination imaging of endocytic and cytoskeletal dynamicsQ27330874
Structural Basis for Negative Cooperativity in Growth Factor Binding to an EGF ReceptorQ27664092
EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapyQ27824812
Imaging intracellular fluorescent proteins at nanometer resolutionQ27860767
Untangling the ErbB signalling networkQ27860884
Detection and enumeration of transformation-defective strains of avian sarcoma virus with molecular hybridizationQ28303841
A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signalingQ28609913
Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factorQ29616395
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cellsQ29616544
Protein-tyrosine kinasesQ29616546
Mapping the number of molecules and brightness in the laser scanning microscopeQ30441376
Single-molecule imaging and fluorescence lifetime imaging microscopy show different structures for high- and low-affinity epidermal growth factor receptors in A431 cells.Q30481027
Multidimensional single-molecule imaging in live cells using total-internal-reflection fluorescence microscopy.Q33247722
Simultaneous widefield single molecule orientation and FRET microscopy in cells.Q33390956
Activated type I phosphatidylinositol kinase is associated with the epidermal growth factor (EGF) receptor following EGF stimulationQ33587507
Nanoscale imaging of epidermal growth factor receptor clustering: effects of inhibitorsQ33661563
Ligand-induced EGF Receptor Oligomerization Is Kinase-dependent and Enhances InternalizationQ39645178
Spatial control of EGF receptor activation by reversible dimerization on living cellsQ39731307
All EGF(ErbB) receptors have preformed homo- and heterodimeric structures in living cells.Q39941394
Preformed oligomeric epidermal growth factor receptors undergo an ectodomain structure change during signalingQ40205920
Local aggregation of hormone–receptor complexes is required for activation by epidermal growth factorQ40226398
Ligand-induced dimer-tetramer transition during the activation of the cell surface epidermal growth factor receptor-A multidimensional microscopy analysisQ40402524
The extracellular domain of the epidermal growth factor receptor. Studies on the affinity and stoichiometry of binding, receptor dimerization and a binding-domain mutantQ41438473
Signal transduction by epidermal growth factor occurs through the subclass of high affinity receptorsQ41590853
Human epidermal growth factor receptor (EGFR) aligned on the plasma membrane adopts key features of Drosophila EGFR asymmetryQ41840132
Regulation of EGFR nanocluster formation by ionic protein-lipid interactionQ42125053
Simultaneous multiple-emitter fitting for single molecule super-resolution imagingQ42726690
Cholesterol levels modulate EGF receptor-mediated signaling by altering receptor function and traffickingQ42811685
Epidermal growth factor stimulates guanine nucleotide binding activity and phosphorylation of ras oncogene proteinsQ42818380
EGFR: tale of the C-terminal tailQ43080915
Ectodomain orientation, conformational plasticity and oligomerization of ErbB1 receptors investigated by molecular dynamics.Q46030232
The ERBB network: at last, cancer therapy meets systems biology.Q54498075
EGFR signaling patterns are regulated by its different ligands.Q55070997
Zwischenmolekulare Energiewanderung und FluoreszenzQ55953948
Nanoscale Organization of the Pathogen Receptor DC-SIGN Mapped by Single-Molecule High-Resolution Fluorescence MicroscopyQ57351025
A chimaeric receptor allows insulin to stimulate tyrosine kinase activity of epidermal growth factor receptorQ59097020
Real-time measurements of kinetics of EGF binding to soluble EGF receptor monomers and dimers support the dimerization model for receptor activationQ72871521
Secondary dimerization between members of the epidermal growth factor receptor familyQ73257880
Image analysis using enhanced spatial correlation functionsQ82794355
Two EGF molecules contribute additively to stabilization of the EGFR dimerQ33885990
Single-molecule imaging of EGFR signalling on the surface of living cellsQ33892648
Quantitative imaging of lateral ErbB1 receptor signal propagation in the plasma membraneQ33926102
Simultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptorQ33981031
Epidermal growth factor receptor activation remodels the plasma membrane lipid environment to induce nanocluster formationQ34045664
Epidermal growth factor receptors are localized to lipid rafts that contain a balance of inner and outer leaflet lipids: a shotgun lipidomics studyQ34099067
Distribution of resting and ligand-bound ErbB1 and ErbB2 receptor tyrosine kinases in living cells using number and brightness analysisQ34151773
Autophosphorylation sites on the epidermal growth factor receptor.Q34245370
Interhead distance measurements in myosin VI via SHRImP support a simplified hand-over-hand modelQ34350508
When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signallingQ34360923
On the nature of low- and high-affinity EGF receptors on living cellsQ34595942
Complex relationship between ligand binding and dimerization in the epidermal growth factor receptorQ34625617
Measuring EGFR separations on cells with ~10 nm resolution via fluorophore localization imaging with photobleaching.Q34708360
ErbB1 dimerization is promoted by domain co-confinement and stabilized by ligand bindingQ35534115
Toward fluorescence nanoscopyQ35574520
Nanometric molecular separation measurements by single molecule photobleaching.Q35633267
The tethered configuration of the EGF receptor extracellular domain exerts only a limited control of receptor functionQ35729931
A structure-based model for ligand binding and dimerization of EGF receptorsQ35730035
Ligand regulation of a constitutively dimeric EGF receptorQ35733874
Oligomerization of the EGF receptor investigated by live cell fluorescence intensity distribution analysisQ35878699
Oncogenic kinase signaling in human neoplasmsQ36009176
Heterogeneity in EGF-binding affinities arises from negative cooperativity in an aggregating systemQ36423352
Oligomerization of epidermal growth factor receptors on A431 cells studied by time-resolved fluorescence imaging microscopy. A stereochemical model for tyrosine kinase receptor activationQ36535729
Architecture and membrane interactions of the EGF receptorQ36923502
Exploring higher-order EGFR oligomerisation and phosphorylation--a combined experimental and theoretical approachQ36974435
Direct analysis of the binding of Src-homology 2 domains of phospholipase C to the activated epidermal growth factor receptorQ37244088
Quantitative proteomics and phosphoproteomics reveal novel insights into complexity and dynamics of the EGFR signaling network.Q37291100
Nanometer-localized multiple single-molecule fluorescence microscopyQ37388631
The spatiotemporal organization of ErbB receptors: insights from microscopyQ37615173
Functional proteomics to dissect tyrosine kinase signalling pathways in cancerQ37780948
Structure-function relationships and supramolecular organization of the EGFR (epidermal growth factor receptor) on the cell surface.Q38180767
The EGFR family: not so prototypical receptor tyrosine kinasesQ38201344
Signal transduction in cancerQ38400912
P304page(s)86-93
P577publication date2015-10-17
P1433published inMethodsQ6823859
P1476titleA tale of the epidermal growth factor receptor: The quest for structural resolution on cells.
P478volume95

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cites work (P2860)
Q47256792A molecular engineering toolbox for the structural biologist
Q26752808Confocal Spectroscopy to Study Dimerization, Oligomerization and Aggregation of Proteins: A Practical Guide
Q92028006EGF Receptor Stalls upon Activation as Evidenced by Complementary Fluorescence Correlation Spectroscopy and Fluorescence Recovery after Photobleaching Measurements
Q90886378Epidermal growth factor receptor: Structure-function informing the design of anticancer therapeutics
Q51578947Methods in integrated structural biology.
Q39434922Role Played by Signalling Pathways in Overcoming BRAF Inhibitor Resistance in Melanoma
Q92934599Structure and Dynamics of the EGF Receptor as Revealed by Experiments and Simulations and Its Relevance to Non-Small Cell Lung Cancer
Q47699567Subdomain 2, Not the Transmembrane Domain, Determines the Dimerization Partner of Growth Hormone Receptor and Prolactin Receptor

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