CD69 expression potentially predicts response to bendamustine and its modulation by ibrutinib or idelalisib enhances cytotoxic effect in chronic lymphocytic leukemia.

scientific article

CD69 expression potentially predicts response to bendamustine and its modulation by ibrutinib or idelalisib enhances cytotoxic effect in chronic lymphocytic leukemia. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.18632/ONCOTARGET.6685
P8608Fatcat IDrelease_amxfl35xkvcafhvjc3ou7k2vbi
P932PMC publication ID4868702
P698PubMed publication ID26701728
P5875ResearchGate publication ID288000802

P50authorElías CampoQ5830202
Dolors ColomerQ43096016
Gaël RouéQ48337597
Sílvia Xargay-TorrentQ55445112
Guillem ClotQ55445114
Marta AymerichQ60651570
Marçal Pastor-AngladaQ85787121
P2093author name stringLaia Rosich
Magda Pinyol
Armando López-Guillermo
Patricia Pérez-Galán
Arnau Montraveta
Mónica López-Guerra
Neus Villamor
Laura Jiménez
Jocabed Roldán
Eriong Lee-Vergés
Sandra Cabezas
Cristina Arimany-Nardí
P2860cites workPharmacokinetic and pharmacodynamic profile of bendamustine and its metabolitesQ27011795
Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemiaQ28255147
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemiaQ29614659
The splicing modulator sudemycin induces a specific antitumor response and cooperates with ibrutinib in chronic lymphocytic leukemia.Q30395427
Bendamustine combined with rituximab in patients with relapsed and/or refractory chronic lymphocytic leukemia: a multicenter phase II trial of the German Chronic Lymphocytic Leukemia Study GroupQ33396737
Bendamustine in combination with rituximab for previously untreated patients with chronic lymphocytic leukemia: a multicenter phase II trial of the German Chronic Lymphocytic Leukemia Study GroupQ33402713
A phase 1/1b study of rituximab, bendamustine, and ibrutinib in patients with untreated and relapsed/refractory non-Hodgkin lymphomaQ33418456
Ibrutinib inhibits BCR and NF-κB signaling and reduces tumor proliferation in tissue-resident cells of patients with CLLQ33714712
CD69 and regulation of the immune functionQ33721814
Evaluation of bendamustine in combination with fludarabine in primary chronic lymphocytic leukemia cellsQ33749652
SF3B1 and other novel cancer genes in chronic lymphocytic leukemiaQ34093678
Bendamustine: mechanism of action and clinical data.Q34169315
Entering the era of targeted therapy for chronic lymphocytic leukemia: impact on the practicing clinician.Q34172063
The lymph node microenvironment promotes B-cell receptor signaling, NF-κB activation, and tumor proliferation in chronic lymphocytic leukemiaQ34542102
Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents.Q34586659
Bendamustine is effective in p53-deficient B-cell neoplasms and requires oxidative stress and caspase-independent signalingQ34599670
The role of phosphatidylinositol 3-kinase-δ in the immunomodulatory effects of lenalidomide in chronic lymphocytic leukemiaQ34923824
The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applicationsQ35029409
CD69 is the crucial regulator of intestinal inflammation: a new target molecule for IBD treatment?Q35155979
Obinutuzumab plus fludarabine/cyclophosphamide or bendamustine in the initial therapy of CLL patients: the phase 1b GALTON trialQ35560022
The Bruton tyrosine kinase inhibitor ibrutinib with chemoimmunotherapy in patients with chronic lymphocytic leukemia.Q35583403
CD69 is independently prognostic in chronic lymphocytic leukemia: a comprehensive clinical and biological profiling study.Q35717883
Co-culture of primary CLL cells with bone marrow mesenchymal cells, CD40 ligand and CpG ODN promotes proliferation of chemoresistant CLL cells phenotypically comparable to those proliferating in vivoQ35781372
Pharmacological and Protein Profiling Suggests Venetoclax (ABT-199) as Optimal Partner with Ibrutinib in Chronic Lymphocytic LeukemiaQ35958056
Initial treatment of CLL: integrating biology and functional statusQ36219647
Molecular pathogenesis of chronic lymphocytic leukemiaQ36290321
Demographics, treatment patterns, safety, and real-world effectiveness in patients aged 70 years and over with chronic lymphocytic leukemia receiving bendamustine with or without rituximab: a retrospective studyQ36883352
Chronic lymphocytic leukemia: molecular heterogeneity revealed by high-throughput genomicsQ36998431
From pathogenesis to treatment of chronic lymphocytic leukaemiaQ37643423
Update on therapy of chronic lymphocytic leukemiaQ37659071
Synergistic anti-tumor activity of acadesine (AICAR) in combination with the anti-CD20 monoclonal antibody rituximab in in vivo and in vitro models of mantle cell lymphomaQ37718466
Mechanism of action: the unique pattern of bendamustine-induced cytotoxicityQ37870438
Human organic cation transporter 1 (hOCT1) as a mediator of bendamustine uptake and cytotoxicity in chronic lymphocytic leukemia (CLL) cellsQ38920650
The HELIOS trial protocol: a phase III study of ibrutinib in combination with bendamustine and rituximab in relapsed/refractory chronic lymphocytic leukemiaQ39180275
Mimicking the tumour microenvironment: three different co-culture systems induce a similar phenotype but distinct proliferative signals in primary chronic lymphocytic leukaemia cellsQ39328617
Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistanceQ39798268
Ibrutinib antagonizes rituximab-dependent NK cell-mediated cytotoxicityQ42401591
Bendamustine in combination with ofatumumab in relapsed or refractory chronic lymphocytic leukemia: a GIMEMA Multicenter Phase II Trial.Q42627572
The γ-secretase inhibitor PF-03084014 combined with fludarabine antagonizes migration, invasion and angiogenesis in NOTCH1-mutated CLL cellsQ42705821
The phosphatidylinositol-3-kinase inhibitor NVP-BKM120 overcomes resistance signals derived from microenvironment by regulating the Akt/FoxO3a/Bim axis in chronic lymphocytic leukemia cellsQ42924738
In vitro evaluation of bendamustine induced apoptosis in B-chronic lymphocytic leukemiaQ44161643
Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1.Q46044632
Gene expression signatures separate B-cell chronic lymphocytic leukaemia prognostic subgroups defined by ZAP-70 and CD38 expression status.Q51979921
Highly purified CD38+ and CD38- sub-clones derived from the same chronic lymphocytic leukemia patient have distinct gene expression signatures despite their monoclonal origin.Q53578680
Renal human organic anion transporter 3 increases the susceptibility of lymphoma cells to bendamustine uptake.Q53670141
Sorafenib targets BCR kinases and blocks migratory and microenvironmental survival signals in CLL cells.Q54333325
Bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukaemia: updated results of a randomized phase III trial.Q55056539
Non-coding recurrent mutations in chronic lymphocytic leukaemiaQ56996904
ERIC recommendations on IGHV gene mutational status analysis in chronic lymphocytic leukemiaQ58042037
The CD69 receptor: a multipurpose cell-surface trigger for hematopoietic cellsQ72768300
CD69 expression in B-cell chronic lymphocytic leukemia: a new prognostic marker ?Q74452999
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectbendamustineQ425745
lymphocyteQ715347
ibrutinibQ5984881
P304page(s)5507-5520
P577publication date2016-02-01
P1433published inOncotargetQ1573155
P1476titleCD69 expression potentially predicts response to bendamustine and its modulation by ibrutinib or idelalisib enhances cytotoxic effect in chronic lymphocytic leukemia
P478volume7

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cites work (P2860)
Q37725415Idelalisib and bendamustine combination is synergistic and increases DNA damage response in chronic lymphocytic leukemia cells
Q90633546Transcriptional Modulation by Idelalisib Synergizes with Bendamustine in Chronic Lymphocytic Leukemia

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