Hepatitis C virus cell entry: a target for novel antiviral strategies to address limitations of direct acting antivirals.

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Hepatitis C virus cell entry: a target for novel antiviral strategies to address limitations of direct acting antivirals. is …
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P6179Dimensions Publication ID1017794478
P356DOI10.1007/S12072-016-9724-7
P698PubMed publication ID27048616
P5875ResearchGate publication ID299943488

P50authorThomas F BaumertQ88786090
Che C ColpittsQ42320812
P2860cites workHepatitis C virus cell-cell transmission in hepatoma cells in the presence of neutralizing antibodiesQ43041465
Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challengeQ43048336
Association between sustained virological response and all-cause mortality among patients with chronic hepatitis C and advanced hepatic fibrosis.Q53118691
Hepatitis C and liver transplantationQ59098576
A mechanistic paradigm for broad-spectrum antivirals that target virus-cell fusionQ21089597
Binding of hepatitis C virus to CD81Q22004178
The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virusQ24307963
Interferon-Free Hepatitis C Treatment before and after Liver Transplantation: The Role of HCV Drug ResistanceQ26781331
Identification of a novel drug lead that inhibits HCV infection and cell-to-cell transmission by targeting the HCV E2 glycoproteinQ27333881
Monoclonal Antibody AP33 Defines a Broadly Neutralizing Epitope on the Hepatitis C Virus E2 Envelope GlycoproteinQ27470798
Different Domains of CD81 Mediate Distinct Stages of Hepatitis C Virus Pseudoparticle EntryQ27473222
Viral and Cellular Determinants of the Hepatitis C Virus Envelope-Heparan Sulfate InteractionQ27477606
Sulfated Homologues of Heparin Inhibit Hepatitis C Virus Entry into Mammalian CellsQ27478383
Human Apolipoprotein E Is Required for Infectivity and Production of Hepatitis C Virus in Cell CultureQ27485012
Identification of a Broadly Cross-Reacting and Neutralizing Human Monoclonal Antibody Directed against the Hepatitis C Virus E2 ProteinQ27485318
Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptorQ27485871
CD81 Is a Central Regulator of Cellular Events Required for Hepatitis C Virus Infection of Human HepatocytesQ27486789
Identification of a Residue in Hepatitis C Virus E2 Glycoprotein That Determines Scavenger Receptor BI and CD81 Receptor Dependency and Sensitivity to Neutralizing AntibodiesQ27487399
The Tight Junction-Associated Protein Occludin Is Required for a Postbinding Step in Hepatitis C Virus Entry and InfectionQ27488990
Human occludin is a hepatitis C virus entry factor required for infection of mouse cellsQ27490169
Apolipoprotein E on hepatitis C virion facilitates infection through interaction with low-density lipoprotein receptorQ27490234
Role of Scavenger Receptor Class B Type I in Hepatitis C Virus Entry: Kinetics and Molecular DeterminantsQ27490535
A broad-spectrum antiviral targeting entry of enveloped virusesQ27491286
Hepatitis C Virus E2 Envelope Glycoprotein Core StructureQ27680704
Structure of the core ectodomain of the hepatitis C virus envelope glycoprotein 2Q27681839
Genetic organization and diversity of the hepatitis C virusQ27860507
CD81 is dispensable for hepatitis C virus cell-to-cell transmission in hepatoma cellsQ28114859
Claudin-1 is a hepatitis C virus co-receptor required for a late step in entryQ28131832
A Novel Small Molecule Inhibitor of Hepatitis C Virus EntryQ28475468
Hepatitis C virus cell-cell transmission and resistance to direct-acting antiviral agentsQ28538891
Claudin association with CD81 defines hepatitis C virus entry.Q29465808
Hepatitis C virus induces CD81 and claudin-1 endocytosisQ30512696
Different requirements for scavenger receptor class B type I in hepatitis C virus cell-free versus cell-to-cell transmissionQ30541733
A peptide derived from hepatitis C virus E2 envelope protein inhibits a post-binding step in HCV entryQ33531362
Viral entry and escape from antibody-mediated neutralization influence hepatitis C virus reinfection in liver transplantationQ34096483
A human claudin-1-derived peptide inhibits hepatitis C virus entryQ34179353
Polyunsaturated liposomes are antiviral against hepatitis B and C viruses and HIV by decreasing cholesterol levels in infected cellsQ34182524
Rigid amphipathic fusion inhibitors, small molecule antiviral compounds against enveloped virusesQ34182763
Novel human SR-BI antibodies prevent infection and dissemination of HCV in vitro and in humanized mice.Q34194575
Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factorQ34245963
Development of oleanane-type triterpenes as a new class of HCV entry inhibitorsQ34344013
Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection.Q34470890
Different anti-HCV profiles of statins and their potential for combination therapy with interferonQ34541863
Phenothiazines inhibit hepatitis C virus entry, likely by increasing the fluidity of cholesterol-rich membranesQ34636137
Silibinin inhibits hepatitis C virus entry into hepatocytes by hindering clathrin-dependent traffickingQ34652154
In vivo evaluation of the cross-genotype neutralizing activity of polyclonal antibodies against hepatitis C virusQ34816677
Hepatitis C virus receptors claudin-1 and occludin after liver transplantation and influence on early viral kinetics.Q34860505
Synergy of entry inhibitors with direct-acting antivirals uncovers novel combinations for prevention and treatment of hepatitis C.Q35135565
Syndecan 4 is involved in mediating HCV entry through interaction with lipoviral particle-associated apolipoprotein EQ35153978
Characterization of hepatitis C virus interaction with heparan sulfate proteoglycansQ35488198
Anti-CD81 antibodies can prevent a hepatitis C virus infection in vivoQ39912694
Scavenger receptor class B type I is a key host factor for hepatitis C virus infection required for an entry step closely linked to CD81.Q40052203
Polyclonal immunoglobulins from a chronic hepatitis C virus patient protect human liver-chimeric mice from infection with a homologous hepatitis C virus strainQ40096322
The roles of CD81 and glycosaminoglycans in the adsorption and uptake of infectious HCV particlesQ40141383
Human apolipoprotein E peptides inhibit hepatitis C virus entry by blocking virus bindingQ40296319
Hepatitis C virus glycoproteins mediate low pH-dependent membrane fusion with liposomesQ40364883
Sofosbuvir and Velpatasvir for HCV in Patients with Decompensated CirrhosisQ40908899
Low density lipoprotein receptor as a candidate receptor for hepatitis C virusQ40972546
Modeling Suggests a Mechanism of Synergy Between Hepatitis C Virus Entry Inhibitors and Drugs of Other ClassesQ40994676
Targeting a host-cell entry factor barricades antiviral-resistant HCV variants from on-therapy breakthrough in human-liver miceQ41033867
Limonium sinense and gallic acid suppress hepatitis C virus infection by blocking early viral entryQ41086265
A small molecule inhibits virion attachment to heparan sulfate- or sialic acid-containing glycansQ42220929
Curing chronic hepatitis C--the arc of a medical triumphQ42225548
HRas signal transduction promotes hepatitis C virus cell entry by triggering assembly of the host tetraspanin receptor complex.Q42990165
Monoclonal anti-claudin 1 antibodies prevent hepatitis C virus infection of primary human hepatocytesQ42999009
The low-density lipoprotein receptor plays a role in the infection of primary human hepatocytes by hepatitis C virus.Q43034249
Monoclonal antibodies against extracellular domains of claudin-1 block hepatitis C virus infection in a mouse modelQ35488854
Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibodyQ35602284
A human monoclonal antibody targeting scavenger receptor class B type I precludes hepatitis C virus infection and viral spread in vitro and in vivoQ35685409
Tannic Acid Inhibits Hepatitis C Virus Entry into Huh7.5 CellsQ35695028
Flunarizine prevents hepatitis C virus membrane fusion in a genotype-dependent manner by targeting the potential fusion peptide within E1.Q35739094
Novel human anti-claudin 1 mAbs inhibit hepatitis C virus infection and may synergize with anti-SRB1 mAb.Q35828072
Broad-spectrum antivirals against viral fusionQ36010083
Pim Kinase Interacts with Nonstructural 5A Protein and Regulates Hepatitis C Virus Entry.Q36080785
Identification of transferrin receptor 1 as a hepatitis C virus entry factorQ36967731
Global control of hepatitis C: where challenge meets opportunityQ37077112
EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapyQ37609988
Mutations that alter use of hepatitis C virus cell entry factors mediate escape from neutralizing antibodiesQ37629584
Scavenger receptor class B type I and the hypervariable region-1 of hepatitis C virus in cell entry and neutralisation.Q37864742
Entry inhibitors and future treatment of hepatitis C.Q38187814
Cellular binding of hepatitis C virus envelope glycoprotein E2 requires cell surface heparan sulfateQ38352468
Treatment of hepatitis C in difficult-to-treat patientsQ38431523
HCV targeting of patients with cirrhosisQ38534820
Quantitative Proteomics Identifies Serum Response Factor Binding Protein 1 as a Host Factor for Hepatitis C Virus EntryQ38849121
Polyphenols Inhibit Hepatitis C Virus Entry by a New Mechanism of ActionQ38850319
Discovery of anti-claudin-1 antibodies as candidate therapeutics against hepatitis C virusQ38915788
Saikosaponin b2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entryQ38934862
Targeting Viral Entry for Treatment of Hepatitis B and C Virus InfectionsQ38951860
Benzhydrylpiperazine compounds inhibit cholesterol-dependent cellular entry of hepatitis C virusQ38975650
Cell death-inducing DFFA-like effector b is required for hepatitis C virus entry into hepatocytesQ38994889
Apolipoprotein E codetermines tissue tropism of hepatitis C virus and is crucial for viral cell-to-cell transmission by contributing to a postenvelopment step of assemblyQ39068693
A small-molecule inhibitor of hepatitis C virus infectivityQ39069509
Arbidol inhibits viral entry by interfering with clathrin-dependent traffickingQ39104403
Turmeric curcumin inhibits entry of all hepatitis C virus genotypes into human liver cellsQ39117420
The antimalarial ferroquine is an inhibitor of hepatitis C virus.Q39205134
Hepatitis C virus attachment mediated by apolipoprotein E binding to cell surface heparan sulfateQ39358973
(-)-Epigallocatechin-3-gallate is a new inhibitor of hepatitis C virus entryQ39439105
The green tea polyphenol, epigallocatechin-3-gallate, inhibits hepatitis C virus entryQ39491188
Small molecule scavenger receptor BI antagonists are potent HCV entry inhibitorsQ39646696
5-(Perylen-3-yl)ethynyl-arabino-uridine (aUY11), an arabino-based rigid amphipathic fusion inhibitor, targets virion envelope lipids to inhibit fusion of influenza virus, hepatitis C virus, and other enveloped virusesQ39788993
P433issue5
P921main subjectHepatitis C virusQ708693
P304page(s)741-748
P577publication date2016-04-05
P1433published inHepatology internationalQ26842730
P1476titleHepatitis C virus cell entry: a target for novel antiviral strategies to address limitations of direct acting antivirals
P478volume10