Insights into human beta-cardiac myosin function from single molecule and single cell studies

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Insights into human beta-cardiac myosin function from single molecule and single cell studies is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1033538366
P356DOI10.1007/S12265-009-9129-2
P932PMC publication ID4342148
P698PubMed publication ID20560001
P5875ResearchGate publication ID44684660

P2093author name stringJames A Spudich
Euan Ashley
Leslie Leinwand
Sivaraj Sivaramakrishnan
P2860cites workMyosin-V is a processive actin-based motorQ22003739
Skeletal muscle expression and abnormal function of beta-myosin in hypertrophic cardiomyopathyQ24309554
Myosin VI is a processive motor with a large step sizeQ24555089
Molecular cloning and characterization of human cardiac alpha- and beta-form myosin heavy chain complementary DNA clones. Regulation of expression during development and pressure overload in human atriumQ24629385
Single-molecule mechanics of R403Q cardiac myosin isolated from the mouse model of familial hypertrophic cardiomyopathyQ28141697
Myosin-IXb is a single-headed and processive motorQ28215994
The mechanism of muscular contractionQ28237595
Differential cross-bridge kinetics of FHC myosin mutations R403Q and R453C in heterozygous mouse myocardiumQ28507314
Cardiac myosin missense mutations cause dilated cardiomyopathy in mouse models and depress molecular motor function.Q28594348
The power stroke of myosin VI and the basis of reverse directionalityQ30478493
R403Q and L908V mutant beta-cardiac myosin from patients with familial hypertrophic cardiomyopathy exhibit enhanced mechanical performance at the single molecule levelQ30656473
Kinetic differences at the single molecule level account for the functional diversity of rabbit cardiac myosin isoformsQ30756973
Single molecule high-resolution colocalization of Cy3 and Cy5 attached to macromolecules measures intramolecular distances through timeQ30854446
Functional consequences of mutations in the smooth muscle myosin heavy chain at sites implicated in familial hypertrophic cardiomyopathyQ30884033
Building and using optical traps to study properties of molecular motorsQ31134487
Hypertrophic cardiomyopathy: etiology, diagnosis, and treatmentQ33156364
ELECTRON MICROSCOPE STUDIES ON THE STRUCTURE OF NATURAL AND SYNTHETIC PROTEIN FILAMENTS FROM STRIATED MUSCLE.Q33191423
Hypertrophic and dilated cardiomyopathy mutations differentially affect the molecular force generation of mouse alpha-cardiac myosin in the laser trap assayQ33277814
The myosin step size: measurement of the unit displacement per ATP hydrolyzed in an in vitro assayQ33793860
Control of cardiac myosin heavy chain gene expressionQ34040340
Prevalence of hypertrophic cardiomyopathy in a general population of young adults. Echocardiographic analysis of 4111 subjects in the CARDIA Study. Coronary Artery Risk Development in (Young) AdultsQ34058337
Kinetic and equilibrium analysis of the myosin ATPaseQ34066040
Hypertrophic cardiomyopathy: a systematic reviewQ34117625
Force measurements by micromanipulation of a single actin filament by glass needlesQ34177181
Sliding distance of actin filament induced by a myosin crossbridge during one ATP hydrolysis cycle.Q34199192
Movement of myosin-coated fluorescent beads on actin cables in vitroQ34266105
Single myosin molecule mechanics: piconewton forces and nanometre stepsQ34338098
Dilated cardiomyopathy: a genetically heterogeneous diseaseQ34871768
Why choose myofibrils to study muscle myosin ATPase?Q35580317
Molecular genetics and genomics of heart failureQ35936390
Kinetic Analysis of Myosin and Actomyosin ATPaseQ36072483
Myosin-X: a molecular motor at the cell's fingertipsQ36248392
Walking with myosin V.Q36354001
Sarcomere length-resting tension relation in single frog atrial cardiac cellsQ36528735
The kinetic mechanism of myosin V.Q36700327
Protein kinase A does not alter economy of force maintenance in skinned rat cardiac trabeculae.Q36701635
Expression of a mutation causing hypertrophic cardiomyopathy disrupts sarcomere assembly in adult feline cardiac myocytesQ36708559
Functional effects of the hypertrophic cardiomyopathy R403Q mutation are different in an alpha- or beta-myosin heavy chain backboneQ36761852
Sarcomere dynamics during muscular contraction and their implications to muscle function.Q36832339
Myosin V from head to tailQ37073565
Modulation of cardiac performance by motor protein gene transferQ37122799
Responses of single-ventricular myocytes to dynamic axial stretchingQ37159932
Fluorescent actin filaments move on myosin fixed to a glass surfaceQ37396490
Direct observation of the mechanochemical coupling in myosin Va during processive movementQ37416808
A new method of attachment of isolated mammalian ventricular myocytes for tension recording: length dependence of passive and active tensionQ41192393
Heterologous expression of a cardiomyopathic myosin that is defective in its actin interactionQ41493794
Actomyosin interaction in striated muscleQ41543090
A novel form of motility in filopodia revealed by imaging myosin-X at the single-molecule levelQ41978648
Motor function and regulation of myosin X.Q43678692
Loaded shortening and power output in cardiac myocytes are dependent on myosin heavy chain isoform expressionQ43713902
The mechanism of myosin VI translocation and its load-induced anchoringQ44790017
Human homozygous R403W mutant cardiac myosin presents disproportionate enhancement of mechanical and enzymatic properties.Q44792718
Myosin VI walks hand-over-hand along actinQ45001874
Cardiac transgenic and gene transfer strategies converge to support an important role for troponin I in regulating relaxation in cardiac myocytes.Q45060973
Contractile dysfunction of cardiomyopathic hamster myocytes is pronounced under high load conditionsQ46502206
Dynamics of the unbound head during myosin V processive translocationQ46692109
Low thyroid function leads to cardiac atrophy with chamber dilatation, impaired myocardial blood flow, loss of arterioles, and severe systolic dysfunctionQ46795007
Myosin step size. Estimation from slow sliding movement of actin over low densities of heavy meromyosinQ47443144
Expression of green fluorescent protein impairs the force-generating ability of isolated rat ventricular cardiomyocytes.Q50736830
Fluorescence imaging with one nanometer accuracy: application to molecular motors.Q50761313
Calcium-independent negative inotropy by beta-myosin heavy chain gene transfer in cardiac myocytes.Q51046536
Microtubules modulate the stiffness of cardiomyocytes against shear stress.Q51812166
Force-length relations in isolated intact cardiomyocytes subjected to dynamic changes in mechanical load.Q53584942
Contractile force measured in unskinned isolated adult rat heart fibresQ54563996
In vitro motilities of the unconventional myosins, brush border myosin-I, and chick brain myosin-V exhibit assay-dependent differences in velocityQ58134478
p38-MAPK Induced Dephosphorylation of α-Tropomyosin Is Associated With Depression of Myocardial Sarcomeric Tension and ATPase ActivityQ58198510
Motor molecules in motionQ59013657
Movement of myosin-coated beads on oriented filaments reconstituted from purified actinQ59061286
Mutations in the motor domain modulate myosin activity and myofibril organizationQ64377437
Sliding velocity of isolated rabbit cardiac myosin correlates with isozyme distributionQ67546911
Evidence of genetic heterogeneity in five kindreds with familial hypertrophic cardiomyopathyQ67742146
Relation of properties of isolated myosin to those of intact muscles of the cat and slothQ68406038
Biochemical and structural studies of actomyosin-like proteins from non-muscle cells. II. Purification, properties, and membrane association of actin from amoebae of Dictyostelium discoideumQ68534864
Control of myosin heavy chain expression in cardiac hypertrophyQ70023080
Cardiac myosin heavy chain mRNA expression and myocardial function in the mouse heartQ70162261
Brain myosin-V is a two-headed unconventional myosin with motor activityQ70488210
Comparison of the myosin and actomyosin ATPase mechanisms of the four types of vertebrate musclesQ70531440
Depressed sliding velocity of isolated cardiac myosin from cardiomyopathic hamsters: evidence for an alteration in mechanical interaction of actomyosinQ70617424
Cardiac V1 and V3 myosins differ in their hydrolytic and mechanical activities in vitroQ71888375
Single-molecule analysis of the actomyosin motor using nano-manipulationQ72310250
The in vitro motility activity of beta-cardiac myosin depends on the nature of the beta-myosin heavy chain gene mutation in hypertrophic cardiomyopathyQ73388735
Membrane potential of rat ventricular myocytes responds to axial stretch in phase, amplitude and speed-dependent mannersQ79284696
Single cell mechanics of rat cardiomyocytes under isometric, unloaded, and physiologically loaded conditionsQ79735185
Carbon fiber technique for the investigation of single-cell mechanics in intact cardiac myocytesQ80093199
Cardiac myosin isoforms from different species have unique enzymatic and mechanical propertiesQ81035642
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)426-440
P577publication date2009-09-29
P1433published inJournal of Cardiovascular Translational ResearchQ6294906
P1476titleInsights into human beta-cardiac myosin function from single molecule and single cell studies
P478volume2

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cites work (P2860)
Q47210536Adaptation and validation of the ACMG/AMP variant classification framework for MYH7-associated inherited cardiomyopathies: recommendations by ClinGen's Inherited Cardiomyopathy Expert Panel
Q36045425Cell-intrinsic functional effects of the α-cardiac myosin Arg-403-Gln mutation in familial hypertrophic cardiomyopathy
Q26770578Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human β-cardiac myosin
Q35075551Effects of troponin T cardiomyopathy mutations on the calcium sensitivity of the regulated thin filament and the actomyosin cross-bridge kinetics of human β-cardiac myosin
Q36083735Electrical and Mechanical Strategies to Enable Cardiac Repair and Regeneration.
Q27320554Ensemble force changes that result from human cardiac myosin mutations and a small-molecule effector
Q98881672Gaining insight into cellular cardiac physiology using single particle tracking
Q37855688How do mutations in contractile proteins cause the primary familial cardiomyopathies?
Q39440818Hypertrophic cardiomyopathy and the myosin mesa: viewing an old disease in a new light
Q34772983Identifying sarcomere gene mutations in hypertrophic cardiomyopathy: a personal history
Q39429314Immortalization of bone marrow-derived porcine mesenchymal stem cells and their differentiation into cells expressing cardiac phenotypic markers.
Q38940777Insights from molecular dynamics simulations for computational protein design
Q34549974Modulating Beta-Cardiac Myosin Function at the Molecular and Tissue Levels.
Q91972985Myocardial Contractility: Historical and Contemporary Considerations
Q36532652Sacrificial layer technique for axial force post assay of immature cardiomyocytes
Q36823735Subtle abnormalities in contractile function are an early manifestation of sarcomere mutations in dilated cardiomyopathy
Q64883689The Molecular Mechanisms of Mutations in Actin and Myosin that Cause Inherited Myopathy.

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