Role of thiols in degradation of proteins by cathepsins

scientific article

Role of thiols in degradation of proteins by cathepsins is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1042/BJ2040471
P932PMC publication ID1158374
P698PubMed publication ID7052070

P2093author name stringLloyd JB
Kooistra T
Millard PC
P2860cites workEvidence for lysosomal reduction of cystine residuesQ66938676
Insulin degradation by lysosomal extracts from rat liver; model for a role of lysosomes in hormone degradationQ67460502
Microsomal mixed-function oxidase-dependent renaturation of reduced ribonucleaseQ67707927
Cystine metabolism in human fibroblasts. Comparison of normal, cystinotic, and gamma-glutamylcysteine synethetase-deficient cellsQ67739092
Involvement of thiol enzymes in the lysosomal breakdown of native and denatured proteinsQ68657955
The specificity of a bovine fibroblast cathepsin D. I. Action on the S-sulfo derivatives of the insulin A and B chains and of porcine glucagonQ69386396
Insulin degradation. IV. Sequential degradation of insulin by rat kidney, heart and skeletal muscle homogenatesQ69505873
Enzymic Reduction of Cystine by Subcellular Fractions of Cultured and Peripheral Leukoyctes from Normal and Cystinotic IndividualsQ70438030
Modulation of the intracellular cystine content of cystinotic fibroblasts by extracellular albuminQ71276566
General specificity of cytoplasmic thioltransferase (thiol:disulfide oxidoreductase) from rat liver for thiol and disulfide substratesQ71992060
A convenient preparation of reduced and S-sulfonated A and B chains of insulinQ72924722
Tissue sulfhydryl groupsQ26778486
Endocytes and breakdown of ribonuclease oligomers by sinusoidal rat liver cells in vivoQ30409212
Cystinotic fibroblasts accumulate cystine from intracellular protein degradationQ35057660
Cystinosis. Intracellular cystine depletion by aminothiols in vitro and in vivoQ35902688
The metabolism of amino acids, peptides, and disulfides in lysosomes of fibroblasts cultured from normal individuals and those with cystinosisQ36334724
The permeability properties of the lysosomal membraneQ37800863
Cathepsin L. A New Proteinase from Rat-Liver LysosomesQ39144357
The reactivity of the disulphide bonds of purified proteins in relationship to primary structureQ39276136
The many forms and functions of cellular proteinases.Q40280504
The reduction of serum albumin, insulin and some simple disulphides by glutathioneQ41818470
Studies on the permeability of rat liver lysosomes to carbohydratesQ42080097
The effect of chemical treatments of albumin and orosomucoid on rate of clearance from the rat bloodstream and rate of pinocytic capture of rat yolk sac cultured in vitroQ42546785
A study of permeability of lysosomes to amino acids and small peptidesQ42921891
Approaches to the treatment of inborn errors of sulphur amino acid and peptide metabolismQ43538702
Monoiodoinsulin. Preparation, purification, and characterization of a biologically active derivative substituted predominantly on tyrosine A14.Q47894753
P433issue2
P407language of work or nameEnglishQ1860
P1104number of pages7
P304page(s)471-477
P577publication date1982-05-01
P1433published inBiochemical JournalQ864221
P1476titleRole of thiols in degradation of proteins by cathepsins
P478volume204

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cites work (P2860)
Q36222502A cysteine-specific lysosomal transport system provides a major route for the delivery of thiol to human fibroblast lysosomes: possible role in supporting lysosomal proteolysis
Q42177692Cystine accumulation in cystinotic fibroblasts from free and protein-linked cystine but not cysteine
Q44869362Delta(9)-tetrahydrocannabinol selectively increases aspartyl cathepsin D proteolytic activity and impairs lysozyme processing by macrophages
Q42200276Disulphide reduction in lysosomes. The role of cysteine
Q34607296Endolysosomal proteolysis and its regulation
Q22011094Enzymatic reduction of disulfide bonds in lysosomes: characterization of a gamma-interferon-inducible lysosomal thiol reductase (GILT)
Q45097915Intracellular location of cysteine transport activity correlates with productive processing of antigen disulfide
Q58960764Modulation of Th1/Th2 immune responses to HIV-1 Tat by new pro-GSH molecules
Q33505847Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions
Q41813176Passive diffusion of non-electrolytes across the lysosome membrane
Q44036735Reducing requirements for hemoglobin hydrolysis by Plasmodium falciparum cysteine proteases
Q42093504Role of thiols, pH and cathepsin D in the lysosomal catabolism of serum albumin
Q38781097The renal Fanconi syndrome in cystinosis: pathogenic insights and therapeutic perspectives

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