Genetics of GABAergic signaling in nicotine and alcohol dependence

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Genetics of GABAergic signaling in nicotine and alcohol dependence is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1046484422
P356DOI10.1007/S00439-011-1108-4
P932PMC publication ID3746562
P698PubMed publication ID22048727

P2093author name stringJun Gu
Ming D Li
Chamindi Seneviratne
Wen-Yan Cui
P2860cites workGABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeletonQ22008682
GATE-16, a membrane transport modulator, interacts with NSF and the Golgi v-SNARE GOS-28Q22253422
Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locusQ24531544
Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillationsQ24533346
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processingQ24597817
Twenty-one-base-pair insertion polymorphism creates an enhancer element and potentiates SLC6A1 GABA transporter promoter activityQ24643332
Markers in the 5'-region of GABRG1 associate to alcohol dependence and are in linkage disequilibrium with markers in the adjacent GABRA2 geneQ24655251
GABRG1 and GABRA2 as independent predictors for alcoholism in two populationsQ24657154
The gamma-aminobutyric acid type A (GABAA) receptor-associated protein (GABARAP) promotes GABAA receptor clustering and modulates the channel kineticsQ24672913
Aut2p and Aut7p, two novel microtubule-associated proteins are essential for delivery of autophagic vesicles to the vacuoleQ27937388
Association of GABRG3 with alcohol dependenceQ28240936
International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor functionQ28275171
Linkage and association studies in African- and Caucasian-American populations demonstrate that SHC3 is a novel susceptibility locus for nicotine dependenceQ28279797
Marital status, alcohol dependence, and GABRA2: evidence for gene-environment correlation and interactionQ28303649
GABAA receptor-associated protein traffics GABAA receptors to the plasma membrane in neuronsQ28581327
Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associationsQ28943421
Novel genes identified in a high-density genome wide association study for nicotine dependenceQ28943515
Role of GABAB receptor in alcohol dependence: Reducing effect of baclofen on alcohol intake and alcohol motivational properties in rats and amelioration of alcohol withdrawal syndrome and alcohol craving in human alcoholicsQ29395989
METAL: fast and efficient meta-analysis of genomewide association scansQ29547217
Genetic dissection of complex traits: guidelines for interpreting and reporting linkage resultsQ29547377
Breaking barriers in the genomics and pharmacogenetics of drug addictionQ30417717
Endophenotypes successfully lead to gene identification: results from the collaborative study on the genetics of alcoholismQ46845849
Confirmation of association of the GABRA2 gene with alcohol dependence by subtype-specific analysis.Q46880953
Forum: Interactions between gene and environment.Q51890081
Association between variants at the GABAAbeta2, GABAAalpha6 and GABAAgamma2 gene cluster and alcohol dependence in a Scottish population.Q52172907
A genomic scan for habitual smoking in families of alcoholics: common and specific genetic factors in substance dependence.Q52285242
Association analysis of exonic variants of the gene encoding the GABAB receptor and alcohol dependence.Q52978243
A genome-wide search for loci contributing to smoking and alcoholism.Q54127480
Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population.Q54136978
Presynaptic CRF1 receptors mediate the ethanol enhancement of GABAergic transmission in the mouse central amygdala.Q55085315
Genomewide Linkage Scan for Nicotine Dependence: Identification of a Chromosome 5 Risk LocusQ57318870
Genetics of alcohol dependenceQ57418861
Genetic association study of GABRA2 single nucleotide polymorphisms and electroencephalography in alcohol dependenceQ58476874
Smoking behavior is under the influence of a major quantitative trait locus on human chromosome 5qQ73271063
Genome search for alcohol dependence using the weighted pairwise correlation linkage method: interesting findings on chromosome 4Q73271168
Genome-wide search for genes affecting the risk for alcohol dependenceQ74594088
Mapping and verification of susceptibility loci for smoking quantity using permutation linkage analysisQ45277259
Association between alcoholism and gamma-amino butyric acid alpha2 receptor subtype in a Russian populationQ46440564
Gamma-aminobutyric acid receptor genes and nicotine dependence: evidence for association from a case-control studyQ46594088
Common and unique biological pathways associated with smoking initiation/progression, nicotine dependence, and smoking cessationQ30435362
New insights into the genetics of addictionQ30435949
Association and interaction analyses of GABBR1 and GABBR2 with nicotine dependence in European- and African-American populationsQ30438529
The genetics of nicotine dependenceQ30439784
A combinatorial approach to detecting gene-gene and gene-environment interactions in family studiesQ30439847
Association of specific haplotypes of neurotrophic tyrosine kinase receptor 2 gene (NTRK2) with vulnerability to nicotine dependence in African-Americans and European-AmericansQ30440508
A genomewide search finds major susceptibility loci for nicotine dependence on chromosome 10 in African AmericansQ30441533
Fine mapping of a linkage region on chromosome 17p13 reveals that GABARAP and DLG4 are associated with vulnerability to nicotine dependence in European-Americans.Q30442321
A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependenceQ30443642
Genome-wide linkage scan for nicotine dependence in European Americans and its converging results with African Americans in the Mid-South Tobacco Family sampleQ30443885
Identifying susceptibility loci for nicotine dependence: 2008 update based on recent genome-wide linkage analysesQ30445428
Grand challenges and opportunities for molecular psychiatry research: a perspectiveQ30453090
Zebrafish for the study of the biological effects of nicotineQ30468155
Nicotine response genetics in the zebrafish.Q30491214
A genome-wide scan to identify loci for smoking rate in the Framingham Heart Study populationQ31049251
Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorderQ33470869
A genome-wide association study of alcohol dependenceQ33740277
Single- and multilocus allelic variants within the GABA(B) receptor subunit 2 (GABAB2) gene are significantly associated with nicotine dependenceQ33942306
Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancerQ33951229
Regional variations in the effects of chronic ethanol administration on GABA(A) receptor expression: potential mechanismsQ33952966
The endocannabinoid system tonically regulates inhibitory transmission and depresses the effect of ethanol in central amygdalaQ33998480
Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients.Q34110582
Confirmation of the localization of the human GABAA receptor alpha 1-subunit gene (GABRA1) to distal 5q by linkage analysisQ34238531
Meta-analysis of 15 genome-wide linkage scans of smoking behaviorQ34286145
Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptorsQ34303326
GABRA6 gene polymorphism and an attenuated stress responseQ34327020
Ethanol-enhanced GABA release: A focus on G protein-coupled receptorsQ34424216
The genetics of addictions: uncovering the genesQ34431107
The genetic epidemiology of smokingQ34478414
GABA(B)-receptor subtypes assemble into functional heteromeric complexes.Q34485514
Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sampleQ34514830
Linkage disequilibrium, haplotype and association studies of a chromosome 4 GABA receptor gene cluster: candidate gene variants for addictionsQ34555160
Dimensional anxiety mediates linkage of GABRA2 haplotypes with alcoholismQ34569426
The role of GABA(A) receptors in the development of alcoholismQ34774410
A meta-analysis of estimated genetic and environmental effects on smoking behavior in male and female adult twinsQ35030849
A combinatorial partitioning method to identify multilocus genotypic partitions that predict quantitative trait variationQ35032069
Impulsiveness and insula activation during reward anticipation are associated with genetic variants in GABRA2 in a family sample enriched for alcoholismQ35194764
Molecular structure and physiological functions of GABA(B) receptorsQ35842984
Detecting epistatic interactions contributing to quantitative traitsQ35860615
Consequences of the evolution of the GABA(A) receptor gene familyQ36216409
Differential effects of GABAB autoreceptor activation on ethanol potentiation of local and lateral paracapsular GABAergic synapses in the rat basolateral amygdalaQ36253398
Role of GABRA2 in moderating subjective responses to alcoholQ36321071
Genetics of nicotine dependence and pharmacotherapyQ36453486
Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPsQ36501908
Pathway-based approaches for analysis of genomewide association studiesQ36512103
Long-term ethanol self-administration by the nonhuman primate, Macaca fascicularis, decreases the benzodiazepine sensitivity of amygdala GABA(A) receptorsQ36528258
Gamma-aminobutyric acid type A receptors and alcoholism: intoxication, dependence, vulnerability, and treatmentQ36585660
The genetics of alcoholism: identifying specific genes through family studiesQ36589478
Overview of the pharmacogenomics of cigarette smokingQ36708951
Identification and characterization of an early estrogen-regulated RNA in cultured guinea-pig endometrial cellsQ36783113
Approach to the genetics of alcoholism: a review based on pathophysiologyQ36899235
The role of GABRA2 in alcohol dependence, smoking, and illicit drug use in an Australian population sampleQ36953929
Environmental and genetic determinants of tobacco use: methodology for a multidisciplinary, longitudinal family-based investigation.Q36983812
The GABA transporter 1 (SLC6A1): a novel candidate gene for anxiety disordersQ37223768
Gene-environment interactions and alcohol use and dependence: current status and future challengesQ37494678
Role of the GABA(B) receptor in alcohol-seeking and drinking behaviorQ37632745
GABAB receptors in reward processesQ37775215
An autosomal linkage scan for cannabis use disorders in the nicotine addiction genetics projectQ40085057
Cloning and characterization of a functional human gamma-aminobutyric acid (GABA) transporter, human GAT-2.Q40133028
Effects of chronic ethanol exposure on GABA receptors and GABAB receptor modulation of 3H-GABA release in the hippocampusQ42444750
Differential GABAB Receptor Modulation of Ethanol Effects on GABA(A) synaptic activity in hippocampal CA1 neuronsQ42472185
Ethanol dependence has limited effects on GABA or glutamate transporters in rat brainQ43592781
Baclofen antagonizes intravenous self-administration of nicotine in mice and ratsQ44129395
Withdrawal from chronic intermittent ethanol treatment changes subunit composition, reduces synaptic function, and decreases behavioral responses to positive allosteric modulators of GABAA receptorsQ44253602
Association of GABA(A) receptors and alcohol dependence and the effects of genetic imprintingQ44295031
Response of nicotine self-administration in the rat to manipulations of mu-opioid and gamma-aminobutyric acid receptors in the ventral tegmental areaQ44331544
Presynaptic delta opioid receptors regulate ethanol actions in central amygdalaQ44332824
Human gamma-aminobutyric acid A receptor alpha2 gene moderates the acute effects of alcohol and brain mRNA expressionQ44933685
Results of a genomewide linkage scan: support for chromosomes 9 and 11 loci increasing risk for cigarette smokingQ44947671
Allelic and haplotypic association of GABRA2 with alcohol dependenceQ44993065
Time-dependent changes in transcriptional profiles within five rat brain regions in response to nicotine treatmentQ45175734
Haplotype-based localization of an alcohol dependence gene to the 5q34 {gamma}-aminobutyric acid type A gene clusterQ45209955
GABRA2 alleles moderate the subjective effects of alcohol, which are attenuated by finasterideQ45258412
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectalcohol dependenceQ4713263
nicotineQ12144
P304page(s)843-855
P577publication date2011-11-03
P1433published inHuman GeneticsQ5937167
P1476titleGenetics of GABAergic signaling in nicotine and alcohol dependence
P478volume131

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cites work (P2860)
Q39001533Alcohol use disorder and GABAB receptor gene polymorphisms in an Italian sample: haplotype frequencies, linkage disequilibrium and association studies
Q51536462Association Study of Gene Polymorphisms in GABA, Serotonin, Dopamine, and Alcohol Metabolism Pathways with Alcohol Dependence in Taiwanese Han Men.
Q30276828Converging findings from linkage and association analyses on susceptibility genes for smoking and other addictions
Q36372867Critical needs in drug discovery for cessation of alcohol and nicotine polysubstance abuse
Q28388372Depressive symptoms among heavy cigarette smokers: the influence of daily rate, gender, and race.
Q30409958Determination of allelic expression of SNP rs1880676 in choline acetyltransferase gene in HeLa cells
Q34503542Ethanol-induced alterations of amino acids measured by in vivo microdialysis in rats: a meta-analysis
Q37698999Gamma-aminobutyric acid system genes--no evidence for a role in alcohol use and abuse in a community-based sample
Q59807426Introducing Precision Addiction Management of Reward Deficiency Syndrome, the Construct That Underpins All Addictive Behaviors
Q30408390Introduction to deep sequencing and its application to drug addiction research with a focus on rare variants
Q26747557Potentiation of Gamma Aminobutyric Acid Receptors (GABAAR) by Ethanol: How Are Inhibitory Receptors Affected?
Q40338574Relative contribution of genetic, individual, and self-efficacy factors to smoking cessation in a Chinese rural population
Q35751057Rule breaking mediates the developmental association between GABRA2 and adolescent substance abuse
Q33911964The genetics of addiction
Q55298285The influence of adolescent nicotine exposure on ethanol intake and brain gene expression.
Q36071415The media and behavioral genetics: Alternatives coexisting with addiction genetics
Q28488809Transcriptome sequencing of gene expression in the brain of the HIV-1 transgenic rat.