Distinct regulation of murine lupus susceptibility genes by the IRF5/Blimp-1 axis

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Distinct regulation of murine lupus susceptibility genes by the IRF5/Blimp-1 axis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.1102311
P932PMC publication ID3244553
P698PubMed publication ID22116829
P5875ResearchGate publication ID51830126

P50authorChee-Mun FangQ54704747
P2093author name stringDivaker Choubey
Ravichandran Panchanathan
Hongzhu Liu
Paula M Pitha
Hongqi Liu
Loren D Erickson
P2860cites workAIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASCQ24319706
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Microarray analysis of gene expression in lupusQ24795089
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Regulation and functions of Blimp-1 in T and B lymphocytesQ28274145
HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNAQ28585347
The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA virusesQ29614469
Fcgamma receptors as regulators of immune responsesQ29615584
Aim2 deficiency in mice suppresses the expression of the inhibitory Fcgamma receptor (FcgammaRIIB) through the induction of the IFN-inducible p202, a lupus susceptibility proteinQ30426448
Aim2 Deficiency Stimulates the Expression of IFN-Inducible Ifi202, a Lupus Susceptibility Murine Gene within the Nba2 Autoimmune Susceptibility LocusQ30429300
Development of murine lupus involves the combined genetic contribution of the SLAM and FcgammaR intervals within the Nba2 autoimmune susceptibility locusQ30433488
Disruption of mutually negative regulatory feedback loop between interferon-inducible p202 protein and the E2F family of transcription factors in lupus-prone miceQ33605468
Critical role of IRF-5 in regulation of B-cell differentiation.Q33740745
IFN regulatory factor 5 is required for disease development in the FcgammaRIIB-/-Yaa and FcgammaRIIB-/- mouse models of systemic lupus erythematosusQ33804141
Contribution of IRF5 in B cells to the development of murine SLE-like disease through its transcriptional control of the IgG2a locusQ33933077
P202: an interferon-inducible negative regulator of cell growthQ34063714
Interferon-inducible p200-family proteins as novel sensors of cytoplasmic DNA: role in inflammation and autoimmunityQ34163340
Gender-dependent Expression of Murine Irf5 Gene: Implications for Sex Bias in AutoimmunityQ34187236
The interferon system. A bird's eye view of its biochemistryQ34248198
Interferon-inducible p202 in the susceptibility to systemic lupusQ34625690
Interferons and viral infectionsQ34968625
Recent insights into the genetic basis of systemic lupus erythematosusQ34980873
Genetic susceptibility to systemic lupus erythematosus in the genomic eraQ35102487
p53 represses class switch recombination to IgG2a through its antioxidant functionQ35606409
Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains.Q35795846
Lupus susceptibility loci in New Zealand miceQ35836652
Type I interferons (alpha/beta) in immunity and autoimmunityQ36072422
Type-I interferon receptor deficiency reduces lupus-like disease in NZB miceQ36370602
Type I interferon in systemic lupus erythematosus and other autoimmune diseasesQ36595839
Interferon-inducible Ifi200-family genes in systemic lupus erythematosusQ36979779
The genetics and biology of Irf5-mediated signaling in lupusQ37030639
Association of the IRF5 risk haplotype with high serum interferon-alpha activity in systemic lupus erythematosus patientsQ37052138
Female and male sex hormones differentially regulate expression of Ifi202, an interferon-inducible lupus susceptibility gene within the Nba2 intervalQ37439495
The type I interferon system in the development of lupusQ37835527
Functional characterization of murine interferon regulatory factor 5 (IRF-5) and its role in the innate antiviral responseQ38531462
An extended set of PRDM1/BLIMP1 target genes links binding motif type to dynamic repressionQ39710644
Transcriptional regulation of Fcgr2b gene by polymorphic promoter region and its contribution to humoral immune responsesQ40698999
Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strainQ40941667
Interferon action: cytoplasmic and nuclear localization of the interferon-inducible 52-kD protein that is encoded by the Ifi 200 gene from the gene 200 clusterQ41574715
B lymphocyte-induced maturation protein (Blimp)-1, IFN regulatory factor (IRF)-1, and IRF-2 can bind to the same regulatory sitesQ42824350
Interferon regulatory factor 5 is critical for the development of lupus in MRL/lpr mice.Q43538775
Interferons as gene activators. Indications for repeated gene duplication during the evolution of a cluster of interferon-activatable genes on murine chromosome 1.Q43856023
Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupusQ45180946
Type I interferon signaling is involved in the spontaneous development of lupus-like disease in B6.Nba2 and (B6.Nba2 x NZW)F(1) mice.Q51736584
Functional dissection of lupus susceptibility loci on the New Zealand black mouse chromosome 1: evidence for independent genetic loci affecting T and B cell activation.Q52006346
Polygenic control of susceptibility to murine systemic lupus erythematosusQ57903408
FcγRIIb controls bone marrow plasma cell persistence and apoptosisQ60268649
Control of multiple autoantibodies linked with a lupus nephritis susceptibility locus in New Zealand black miceQ73370092
Genetic dissection of B cell traits in New Zealand black mice. The expanded population of B cells expressing up-regulated costimulatory molecules shows linkage to Nba2Q73441047
Evidence for an interferon-inducible gene, Ifi202, in the susceptibility to systemic lupusQ74540694
Increased expression of Ifi202, an IFN-activatable gene, in B6.Nba2 lupus susceptible mice inhibits p53-mediated apoptosisQ83276319
IRF5 and B cells in LUPUS developmentQ84727759
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)270-278
P577publication date2011-11-23
P1433published inJournal of ImmunologyQ3521441
P1476titleDistinct regulation of murine lupus susceptibility genes by the IRF5/Blimp-1 axis
P478volume188

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Q36433828Interferon-Regulatory Factor 5-Dependent Signaling Restricts Orthobunyavirus Dissemination to the Central Nervous System
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Q30415556Murine BAFF expression is up-regulated by estrogen and interferons: implications for sex bias in the development of autoimmunity
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Q26858821Role of type I interferons in the activation of autoreactive B cells

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