XL-184, a MET, VEGFR-2 and RET kinase inhibitor for the treatment of thyroid cancer, glioblastoma multiforme and NSCLC.

scientific article

XL-184, a MET, VEGFR-2 and RET kinase inhibitor for the treatment of thyroid cancer, glioblastoma multiforme and NSCLC. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P932PMC publication ID3268517
P698PubMed publication ID20127563

P2093author name stringYing Zhang
Roger Abounader
David Schiff
Fadila Guessous
Alex Kofman
P2860cites workComprehensive genomic characterization defines human glioblastoma genes and core pathwaysQ24656128
Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesisQ24683896
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signalingQ27851406
Signal transduction via the stem cell factor receptor/c-KitQ28291675
Lung cancerQ29615473
Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapiesQ29615606
Malignant gliomas in adultsQ29615708
Constitutive RET tyrosine kinase activation in hereditary medullary thyroid cancer: clinical opportunitiesQ30319080
Emerging role of epidermal growth factor receptor inhibition in therapy for advanced malignancy: focus on NSCLC.Q35669147
Intracellular signal transduction pathway proteins as targets for cancer therapy.Q36177026
Targeting VEGF in cancer therapyQ36380193
Therapeutic advances in the treatment of glioblastoma: rationale and potential role of targeted agentsQ36395924
Mechanisms of Disease: cancer targeting and the impact of oncogenic RET for medullary thyroid carcinoma therapy.Q36613519
FLT3 mutations: biology and treatmentQ36662153
Medullary thyroid cancer: therapeutic targets and molecular markersQ36667663
Dysregulated RET signaling in thyroid cancer.Q37172765
MET as a target for treatment of chest tumorsQ37232416
Inhibitors of vascular endothelial growth factor in cancerQ37294225
Suppression of glioblastoma angiogenicity and tumorigenicity by inhibition of endogenous expression of vascular endothelial growth factorQ37408097
Angiogenesis in the treatment of non-small cell lung cancerQ37435385
Emerging therapeutic targets in non-small cell lung cancerQ37435391
Vandetanib (ZD6474), a dual inhibitor of vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR) tyrosine kinases: current status and future directions.Q37435425
Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer.Q40453775
Modulation of the c-Met/hepatocyte growth factor pathway in small cell lung cancer.Q40751631
Scatter factor promotes motility of human glioma and neuromicrovascular endothelial cellsQ41071769
Scatter factor/hepatocyte growth factor expression enhances human glioblastoma tumorigenicity and growthQ41103718
Expression and localization of scatter factor/hepatocyte growth factor in human astrocytomasQ42038344
Suppression of Tie-1 in endothelial cells in vitro induces a change in the genome-wide expression profile reflecting an inflammatory functionQ43149105
Prognostic significance of c-Met expression in glioblastomasQ46170165
Basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) levels, as prognostic indicators in NSCLC.Q47955121
In vivo targeting of SF/HGF and c-met expression via U1snRNA/ribozymes inhibits glioma growth and angiogenesis and promotes apoptosisQ48700301
Inhibition of glioma angiogenesis and growth in vivo by systemic treatment with a monoclonal antibody against vascular endothelial growth factor receptor-2.Q48789795
Reversion of human glioblastoma malignancy by U1 small nuclear RNA/ribozyme targeting of scatter factor/hepatocyte growth factor and c-met expressionQ73004517
Medullary thyroid carcinomaQ80541075
Glioblastoma multiforme: an emerging paradigm of anti-VEGF therapyQ80914233
Anti-VEGF therapies for malignant glioma: treatment effects and escape mechanismsQ83588875
P433issue2
P921main subjectglioblastomaQ282142
cabozantinibQ795057
thyroid cancerQ826522
P304page(s)112-121
P577publication date2010-02-01
P1433published inIDrugs: the Investigational Drugs JournalQ15752554
P1476titleXL-184, a MET, VEGFR-2 and RET kinase inhibitor for the treatment of thyroid cancer, glioblastoma multiforme and NSCLC
P478volume13