The zebrafish merovingian mutant reveals a role for pH regulation in hair cell toxicity and function

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The zebrafish merovingian mutant reveals a role for pH regulation in hair cell toxicity and function is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1242/DMM.016576
P932PMC publication ID4073274
P698PubMed publication ID24973752
P5875ResearchGate publication ID263514305

P50authorDavid W RaibleQ90821573
Edwin RubelQ29922068
Tamara M. StawickiQ50635837
P2093author name stringKelly N Owens
Tor Linbo
Katherine E Reinhart
P2860cites workIntravesical chemotherapy. Studies on the relationship between pH and cytotoxicityQ70301658
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OtotoxicityQ28218863
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Loss of Slc4a1b chloride/bicarbonate exchanger function protects mechanosensory hair cells from aminoglycoside damage in the zebrafish mutant persephoneQ28484349
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Mice deficient in H+-ATPase a4 subunit have severe hearing impairment associated with enlarged endolymphatic compartments within the inner ear.Q30453338
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Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventionsQ30476563
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Loss of cochlear HCO3- secretion causes deafness via endolymphatic acidification and inhibition of Ca2+ reabsorption in a Pendred syndrome mouse modelQ30494661
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Acid-base regulation in fishes: cellular and molecular mechanisms.Q34736977
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Ototoxicity of cisplatinum in children and adolescentsQ35982630
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The role of pH dynamics and the Na+/H+ antiporter in the etiopathogenesis and treatment of cancer. Two faces of the same coin--one single natureQ36228788
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Lack of pendrin HCO3- transport elevates vestibular endolymphatic [Ca2+] by inhibition of acid-sensitive TRPV5 and TRPV6 channelsQ36835443
Functional mechanotransduction is required for cisplatin-induced hair cell death in the zebrafish lateral line.Q36883651
Functional significance of channels and transporters expressed in the inner ear and kidneyQ36899732
New insights into fish ion regulation and mitochondrion-rich cellsQ36906434
The development of the parathyroid gland: from fish to humanQ37228143
Genetic variants associated with cisplatin-induced ototoxicityQ37293994
Genetics of aminoglycoside-induced and prelingual non-syndromic mitochondrial hearing impairment: a reviewQ37334174
Mechanism of development of ionocytes rich in vacuolar-type H(+)-ATPase in the skin of zebrafish larvaeQ37362474
Hearing loss: mechanisms revealed by genetics and cell biologyQ37582921
Mitochondrial 12S rRNA mutations associated with aminoglycoside ototoxicityQ37806816
Structure and function of ionocytes in the freshwater fish gillQ38043802
Zebrafish gcm2 is required for gill filament budding from pharyngeal ectodermQ38333476
Zebrafish gcmb is required for pharyngeal cartilage formation.Q38337394
The transcription factor, glial cell missing 2, is involved in differentiation and functional regulation of H+-ATPase-rich cells in zebrafish (Danio rerio).Q38356857
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Uptake of gentamicin by bullfrog saccular hair cells in vitroQ38841951
FM1-43 dye behaves as a permeant blocker of the hair-cell mechanotransducer channel.Q39414905
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Signal for attachment of a phospholipid membrane anchor in decay accelerating factorQ42068037
Intracellular pH regulation in isolated cochlear outer hair cells of the guinea‐pigQ42451211
Effects of pH on intracellular calcium levels in isolated cochlear outer hair cells of guinea pigsQ42462902
Effects of gentamicin and pH on [Ca2+]i in apical and basal outer hair cells from guinea pigs.Q42506314
Vesicular glutamate transporter 3 is required for synaptic transmission in zebrafish hair cells.Q42525197
pHluorin2: an enhanced, ratiometric, pH-sensitive green florescent proteinQ42860027
Mechanism of acid adaptation of a fish living in a pH 3.5 lake.Q44280893
Anion exchanger 1b, but not sodium-bicarbonate cotransporter 1b, plays a role in transport functions of zebrafish H+-ATPase-rich cellsQ44869715
Early effects of acetazolamide on anionic activities of the guinea pig endolymph: evidence for active function of carbonic anhydrase in the cochleaQ45197049
Plasma membrane calcium ATPase required for semicircular canal formation and otolith growth in the zebrafish inner ear.Q46121498
Localization of pH regulating proteins H+ATPase and Cl-/HCO3- exchanger in the guinea pig inner ear.Q46190394
Studies on (Na+-K+)-activated ATPase. XXIV. Localization and properties of ATPase in the inner ear of the guinea pig.Q46358522
A GFP-based genetic screen reveals mutations that disrupt the architecture of the zebrafish retinotectal projectionQ46522442
The aminoglycoside antibiotic dihydrostreptomycin rapidly enters mouse outer hair cells through the mechano-electrical transducer channelsQ46580525
The use of zebrafish for assessing ototoxic and otoprotective agentsQ46598347
Proton pump-rich cell secretes acid in skin of zebrafish larvaeQ46691199
Defective calmodulin-dependent rapid apical endocytosis in zebrafish sensory hair cell mutantsQ47073325
Knockdown of V-ATPase subunit A (atp6v1a) impairs acid secretion and ion balance in zebrafish (Danio rerio).Q47073618
Round window pH manipulation alters the ototoxicity of systemic cisplatinQ48105369
Influence of pH on the ototoxicity of cisplatin: a round window application studyQ48373645
Isolation and expression of two zebrafish homologues of parvalbumin genes related to chicken CPV3 and mammalian oncomodulinQ48374262
Genetic causes and mechanisms of distal renal tubular acidosisQ50358114
Vestibular hair bundles control pH with (Na+, K+)/H+ exchangers NHE6 and NHE9.Q50461676
Prevalence and characteristics of persons with hearing trouble: United States, 1990-91.Q50525672
Potentials of outer hair cells and their membrane properties in cationic environments.Q50943549
How can teleostean inner ear hair cells maintain the proper association with the accreting otolith?Q51436188
Functional regulation of H+-ATPase-rich cells in zebrafish embryos acclimated to an acidic environment.Q51825787
GATEWAY recombinational cloning: application to the cloning of large numbers of open reading frames or ORFeomes.Q53901952
Texas Red-X and Rhodamine Red-X, New Derivatives of Sulforhodamine 101 and Lissamine Rhodamine B with Improved Labeling and Fluorescence PropertiesQ56814528
Measurement of potassium and chloride ion concentrations in the cupulae of the lateral lines of Xenopus laevisQ67774391
The cochlear potentials. II. The nature of the cochlear endolymphatic resting potentialQ68464063
P4510describes a project that usesImageJQ1659584
P433issue7
P304page(s)847-856
P577publication date2014-07-01
P1433published inDisease Models & MechanismsQ1524006
P1476titleThe zebrafish merovingian mutant reveals a role for pH regulation in hair cell toxicity and function
P478volume7

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cites work (P2860)
Q50432958Carbonic Anhydrase Inhibitors Induce Developmental Toxicity During Zebrafish Embryogenesis, Especially in the Inner Ear.
Q37079612Cilia-Associated Genes Play Differing Roles in Aminoglycoside-Induced Hair Cell Death in Zebrafish
Q37610685Fluorescent aminoglycosides reveal intracellular trafficking routes in mechanosensory hair cells
Q47194882Inhibition of Mitochondrial Division Attenuates Cisplatin-Induced Toxicity in the Neuromast Hair Cells.
Q90175901Mechanotransduction Activity Facilitates Hair Cell Toxicity Caused by the Heavy Metal Cadmium
Q64951961Pregnancy-associated plasma protein-aa supports hair cell survival by regulating mitochondrial function.
Q42712216Spotlight on zebrafish: translational impact
Q61814532The role of retrograde intraflagellar transport genes in aminoglycoside-induced hair cell death
Q35094539Using the zebrafish lateral line to uncover novel mechanisms of action and prevention in drug-induced hair cell death