GRP78 upregulation by atheroprone shear stress via p38-, alpha2beta1-dependent mechanism in endothelial cells

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GRP78 upregulation by atheroprone shear stress via p38-, alpha2beta1-dependent mechanism in endothelial cells is …
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scholarly articleQ13442814

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P356DOI10.1161/ATVBAHA.108.167999
P932PMC publication ID2723835
P698PubMed publication ID18556570

P50authorBrett R BlackmanQ106705156
P2093author name stringNicole E Hastings
Ryan E Feaver
Andrew Pryor
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Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cellsQ28140489
Tumour necrosis factor receptor 1 mediates endoplasmic reticulum stress-induced activation of the MAP kinase JNKQ28508892
Sarco/endoplasmic reticulum calcium ATPase-2 expression is regulated by ATF6 during the endoplasmic reticulum stress response: intracellular signaling of calcium stress in a cardiac myocyte model systemQ28578430
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein responseQ29547299
Regulation of MAP Kinase Signaling Modules by Scaffold Proteins in MammalsQ29619598
The subendothelial extracellular matrix modulates NF-kappaB activation by flow: a potential role in atherosclerosisQ30436462
Spatial and spectral heterogeneity of time-varying shear stress profiles in the carotid bifurcation by phase-contrast MRI.Q30442053
Atherosclerosis-prone hemodynamics differentially regulates endothelial and smooth muscle cell phenotypes and promotes pro-inflammatory primingQ30444661
Platelet adhesion to collagen under flow causes dissociation of a phosphoprotein complex of heat-shock proteins and protein phosphatase 1.Q30470899
In Vivo Interrogation of the Molecular Display of Atherosclerotic Lesion SurfacesQ31017247
Regulation of tissue factor--mediated initiation of the coagulation cascade by cell surface grp78.Q33216800
Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteinsQ33262919
High levels of the molecular chaperone Mdg1/ERdj4 reflect the activation state of endothelial cells.Q34265922
GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic developmentQ35070987
Misfolded proteins, endoplasmic reticulum stress and neurodegenerationQ35941821
Role of the unfolded protein response in cell deathQ36351719
Coexisting proinflammatory and antioxidative endothelial transcription profiles in a disturbed flow region of the adult porcine aorta.Q36602479
Functional coupling of p38-induced up-regulation of BiP and activation of RNA-dependent protein kinase-like endoplasmic reticulum kinase to drug resistance of dormant carcinoma cells.Q36836856
Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and -resistant regions of human vasculature.Q37570619
The extracellular matrix as a cell survival factorQ40241699
Integrin alpha2beta1 mediates isoform-specific activation of p38 and upregulation of collagen gene transcription by a mechanism involving the alpha2 cytoplasmic tailQ42075812
The unfolded protein response is an important regulator of inflammatory genes in endothelial cellsQ42500350
Endoplasmic reticulum stress triggers an acute proteasome-dependent degradation of ATF6.Q42827925
The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophagesQ44542540
Sphingosine kinase-1 mediates TNF-alpha-induced MCP-1 gene expression in endothelial cells: upregulation by oscillatory flowQ44932366
Association of multiple cellular stress pathways with accelerated atherosclerosis in hyperhomocysteinemic apolipoprotein E-deficient miceQ44947007
Activation of the unfolded protein response occurs at all stages of atherosclerotic lesion development in apolipoprotein E-deficient miceQ46421418
Cholesterol is the major component of native lipoproteins activating the p38 mitogen-activated protein kinasesQ46704647
Peroxynitrite causes endoplasmic reticulum stress and apoptosis in human vascular endothelium: implications in atherogenesisQ46740172
CAMP-response element-binding protein mediates tumor necrosis factor-alpha-induced vascular cell adhesion molecule-1 expression in endothelial cellsQ64377796
Expression of ICAM-1 and VCAM-1 and monocyte adherence in arteries exposed to altered shear stressQ71693098
ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial treeQ72689998
Oxidative stress-induced actin reorganization mediated by the p38 mitogen-activated protein kinase/heat shock protein 27 pathway in vascular endothelial cellsQ73106953
A new in vitro model to evaluate differential responses of endothelial cells to simulated arterial shear stress waveformsQ74630961
Flow antagonizes TNF-alpha signaling in endothelial cells by inhibiting caspase-dependent PKC zeta processingQ80382206
Central role of the scaffold protein tumor necrosis factor receptor-associated factor 2 in regulating endoplasmic reticulum stress-induced apoptosisQ81507240
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
P304page(s)1534-1541
P577publication date2008-06-12
P1433published inArteriosclerosis, Thrombosis, and Vascular BiologyQ4797542
P1476titleGRP78 upregulation by atheroprone shear stress via p38-, alpha2beta1-dependent mechanism in endothelial cells
P478volume28

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