Characterization of the gating brake in the I-II loop of Ca(v)3.2 T-type Ca(2+) channels

scientific article

Characterization of the gating brake in the I-II loop of Ca(v)3.2 T-type Ca(2+) channels is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M708761200
P932PMC publication ID2276388
P698PubMed publication ID18218623

P50authorAmy Van DeusenQ55135180
Edward Perez-ReyesQ56951168
Joel P BaumgartQ57237577
Juan C GomoraQ57238198
Iuliia VitkoQ62607256
Igor A ShumilinQ99633916
P2093author name stringSvetlana Sokolova
Manuel Soriano-García
Imilla I Arias-Olguín
Michal Fortuna
P2860cites workCa(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autismQ28117072
Association between genetic variation of CACNA1H and childhood absence epilepsyQ28191095
Functional characterization and neuronal modeling of the effects of childhood absence epilepsy variants of CACNA1H, a T-type calcium channelQ28250190
Crystal structure of a mammalian voltage-dependent Shaker family K+ channelQ28260421
International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channelsQ28289138
Inactivation determinants in segment IIIS6 of Ca(v)3.1Q28364312
3D-Jury: a simple approach to improve protein structure predictionsQ29615989
The use of circular dichroism in the investigation of protein structure and function.Q30332031
Transfer of beta subunit regulation from high to low voltage-gated Ca2+ channelsQ30437245
The I-II loop controls plasma membrane expression and gating of Ca(v)3.2 T-type Ca2+ channels: a paradigm for childhood absence epilepsy mutationsQ30442572
Gating kinetics of the alpha1I T-type calcium channelQ30442669
Voltage sensor conformations in the open and closed states in ROSETTA structural models of K(+) channelsQ34624463
Properties of two types of calcium channels in clonal pituitary cellsQ36412012
Pore structure influences gating properties of the T-type Ca2+ channel alpha1GQ36412407
How does voltage open an ion channel?Q36480474
Classes of calcium channels in vertebrate cellsQ38269272
Evidence for common structural determinants of activation and inactivation in T-type Ca2+ channelsQ40235133
Role of Domain IV/S4 outermost arginines in gating of T-type calcium channelsQ40379542
Gating of the expressed Cav3.1 calcium channel.Q40692200
Differences in apparent pore sizes of low and high voltage-activated Ca2+ channelsQ44116120
A thermodynamic scale for the helix-forming tendencies of the commonly occurring amino acidsQ44211659
Voltage sensor of Kv1.2: structural basis of electromechanical couplingQ46588794
Influence of proline residues on protein conformationQ47638868
Contrasting biophysical and pharmacological properties of T-type and R-type calcium channels.Q48666040
SOPMA: significant improvements in protein secondary structure prediction by consensus prediction from multiple alignments.Q52321797
A superfamily of ion channelsQ59017138
A low voltage-activated, fully inactivating Ca channel in vertebrate sensory neuronesQ59075458
P433issue13
P407language of work or nameEnglishQ1860
P304page(s)8136-8144
P577publication date2008-01-24
P1433published inJournal of Biological ChemistryQ867727
P1476titleCharacterization of the gating brake in the I-II loop of Ca(v)3.2 T-type Ca(2+) channels
P478volume283

Reverse relations

cites work (P2860)
Q30437894Alternative splicing within the I-II loop controls surface expression of T-type Ca(v)3.1 calcium channels
Q64102676Atomic Mechanisms of Timothy Syndrome-Associated Mutations in Calcium Channel Cav1.2
Q45069125Calmodulin regulates Cav3 T-type channels at their gating brake.
Q38187012Cav3 T-type channels: regulators for gating, membrane expression, and cation selectivity
Q30429903Characterization of the gating brake in the I-II loop of CaV3 T-type calcium channels
Q64267868Compound heterozygous CACNA1H mutations associated with severe congenital amyotrophy
Q30278810Contrasting the roles of the I-II loop gating brake in CaV3.1 and CaV3.3 calcium channels
Q53448717Contribution of S4 segments and S4-S5 linkers to the low-voltage activation properties of T-type CaV3.3 channels.
Q30410238Cooperative activation of the T-type CaV3.2 channel: interaction between Domains II and III.
Q42912721Cysteines in the loop between IS5 and the pore helix of Ca(V)3.1 are essential for channel gating
Q41849996Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue.
Q28728383Gene transcription and splicing of T-type channels are evolutionarily-conserved strategies for regulating channel expression and gating
Q92883641Genetic T-type calcium channelopathies
Q30441251I-II loop structural determinants in the gating and surface expression of low voltage-activated calcium channels
Q38880329Inhibition of Cav3.2 T-type Calcium Channels by Its Intracellular I-II Loop.
Q30457231Ins and outs of T-channel structure function
Q44359012Mechanisms by which a CACNA1H mutation in epilepsy patients increases seizure susceptibility
Q36877182Neurochemical and behavioral features in genetic absence epilepsy and in acutely induced absence seizures
Q21144219Orientation of the calcium channel beta relative to the alpha(1)2.2 subunit is critical for its regulation of channel activity
Q51150804Pharmacogenetics of antiepileptic drug efficacy in childhood absence epilepsy.
Q36268559Phosphorylation of the Cav3.2 T-type calcium channel directly regulates its gating properties
Q27679374The role of a voltage-dependent Ca2+ channel intracellular linker: a structure-function analysis
Q30427770The voltage dependence of gating currents of the neuronal CA(v)3.3 channel is determined by the gating brake in the I-II loop
Q33748128Transient and big are key features of an invertebrate T-type channel (LCav3) from the central nervous system of Lymnaea stagnalis

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