| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2007PNAS..10417447P |
| P356 | DOI | 10.1073/PNAS.0707173104 |
| P932 | PMC publication ID | 2077276 |
| P698 | PubMed publication ID | 17959774 |
| P5875 | ResearchGate publication ID | 5885633 |
| P50 | author | William F. Crowley | Q30116265 |
| Duarte Pignatelli | Q43796522 | ||
| Chengkang Zhang | Q58803608 | ||
| Nelly Pitteloud | Q88221528 | ||
| Lacey Plummer | Q106489974 | ||
| P2093 | author name string | Taneli Raivio | |
| Qun-Yong Zhou | |||
| Jia-Da Li | |||
| Pamela L Mellon | |||
| Lindsay W Cole | |||
| Elka E Jacobson-Dickman | |||
| P2860 | cites work | Kallmann syndrome: mutations in the genes encoding prokineticin-2 and prokineticin receptor-2 | Q21092497 |
| Identification of two prokineticin cDNAs: recombinant proteins potently contract gastrointestinal smooth muscle | Q24290954 | ||
| A gene deleted in Kallmann's syndrome shares homology with neural cell adhesion and axonal path-finding molecules | Q24311797 | ||
| Digenic mutations account for variable phenotypes in idiopathic hypogonadotropic hypogonadism | Q24675675 | ||
| Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54 | Q24685744 | ||
| The candidate gene for the X-linked Kallmann syndrome encodes a protein related to adhesion molecules | Q28118633 | ||
| Isolation and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors | Q28203358 | ||
| Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor | Q28206106 | ||
| The GPR54 gene as a regulator of puberty | Q28211950 | ||
| Molecular cloning and characterization of prokineticin receptors | Q28214578 | ||
| Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus | Q28509233 | ||
| A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labelled cRNA probes | Q29615205 | ||
| Quality control of mRNA function | Q34156109 | ||
| A family with hypogonadotropic hypogonadism and mutations in the gonadotropin-releasing hormone receptor | Q34446712 | ||
| Abnormal development of the olfactory bulb and reproductive system in mice lacking prokineticin receptor PKR2 | Q34572987 | ||
| Mutations in fibroblast growth factor receptor 1 cause both Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism | Q34597433 | ||
| Minireview: recent progress in gonadotropin-releasing hormone neuronal migration. | Q36350874 | ||
| Dependence of olfactory bulb neurogenesis on prokineticin 2 signaling | Q38324527 | ||
| Structural determinants required for the bioactivities of prokineticins and identification of prokineticin receptor antagonists | Q44772896 | ||
| Prokineticin 2 is a target gene of proneural basic helix-loop-helix factors for olfactory bulb neurogenesis | Q46056823 | ||
| Heterogeneity in the mutations responsible for X chromosome-linked Kallmann syndrome | Q48125476 | ||
| Hypogonadotropic hypogonadism and peripheral neuropathy in Ebf2-null mice | Q48432967 | ||
| Recommendations for a nomenclature system for human gene mutations. Nomenclature Working Group | Q48771295 | ||
| Brain grafts reverse hypogonadism of gonadotropin releasing hormone deficiency | Q48920833 | ||
| Identification and pharmacological characterization of prokineticin 2 beta as a selective ligand for prokineticin receptor 1. | Q48964677 | ||
| Loss-of-function mutations in FGFR1 cause autosomal dominant Kallmann syndrome | Q50336618 | ||
| Clinical and laboratory heterogeneity in idiopathic hypogonadotropic hypogonadism | Q67498899 | ||
| P433 | issue | 44 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | idiopathy | Q594841 |
| hypogonadism | Q938107 | ||
| Kallmann syndrome | Q1165179 | ||
| P304 | page(s) | 17447-17452 | |
| P577 | publication date | 2007-10-24 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | Loss-of-function mutation in the prokineticin 2 gene causes Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism | |
| P478 | volume | 104 |
| Q24613193 | A genetic basis for functional hypothalamic amenorrhea |
| Q37616859 | Absence of central circadian pacemaker abnormalities in humans with loss of function mutation in prokineticin 2 |
| Q36231696 | An ancient founder mutation in PROKR2 impairs human reproduction |
| Q28511610 | Axl and Tyro3 modulate female reproduction by influencing gonadotropin-releasing hormone neuron survival and migration |
| Q51963826 | Biallelic mutations in the prokineticin-2 gene in two sporadic cases of Kallmann syndrome. |
| Q37553175 | Bv8/Prokineticins and their Receptors A New Pronociceptive System |
| Q24595634 | CHD7 mutations in patients initially diagnosed with Kallmann syndrome--the clinical overlap with CHARGE syndrome |
| Q93036979 | Characterization of the human GnRH neuron developmental transcriptome using a GNRH1-TdTomato reporter line in human pluripotent stem cells |
| Q35623991 | Clocks on top: the role of the circadian clock in the hypothalamic and pituitary regulation of endocrine physiology |
| Q35065543 | Combined pituitary hormone deficiency with unique pituitary dysplasia and morning glory syndrome related to a heterozygous PROKR2 mutation |
| Q28394555 | Commentary: the year in endocrine genetics for basic scientists |
| Q35409577 | Critical role for prokineticin 2 in CNS autoimmunity |
| Q37223928 | Cytokine properties of prokineticins |
| Q24309428 | Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and mice |
| Q28589834 | Defective gonadotropin-releasing hormone neuron migration in mice lacking SEMA3A signalling through NRP1 and NRP2: implications for the aetiology of hypogonadotropic hypogonadism |
| Q34162228 | Defective migration of neuroendocrine GnRH cells in human arrhinencephalic conditions |
| Q92904097 | Delayed Puberty-Phenotypic Diversity, Molecular Genetic Mechanisms, and Recent Discoveries |
| Q30356438 | Deletion of Vax1 from Gonadotropin-Releasing Hormone (GnRH) Neurons Abolishes GnRH Expression and Leads to Hypogonadism and Infertility. |
| Q51029666 | Digenic Inheritance of PROKR2 and WDR11 Mutations in Pituitary Stalk Interruption Syndrome. |
| Q87993928 | Discovering Genes Essential to the Hypothalamic Regulation of Human Reproduction Using a Human Disease Model: Adjusting to Life in the "-Omics" Era |
| Q36433718 | Discovering Genes Essential to the Hypothalamic Regulation of Human Reproduction Using a Human Disease Model: Adjusting to Life in the "-Omics" Era. |
| Q34947403 | Disease-causing mutation in PKR2 receptor reveals a critical role of positive charges in the second intracellular loop for G-protein coupling and receptor trafficking |
| Q34214766 | Dysregulation of Semaphorin7A/β1-integrin signaling leads to defective GnRH-1 cell migration, abnormal gonadal development and altered fertility |
| Q27000649 | Etiology and treatment of hypogonadism in adolescents |
| Q28265981 | Etiology and treatment of hypogonadism in adolescents |
| Q34628288 | Exogenous kisspeptin administration as a probe of GnRH neuronal function in patients with idiopathic hypogonadotropic hypogonadism |
| Q28386577 | Expanding the phenotype and genotype of female GnRH deficiency |
| Q36544678 | Expression of prokineticin-receptor2(PK-R2) is a new prognostic factor in human colorectal cancer |
| Q35458207 | FGFR1 and PROKR2 rare variants found in patients with combined pituitary hormone deficiencies |
| Q37135450 | Female hypogonadism: evaluation of the hypothalamic-pituitary-ovarian axis |
| Q38353683 | Fezf1 is required for penetration of the basal lamina by olfactory axons to promote olfactory development |
| Q37681140 | Functional consequences of AXL sequence variants in hypogonadotropic hypogonadism |
| Q34075966 | Functional rescue of Kallmann syndrome-associated prokineticin receptor 2 (PKR2) mutants deficient in trafficking |
| Q35256585 | G protein-coupled receptors involved in GnRH regulation: molecular insights from human disease |
| Q37261655 | GNRH1 mutations in patients with idiopathic hypogonadotropic hypogonadism |
| Q38596690 | Gene Targeting in Neuroendocrinology |
| Q36100642 | Genetic Overlap between Holoprosencephaly and Kallmann Syndrome. |
| Q34191671 | Genetic counseling for isolated GnRH deficiency |
| Q33937715 | Genetic determinants of pubertal timing in the general population. |
| Q90569848 | Genetics of congenital hypogonadotropic hypogonadism: peculiarities and phenotype of an oligogenic disease |
| Q21296724 | Genetics of isolated hypogonadotropic hypogonadism: role of GnRH receptor and other genes |
| Q34443063 | GnRH, anosmia and hypogonadotropic hypogonadism--where are we? |
| Q30424272 | GnRH-deficient phenotypes in humans and mice with heterozygous variants in KISS1/Kiss1. |
| Q34433460 | Gonadotropin-releasing hormone (GnRH) neuron migration: initiation, maintenance and cessation as critical steps to ensure normal reproductive function |
| Q90405710 | Gonadotropin-releasing hormone neuron development in vertebrates |
| Q24307650 | Heparan sulfate 6-O-sulfotransferase 1, a gene involved in extracellular sugar modifications, is mutated in patients with idiopathic hypogonadotrophic hypogonadism |
| Q30370622 | Heterozygous deletion of ventral anterior homeobox (vax1) causes subfertility in mice |
| Q24628946 | Human GnRH deficiency: a unique disease model to unravel the ontogeny of GnRH neurons |
| Q33693788 | Human genetic disorders of axon guidance |
| Q44374594 | Identification of two novel missense mutations in the KAL1 gene in Han Chinese subjects with Kallmann Syndrome |
| Q37417487 | Impaired fibroblast growth factor receptor 1 signaling as a cause of normosmic idiopathic hypogonadotropic hypogonadism |
| Q35126506 | Incidence, phenotypic features and molecular genetics of Kallmann syndrome in Finland |
| Q89603411 | Insight Into the Ontogeny of GnRH Neurons From Patients Born Without a Nose |
| Q35580592 | Isolated GnRH deficiency: a disease model serving as a unique prism into the systems biology of the GnRH neuronal network |
| Q79790438 | Kallmann syndrome |
| Q38078017 | Kallmann syndrome in women: from genes to diagnosis and treatment |
| Q50133432 | Kallmann syndrome: phenotype and genotype of hypogonadotropic hypogonadism |
| Q47716482 | Light-Dependent Regulation of Sleep and Wake States by Prokineticin 2 in Zebrafish |
| Q38218950 | Malformation syndromes associated with disorders of sex development |
| Q92220057 | Metformin Ameliorates Testicular Damage in Male Mice with Streptozotocin-Induced Type 1 Diabetes through the PK2/PKR Pathway |
| Q37071231 | Mutation analyses in pedigrees and sporadic cases of ethnic Han Chinese Kallmann syndrome patients. |
| Q37017449 | Mutational analysis of TAC3 and TACR3 genes in patients with idiopathic central pubertal disorders |
| Q24657612 | Mutations in CHD7, encoding a chromatin-remodeling protein, cause idiopathic hypogonadotropic hypogonadism and Kallmann syndrome |
| Q34146811 | Mutations in FEZF1 cause Kallmann syndrome |
| Q36938312 | Mutations in prokineticin 2 and prokineticin receptor 2 genes in human gonadotrophin-releasing hormone deficiency: molecular genetics and clinical spectrum. |
| Q24292996 | NELF is a nuclear protein involved in hypothalamic GnRH neuronal migration |
| Q37466322 | Nasal embryonic LHRH factor (NELF) mutations in patients with normosmic hypogonadotropic hypogonadism and Kallmann syndrome. |
| Q34225321 | Neonatal gonadotropin therapy in male congenital hypogonadotropic hypogonadism. |
| Q36672226 | New genes controlling human reproduction and how you find them |
| Q36284895 | Novel application of luciferase assay for the in vitro functional assessment of KAL1 variants in three females with septo-optic dysplasia (SOD). |
| Q55006597 | Olfactory epithelium: Cells, clinical disorders, and insights from an adult stem cell niche. |
| Q35654194 | Olfactory phenotypic spectrum in idiopathic hypogonadotropic hypogonadism: pathophysiological and genetic implications |
| Q34093958 | Oligogenic basis of isolated gonadotropin-releasing hormone deficiency. |
| Q37015568 | Ontogenesis of gonadotropin-releasing hormone neurons: a model for hypothalamic neuroendocrine cell development. |
| Q36760693 | PROK2/PROKR2 Signaling and Kallmann Syndrome. |
| Q24317396 | PROKR2 missense mutations associated with Kallmann syndrome impair receptor signalling activity |
| Q41874602 | Profiles of Periglomerular Cells in the Olfactory Bulb of Prokineticin Type 2 Receptor-deficient Mice |
| Q36413420 | Prokineticin 2 (PROK2) is an important factor for angiogenesis in colorectal cancer |
| Q33604579 | Prokineticin 2 is a hypothalamic neuropeptide that potently inhibits food intake |
| Q35887325 | Prokineticin 2 is an endangering mediator of cerebral ischemic injury |
| Q39663171 | Prokineticin-1/endocrine gland-derived vascular endothelial growth factor is a survival factor for human multiple myeloma cells |
| Q91317443 | Prokineticin-2 and ghrelin robustly influence the sexual and ingestive behaviors of female Syrian hamsters |
| Q37329938 | Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration |
| Q38635211 | Prokineticins in central and peripheral control of human reproduction. |
| Q26823052 | Prokineticins: new regulatory peptides in human reproduction |
| Q45164304 | Quantitative magnetic resonance imaging evaluation of the olfactory system in Kallmann syndrome: correlation with a clinical smell test. |
| Q37130382 | Reproductive functions of kisspeptin and Gpr54 across the life cycle of mice and men |
| Q36589407 | Responsiveness to a physiological regimen of GnRH therapy and relation to genotype in women with isolated hypogonadotropic hypogonadism |
| Q36141317 | Rites of passage through puberty: a complex genetic ensemble |
| Q28393740 | Role of seminiferous tubular development in determining the FSH versus LH responsiveness to GnRH in early sexual maturation |
| Q24307518 | SEMA3A deletion in a family with Kallmann syndrome validates the role of semaphorin 3A in human puberty and olfactory system development |
| Q92992906 | Septo-optic dysplasia caused by a novel FLNA splice site mutation: a case report |
| Q47729132 | Sexually dimorphic distribution of Prokr2 neurons revealed by the Prokr2-Cre mouse model |
| Q28540891 | Signaling role of prokineticin 2 on the estrous cycle of female mice |
| Q33984838 | TAC3/TACR3 mutations reveal preferential activation of gonadotropin-releasing hormone release by neurokinin B in neonatal life followed by reversal in adulthood |
| Q52430839 | TBX20 Regulates Angiogenesis Through the PROK2-PROKR1 Pathway. |
| Q33424478 | Temporally regulated traffic of HuR and its associated ARE-containing mRNAs from the chromatoid body to polysomes during mouse spermatogenesis |
| Q92314899 | The PROK2/PROKR2 signaling pathway is required for the migration of most olfactory bulb interneurons |
| Q42645262 | The SRC homology 2 domain protein Shep1 plays an important role in the penetration of olfactory sensory axons into the forebrain. |
| Q33830319 | The genetic and molecular basis of idiopathic hypogonadotropic hypogonadism |
| Q34113064 | The long-term clinical follow-up and natural history of men with adult-onset idiopathic hypogonadotropic hypogonadism |
| Q48727907 | The neurokinin B pathway in human reproduction |
| Q35551224 | The puzzles of the prokineticin 2 pathway in human reproduction |
| Q34262602 | The role of prokineticins in the pathogenesis of hypogonadotropic hypogonadism |
| Q28385113 | The role of the prokineticin 2 pathway in human reproduction: evidence from the study of human and murine gene mutations |
| Q42694560 | The terminal nerve plays a prominent role in GnRH-1 neuronal migration independent from proper olfactory and vomeronasal connections to the olfactory bulbs |
| Q42778008 | Transcription Factors Sp8 and Sp9 Coordinately Regulate Olfactory Bulb Interneuron Development |
| Q35757433 | Transcriptomic Analysis and Meta-Analysis of Human Granulosa and Cumulus Cells |
| Q30422142 | Uncovering novel reproductive defects in neurokinin B receptor null mice: closing the gap between mice and men. |
| Q49437047 | Update on the Genetics of Idiopathic Hypogonadotropic Hypogonadism |
| Q36730242 | Variations in PROKR2, but not PROK2, are associated with hypopituitarism and septo-optic dysplasia. |
| Q36201503 | When genetic load does not correlate with phenotypic spectrum: lessons from the GnRH receptor (GNRHR). |
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