CD40 signaling pathway: anti-CD40 monoclonal antibody induces rapid dephosphorylation and phosphorylation of tyrosine-phosphorylated proteins including protein tyrosine kinase Lyn, Fyn, and Syk and the appearance of a 28-kD tyrosine phosphorylated p

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CD40 signaling pathway: anti-CD40 monoclonal antibody induces rapid dephosphorylation and phosphorylation of tyrosine-phosphorylated proteins including protein tyrosine kinase Lyn, Fyn, and Syk and the appearance of a 28-kD tyrosine phosphorylated p is …
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scholarly articleQ13442814

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P356DOI10.1084/JEM.179.6.1923
P932PMC publication ID2191516
P698PubMed publication ID7515102

P2093author name stringF Gaskin
S M Fu
J T Parsons
M Faris
P2860cites workZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chainQ24294340
Expression and structure of the human NGF receptorQ24295226
Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase C gamma 2Q24680231
A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomasQ28115527
A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cellsQ28187669
CSK: a protein-tyrosine kinase involved in regulation of src family kinasesQ28283266
Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemiaQ30195143
CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cellsQ30442717
Defective expression of the CD40 ligand in X chromosome-linked immunoglobulin deficiency with normal or elevated IgMQ30454072
Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretionQ31147001
Rapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphataseQ34297751
The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinasesQ34355151
Constitutive activation of Src family kinases in mouse embryos that lack Csk.Q34366689
Stimulation of protein tyrosine phosphorylation by the B-lymphocyte antigen receptorQ34561889
Activation of human B cells mediated through two distinct cell surface differentiation antigens, Bp35 and Bp50Q35612157
Interleukin 10 and transforming growth factor beta cooperate to induce anti-CD40-activated naive human B cells to secrete immunoglobulin A.Q36231002
Isolated human follicular dendritic cells display a unique antigenic phenotypeQ36356417
Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinasesQ37582902
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B-lymphocyte signal transduction in response to anti-immunoglobulin and bacterial lipopolysaccharide.Q39508590
Isolation and immunological characterization of a major surface glycoprotein (gp54) preferentially expressed on certain human B cellsQ40712659
The MB-1/B29 heterodimer couples the B cell antigen receptor to multiple src family protein tyrosine kinasesQ41109011
Temporal association of CD40 antigen expression with discrete stages of human B-cell ontogeny and the efficacy of anti-CD40 immunotoxins against clonogenic B-lineage acute lymphoblastic leukemia as well as B-lineage non-Hodgkin's lymphoma cellsQ41138034
Rescue of signaling by a chimeric protein containing the cytoplasmic domain of CD45.Q41559108
Restoration of T cell receptor-mediated signal transduction by transfection of CD45 cDNA into a CD45-deficient variant of the Jurkat T cell lineQ41608496
Transmembrane signals generated through MHC class II, CD19, CD20, CD39, and CD40 antigens induce LFA-1-dependent and independent adhesion in human B cells through a tyrosine kinase-dependent pathwayQ41652906
Regulation of B cell antigen receptor signal transduction and phosphorylation by CD45.Q41678661
CD40 signaling activates CD11a/CD18 (LFA-1)-mediated adhesion in B cellsQ41691263
Association between the PDGF receptor and members of the src family of tyrosine kinasesQ41725198
Identification of the intracytoplasmic region essential for signal transduction through a B cell activation molecule, CD40.Q41727367
Ligand-mediated negative regulation of a chimeric transmembrane receptor tyrosine phosphataseQ46161173
Cloning of TRAP, a ligand for CD40 on human T cellsQ48147375
Anti-CD45 inhibition of human B cell proliferation depends on the nature of activation signals and the state of B cell activation. A study with anti-IgM and anti-CDw40 antibodies.Q54351316
CD40 Ligand Gene Defects Responsible for X-Linked Hyper-IgM SyndromeQ55670500
CD40 ligand mutations in X-linked immunodeficiency with hyper-IgMQ58478788
Mechanism of antigen-driven selection in germinal centresQ59072211
Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgMQ59086599
Analysis of expression and function of CD40 on normal and leukemic human B cell precursorsQ67675057
CD40 stimulation provides an IFN-gamma-independent and IL-4-dependent differentiation signal directly to human B cells for IgE productionQ67684725
Soluble forms of CD40 inhibit biologic responses of human B cellsQ67897905
CD40 is functionally expressed on human thymic epithelial cellsQ67898173
CD45 expression by B cells. Expression of different CD45 isoforms by subpopulations of activated B cellsQ67902006
B lymphocyte activation is accompanied by phosphorylation of a 72-kDa protein-tyrosine kinaseQ67941194
Resting B lymphocytes can be triggered directly through the CDw40 (Bp50) antigen. A comparison with IL-4-mediated signalingQ68091384
Augmentation of normal and malignant B cell proliferation by monoclonal antibody to the B cell-specific antigen BP50 (CDW40)Q68812651
Activation of human B lymphocytes through CD40 and interleukin 4Q69099068
Antibodies to the common leukocyte antigen (T200) inhibit an early phase in the activation of resting human B cellsQ70028310
Regulation of TCR signaling by CD45 lacking transmembrane and extracellular domainsQ70664749
The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndromeQ72068543
Immunoregulatory role of CD40 in human B cell differentiationQ72070061
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectantibodyQ79460
phosphorylationQ242736
monoclonal antibodyQ422248
P304page(s)1923-1931
P577publication date1994-06-01
P1433published inJournal of Experimental MedicineQ3186912
P1476titleCD40 signaling pathway: anti-CD40 monoclonal antibody induces rapid dephosphorylation and phosphorylation of tyrosine-phosphorylated proteins including protein tyrosine kinase Lyn, Fyn, and Syk and the appearance of a 28-kD tyrosine phosphorylated p
P478volume179