In vitro proteolytic processing of the MD145 norovirus ORF1 nonstructural polyprotein yields stable precursors and products similar to those detected in calicivirus-infected cells.

scientific article

In vitro proteolytic processing of the MD145 norovirus ORF1 nonstructural polyprotein yields stable precursors and products similar to those detected in calicivirus-infected cells. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/JVI.77.20.10957-10974.2003
P932PMC publication ID224964
P698PubMed publication ID14512545

P50authorGaël BelliotQ64385777
Stanislav SosnovtsevQ117771310
P2093author name stringKim Y Green
Mark Garfield
Tanaji Mitra
Carl Hammer
P2860cites workHepatitis A virus 3C proteinase substrate specificityQ41890226
Sequence and genome organization of a human small round-structured (Norwalk-like) virusQ42615606
Complete nucleotide sequence of the chiba virus genome and functional expression of the 3C-like protease in Escherichia coliQ42639132
The genome of hawaii virus and its relationship with other members of the caliciviridaeQ42659575
Substrate specificity of the Norwalk virus 3C-like proteinaseQ42685020
Protein 3CD is the major poliovirus proteinase responsible for cleavage of the P1 capsid precursorQ44133857
Rabbit hemorrhagic disease virus: genome organization and polyprotein processing of a calicivirus studied after transient expression of cDNA constructsQ45740124
Poliovirus protein 3CD is the active protease for processing of the precursor protein P1 in vitroQ69832090
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingQ25938984
3C-like protease of rabbit hemorrhagic disease virus: identification of cleavage sites in the ORF1 polyprotein and analysis of cleavage specificityQ27480312
On the size of the active site in proteases. I. PapainQ27860826
Food-related illness and death in the United StatesQ29615940
Processing map and essential cleavage sites of the nonstructural polyprotein encoded by ORF1 of the feline calicivirus genomeQ30453275
Cleavage of the feline calicivirus capsid precursor is mediated by a virus-encoded proteinase.Q33783099
Norwalk virus open reading frame 3 encodes a minor structural proteinQ33808077
Mapping of the feline calicivirus proteinase responsible for autocatalytic processing of the nonstructural polyprotein and identification of a stable proteinase-polymerase precursor protein.Q33817321
Open reading frame 1 of the Norwalk-like virus Camberwell: completion of sequence and expression in mammalian cellsQ33825740
Proteinase-polymerase precursor as the active form of feline calicivirus RNA-dependent RNA polymeraseQ33836064
Polypeptide p41 of a Norwalk-like virus is a nucleic acid-independent nucleoside triphosphataseQ33837197
Identification of further proteolytic cleavage sites in the Southampton calicivirus polyprotein by expression of the viral protease in E. coli.Q33854776
Identification of a distinct common strain of "Norwalk-like viruses" having a global distributionQ33860636
Genetic classification of "Norwalk-like viruses..Q33914454
The molecular biology of human calicivirusesQ34302690
Identification of active-site amino acid residues in the Chiba virus 3C-like proteaseQ34340064
Polyprotein processing in Southampton virus: identification of 3C-like protease cleavage sites by in vitro mutagenesis.Q34381405
A cellular cofactor facilitates efficient 3CD cleavage of the poliovirus P1 precursor.Q36686958
A predominant role for Norwalk-like viruses as agents of epidemic gastroenteritis in Maryland nursing homes for the elderly.Q36691391
Sequence and genomic organization of Norwalk virusQ36771587
Proteolytic cleavage of encephalomyocarditis virus capsid region substrates by precursors to the 3C enzymeQ36781372
Role for the P4 amino acid residue in substrate utilization by the poliovirus 3CD proteinaseQ36821479
Molecular characterization of a bovine enteric calicivirus: relationship to the Norwalk-like viruses.Q39549079
Detection of viral proteins after infection of cultured hepatocytes with rabbit hemorrhagic disease virusQ39578776
Identification and characterization of a 3C-like protease from rabbit hemorrhagic disease virus, a calicivirus.Q40041889
Cleavage of synthetic peptides by purified poliovirus 3C proteinaseQ41269850
P433issue20
P921main subjectproteolysisQ33123
norovirusQ1142751
P304page(s)10957-10974
P577publication date2003-10-01
P1433published inJournal of VirologyQ1251128
P1476titleIn vitro proteolytic processing of the MD145 norovirus ORF1 nonstructural polyprotein yields stable precursors and products similar to those detected in calicivirus-infected cells
P478volume77

Reverse relations

cites work (P2860)
Q38835886A Cell-based Fluorescence Resonance Energy Transfer (FRET) Sensor Reveals Inter- and Intragenogroup Variations in Norovirus Protease Activity and Polyprotein Cleavage
Q28552137A Conserved Interaction between a C-Terminal Motif in Norovirus VPg and the HEAT-1 Domain of eIF4G Is Essential for Translation Initiation
Q40089931A Proposal for a Structural Model of the Feline Calicivirus Protease Bound to the Substrate Peptide under Physiological Conditions
Q40065238A large outbreak of acute gastroenteritis in Shippensburg, Pennsylvania, 1972 revisited: evidence for common source exposure to a recombinant GII.Pg/GII.3 norovirus.
Q34092733A norovirus protease structure provides insights into active and substrate binding site integrity
Q36506922A single-amino-acid change in murine norovirus NS1/2 is sufficient for colonic tropism and persistence
Q37092522Animal noroviruses.
Q37753212Antiviral strategies to control calicivirus infections
Q35705814Calicivirus 3C-like proteinase inhibits cellular translation by cleavage of poly(A)-binding protein.
Q35880360Carlow virus, a 2002 GII.4 variant Norovirus strain from Ireland
Q34112325Characterization and inhibition of norovirus proteases of genogroups I and II using a fluorescence resonance energy transfer assay
Q31151375Characterization of a rhesus monkey calicivirus representing a new genus of Caliciviridae
Q35192204Characterization of emerging GII.g/GII.12 noroviruses from a gastroenteritis outbreak in the United States in 2010
Q46449685Characterization of the norovirus 3C-like protease
Q35023930Cleavage map and proteolytic processing of the murine norovirus nonstructural polyprotein in infected cells
Q39354878Clinical relevance and genotypes of circulating noroviruses in northern Taiwan, 2006-2011.
Q42685169Comparative site-directed mutagenesis in the catalytic amino acid triad in calicivirus proteases
Q54377364Comparison of the replication properties of murine and human calicivirus RNA-dependent RNA polymerases.
Q42326359Complete genome of the human norovirus GIV.1 strain Lake Macquarie virus
Q42666418Complete genome sequence and phylogenetic analysis of a recombinant Korean norovirus, CBNU1, recovered from a 2006 outbreak
Q34826743Comprehensive review of human sapoviruses
Q35826200Contribution of intra- and interhost dynamics to norovirus evolution
Q27643088Crystal structure of norwalk virus polymerase reveals the carboxyl terminus in the active site cleft
Q37062340Current tools for norovirus drug discovery
Q34262075Development of a Gaussia luciferase-based human norovirus protease reporter system: cell type-specific profile of Norwalk virus protease precursors and evaluation of inhibitors
Q39037380Development of enhanced primer sets for detection of norovirus
Q34184676Discovery and genomic characterization of noroviruses from a gastroenteritis outbreak in domestic cats in the US
Q34046026Divergent evolution of norovirus GII/4 by genome recombination from May 2006 to February 2009 in Japan
Q42284135Enzyme kinetics of the human norovirus protease control virus polyprotein processing order.
Q31153401Expression of the murine norovirus (MNV) ORF1 polyprotein is sufficient to induce apoptosis in a virus-free cell model
Q36187376Gastroenteritis Outbreaks Associated with the Emergence of the New GII.4 Sydney Norovirus Variant during the Epidemic of 2012/13 in Shenzhen City, China
Q42622059Genetic diversity and recombination of murine noroviruses in immunocompromised mice
Q38379420Genomic analysis of the evolutionary lineage of Norovirus GII.4 from archival specimens during 1975-1987 in Tokyo
Q33435415Genomic characterization of swine caliciviruses representing a new genus of Caliciviridae
Q38663294Glutamyl Endopeptidases: The Puzzle of Substrate Specificity
Q35914435Highly conserved configuration of catalytic amino acid residues among calicivirus-encoded proteases.
Q96953592Human Norovirus Proteins: Implications in the Replicative Cycle, Pathogenesis, and the Host Immune Response
Q34162531Inherent structural disorder and dimerisation of murine norovirus NS1-2 protein
Q47595280Membrane alterations induced by nonstructural proteins of human norovirus.
Q39967103Model systems for the study of human norovirus Biology
Q30426537Molecular characterization of norovirus GII strains identified in Albania
Q42216292Molecular epidemiology of noroviruses in Northern Greece, 2005-2006.
Q36477975Murine norovirus: a model system to study norovirus biology and pathogenesis
Q48706045Norovirus classification and proposed strain nomenclature
Q33652840Norovirus non-structural protein p20 leads to impaired restitution of epithelial defects by inhibition of actin cytoskeleton remodelling
Q30351399Norovirus protein structure and function.
Q33781094Norovirus proteinase-polymerase and polymerase are both active forms of RNA-dependent RNA polymerase
Q36275589Norovirus vaccines and potential antinorovirus drugs: recent advances and future perspectives
Q33569848Norovirus-Mediated Modification of the Translational Landscape via Virus and Host-Induced Cleavage of Translation Initiation Factors
Q56143738Norovirus: an overview
Q35148970Noroviruses: The leading cause of gastroenteritis worldwide
Q37423012Norwalk virus N-terminal nonstructural protein is associated with disassembly of the Golgi complex in transfected cells
Q36662886Nucleotidylylation of the VPg protein of a human norovirus by its proteinase-polymerase precursor protein
Q36825578Open reading frame phylogenetic analysis on the cloud
Q28392368Pathogenesis of noroviruses, emerging RNA viruses
Q34281184Plasmid-based human norovirus reverse genetics system produces reporter-tagged progeny virus containing infectious genomic RNA.
Q36711802Porcine enteric caliciviruses: genetic and antigenic relatedness to human caliciviruses, diagnosis and epidemiology
Q36009523Porcine noroviruses related to human noroviruses
Q36860728Protein-Protein Interactions Inferred from Domain-Domain Interactions in Genogroup II Genotype 4 Norovirus Sequences
Q33843030Proteolytic processing of sapovirus ORF1 polyprotein
Q86093462RNA binding by human Norovirus 3C-like proteases inhibits protease activity
Q34400085Recombinant porcine norovirus identified from piglet with diarrhea
Q30428830Recombination within the pandemic norovirus GII.4 lineage
Q35865077Recovery of infectious murine norovirus using pol II-driven expression of full-length cDNA.
Q33900425Replication and packaging of Norwalk virus RNA in cultured mammalian cells
Q39954938Sapovirus-like particles derived from polyprotein
Q46329318Saturation mutagenesis reveals that GLU54 of norovirus 3C-like protease is not essential for the proteolytic activity
Q27676085Structural Basis of Substrate Specificity and Protease Inhibition in Norwalk Virus
Q43277787Structural and biological constraints on diversity of regions immediately upstream of cleavage sites in calicivirus precursor proteins
Q27675897Structural and dynamics characterization of norovirus protease
Q41975506Structural and functional characterization of sapovirus RNA-dependent RNA polymerase
Q36208341Structural basis for specific recognition of substrates by sapovirus protease
Q41257306Structure determination of Murine Norovirus NS6 proteases with C-terminal extensions designed to probe protease-substrate interactions.
Q27681097Structure of a Murine Norovirus NS6 Protease-Product Complex Revealed by Adventitious Crystallisation
Q30239859Structure(s), function(s), and inhibition of the RNA-dependent RNA polymerase of noroviruses
Q42155699Structure-based design and functional studies of novel noroviral 3C protease chimaeras offer insights into substrate specificity.
Q27486391Structure-function relationships among RNA-dependent RNA polymerases
Q24629310Structures of the compact helical core domains of feline calicivirus and murine norovirus VPg proteins
Q56877865Subcellular localization of the MNV-1 ORF1 proteins and their potential roles in the formation of the MNV-1 replication complex
Q36532810Substrate specificity of Tulane virus protease.
Q51619877Survival strategies of human norovirus
Q34262232The p4-p2' amino acids surrounding human norovirus polyprotein cleavage sites define the core sequence regulating self-processing order.
Q40044140Therapeutics and Immunoprophylaxis Against Noroviruses and Rotaviruses: The Past, Present, and Future
Q34647772X-ray crystallographic structure of the Norwalk virus protease at 1.5-A resolution
Q43634566cDNA cloning of Korean human norovirus and nucleotidylylation of VPg by norovirus RNA-dependent RNA polymerase

Search more.