Fueling and imaging brain activation

scientific article

Fueling and imaging brain activation is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1042/AN20120021
P932PMC publication ID3401074
P698PubMed publication ID22612861
P5875ResearchGate publication ID225052091

P50authorGerald A DienelQ91152814
P2860cites workBrain glycogen-new perspectives on its metabolic function and regulation at the subcellular levelQ21129443
The Contribution of Blood Lactate to Brain Energy Metabolism in Humans Measured by Dynamic 13C Nuclear Magnetic Resonance SpectroscopyQ22336991
Acetate transport and utilization in the rat brainQ22337083
Lactate fuels the human brain during exerciseQ22337122
High intensity exercise decreases global brain glucose uptake in humansQ24547219
Lactate rise detected by 1H NMR in human visual cortex during physiologic stimulationQ24564399
Simultaneous measurement of glucose transport and utilization in the human brainQ24629689
Regional aerobic glycolysis in the human brainQ24631922
The in vivo neuron-to-astrocyte lactate shuttle in human brain: evidence from modeling of measured lactate levels during visual stimulationQ24648293
Baseline brain energy supports the state of consciousnessQ24650629
Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscleQ24650995
Metabolic and hemodynamic events after changes in neuronal activity: current hypotheses, theoretical predictions and in vivo NMR experimental findingsQ24655314
Supply and demand in cerebral energy metabolism: the role of nutrient transportersQ24671074
Integration of the subarachnoid space and lymphatics: is it time to embrace a new concept of cerebrospinal fluid absorption?Q24816832
Searching for a baseline: functional imaging and the resting human brainQ28190070
Spare respiratory capacity, oxidative stress and excitotoxicityQ28264586
2-Deoxy-D-glucose reduces epilepsy progression by NRSF-CtBP-dependent metabolic regulation of chromatin structureQ28268494
Net sugar transport is a multistep process. Evidence for cytosolic sugar binding sites in erythrocytesQ28284560
Effect of salbutamol on regional cerebral oxygen consumption, flow and capillary and arteriolar perfusionQ28334478
The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitorsQ28339341
Calmodulin kinase pathway mediates the K+-induced increase in Gap junctional communication between mouse spinal cord astrocytesQ28346561
Structural plasticity of perisynaptic astrocyte processes involves ezrin and metabotropic glutamate receptors.Q28582615
Mechanisms of Cyclic AMP Regulation in Cerebral Anoxia and Their Relationship to GlycogenolysisQ72850417
Distribution of Glut1 glucose transporters in different brain structures compared to glucose utilization and capillary density of adult rat brainsQ73089287
Cerebral glucose utilization and glucose transporter expression: response to water deprivation and restorationQ73315296
Negligible glucose-6-phosphatase activity in cultured astrogliaQ73593728
Extracellular-intracellular distribution of glucose and lactate in the rat brain assessed noninvasively by diffusion-weighted 1H nuclear magnetic resonance spectroscopy in vivoQ73707529
Monocarboxylic acid transporters, MCT1 and MCT2, in cortical astrocytes in vitro and in vivoQ73742856
Astrocytic glycogen influences axon function and survival during glucose deprivation in central white matterQ74339132
Astrocyte activation in vivo during graded photic stimulationQ80858692
The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortexQ81567207
Asymmetric transport of a fluorescent glucose analogue by human erythrocytesQ93606953
Effects of ammonia and beta-methylene-DL-aspartate on the oxidation of glucose and pyruvate by neurons and astrocytes in primary cultureQ70402920
Cerebral oxidative metabolism and blood flow during acute hypoglycemia and recovery in unanesthetized ratsQ70431190
The kinetics, substrate, and inhibitor specificity of the monocarboxylate (lactate) transporter of rat liver cells determined using the fluorescent intracellular pH indicator, 2',7'-bis(carboxyethyl)-5(6)-carboxyfluoresceinQ70889972
Sodium-dependent glutamate uptake as an activator of oxidative metabolism in primary astrocyte cultures from newborn ratQ70913706
Metabolic changes in cerebral cortex, hippocampus, and cerebellum during sustained bicuculline-induced seizuresQ70977754
A study of the kinetic behaviour of glucose based on simultaneous estimates of influx and phosphorylation in brain regions of rats in different physiological statesQ71569989
Relative levels of hexokinase in isolated neuronal, astrocytic, and oligodendroglial fractions from rat brainQ71689882
A metabolic map of cytochrome oxidase in the rat brain: histochemical, densitometric and biochemical studiesQ72303009
Glycogen in astrocytes: possible function as lactate supply for neighboring cellsQ72558138
Substrate changes in peripheral nerve during ischaemia and Wallerian degenerationQ72595561
Astrocytic contributions to bioenergetics of cerebral ischemiaQ36104665
How astrocytes feed hungry neurons.Q36217316
Changes in local cerebral glucose utilization during rewarding brain stimulationQ36248403
Effects of anesthesia on functional activation of cerebral blood flow and metabolismQ36317438
Neuronal and astrocytic shuttle mechanisms for cytosolic-mitochondrial transfer of reducing equivalents: current evidence and pharmacological toolsQ36347960
Neuronal-glial glucose oxidation and glutamatergic-GABAergic function.Q36366441
The redox switch/redox coupling hypothesisQ36418515
Effect of acute and recurrent hypoglycemia on changes in brain glycogen concentrationQ36513153
The estimation of rates of utilization of glucose and ketone bodies in the brain of the suckling rat using compartmental analysis of isotopic dataQ36516122
Attempts to combine 2-deoxyglucose autoradiography and tyrosine hydroxylase immunohistochemistryQ36588887
Astrocyte glycogen and brain energy metabolismQ36894700
New insights into central roles of cerebral oxygen metabolism in the resting and stimulus-evoked brainQ37035278
Energy substrates to support glutamatergic and GABAergic synaptic function: role of glycogen, glucose and lactateQ37059461
Inhibition of monocarboxylate transporter 2 in the retrotrapezoid nucleus in rats: a test of the astrocyte-neuron lactate-shuttle hypothesisQ37103000
Astrocytic involvement in learning and memory consolidationQ37156963
Brain energetics (thought needs food).Q37312914
Human brain glycogen metabolism during and after hypoglycemiaQ37317432
Increased tricarboxylic acid cycle flux in rat brain during forepaw stimulation detected with 1H[13C]NMR.Q37428318
What learning in day-old chickens can teach a neurochemist: focus on astrocyte metabolismQ37459040
Steady-state brain glucose transport kinetics re-evaluated with a four-state conformational modelQ37481984
Astroglial networks: a step further in neuroglial and gliovascular interactions.Q37678191
Food for thought: the importance of glucose and other energy substrates for sustaining brain function under varying levels of activityQ37826510
Why does the brain (not) have glycogen?Q37845323
The in vivo neurochemistry of the brain during general anesthesiaQ37924850
Multifunctional roles of NAD⁺ and NADH in astrocytesQ38000068
Tonotopic organization in the central auditory pathway of the Mongolian gerbil: a 2-deoxyglucose study.Q38578556
The metabolic fate of 13N-labeled ammonia in rat brainQ39252649
Inhibition of lactate transport and glycolysis in Ehrlich ascites tumor cells by bioflavonoidsQ39268014
Comparison of cerebral glucose metabolic rates measured with fluorodeoxyglucose and glucose labeled in the 1, 2, 3-4, and 6 positions using double label quantitative digital autoradiographyQ39298298
The Pasteur effect and the relations between respiration and fermentationQ39886463
Control of the redox state of the pyridine nucleotides in the rat cerebral cortex. Effect of electroshock-induced seizuresQ39938200
Decreased rate of glucose utilization by rat brain in vivo after exposure to atmospheres containing high concentrations of CO2Q39963377
Stimulation-induced increases of astrocytic oxidative metabolism in rats and humans investigated with 1-11C-acetateQ40057390
The energy use associated with neural computation in the cerebellumQ40181462
Substrate utilization and brain developmentQ40247219
Cerebral energy metabolism during experimental status epilepticusQ40327119
Aerobic production and utilization of lactate satisfy increased energy demands upon neuronal activation in hippocampal slices and provide neuroprotection against oxidative stressQ40385439
Oxidative metabolism in cultured rat astroglia: effects of reducing the glucose concentration in the culture medium and of D-aspartate or potassium stimulation.Q46562383
Invalidity of criticisms of the deoxyglucose method based on alleged glucose-6-phosphatase activity in brainQ46634404
Metabolic alterations in focally activated primary somatosensory cortex of alpha-chloralose-anesthetized rats measured by 1H MRS at 11.7 T.Q46719366
Essential role of aralar in the transduction of small Ca2+ signals to neuronal mitochondria.Q46790347
Glutamate receptor-dependent increments in lactate, glucose and oxygen metabolism evoked in rat cerebellum in vivo.Q46813863
The cerebral metabolic ratio is not affected by oxygen availability during maximal exercise in humansQ46954372
Pentylenetetrazol-induced status epilepticus up-regulates the expression of glucose transporter mRNAs but not proteins in the immature rat brainQ46975263
Tracer 2-deoxyglucose kinetics in brain regions of rats given kainic acidQ48093201
Measuring brain glucose phosphorylation with labeled glucoseQ48093900
Oxidation of (14)C-labeled compounds perfused by microdialysis in the brains of free-moving ratsQ48118088
Noninvasive measurements of [1-(13)C]glycogen concentrations and metabolism in rat brain in vivoQ48127737
Regional cerebral oxidative and total glucose consumption during rest and activation studied with positron emission tomographyQ48131635
Glutamine--a major substrate for nerve endingsQ48185297
The Kety-Schmidt technique for repeated measurements of global cerebral blood flow and metabolism in the conscious rat.Q48197592
Measurement of local cerebral blood flow with iodo [14C] antipyrineQ48230786
Carrier-mediated transport of lactic acid in cultured neurons and astrocytes.Q48237604
Cerebral oxygen/glucose ratio is low during sensory stimulation and rises above normal during recovery: excess glucose consumption during stimulation is not accounted for by lactate efflux from or accumulation in brain tissueQ48241121
Rapid efflux of lactate from cerebral cortex during K+ -induced spreading cortical depressionQ48241132
Studies on the relationship between cerebral glucose transport and phosphorylation using 2-deoxyglucoseQ48268455
Synthesis of deoxyglucose-1-phosphate, deoxyglucose-1,6-bisphosphate, and other metabolites of 2-deoxy-D-[14C]glucose in rat brain in vivo: influence of time and tissue glucose levelQ48271191
Energy on demandQ48283930
Functional imaging of focal brain activation in conscious rats: impact of [(14)C]glucose metabolite spreading and releaseQ48292498
Metabolites of 2-deoxy-[14C]glucose in plasma and brain: influence on rate of glucose utilization determined with deoxyglucose method in rat brainQ48324469
Regional blood-brain glucose transfer in the rat: a novel double-membrane kinetic analysisQ48337408
Human brain glycogen content and metabolism: implications on its role in brain energy metabolismQ48355244
Glucose consumption in the cerebral cortex of rat during bicuculline-induced status epilipticusQ48360907
Cerebral blood flow and metabolic rate early and late in prolonged epileptic seizures induced in rats by bicucullineQ48365590
Can experimental conditions explain the discrepancy over glutamate stimulation of aerobic glycolysis?Q48371480
Relative cerebral glucose uptake of neuronal perikarya and neuropil determined with 2-deoxyglucose in resting and swimming ratQ48381198
Regulation of energy metabolism in synaptic terminals and cultured rat brain astrocytes: differences revealed using aminooxyacetateQ48390156
Competition between glucose and lactate as oxidative energy substrates in both neurons and astrocytes: a comparative NMR studyQ48412134
Activation-induced resetting of cerebral oxygen and glucose uptake in the rat.Q48431645
Red and white brainQ48455036
The Effects of Acute Carbon Monoxide Intoxication on the Cerebral Energy Metabolism of the RatQ48457400
Effect of alpha-chloralose, halothane, pentobarbital and nitrous oxide anesthesia on metabolic coupling in somatosensory cortex of ratQ48484586
Cerebral ammonia metabolism in hyperammonemic ratsQ48486235
Increased oxygen consumption in the somatosensory cortex of alpha-chloralose anesthetized rats during forepaw stimulation determined using MRS at 11.7 TeslaQ48488575
Cerebral energy metabolism, pH, and blood flow during seizures in the cat.Q48501813
Influence of tissue acidosis upon restitution of brain energy metabolism following total ischemiaQ48522642
Expression of the monocarboxylate transporter MCT2 by rat brain gliaQ48524243
Provenance of the acetyl group of acetylcholine and compartmentation of acetyl-CoA and Krebs cycle intermediates in the brain in vivoQ48549362
In vivo 13C NMR spectroscopy and metabolic modeling in the brain: a practical perspectiveQ48553223
Steady-state cerebral glucose concentrations and transport in the human brain.Q48568618
Determination of local brain glucose level with [14C]methylglucose: effects of glucose supply and demandQ48578933
Pyruvate protects neurons against hydrogen peroxide-induced toxicityQ48579857
Oxidative glucose metabolism in rat brain during single forepaw stimulation: a spatially localized 1H[13C] nuclear magnetic resonance studyQ48606375
Effects of dorsal raphe stimulation on cerebral glucose utilization in the anaesthetized rat.Q48608081
A temporary local energy pool coupled to neuronal activity: fluctuations of extracellular lactate levels in rat brain monitored with rapid-response enzyme-based sensor.Q48610328
2-Deoxyglucose incorporation into rat brain glycogen during measurement of local cerebral glucose utilization by the 2-deoxyglucose methodQ48617729
Optimal freezing conditions for cerebral metabolites in ratsQ48621135
Tripartite synapses: glia, the unacknowledged partnerQ29615224
An energy budget for signaling in the grey matter of the brainQ29616192
Glial and neuronal control of brain blood flowQ29620058
Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilizationQ29620724
Brain lactate metabolism: the discoveries and the controversiesQ30452931
Predominant enhancement of glucose uptake in astrocytes versus neurons during activation of the somatosensory cortexQ30475536
Changes in glucose uptake rather than lactate shuttle take center stage in subserving neuroenergetics: evidence from mathematical modeling.Q30476702
Evaluation of cerebral acetate transport and metabolic rates in the rat brain in vivo using 1H-[13C]-NMRQ30478428
Astrocytes are poised for lactate trafficking and release from activated brain and for supply of glucose to neuronsQ30479376
Selective astrocytic gap junctional trafficking of molecules involved in the glycolytic pathway: impact on cellular brain imagingQ30480246
Trafficking of glucose, lactate, and amyloid-beta from the inferior colliculus through perivascular routesQ30480759
Exchange-mediated dilution of brain lactate specific activity: implications for the origin of glutamate dilution and the contributions of glutamine dilution and other pathwaysQ30481725
Calcium signaling in brain mitochondria: interplay of malate aspartate NADH shuttle and calcium uniporter/mitochondrial dehydrogenase pathwaysQ30482681
A glycogen phosphorylase inhibitor selectively enhances local rates of glucose utilization in brain during sensory stimulation of conscious rats: implications for glycogen turnoverQ30483314
Astrocytic connexin distributions and rapid, extensive dye transfer via gap junctions in the inferior colliculus: implications for [(14)C]glucose metabolite traffickingQ30483418
Imaging brain activation: simple pictures of complex biologyQ30484843
The lactic acid response to alkalosis in panic disorder : an integrative reviewQ30632817
In vivo NMR studies of the glutamate neurotransmitter flux and neuroenergetics: implications for brain function.Q30761238
The physiology and metabolism of neuronal activation: in vivo studies by NMR and other methods.Q30887514
Energy metabolism in astrocytes: high rate of oxidative metabolism and spatiotemporal dependence on glycolysis/glycogenolysisQ31048542
Dynamics of lactate concentration and blood oxygen level-dependent effect in the human visual cortex during repeated identical stimuliQ31113733
Effects of L-glutamate, D-aspartate, and monensin on glycolytic and oxidative glucose metabolism in mouse astrocyte cultures: further evidence that glutamate uptake is metabolically driven by oxidative metabolismQ32062164
Pathway-specific variations in neurovascular and neurometabolic coupling in rat primary somatosensory cortexQ33425177
Cerebral blood flow response to functional activationQ33500966
Frequency-dependent neural activity, CBF, and BOLD fMRI to somatosensory stimuli in isoflurane-anesthetized ratsQ33547243
Interpreting oxygenation-based neuroimaging signals: the importance and the challenge of understanding brain oxygen metabolismQ33628659
Hyperglycaemia and diabetes impair gap junctional communication among astrocytesQ33731300
Response to 'comment on recent modeling studies of astrocyte-neuron metabolic interactions': much ado about nothing.Q33852904
Functional integration of the transport of ammonium, glutamate and glutamine in astrocytesQ33919353
Nonlinear coupling between cerebral blood flow, oxygen consumption, and ATP production in human visual cortexQ33929504
Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic functionQ33966115
CBF, BOLD, CBV, and CMRO(2) fMRI signal temporal dynamics at 500-msec resolutionQ33978524
13C MRS studies of neuroenergetics and neurotransmitter cycling in humansQ34007144
Astrocyte-neuron lactate transport is required for long-term memory formationQ34025968
Development of enzymes of energy metabolism in the neonatal mammalian brain.Q40559762
Effects of overexpression of the liver subunit of 6-phosphofructo-1-kinase on the metabolism of a cultured mammalian cell lineQ40839050
Glucose and ketone body utilization by the brain of neonatal ratsQ40874213
Comment on recent modeling studies of astrocyte-neuron metabolic interactionsQ41185486
Glycogenolysis in Astrocytes Supports Blood-Borne Glucose Channeling Not Glycogen-Derived Lactate Shuttling to Neurons: Evidence from Mathematical ModelingQ41185691
Cerebral energy metabolism, glucose transport and blood flow: changes with maturation and adaptation to hypoglycaemia.Q41373260
Influence of ascending serotonergic pathways on glucose use in the conscious rat brain. I. Effects of electrolytic or neurotoxic lesions of the dorsal and/or median raphé nucleusQ41435719
Bioenergetic analysis of isolated cerebrocortical nerve terminals on a microgram scale: spare respiratory capacity and stochastic mitochondrial failureQ41494079
Use of beta-methylene-D,L-aspartate to assess the role of aspartate aminotransferase in cerebral oxidative metabolismQ41587168
Regional enzyme development in rat brain. Enzymes associated with glucose utilizationQ41594535
Intracellular pH as a regulatory signal in astrocyte metabolismQ41595185
Metabolic trafficking through astrocytic gap junctionsQ41595204
Kinetics of blood-brain barrier transport of pyruvate, lactate and glucose in suckling, weanling and adult ratsQ41743130
Effect of hypoglycemia on brain glycogen metabolism in vivoQ41815088
Acid lability of metabolites of 2-deoxyglucose in rat brain: implications for estimates of kinetic parameters of deoxyglucose phosphorylation and transport between blood and brainQ41910378
Overproduction of glycolytic enzymes in yeastQ41954667
The Effect of Nitrous Oxide on Oxygen Consumption and Blood Flow in the Cerebral Cortex of the RatQ41960097
The acute action of ammonia on rat brain metabolism in vivoQ41992218
Brain metabolism dictates the polarity of astrocyte control over arteriolesQ42089441
Development of mitochondrial energy metabolism in rat brainQ42104815
Signaling at the gliovascular interface.Q42451204
Dynamic measurements of cerebral pentose phosphate pathway activity in vivo using [1,6-13C2,6,6-2H2]glucose and microdialysis.Q42489346
Astroglial gap junction communication is increased by treatment with either glutamate or high K+ concentration.Q42490956
The specificity and metabolic implications of the inhibition of pyruvate transport in isolated mitochondria and intact tissue preparations by alpha-Cyano-4-hydroxycinnamate and related compoundsQ42554050
Novel model of neuronal bioenergetics: postsynaptic utilization of glucose but not lactate correlates positively with Ca2+ signalling in cultured mouse glutamatergic neurons.Q42556097
Is lactate a volume transmitter of metabolic states of the brain?Q42577305
Brain glutamine synthesis requires neuronal-born aspartate as amino donor for glial glutamate formation.Q42652594
Cerebral oxygen delivery and consumption during evoked neural activityQ42736688
The kinetics, substrate and inhibitor specificity of the lactate transporter of Ehrlich-Lettre tumour cells studied with the intracellular pH indicator BCECF.Q42829884
Remarkable increase in 14C-acetate uptake in an epilepsy model rat brain induced by lithium-pilocarpineQ43243427
Differentiation of glucose transport in human brain gray and white matterQ43595507
Preferential labeling of glial and meningial brain tumors with [2-(14)C]acetateQ43694533
In vivo measurements of brain glucose transport using the reversible Michaelis-Menten model and simultaneous measurements of cerebral blood flow changes during hypoglycemiaQ43697770
Glycolysis in neurons, not astrocytes, delays oxidative metabolism of human visual cortex during sustained checkerboard stimulation in vivoQ43820411
Alpha-cyano-4-hydroxycinnamate decreases both glucose and lactate metabolism in neurons and astrocytes: implications for lactate as an energy substrate for neuronsQ43825319
Local uptake of (14)C-labeled acetate and butyrate in rat brain in vivo during spreading cortical depressionQ43825340
Lactate efflux and the neuroenergetic basis of brain functionQ43825919
Blood-brain transfer of glucose and glucose analogs in newborn ratsQ43887422
Astrocyte glycogen sustains neuronal activity during hypoglycemia: studies with the glycogen phosphorylase inhibitor CP-316,819 ([R-R*,S*]-5-chloro-N-[2-hydroxy-3-(methoxymethylamino)-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-carboxamide).Q43987358
High glycogen levels in brains of rats with minimal environmental stimuli: implications for metabolic contributions of working astrocytesQ44240564
Generalized sensory stimulation of conscious rats increases labeling of oxidative pathways of glucose metabolism when the brain glucose-oxygen uptake ratio risesQ44240565
Effect of reactive cell density on net [2-14C]acetate uptake into rat brain: labeling of clusters containing GFAP+- and lectin+-immunoreactive cellsQ44268129
Behavioral training increases local astrocytic metabolic activity but does not alter outcome of mild transient ischemiaQ44280682
Influence of the Malate-Aspartate Shuttle on Oxidative Metabolism in SynaptosomesQ44351318
Glycogen regulation and functional role in mouse white matterQ44392771
Metabolic mapping in mammalian retina: a biochemical and 3H-2-deoxyglucose autoradiographic studyQ44541969
Developmental switch in brain nutrient transporter expression in the rat.Q44610876
Lactate is a preferential oxidative energy substrate over glucose for neurons in cultureQ44644241
Blood flow and glucose consumption in the optic nerve, retina and brain: effects of high intraocular pressureQ44684551
Correlation between local monocarboxylate transporter 1 (MCT1) and glucose transporter 1 (GLUT1) densities in the adult rat brainQ44732421
High extracellular K+ levels stimulate acetate oxidation in brain slices from well and malnourished ratsQ44983523
Selective uptake of [14C]2-deoxyglucose by neurons and astrocytes: high-resolution microautoradiographic imaging by cellular 14C-trajectography combined with immunohistochemistryQ45050950
Over-estimation of glucose-6-phosphatase activity in brain in vivo. Apparent difference in rates of [2-3H]glucose and [U-14C]glucose utilization is due to contamination of precursor pool with 14C-labeled products and incomplete recovery of 14C-labelQ45109328
Cerebral glucose utilization: comparison of [14C]deoxyglucose and [6-14C]glucose quantitative autoradiographyQ45148395
Neuroglial metabolism in the awake rat brain: CO2 fixation increases with brain activity.Q45188907
Activation of astrocytes in brain of conscious rats during acoustic stimulation: acetate utilization in working brainQ45247899
The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1.Q45735127
Neuronal glucose but not lactate utilization is positively correlated with NMDA-induced neurotransmission and fluctuations in cytosolic Ca2+ levels.Q46037718
Blood lactate is an important energy source for the human brain.Q46066218
Factors affecting the turnover of cerebral glycogen and limit dextrin in vivoQ48656244
Ca²⁺ signals of astrocytes are modulated by the NAD⁺/NADH redox stateQ48680039
Improved resolution of the 2-deoxy-D-glucose techniqueQ48703966
The effect of moderate and marked hypercapnia upon the energy state and upon the cytoplasmic NADH-NAD+ ratio of the rat brainQ48718889
Relationships between extraction and metabolism of glucose, blood flow, and tissue blood volume in regions of rat brainQ48740840
Rapid changes in local extracellular rat brain glucose observed with an in vivo glucose sensor.Q48754601
Modeling the dependence of hexose distribution volumes in brain on plasma glucose concentration: implications for estimation of the local 2-deoxyglucose lumped constantQ48783764
Local cerebral glucose consumption in the rat. II. Effects of unilateral substantia nigra stimulation in conscious and in halothane-anesthetized animalsQ48809025
Confounding effects of anesthesia on functional activation in rodent brain: a study of halothane and alpha-chloralose anesthesiaQ48821137
Gap junctions mediate intercellular spread of sodium between hippocampal astrocytes in situ.Q48822281
Influence of plasma glucose concentration on lumped constant of the deoxyglucose method: effects of hyperglycemia in the rat.Q48868857
Sugar transport across the blood-brain barrierQ48887184
Positron emission tomographic measurements of cerebral glucose utilization using [1-11C]D-glucoseQ48946380
Astrocytic energy metabolism and glutamate formation--relevance for 13C-NMR spectroscopy and importance of cytosolic/mitochondrial traffickingQ48960407
Cerebral metabolic responses to electroconvulsive shock and their modification by hypercapniaQ48961222
Exercise-induced changes in local cerebral glucose utilization in the rat.Q48968876
Glycolysis: link between PET and proton MR spectroscopic studies of the brainQ49123000
Energy-metabolizing enzymes in brain regions of adult and aging ratsQ49149434
Effects of electrical stimulation on metabolites in brain of decapitated miceQ51212633
Effects of convulsants on energy reserves in the cerebral cortexQ51212637
Precursors in vivo of glutamate, aspartate and their derivatives of rat brainQ51229612
Multiple hexokinases of rat tissues. Purification and comparison of soluble forms.Q51230657
Kinetic evidence for multiple binding sites on phosphofructokinase.Q51235228
Regional energy reserves in mouse brain and changes with ischaemia and anaesthesia.Q51238116
THE RELATIONSHIPS BETWEEN SUBSTRATES AND ENZYMES OF GLYCOLYSIS IN BRAINQ51279814
EFFECT OF ISCHEMIA ON KNOWN SUBSTRATES AND COFACTORS OF THE GLYCOLYTIC PATHWAY IN BRAINQ51279822
Substrate specificity of brain hexokinase.Q51340833
Barbiturate-enhanced detection of brain lesions by carbon-14-labeled 2-deoxyglucose autoradiography.Q51855566
The effects of apomorphine upon local cerebral glucose utilization in conscious rats and in rats anesthetized with chloral hydrate.Q51855975
Kinetics of regional blood-brain barrier transport and brain phosphorylation of glucose and 2-deoxyglucose the barbiturate-anesthetized rat.Q51862845
Persistent resetting of the cerebral oxygen/glucose uptake ratio by brain activation: evidence obtained with the Kety-Schmidt technique.Q52016550
Labeling of metabolic pools by [6-14C]glucose during K(+)-induced stimulation of glucose utilization in rat brain.Q52020186
Direct measurement of the lambda of the lumped constant of the deoxyglucose method in rat brain: determination of lambda and lumped constant from tissue glucose concentration or equilibrium brain/plasma distribution ratio for methylglucose.Q52053201
Local Cerebral Glucose Utilization in Controlled Graded Levels of Hyperglycemia in the Conscious RatQ52070094
Kinetics of transport and phosphorylation of 2-fluoro-2-deoxy-D-glucose in rat brain.Q52710123
A method for the simultaneous estimation of regional rates of glucose influx and phosphorylation in rat brain using radiolabeled 2-deoxyglucose.Q52734183
Exogenous glutamate concentration regulates the metabolic fate of glutamate in astrocytes.Q53707600
Functional glucokinase isoforms are expressed in rat brain.Q53912475
High glucose-induced expression of inflammatory cytokines and reactive oxygen species in cultured astrocytes.Q54333558
Determination of the deoxyglucose and glucose phosphorylation ratio and the lumped constant in rat brain and a transplantable rat glioma.Q55485251
Sensitive Reduction in 14C-acetate Uptake in a Short-term Ischemic Rat BrainQ60430785
Cerebral metabolic and circulatory changes in the rat during sustained seizures induced bydl-homocysteineQ66971426
Local cerebral glucose utilization of the awake rat during chronic administration of nicotineQ67998714
Quantitative autoradiographic measurement of local cerebral glucose utilization in freely moving rats during postnatal developmentQ68074220
Effect of pH on the kinetics of frog muscle phosphofructokinaseQ68385753
Functional activation of cerebral blood flow and metabolism before and after global ischemia of rat brainQ68437191
Topography of capillary density, glucose metabolism, and microvascular function within the rat inferior colliculusQ68962919
High resolution autoradiography at the regional topographic level with [14C]2-deoxyglucose and [3H]2-deoxyglucoseQ69074403
Glycolysis-induced discordance between glucose metabolic rates measured with radiolabeled fluorodeoxyglucose and glucoseQ69385840
Why the deoxyglucose method has proven so useful in cerebral activation studies: the unappreciated prevalence of stimulation-induced glycolysisQ69385848
Metabolic anatomy of brain: a comparison of regional capillary density, glucose metabolism, and enzyme activitiesQ34042786
Functional neuroimaging: a physiological perspectiveQ34046727
The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat.Q34062645
Lactate produced by glycogenolysis in astrocytes regulates memory processingQ34105200
Neurovascular and Neurometabolic Couplings in Dynamic Calibrated fMRI: Transient Oxidative Neuroenergetics for Block-Design and Event-Related Paradigms.Q34117072
Nonoxidative glucose consumption during focal physiologic neural activityQ34171272
Lactate transport and metabolism in the human brain: implications for the astrocyte-neuron lactate shuttle hypothesis.Q34174468
Aminooxyacetic acid inhibits the malate-aspartate shuttle in isolated nerve terminals and prevents the mitochondria from utilizing glycolytic substratesQ34185845
In vivo evidence for lactate as a neuronal energy sourceQ34185971
The [18F]fluorodeoxyglucose method for the measurement of local cerebral glucose utilization in manQ34186254
Evidence for a 'paravascular' fluid circulation in the mammalian central nervous system, provided by the rapid distribution of tracer protein throughout the brain from the subarachnoid spaceQ34197376
Developmental changes in the Ca2+-regulated mitochondrial aspartate-glutamate carrier aralar1 in brain and prominent expression in the spinal cord.Q34199388
Lactate: a preferred fuel for human brain metabolism in vivoQ34204521
The subcellular distribution and properties of hexokinases in the guinea-pig cerebral cortexQ34243892
The energetics of CNS white matter.Q34244625
Astroglial contribution to brain energy metabolism in humans revealed by 13C nuclear magnetic resonance spectroscopy: elucidation of the dominant pathway for neurotransmitter glutamate repletion and measurement of astrocytic oxidative metabolismQ34370800
Dynamic uncoupling and recoupling of perfusion and oxidative metabolism during focal brain activation in man.Q34378252
Do active cerebral neurons really use lactate rather than glucose?Q34384249
Intracellular fate of 2-NBDG, a fluorescent probe for glucose uptake activity, in Escherichia coli cellsQ34412777
Glucose and lactate metabolism during brain activationQ34464755
Fuelling cerebral activity in exercising man.Q34482022
Oxidative and nonoxidative metabolism of excited neurons and astrocytesQ34504180
Sustained neuronal activation raises oxidative metabolism to a new steady-state level: evidence from 1H NMR spectroscopy in the human visual cortexQ34573179
Brain Glutamine Synthesis Requires Neuronal Aspartate: A CommentaryQ34627490
Activity-dependent regulation of energy metabolism by astrocytes: an updateQ34656867
Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunologyQ34738708
Spatiotemporal evolution of the functional magnetic resonance imaging response to ultrashort stimuliQ34807796
Intrinsic bioenergetic properties and stress sensitivity of dopaminergic synaptosomesQ34868333
Stimulated changes in localized cerebral energy consumption under anesthesiaQ35070881
"Overshoot" of O₂ is required to maintain baseline tissue oxygenation at locations distal to blood vesselsQ35287793
Energy Substrates for Neurons during Neural Activity: A Critical Review of the Astrocyte-Neuron Lactate Shuttle HypothesisQ35576702
Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjectsQ35591436
Neuroenergetics: calling upon astrocytes to satisfy hungry neuronsQ35677227
Neurobiology of panic and pH chemosensation in the brainQ35686869
Brain glycogen content and metabolism in subjects with type 1 diabetes and hypoglycemia unawarenessQ35738318
Nutrition during brain activation: does cell-to-cell lactate shuttling contribute significantly to sweet and sour food for thought?Q35774454
Astroglial pentose phosphate pathway rates in response to high-glucose environments.Q35846489
Anesthesia and the quantitative evaluation of neurovascular couplingQ36079285
Sweet sixteen for ANLS.Q36079324
Role of NMDA receptor upon [14C]acetate uptake into intact rat brainQ46117871
Factors that control the effect of pH on glycolysis in leukocytesQ46334031
Coupling of cerebral blood flow and oxygen consumption during physiological activation and deactivation measured with fMRI.Q46394838
Sensory stimulation induces local cerebral glycogenolysis: demonstration by autoradiographyQ46522050
P275copyright licenseCreative Commons Attribution-NonCommercial 2.5 GenericQ19113746
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectbrainQ1073
nervous systemQ9404
energy metabolismQ30225378
P577publication date2012-07-20
P1433published inASN NeuroQ20312578
P1476titleFueling and imaging brain activation
P478volume4

Reverse relations

cites work (P2860)
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