Membrane-anchored uPAR regulates the proliferation, marrow pool size, engraftment, and mobilization of mouse hematopoietic stem/progenitor cells.

scientific article

Membrane-anchored uPAR regulates the proliferation, marrow pool size, engraftment, and mobilization of mouse hematopoietic stem/progenitor cells. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1172/JCI36010
P932PMC publication ID2662545
P698PubMed publication ID19273908
P5875ResearchGate publication ID24189200

P50authorCatherine VerfaillieQ615166
Peter CarmelietQ2074300
Francesco BlasiQ38329340
Nicolai SideniusQ41875088
Lieve MoonsQ50923690
Annapaola AndolfoQ95966302
P2093author name stringMieke Dewerchin
Marc Tjwa
Koen Theunissen
Rute Moura
Maria De Mol
Sandra Jansen
P2860cites workRecruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligandQ24644662
Metalloproteases cleave the urokinase-type plasminogen activator receptor in the D1-D2 linker region and expose epitopes not present in the intact soluble receptorQ28219045
Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow nicheQ28505006
Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CMLQ29614278
SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cellsQ29615006
Plasmin cleaves the juxtamembrane domain and releases truncated species of the urokinase receptor (CD87) from human bronchial epithelial cells.Q31110978
Urokinase-type plasminogen activator receptor (CD87) is a ligand for integrins and mediates cell-cell interaction.Q31506532
Homing and engraftment potential of Sca-1(+)lin(-) cells fractionated on the basis of adhesion molecule expression and position in cell cycleQ33180893
The VLA4/VCAM-1 adhesion pathway defines contrasting mechanisms of lodgement of transplanted murine hemopoietic progenitors between bone marrow and spleenQ33859887
The fibrinolytic receptor for urokinase activates the G protein-coupled chemotactic receptor FPRL1/LXA4R.Q34009345
uPAR: a versatile signalling orchestratorQ34162183
Roles of Sca-1 in hematopoietic stem/progenitor cell functionQ34427296
Deletion of alpha4 integrins from adult hematopoietic cells reveals roles in homeostasis, regeneration, and homing.Q34988228
Direct adhesion to bone marrow stroma via fibronectin receptors inhibits hematopoietic progenitor proliferationQ35751079
Hierarchy of molecular-pathway usage in bone marrow homing and its shift by cytokines.Q35848474
The human hematopoietic stem cell compartment is heterogeneous for CXCR4 expressionQ35851822
Altered proliferative response by T lymphocytes of Ly-6A (Sca-1) null miceQ36380511
Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fatesQ36403978
Endothelial selectins and vascular cell adhesion molecule-1 promote hematopoietic progenitor homing to bone marrowQ36735787
Plasmin therapy enhances mobilization of HPCs after G-CSFQ36969719
The plasminogen fibrinolytic pathway is required for hematopoietic regenerationQ37106230
Bleomycin-induced pulmonary fibrosis in fibrinogen-null mice.Q37271801
Generation and characterization of urokinase receptor-deficient miceQ37351869
Mobilization and homing of peripheral blood progenitors is related to reversible downregulation of alpha4 beta1 integrin expression and functionQ37382736
c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiationQ37620912
Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo.Q38361644
The cleavage of the urokinase receptor regulates its multiple functionsQ40701611
G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4.Q40724468
Anti-VLA4/VCAM-1-induced mobilization requires cooperative signaling through the kit/mkit ligand pathwayQ40863085
Proteolytic cleavage of the urokinase receptor substitutes for the agonist-induced chemotactic effectQ41064411
CD34-deficient mice have reduced eosinophil accumulation after allergen exposure and show a novel crossreactive 90-kD protein.Q41204159
Two alternatively spliced mouse urokinase receptor mRNAs with different histological localization in the gastrointestinal tractQ41877722
Endothelial protein C receptor (CD201) explicitly identifies hematopoietic stem cells in murine bone marrowQ42070051
Efficient transplantation via antibody-based clearance of hematopoietic stem cell nichesQ42083509
Fibrinolysis-independent role of plasmin and its activators in the haematopoietic recovery after myeloablationQ42389714
SHIP deficiency enhances HSC proliferation and survival but compromises homing and repopulationQ42509077
Lack of alpha4 integrin expression in stem cells restricts competitive function and self-renewal activityQ42742283
Molecular pathways in bone marrow homing: dominant role of alpha(4)beta(1) over beta(2)-integrins and selectinsQ43757332
Hematopoietic stem cell and progenitor defects in Sca-1/Ly-6A-null miceQ44189610
Granulocyte colony-stimulating factor induces the release in the bone marrow of proteases that cleave c-KIT receptor (CD117) from the surface of hematopoietic progenitor cellsQ44319078
PSGL-1 participates in E-selectin-mediated progenitor homing to bone marrow: evidence for cooperation between E-selectin ligands and alpha4 integrin.Q44451874
Membrane-bound stem cell factor is a key regulator in the initial lodgment of stem cells within the endosteal marrow region.Q44684690
The soluble D2D3(88-274) fragment of the urokinase receptor inhibits monocyte chemotaxis and integrin-dependent cell adhesionQ44918155
Effects of Disruption of The Plasminogen Gene on Thrombosis, Growth, and Health in MiceQ45867476
Region- and age-specific deficits in gamma-aminobutyric acidergic neuron development in the telencephalon of the uPAR(-/-) mouseQ46605342
Role of adhesion molecules in the homing and mobilization of murine hematopoietic stem and progenitor cellsQ47781655
Soluble c-kit receptor mobilizes hematopoietic stem cells to peripheral blood in miceQ47860870
Reduced retention of radioprotective hematopoietic cells within the bone marrow microenvironment in CXCR4-/- chimeric mice.Q53743494
Spleen-Colony Formation in Anemic Mice of Genotype WWQ56246878
Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failureQ62383757
Urokinase-type plasminogen activation in three human breast cancer cell lines correlates with their in vitro invasivenessQ71171008
Competitive repopulation: a new assay for long-term stem cell functional capacityQ72124567
Phenotypic and functional changes induced at the clonal level in hematopoietic stem cells after 5-fluorouracil treatmentQ73358664
Soluble urokinase receptor levels correlate with number of circulating tumor cells in acute myeloid leukemia and decrease rapidly during chemotherapyQ73393754
Homing efficiency, cell cycle kinetics, and survival of quiescent and cycling human CD34(+) cells transplanted into conditioned NOD/SCID recipientsQ77678262
Current mechanistic scenarios in hematopoietic stem/progenitor cell mobilizationQ79267157
In vivo activity of the cleaved form of soluble urokinase receptor: a new hematopoietic stem/progenitor cell mobilizerQ79362744
A direct link between expression of urokinase plasminogen activator receptor, growth rate and oncogenic transformation in mouse embryonic fibroblastsQ80027715
Involvement of the urokinase-type plasminogen activator receptor in hematopoietic stem cell mobilizationQ80884356
Increased soluble urokinase plasminogen activator receptor (suPAR) serum levels after granulocyte colony-stimulating factor treatment do not predict successful progenitor cell mobilization in vivoQ83101468
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)1008-1018
P577publication date2009-03-09
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleMembrane-anchored uPAR regulates the proliferation, marrow pool size, engraftment, and mobilization of mouse hematopoietic stem/progenitor cells
P478volume119

Reverse relations

cites work (P2860)
Q47101799Beta Adrenergic Signaling: A Targetable Regulator of Angiosarcoma and Hemangiosarcoma
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Q36772330Evidence that a lipolytic enzyme--hematopoietic-specific phospholipase C-β2--promotes mobilization of hematopoietic stem cells by decreasing their lipid raft-mediated bone marrow retention and increasing the promobilizing effects of granulocytes
Q39003470Extracellular molecules in hematopoietic stem cell mobilisation
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Q34053623High molecular weight kininogen binds phosphatidylserine and opsonizes urokinase plasminogen activator receptor-mediated efferocytosis
Q41761236Involvement of urokinase receptor in the cross-talk between human hematopoietic stem cells and bone marrow microenvironment
Q38369838Membrane lipid rafts, master regulators of hematopoietic stem cell retention in bone marrow and their trafficking
Q33629803Microglia and the urokinase plasminogen activator receptor/uPA system in innate brain inflammation
Q89558892Mobilized peripheral blood: an updated perspective
Q34253089Novel evidence that crosstalk between the complement, coagulation and fibrinolysis proteolytic cascades is involved in mobilization of hematopoietic stem/progenitor cells (HSPCs)
Q36647485PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells
Q33818848Plasminogen regulates cardiac repair after myocardial infarction through its noncanonical function in stem cell homing to the infarcted heart
Q35173760Plasminogen regulates stromal cell-derived factor-1/CXCR4-mediated hematopoietic stem cell mobilization by activation of matrix metalloproteinase-9.
Q37660895Regulation of cell signalling by uPAR.
Q60919548Regulatory Roles of Sortilin and SorLA in Immune-Related Processes
Q38583085Role of mesenchymal stem cell-derived fibrinolytic factor in tissue regeneration and cancer progression
Q36997616Role of urokinase receptor in tumor progression and development
Q37477918Sphingosine-1-phosphate-mediated mobilization of hematopoietic stem/progenitor cells during intravascular hemolysis requires attenuation of SDF-1-CXCR4 retention signaling in bone marrow
Q38822690Stroma-Derived Connective Tissue Growth Factor Maintains Cell Cycle Progression and Repopulation Activity of Hematopoietic Stem Cells In Vitro
Q35041174The ins and outs of hematopoietic stem cells: studies to improve transplantation outcomes
Q38057219The plasminogen system in regulating stem cell mobilization
Q36124907The role of novel and known extracellular matrix and adhesion molecules in the homeostatic and regenerative bone marrow microenvironment
Q40131882The soluble form of LR11 protein is a regulator of hypoxia-induced, urokinase-type plasminogen activator receptor (uPAR)-mediated adhesion of immature hematological cells.
Q38863136Urokinase receptor and CXCR4 are regulated by common microRNAs in leukaemia cells.

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