Repurposing of the Open Access Malaria Box for Kinetoplastid Diseases Identifies Novel Active Scaffolds against Trypanosomatids

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Repurposing of the Open Access Malaria Box for Kinetoplastid Diseases Identifies Novel Active Scaffolds against Trypanosomatids is …
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scholarly articleQ13442814

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P356DOI10.1177/1087057115569155
P698PubMed publication ID25690568
P5875ResearchGate publication ID272513423

P50authorJean-Robert IosetQ124670633
Marcel KaiserQ30347237
P2093author name stringLouis Maes
Thomas Spangenberg
Leela Pavan Tadoori
P2860cites workTargeting Trypanothione Metabolism in Trypanosomatid Human ParasitesQ37782110
Folate metabolism in human malaria parasites--75 years on.Q38090355
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Effectiveness of a 10-day melarsoprol schedule for the treatment of late-stage human African trypanosomiasis: confirmation from a multinational study (IMPAMEL II).Q39436993
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Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activityQ41824183
Rationally designed selective inhibitors of trypanothione reductase. Phenothiazines and related tricyclics as lead structuresQ42152987
2,4-Diaminopyrimidines as inhibitors of Leishmanial and Trypanosomal dihydrofolate reductaseQ44615883
Thousands of chemical starting points for antimalarial lead identificationQ24289329
Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug DiscoveryQ27861956
Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasisQ28271849
Tolerance and safety of nifurtimox in patients with chronic chagas diseaseQ28295159
Geographical variation in the response of visceral leishmaniasis to paromomycin in East Africa: a multicentre, open-label, randomized trialQ28475917
Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51Q28481694
Isothermal microcalorimetry, a new tool to monitor drug action against Trypanosoma brucei and Plasmodium falciparumQ28484117
The open access malaria box: a drug discovery catalyst for neglected diseasesQ28533977
Orally active antischistosomal early leads identified from the open access malaria boxQ28538566
New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassaysQ29615588
Chemical genetics of Plasmodium falciparumQ29617272
Identification of Cryptosporidium parvum active chemical series by Repurposing the open access malaria boxQ30486772
Design, synthesis and evaluation of 2,4-diaminoquinazolines as inhibitors of trypanosomal and leishmanial dihydrofolate reductase.Q31152213
Identification and optimization of an aminoalcohol-carbazole series with antimalarial propertiesQ33636074
Use of isothermal microcalorimetry to monitor microbial activities.Q34020076
Leishmaniasis: an update of current pharmacotherapyQ34318765
Screening strategies to identify new chemical diversity for drug development to treat kinetoplastid infectionsQ34975777
Anti-infective potential of natural products: how to develop a stronger in vitro 'proof-of-concept'.Q36477657
Pharmacokinetics, Trypanosoma brucei gambiense efficacy, and time of drug action of DB829, a preclinical candidate for treatment of second-stage human African trypanosomiasisQ37263574
Side effects of benznidazole as treatment in chronic Chagas disease: fears and realitiesQ37404837
Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: implications for Chagas disease drug discovery and developmentQ37732551
P433issue5
P921main subjectmalariaQ12156
TrypanosomatidaeQ132954
P304page(s)634-645
P577publication date2015-02-17
P1433published inJournal of Biomolecular ScreeningQ6294856
P1476titleRepurposing of the Open Access Malaria Box for Kinetoplastid Diseases Identifies Novel Active Scaffolds against Trypanosomatids
P478volume20

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