Sns and Kirre, the Drosophila orthologs of Nephrin and Neph1, direct adhesion, fusion and formation of a slit diaphragm-like structure in insect nephrocytes.

scientific article

Sns and Kirre, the Drosophila orthologs of Nephrin and Neph1, direct adhesion, fusion and formation of a slit diaphragm-like structure in insect nephrocytes. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1242/DEV.031609
P932PMC publication ID2729346
P698PubMed publication ID19515699

P50authorElspeth PearceQ84041915
P2093author name stringFengli Guo
Shufei Zhuang
Rhonda Trimble
Susan M Abmayr
Huanjie Shao
P2860cites workNck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytesQ24307359
Positionally cloned gene for a novel glomerular protein--nephrin--is mutated in congenital nephrotic syndromeQ24314612
NEPH1 defines a novel family of podocin interacting proteinsQ24317419
Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRINQ24550913
Nephrin is specifically located at the slit diaphragm of glomerular podocytesQ24644718
Neph1 and nephrin interaction in the slit diaphragm is an important determinant of glomerular permeabilityQ24669831
Fab1 phosphatidylinositol 3-phosphate 5-kinase controls trafficking but not silencing of endocytosed receptorsQ24671705
A positive feedback loop between Dumbfounded and Rolling pebbles leads to myotube enlargement in DrosophilaQ24678756
Homodimerization and heterodimerization of the glomerular podocyte proteins nephrin and NEPH1Q28186665
Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathwayQ28187612
The carboxyl terminus of Neph family members binds to the PDZ domain protein zonula occludens-1Q28208445
Nephrin and Neph1 co-localize at the podocyte foot process intercellular junction and form cis hetero-oligomersQ28577451
The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal deathQ28588477
Neph1 cooperates with nephrin to transduce a signal that induces actin polymerizationQ28594662
Unraveling the mechanisms of glomerular ultrafiltration: nephrin, a key component of the slit diaphragmQ28611496
Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerizationQ30159868
Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck.Q30176648
Discovery of the congenital nephrotic syndrome gene discloses the structure of the mysterious molecular sieve of the kidneyQ33759934
Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomographyQ33844627
Signaling at the slit diaphragmQ35778324
Nephrin promotes cell-cell adhesion through homophilic interactionsQ35843335
Reversible blockage of membrane retrieval and endocytosis in the garland cell of the temperature-sensitive mutant of Drosophila melanogaster, shibirets1.Q36207608
Hsc70 is required for endocytosis and clathrin function in Drosophila.Q36323720
Analysis of the cell adhesion molecule sticks-and-stones reveals multiple redundant functional domains, protein-interaction motifs and phosphorylated tyrosines that direct myoblast fusion in Drosophila melanogasterQ36515837
Nephrin--a unique structural and signaling protein of the kidney filterQ36927196
The immunoglobulin superfamily member Hbs functions redundantly with Sns in interactions between founder and fusion-competent myoblastsQ37201425
The insect nephrocyte is a podocyte-like cell with a filtration slit diaphragmQ39923639
A critical function for the actin cytoskeleton in targeted exocytosis of prefusion vesicles during myoblast fusionQ40147673
Preferential adhesion mediated by Hibris and Roughest regulates morphogenesis and patterning in the Drosophila eye.Q40413614
Drosophila SNS, a member of the immunoglobulin superfamily that is essential for myoblast fusion.Q40443633
SCAR/WAVE and Arp2/3 are crucial for cytoskeletal remodeling at the site of myoblast fusionQ40887859
Role of nephrin in cell junction formation in human nephrogenesisQ41778709
Nephrin localizes to the slit pore of the glomerular epithelial cellQ42610945
Membrane pinch-off and reinsertion observed in living cells of DrosophilaQ46547196
Transformational process of the endosomal compartment in nephrocytes of Drosophila melanogasterQ46600582
WASP and SCAR have distinct roles in activating the Arp2/3 complex during myoblast fusionQ47070382
Drosophila Lame duck, a novel member of the Gli superfamily, acts as a key regulator of myogenesis by controlling fusion-competent myoblast developmentQ47070597
The Drosophila tamou gene, a component of the activating pathway of extramacrochaetae expression, encodes a protein homologous to mammalian cell-cell junction-associated protein ZO-1.Q47070786
Characterization of Drosophila hibris, a gene related to human nephrinQ47070804
The immunoglobulin-like protein Hibris functions as a dose-dependent regulator of myoblast fusion and is differentially controlled by Ras and Notch signalingQ47070961
Drosophila dumbfounded: a myoblast attractant essential for fusionQ47071602
rst and its paralogue kirre act redundantly during embryonic muscle development in DrosophilaQ47072376
Determinants of vascular permeability in the kidney glomerulusQ48300844
Crumbs, a component of the apical membrane, is required for zonula adherens formation in primary epithelia of Drosophila.Q52200621
Polychaetoid is required to restrict segregation of sensory organ precursors from proneural clusters in Drosophila.Q52200762
Rop and Ras2, members of the Sec1 and Ras families, are localized in the outer membranes of labyrinthine channels and vesicles of Drosophila nephrocyte, the Garland cellQ52537074
SNS: Adhesive properties, localization requirements and ectodomain dependence in S2 cells and embryonic myoblasts.Q52652934
Mitosis and the presence of binucleate cells among glomerular podocytes in diseased human kidneysQ71898841
The ultrastructure of the wreath cells ofDrosophila melanogaster larvaeQ72373384
P433issue14
P407language of work or nameEnglishQ1860
P921main subjectinsectQ1390
DrosophilaQ312154
Roughest Dmel_CG4125Q29814548
Kin of irre Dmel_CG3653Q29815272
P1104number of pages10
P304page(s)2335-2344
P577publication date2009-06-10
P1433published inDevelopmentQ3025404
P1476titleSns and Kirre, the Drosophila orthologs of Nephrin and Neph1, direct adhesion, fusion and formation of a slit diaphragm-like structure in insect nephrocytes
P478volume136

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