A combined theoretical and experimental study of the ammonia tunnel in carbamoyl phosphate synthetase

scientific article

A combined theoretical and experimental study of the ammonia tunnel in carbamoyl phosphate synthetase is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1021/JA902557R
P932PMC publication ID2748306
P698PubMed publication ID19569682
P5875ResearchGate publication ID26333523

P50authorFrank M RaushelQ56985507
P2093author name stringYubo Fan
Qiang Shao
Yi-Qin Gao
Liliya Lund
P2860cites workDevelopment of the Colle-Salvetti correlation-energy formula into a functional of the electron densityQ21708802
Density-functional exchange-energy approximation with correct asymptotic behaviorQ21709057
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The structure of carbamoyl phosphate synthetase determined to 2.1 A resolutionQ27617647
Three-dimensional structure of Escherichia coli asparagine synthetase B: a short journey from substrate to productQ27620599
The small subunit of carbamoyl phosphate synthetase: snapshots along the reaction pathwayQ27620602
Channeling of ammonia in glucosamine-6-phosphate synthaseQ27636096
Structural evidence for ammonia tunneling across the (beta alpha)(8) barrel of the imidazole glycerol phosphate synthase bienzyme complexQ27637726
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Regulation of active site coupling in glutamine-dependent NAD(+) synthetaseQ27654039
Coupled formation of an amidotransferase interdomain ammonia channel and a phosphoribosyltransferase active siteQ27745868
The SWISS-MODEL workspace: a web-based environment for protein structure homology modellingQ27860637
Structure of carbamoyl phosphate synthetase: a journey of 96 A from substrate to productQ28239846
Tunneling of intermediates in enzyme-catalyzed reactionsQ28259892
Role of conserved residues within the carboxy phosphate domain of carbamoyl phosphate synthetaseQ28296603
Development and testing of a general amber force fieldQ29547642
Perforation of the tunnel wall in carbamoyl phosphate synthetase derails the passage of ammonia between sequential active sitesQ34318162
Enzymes with molecular tunnelsQ35177322
DNA sequence of the carA gene and the control region of carAB: tandem promoters, respectively controlled by arginine and the pyrimidines, regulate the synthesis of carbamoyl-phosphate synthetase in Escherichia coli K-12.Q36264803
Role of the four conserved histidine residues in the amidotransferase domain of carbamoyl phosphate synthetaseQ38333908
Binding of allosteric effectors to carbamyl-phosphate synthetase from Escherichia coliQ40046996
Kinetic mechanism of Escherichia coli carbamoyl-phosphate synthetaseQ40196165
Determination of rate-limiting steps of Escherichia coli carbamoyl-phosphate synthase. Rapid quench and isotope partitioning experimentsQ40243505
Detailed mechanism for AmtB conducting NH4+/NH3: molecular dynamics simulations.Q42989377
Development of polyphosphate parameters for use with the AMBER force field.Q44449257
Structural basis for tRNA-dependent amidotransferase function.Q46745511
Mechanism for the transport of ammonia within carbamoyl phosphate synthetase determined by molecular dynamics simulationsQ46791308
Glutamine binding opens the ammonia channel and activates glucosamine-6P synthaseQ46844173
Physiology and genetics of carbamoylphosphate synthesis in Escherichia coli K12.Q53963135
A molecular wedge for triggering the amidotransferase activity of carbamoyl phosphate synthetase.Q54637738
Glutamine-dependent NAD+SynthetaseQ57734378
Regulation and mutation affecting a glutamine dependent formation of carbamyl phosphate in Escherichia coliQ71160563
Control of Escherichia coli Carbamyl Phosphate Synthetase by Purine and Pyrimidine Nucleotides*Q71209964
Synchronization of the three reaction centers within carbamoyl phosphate synthetaseQ73811557
P433issue29
P407language of work or nameEnglishQ1860
P304page(s)10211-10219
P577publication date2009-07-01
P1433published inJournal of the American Chemical SocietyQ898902
P1476titleA combined theoretical and experimental study of the ammonia tunnel in carbamoyl phosphate synthetase
P478volume131