Ethanol effects on GABA-gated current in a model of increased alpha4betadelta GABAA receptor expression depend on time course and preexposure to low concentrations of the drug

scientific article

Ethanol effects on GABA-gated current in a model of increased alpha4betadelta GABAA receptor expression depend on time course and preexposure to low concentrations of the drug is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.ALCOHOL.2007.04.007
P932PMC publication ID2658629
P698PubMed publication ID17591545
P5875ResearchGate publication ID6244982

P50authorSheryl S. SmithQ43243561
P2093author name stringQi Hua Gong
P2860cites workLow-dose alcohol actions on alpha4beta3delta GABAA receptors are reversed by the behavioral alcohol antagonist Ro15-4513Q24548486
Ethanol potently and competitively inhibits binding of the alcohol antagonist Ro15-4513 to alpha4/6beta3delta GABAA receptorsQ24548490
Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptorsQ24673026
Short-term exposure to a neuroactive steroid increases alpha4 GABA(A) receptor subunit levels in association with increased anxiety in the female ratQ28345578
Alcohol actions on GABA(A) receptors: from protein structure to mouse behavior.Q30328276
Effects of a low dose of ethanol in an animal model of premenstrual anxietyQ30430592
Hormonally regulated alpha(4)beta(2)delta GABA(A) receptors are a target for alcoholQ30481041
Short-term steroid treatment increases delta GABAA receptor subunit expression in rat CA1 hippocampus: pharmacological and behavioral effectsQ30481043
Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptorsQ33717685
Alcohol-induced motor impairment caused by increased extrasynaptic GABA(A) receptor activityQ33787183
Is premenstrual dysphoric disorder a distinct clinical entity?Q33934979
Ethanol enhances alpha 4 beta 3 delta and alpha 6 beta 3 delta gamma-aminobutyric acid type A receptors at low concentrations known to affect humansQ34277701
Perisynaptic localization of delta subunit-containing GABA(A) receptors and their activation by GABA spillover in the mouse dentate gyrus.Q34277867
Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors.Q34440513
Ethanol increases GABAergic transmission at both pre- and postsynaptic sites in rat central amygdala neuronsQ34763227
Ethanol stimulates gamma-aminobutyric acid receptor-mediated chloride transport in rat brain synaptoneurosomesQ35609817
Sensorimotor and physiological effects of various alcoholic beveragesQ35957621
Protein kinase C regulation of GABAA receptorsQ36017807
Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by alpha5 subunit-containing gamma-aminobutyric acid type A receptorsQ37074693
Low ethanol concentrations enhance GABAergic inhibitory postsynaptic potentials in hippocampal pyramidal neurons only after block of GABAB receptorsQ37613630
The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalonQ38330309
The delta subunit of gamma-aminobutyric acid type A receptors does not confer sensitivity to low concentrations of ethanol.Q40354319
Biological function of GABAA/benzodiazepine receptor heterogeneityQ40403891
Activation of GABA(A) receptors containing the alpha4 subunit by GABA and pentobarbitalQ40589518
Desensitization mechanism of GABA receptors revealed by single oocyte binding and receptor function.Q40704823
Dominant gating governing transient GABA(A) receptor activity: a first latency and Po/o analysis.Q40781489
Ethanol enhances GABA-induced 36Cl-influx in primary spinal cord cultured neuronsQ42525667
Characterization of discriminative stimulus effects of the neuroactive steroid pregnanolone.Q43575475
GABA(A)-receptor delta subunit knockout mice have multiple defects in behavioral responses to ethanolQ43847997
Receptors with different affinities mediate phasic and tonic GABA(A) conductances in hippocampal neurons.Q43990181
Effect of a dose of ethanol on acute tolerance and ethanol consumption in alcohol drinker(UChB) and non-drinker (UChA) rats.Q44070049
Conditional rescue of protein kinase C epsilon regulates ethanol preference and hypnotic sensitivity in adult mice.Q44213507
Anxiogenic effects of neurosteroid exposure: sex differences and altered GABAA receptor pharmacology in adult ratsQ44329196
Brain ethanol concentrations and ethanol discrimination in rats: effects of dose and timeQ44396475
Ethanol Inhibits α-Amino-3-hydyroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Function in Central Nervous System Neurons by Stabilizing DesensitizationQ44432169
Benzodiazepine agonist and inverse agonist actions on GABAA receptor-operated chloride channels. II. Chronic effects of ethanol.Q44632977
The distribution of thirteen GABAA receptor subunit mRNAs in the rat brain. III. Embryonic and postnatal developmentQ44767968
Alcohol enhances GABAergic transmission to cerebellar granule cells via an increase in Golgi cell excitability.Q44844941
Altered sensitivity to alcohol in the late luteal phase among patients with premenstrual dysphoric disorderQ44864438
Altered pharmacology of synaptic and extrasynaptic GABAA receptors on CA1 hippocampal neurons is consistent with subunit changes in a model of alcohol withdrawal and dependenceQ44883361
Ethanol administration rapidly reverses alpha4 GABAA receptor subunit upregulation following steroid exposureQ44912581
Discriminative stimulus effects of ethanol in mice lacking the gamma-aminobutyric acid type A receptor delta subunitQ44940005
No difference in responsiveness to a low dose of alcohol between healthy women and men.Q44976342
Characterization of acute functional tolerance to the hypnotic effects of ethanol in miceQ44977085
Low ethanol concentrations selectively augment the tonic inhibition mediated by delta subunit-containing GABAA receptors in hippocampal neurons.Q45072876
Functional and structural analysis of the GABAA receptor alpha 1 subunit during channel gating and alcohol modulationQ45136842
Tiagabine reduces ethanol reward in C57BL/6 mice under acute and chronic administration regimensQ46376318
Chronic intermittent ethanol treatment in rats increases GABA(A) receptor alpha4-subunit expression: possible relevance to alcohol dependenceQ46909881
Benzodiazepine, barbiturate, ethanol and hypnotic steroid hormone modulation of GABA-mediated chloride ion transport in rat brain synaptoneurosomes.Q48160357
A selective imidazobenzodiazepine antagonist of ethanol in the rat.Q48265680
The effects of ethanol on EEG activity in males at risk for alcoholismQ48281398
A new naturally occurring GABA(A) receptor subunit partnership with high sensitivity to ethanolQ48341591
Lanthanum-mediated modification of GABAA receptor deactivation, desensitization and inhibitory synaptic currents in rat cerebellar neurons.Q48406509
Effects of ethanol on tonic GABA currents in cerebellar granule cells and mammalian cells recombinantly expressing GABA(A) receptorsQ48470142
GABA(A) receptor alpha4 subunit suppression prevents withdrawal properties of an endogenous steroidQ48472565
Social isolation-induced increase in alpha and delta subunit gene expression is associated with a greater efficacy of ethanol on steroidogenesis and GABA receptor functionQ48485640
Patients with premenstrual syndrome have a different sensitivity to a neuroactive steroid during the menstrual cycle compared to control subjectsQ48507572
Ethanol modulates the interaction of the endogenous neurosteroid allopregnanolone with the alpha1beta2gamma2L GABAA receptorQ48643666
Bidirectional alterations of GABA(A) receptor subunit peptide levels in rat cortex during chronic ethanol consumption and withdrawal.Q48677442
Behavioral responses to ethanol in light and moderate social drinkers following naltrexone pretreatmentQ48739532
Inhibition of rho1 receptor GABAergic currents by alcohols and volatile anesthetics.Q49016208
Picrotoxinin receptor ligand blocks anti-punishment effects of alcohol.Q52249808
Effects of ethanol on startle responding in alcohol-preferring and -non-preferring rats.Q52541829
Ethanol stimulates GABA receptor-mediated Cl- ion flux in vitro: possible relationship to the anxiolytic and intoxicating actions of alcoholQ69912954
Acute and chronic alcohol tolerance in humans: effects of dose and consecutive days of exposureQ72543236
Slow desensitization regulates the availability of synaptic GABA(A) receptorsQ73119652
Acute tolerance during intravenous infusion of alcohol: comparison of performance during ascending and steady state concentrations--a pilot studyQ73289921
Contrasting actions of lanthanum on different recombinant gamma-aminobutyric acid receptor isoforms expressed in L929 fibroblastsQ73467360
Acute alcohol tolerance in social drinkers: Changes in subjective effects dependent on the alcohol dose and prior alcohol experienceQ73481340
GABAA receptor subunit gamma2 and delta subtypes confer unique kinetic properties on recombinant GABAA receptor currents in mouse fibroblastsQ77610176
P433issue3
P304page(s)223-231
P577publication date2007-05-01
P1433published inAlcoholQ15724430
P1476titleEthanol effects on GABA-gated current in a model of increased alpha4betadelta GABAA receptor expression depend on time course and preexposure to low concentrations of the drug
P478volume41

Reverse relations

cites work (P2860)
Q28265814A controlled trial of flumazenil and gabapentin for initial treatment of methylamphetamine dependence
Q55234297Effects of Ethanol on Sensory Inputs to the Medial Giant Interneurons of Crayfish.
Q39289210Effects of acute alcohol on excitability in the CNS.
Q35061649Ethanol, not detectably metabolized in brain, significantly reduces brain metabolism, probably via action at specific GABA(A) receptors and has measureable metabolic effects at very low concentrations
Q60053955Ethanol-induced enhancement of inhibitory synaptic transmission in the rat spinal substantia gelatinosa
Q24561815The role of sex steroids in catamenial epilepsy and premenstrual dysphoric disorder: implications for diagnosis and treatment

Search more.