Sequential phase II Southwest Oncology Group studies (S0112 and S0301) of daunorubicin and cytarabine by continuous infusion, without and with ciclosporin, in older patients with previously untreated acute myeloid leukaemia

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Sequential phase II Southwest Oncology Group studies (S0112 and S0301) of daunorubicin and cytarabine by continuous infusion, without and with ciclosporin, in older patients with previously untreated acute myeloid leukaemia is …
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scholarly articleQ13442814

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P356DOI10.1111/J.1365-2141.2009.07919.X
P932PMC publication ID2967366
P698PubMed publication ID19821823
P5875ResearchGate publication ID26887556

P50authorAlan F ListQ63634762
Frederick R. AppelbaumQ75025725
Thomas R ChaunceyQ75025754
Harry P ErbaQ93114769
Cheryl L. WillmanQ110811050
Marilyn L SlovakQ114428079
Holly GundackerQ114777553
Shaker R DakhilQ114777556
P2093author name stringMazyar Shadman
I-Ming Chen
Kenneth J Kopecky
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Outcome after induction chemotherapy for older patients with acute myeloid leukemia is not improved with mitoxantrone and etoposide compared to cytarabine and daunorubicin: a Southwest Oncology Group studyQ34528336
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Combination of quinine as a potential reversing agent with mitoxantrone and cytarabine for the treatment of acute leukemias: a randomized multicenter study.Q41175330
Synergistic reversal of multidrug-resistance phenotype in acute myeloid leukemia cells by cyclosporin A and cremophor EL.Q41483617
Treatment of poor prognosis AML patients using PSC833 (valspodar) plus mitoxantrone, etoposide, and cytarabine (PSC-MEC).Q41692610
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Cyclosporine inhibition of P-glycoprotein in chronic myeloid leukemia blast phase.Q44102028
Quinine as a multidrug resistance inhibitor: a phase 3 multicentric randomized study in adult de novo acute myelogenous leukemiaQ44381147
Proof without prejudice: use of the Kolmogorov-Smirnov test for the analysis of histograms from flow systems and other sourcesQ44578925
Dose escalation studies of cytarabine, daunorubicin, and etoposide with and without multidrug resistance modulation with PSC-833 in untreated adults with acute myeloid leukemia younger than 60 years: final induction results of Cancer and Leukemia GrQ45130073
A phase I trial of continuous infusion of the multidrug resistance inhibitor zosuquidar with daunorubicin and cytarabine in acute myeloid leukemia.Q46183389
The value of the MDR1 reversal agent PSC-833 in addition to daunorubicin and cytarabine in the treatment of elderly patients with previously untreated acute myeloid leukemia (AML), in relation to MDR1 status at diagnosisQ46580597
Mitoxantrone, etoposide, and cytarabine plus cyclosporine for patients with relapsed or refractory acute myeloid leukemia: an Eastern Cooperative Oncology Group pilot study.Q54104948
Enhancement of daunorubicin accumulation, retention, and cytotoxicity by verapamil or cyclosporin A in blast cells from patients with previously untreated acute myeloid leukemia.Q54233564
Parallel phase I studies of daunorubicin given with cytarabine and etoposide with or without the multidrug resistance modulator PSC-833 in previously untreated patients 60 years of age or older with acute myeloid leukemia: results of cancer and leukQ73181830
Acute myeloid leukemia in the elderly: assessment of multidrug resistance (MDR1) and cytogenetics distinguishes biologic subgroups with remarkably distinct responses to standard chemotherapy. A Southwest Oncology Group studyQ73292530
Frequency and clinical significance of the expression of the multidrug resistance proteins MDR1/P-glycoprotein, MRP1, and LRP in acute myeloid leukemia: a Southwest Oncology Group StudyQ78039803
Influence of genetic polymorphisms in CYP3A4, CYP3A5, GSTP1, GSTM1, GSTT1 and MDR1 genes on survival and therapy-related toxicity in multiple myelomaQ79765272
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectleukemiaQ29496
cytarabineQ180983
cyclosporineQ367700
daunorubicinQ411659
P304page(s)48-58
P577publication date2009-10-11
P1433published inBritish Journal of HaematologyQ4970200
P1476titleSequential phase II Southwest Oncology Group studies (S0112 and S0301) of daunorubicin and cytarabine by continuous infusion, without and with ciclosporin, in older patients with previously untreated acute myeloid leukaemia
P478volume148