Infralimbic D2 Receptors Are Necessary for Fear Extinction and Extinction-Related Tone Responses

scientific article published on December 1, 2010

Infralimbic D2 Receptors Are Necessary for Fear Extinction and Extinction-Related Tone Responses is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BIOPSYCH.2010.08.014
P953full work available at URLhttps://europepmc.org/articles/pmc2981677?pdf=render
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20926066/pdf/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20926066/?tool=EBI
https://europepmc.org/articles/PMC2981677
https://europepmc.org/articles/PMC2981677?pdf=render
https://api.elsevier.com/content/article/PII:S0006322310008498?httpAccept=text/xml
https://doi.org/10.1016/j.biopsych.2010.08.014
https://api.elsevier.com/content/article/PII:S0006322310008498?httpAccept=text/plain
P932PMC publication ID2981677
P698PubMed publication ID20926066
P5875ResearchGate publication ID47356906

P50authorDevin MuellerQ50744429
P2093author name stringChristian Bravo-Rivera
Gregory J. Quirk
P2860cites workAn Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behaviorQ24310712
Distinct functions of the two isoforms of dopamine D2 receptorsQ28138415
The role of ventromedial prefrontal cortex in the recovery of extinguished fearQ28143094
Systemic blockade of D2-like dopamine receptors facilitates extinction of conditioned fear in miceQ28265467
Prefrontal dopamine D4 receptors are involved in encoding fear extinctionQ28574273
A subpopulation of neurons in the medial prefrontal cortex encodes emotional learning with burst and frequency codes through a dopamine D4 receptor-dependent basolateral amygdala inputQ28581654
Neurons in medial prefrontal cortex signal memory for fear extinctionQ29619996
A role for dopamine D2 receptors in reversal learningQ33865602
Inhibition of amygdaloid dopamine D2 receptors impairs emotional learning measured with fear-potentiated startleQ33943186
Prefrontocortical dopamine loss in rats delays long-term extinction of contextual conditioned fear, and reduces social interaction without affecting short-term social interaction memoryQ34182918
Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic DrugsQ34192438
Dopamine receptor signalingQ34364279
Activation of orbital and medial prefrontal cortex by methylphenidate in cocaine-addicted subjects but not in controls: relevance to addiction.Q34411360
Antipsychotic drug doses and neuroleptic/dopamine receptorsQ34455159
Haloperidol-induced catalepsy is mediated by postsynaptic dopamine receptorsQ34716127
New vistas on amygdala networks in conditioned fearQ35814347
Brain mechanisms of fear extinction: historical perspectives on the contribution of prefrontal cortex.Q36368325
Extinction memory is impaired in schizophreniaQ37087825
Extending fear extinction beyond anxiety disordersQ42428580
Blockade of dopamine activity in the nucleus accumbens impairs learning extinction of conditioned fearQ43162606
Acute systemic blockade of D2 receptors does not accelerate the extinction of cocaine-associated place preferenceQ43274173
Atropine acts in the ventral striatum to reduce raclopride-induced catalepsy.Q43774232
Improved short-term spatial memory but impaired reversal learning following the dopamine D(2) agonist bromocriptine in human volunteers.Q43858315
A role for the prefrontal cortex in stress- and cocaine-induced reinstatement of cocaine seeking in ratsQ44222954
Selective D2 receptor actions on the functional circuitry of working memoryQ44757222
Consolidation of fear extinction requires protein synthesis in the medial prefrontal cortex.Q44950452
Multiple dopamine receptor subtypes in the medial prefrontal cortex of the rat regulate set-shiftingQ46597031
D1- and D2-receptor antagonists induce catalepsy via different efferent striatal pathways [corrected].Q46765227
Noradrenergic signaling in infralimbic cortex increases cell excitability and strengthens memory for fear extinctionQ46815741
Time course of extracellular catecholamine and glutamate levels in the rat medial prefrontal cortex during and after extinction of conditioned fearQ48090881
Stimulation of Medial Prefrontal Cortex Decreases the Responsiveness of Central Amygdala Output NeuronsQ48189814
Consolidation of fear extinction requires NMDA receptor-dependent bursting in the ventromedial prefrontal cortexQ48243061
Cellular distribution of dopamine D1 and D2 receptors in rat medial prefrontal cortexQ48270743
3[H]-Sulpiride labels mesolimbic non-dopaminergic sites that bind antidepressant drugsQ48435911
Prefrontal infusion of PD098059 immediately after fear extinction training blocks extinction-associated prefrontal synaptic plasticity and decreases prefrontal ERK2 phosphorylationQ48492519
Layer V neurons bear the majority of mRNAs encoding the five distinct dopamine receptor subtypes in the primate prefrontal cortexQ48574693
Fast spiking and regular spiking neural correlates of fear conditioning in the medial prefrontal cortex of the rat.Q48907072
Effects of raclopride on exploratory locomotor activity, treadmill locomotion, conditioned avoidance behaviour and catalepsy in rats: behavioural profile comparisons between raclopride, haloperidol and preclamolQ48960927
Dopamine D2 receptor occupancy predicts catalepsy and the suppression of conditioned avoidance response behavior in ratsQ50107145
The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat.Q50933545
Postextinction infusion of a mitogen-activated protein kinase inhibitor into the medial prefrontal cortex impairs memory of the extinction of conditioned fear.Q50990449
Electrical stimulation of medial prefrontal cortex reduces conditioned fear in a temporally specific manner.Q51002003
Predicting how equipotent doses of chlorpromazine, haloperidol, sulpiride, raclopride and clozapine reduce locomotor activity in miceQ73740499
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)1055-1060
P577publication date2010-12-01
P1433published inBiological PsychiatryQ4914961
P1476titleInfralimbic D2 receptors are necessary for fear extinction and extinction-related tone responses
Infralimbic D2 Receptors Are Necessary for Fear Extinction and Extinction-Related Tone Responses
P478volume68

Reverse relations

cites work (P2860)
Q55379557A dopaminergic switch for fear to safety transitions.
Q57177225A translational perspective on neural circuits of fear extinction: Current promises and challenges
Q27687716A unifying model of the role of the infralimbic cortex in extinction and habits
Q47867686Activation of Nigrostriatal Dopamine Neurons during Fear Extinction Prevents the Renewal of Fear
Q36696580Adolescent social defeat alters N-methyl-D-aspartic acid receptor expression and impairs fear learning in adulthood.
Q33650040Aripiprazole Facilitates Extinction of Conditioned Fear in Adolescent Rats.
Q37022479Bidirectional modulation of infralimbic dopamine D1 and D2 receptor activity regulates flexible reward seeking
Q64076507Cognitive Flexibility Training Improves Extinction Retention Memory and Enhances Cortical Dopamine With and Without Traumatic Stress Exposure
Q35564245Control Over Stress Accelerates Extinction of Drug Seeking Via Prefrontal Cortical Activation
Q35596773Could dopamine agonists aid in drug development for anorexia nervosa?
Q96235283Distinct signals in medial and lateral VTA dopamine neurons modulate fear extinction at different times
Q28302559Dopamine and extinction: a convergence of theory with fear and reward circuitry
Q59329146Dopamine neurons drive fear extinction learning by signaling the omission of expected aversive outcomes
Q57296787Dopamine signals related to appetitive and aversive events in paradigms that manipulate reward and avoidability
Q57459359Dopamine-dependent prefrontal reactivations explain long-term benefit of fear extinction
Q95831475Dopamine: from prediction error to psychotherapy
Q94591473Dopaminergic Plasticity in the Bilateral Hippocampus Following Threat Reversal in Humans
Q48435056Dopaminergic control of long-term depression/long-term potentiation threshold in prefrontal cortex.
Q42574346Empirical support for an involvement of the mesostriatal dopamine system in human fear extinction
Q37650463Enhancing dopaminergic signaling and histone acetylation promotes long-term rescue of deficient fear extinction.
Q47599749Escitalopram reversed the traumatic stress-induced depressed and anxiety-like symptoms but not the deficits of fear memory
Q30382252Exercise Augmentation of Exposure Therapy for PTSD: Rationale and Pilot Efficacy Data
Q48295554Facilitation of fear extinction by the 5-HT(1A) receptor agonist tandospirone: possible involvement of dopaminergic modulation
Q37156104Failure of neural responses to safety cues in schizophrenia
Q38777375Fear Memory
Q30459672Fear conditioning, synaptic plasticity and the amygdala: implications for posttraumatic stress disorder
Q28254365Fear extinction as a model for translational neuroscience: ten years of progress
Q36948897Fear extinction induces mGluR5-mediated synaptic and intrinsic plasticity in infralimbic neurons
Q27011901From the neurobiology of extinction to improved clinical treatments
Q37380077Going and stopping: dichotomies in behavioral control by the prefrontal cortex
Q35545600Highly differentiated cellular and circuit properties of infralimbic pyramidal neurons projecting to the periaqueductal gray and amygdala
Q35844331Human fear reconsolidation and allelic differences in serotonergic and dopaminergic genes
Q104509597Infralimbic cortical glutamate output is necessary for the neural and behavioral consequences of chronic stress
Q38652284Inhibition of serotonin transporters disrupts the enhancement of fear memory extinction by 3,4-methylenedioxymethamphetamine (MDMA).
Q40033873Involvement of Dopamine D1/D5 and D2 Receptors in Context-Dependent Extinction Learning and Memory Reinstatement
Q28396555Mechanisms to medicines: elucidating neural and molecular substrates of fear extinction to identify novel treatments for anxiety disorders
Q26767636Modulation of Fear Extinction by Stress, Stress Hormones and Estradiol: A Review
Q26853333Neural and cellular mechanisms of fear and extinction memory formation
Q33906630Neural structures mediating expression and extinction of platform-mediated avoidance.
Q64240028Neurochemical and molecular mechanisms underlying the retrieval-extinction effect
Q30377907Overexpression of Protein Kinase Mζ in the Prelimbic Cortex Enhances the Formation of Long-Term Fear Memory
Q27006437Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders
Q42113618Potent attenuation of context fear by extinction training contiguous with acquisition.
Q48090161Prefrontal Dopamine D1 and D2 Receptors Regulate Dissociable Aspects of Decision Making via Distinct Ventral Striatal and Amygdalar Circuits.
Q37656934Prefrontal Dopaminergic Mechanisms of Extinction in Adolescence Compared to Adulthood in Rats.
Q91793647Prefrontal circuits signaling active avoidance retrieval and extinction
Q33993616Prefrontal cortical regulation of fear learning
Q38102685Prefrontal dopamine and behavioral flexibility: shifting from an "inverted-U" toward a family of functions
Q48128790Ramelteon Improves Post-traumatic Stress Disorder-Like Behaviors Exhibited by Fatty Acid-Binding Protein 3 Null Mice.
Q33813007Regulation of Fear Extinction in the Basolateral Amygdala by Dopamine D2 Receptors Accompanied by Altered GluR1, GluR1-Ser845 and NR2B Levels
Q28273912Role of Dopamine 2 Receptor in Impaired Drug-Cue Extinction in Adolescent Rats
Q30466738Seeking a spotless mind: extinction, deconsolidation, and erasure of fear memory
Q28292444Single dose of L-dopa makes extinction memories context-independent and prevents the return of fear
Q90493516Sleep Deprivation Disrupts Acquisition of Contextual Fear Extinction by Affecting Circadian Oscillation of Hippocampal-Infralimbic proBDNF
Q36023656The DA antagonist tiapride impairs context-related extinction learning in a novel context without affecting renewal
Q39490355The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory
Q64105408Therapeutic Challenges of Post-traumatic Stress Disorder: Focus on the Dopaminergic System

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